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2. Identifying Abnormal Exertional Breathlessness in COPD: Comparing Modified Medical Research Council and COPD Assessment Test With Cardiopulmonary Exercise Testing

Author

FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, Lewthwaite, Hayley, Bourbeau, Jean, and Tan, Wan C.

Published
2025
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3. Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial

Author

Belle-Isle, Jasmin, Nadeau, Jerome, Killorn, William, Francoeur, Bruno, Millaire, Emilie, Pek, Bonavuth, Ferguson, Murdo, Maltais, Francois, Killian, Kieran, Mazza, Giuseppe, Melenka, Lyle, Walker, Brandie, Bergeron, Celine, FitzGerald, John, Weinreich, Ulla Møller, Bendstrup, Elisabeth, Porsbjerg, Celeste, Ulrik, Charlotte, Titlestad, Ingrid, Meyer, Christian, Hilberg, Ole, Couturaud, Francis, Andrejak, Claire, Bourdin, Arnaud, Devouassoux, Gilles, Pepin, Jean-Louis, Chanez, Pascal, Cavailles, Arnaud, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Schultz, Thomas, Bar-Shai, Amir, Wand, Ori, Adir, Yochai, Berkman, Neville, Fink, Gershon, Shitrit, David, Izbicki, Gabriel, Raviv, Yael, Wielders, Pascal, Goosens, Martijn, Heller-Baan, Roxane, in't Veen, Johannes, Custers, Frank, Oh, Yeon-Mok, Lee, YongChul, Kim, Jaeyeol, Yoo, Kwang-Ha, Park, Jung-Won, Lee, Sang Haak, Ahn, Joong Hyun, Lee, Sook Young, Kim, Jin Woo, Lee, Kwan Ho, Caballero, Luis Mateos, Naval Sendra, Elsa, Ramos Barbón, David, Velasco Garrido, José Luis, Alcázar Navarrete, Bernardino, Saralaya, Dinesh, Crooks, Michael, Shah, Pallav, Chaudhuri, Rekha, de Soyza, Anthony, Nordstrom, Monica, Dwarakanath, Akshay, Weinstein, Steven, Pham, David, Mitchell, John, Spangenthal, Selwyn, Surdulescu, Sever, Denenberg, Michael, Alpizar, Sady, Maybee, David, Moriarty, Timothy, Fakih, Faisal, Beasley, Richard, Heuer, Marvin, Patel, Amit, Dorf, Jeffrey, Martinez, Rafael, Kureishy, Shahrukh, Klein, Ryan, Hewitt, Mitzie, Cole, Jeremy, Robinette, Emory, Cordasco, Edward, Garver, Robert, Criner, Gerard, Sciurba, Frank, Kerwin, Edward, Lucksinger, Gregg, Delgado, John, Russian, David, Chupp, Geoffrey, Singh, Dave, Brightling, Christopher E, Rabe, Klaus F, Han, MeiLan K, Christenson, Stephanie A, Drummond, M Bradley, Papi, Alberto, Pavord, Ian D, Molfino, Nestor A, Almqvist, Gun, Kotalik, Ales, Hellqvist, Åsa, Gołąbek, Monika, Sindhwani, Navreet S, and Ponnarambil, Sandhia S

Published
2025
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4. Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort

Author

Boumtje, Véronique, Manikpurage, Hasanga D., Li, Zhonglin, Gaudreault, Nathalie, Armero, Victoria Saavedra, Boudreau, Dominique K., Renaut, Sébastien, Henry, Cyndi, Racine, Christine, Eslami, Aida, Bougeard, Stéphanie, Vigneau, Evelyne, Morissette, Mathieu, Arsenault, Benoit J., Labbé, Catherine, Laliberté, Anne-Sophie, Martel, Simon, Maltais, François, Couture, Christian, Desmeules, Patrice, Mathieu, Patrick, Thériault, Sébastien, Joubert, Philippe, and Bossé, Yohan

Published
2024
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5. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, and Lewthwaite, Hayley

Published
2024
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8. Effects of Tiotropium/Olodaterol on Activity-Related Breathlessness, Exercise Endurance and Physical Activity in Patients with COPD: Narrative Review with Meta-/Pooled Analyses

Author

Maltais, François, de la Hoz, Alberto, Casaburi, Richard, and O’Donnell, Denis

Subjects
Behavioral and Social Science, Mind and Body, Lung, Chronic Obstructive Pulmonary Disease, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Respiratory, Adrenergic beta-2 Receptor Agonists, Benzoxazines, Bronchodilator Agents, Drug Combinations, Dyspnea, Exercise, Humans, Pulmonary Disease, Chronic Obstructive, Quality of Life, Tiotropium Bromide, Treatment Outcome, Clinical Research, Clinical Trials and Supportive Activities, Good Health and Well Being, Clinical Trials as Topic, Data Interpretation, Statistical, Disease Progression, Drug Therapy, Combination, Exercise Tolerance, Forced Expiratory Volume, Health Status Indicators, Severity of Illness Index, Surveys and Questionnaires, Breathlessness, Chronic obstructive pulmonary disease, Dyspnoea, Exercise endurance, Hyperinflation, Inspiratory capacity, Meta-analysis, Physical activity, Pooled analysis, Tiotropium/olodaterol, Pharmacology and Pharmaceutical Sciences, General Clinical Medicine
Abstract

One of the most debilitating symptoms of chronic obstructive pulmonary disease (COPD) is breathlessness, which leads to avoidance of physical activities in daily living and hastens clinical deterioration. Treatment of patients with COPD with inhaled long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) combination therapy improves airflow limitation, reduces breathlessness compared with LAMA or LABA monotherapies, and improves health status and quality of life. A large clinical trial programme focusing on the effects of tiotropium/olodaterol combination therapy demonstrated that this LAMA/LABA combination improves lung function and reduces hyperinflation (assessed by serial inspiratory capacity measurements) compared with either tiotropium alone or placebo in patients with COPD. Tiotropium/olodaterol also increases exercise endurance capacity and improves patient perception of the intensity of breathlessness compared with placebo. In this narrative review, we focus on the relationship between improving symptoms during activity, the ability to remain active in daily life and how this may impact quality of life. We consider the benefits of therapy optimisation by means of dual bronchodilation with tiotropium/olodaterol, and present new data from meta-analyses/pooled analyses showing that tiotropium/olodaterol improves inspiratory capacity compared with placebo and tiotropium and improves exercise endurance time compared with placebo after 6 weeks of treatment. We also discuss the importance of taking a holistic approach to improving physical activity, including pulmonary rehabilitation and exercise programmes in parallel with bronchodilator therapy and psychological programmes to support behaviour change.

Published
2021

10. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study

Author

FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Bourbeau, Jean, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candace, Krishnan, Suurya, Tan, Wan C., Farias, Raquel, and Aaron, Shawn D.

Published
2023
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11. Identifying Abnormal Exertional Breathlessness in COPD

Author

Ekström, Magnus, Lewthwaite, Hayley, Li, Pei Zhi, Bourbeau, Jean, Tan, Wan C., Jensen, Dennis, FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Song, Zhi, Benedetti, Andrea, Jensen, Dennis, Fortier, Yvan, Kirby, Miranda, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Mancino, Palmina, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Dumonceaux, Curtis, Machado, Lisette, Hernandez, Paul, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Aaron, Shawn, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Maltais, François, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, and Leuschen, Candice

Abstract

COPD management is guided by the respiratory symptom burden, assessed using the modified Medical Research Council (mMRC) scale, the COPD Assessment Test (CAT), or both.

Published
2025
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12. COPD: Providing the right treatment for the right patient at the right time

Author

Agusti, Alvar, Ambrosino, Nicolino, Blackstock, Felicity, Bourbeau, Jean, Casaburi, Richard, Celli, Bartolome, Criner, Gerard J., Crouch, Rebecca, Negro, Roberto W. Dal, Dreher, Michael, Garvey, Chris, Gerardi, Daniel A., Goldstein, Roger, Hanania, Nicola A., Holland, Anne E., Kaur, Antarpreet, Lareau, Suzanne, Lindenauer, Peter K., Mannino, David, Make, Barry, Maltais, François, Marciniuk, Jeffrey D., Meek, Paula, Morgan, Mike, Pepin, Jean-Louis, Reardon, Jane Z., Rochester, Carolyn L., Singh, Sally, Spruit, Martijn A., Steiner, Michael C., Troosters, Thierry, Vitacca, Michele, Clini, Enico, Jardim, Jose, Nici, Linda, Raskin, Jonathan, and ZuWallack, Richard

Published
2023
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13. Comparative measurement properties of constant work rate cycling and the endurance shuttle walking test in COPD: the TORRACTO® clinical trial

Author

Maltais, François, O’Donnell, Denis E, Hamilton, Alan, Zhao, Yihua, and Casaburi, Richard

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Clinical Trials and Supportive Activities, Clinical Research, Chronic Obstructive Pulmonary Disease, Lung, Respiratory, Adrenergic beta-2 Receptor Agonists, Aged, Benzoxazines, Bicycling, Bronchodilator Agents, Cholinergic Antagonists, Double-Blind Method, Drug Combinations, Exercise Test, Exercise Tolerance, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Pulmonary Disease, Chronic Obstructive, Recovery of Function, Reproducibility of Results, Time Factors, Tiotropium Bromide, Treatment Outcome, Walk Test, clinical trials, COPD pharmacology, exercise, exercise testing, physical activity, Respiratory System
Abstract

BackgroundExercise tolerance is an important endpoint in chronic obstructive pulmonary disease (COPD) clinical trials. Little is known about the comparative measurement properties of constant work rate cycle ergometry (CWRCE) and the endurance shuttle walking test (ESWT). The objective of this sub-analysis of the TORRACTO® study was to directly compare the endurance measurement properties of CWRCE and ESWT in patients with COPD in a multicentre, multinational setting. We predicted that both tests would be similarly reliable, but that the ESWT would be more responsive to bronchodilation than CWRCE.MethodsThis analysis included 151 patients who performed CWRCE and ESWT at baseline and week 6 after receiving once-daily placebo, tiotropium/olodaterol (T/O) 2.5/5 μg or T/O 5/5 μg. Reproducibility was assessed by comparing their respective performance at baseline and week 6 in the placebo group. Responsiveness to bronchodilation was assessed by comparing endurance time at week 6 with T/O with baseline values and placebo. The locus of symptom limitation and end-exercise Borg scales for breathing and leg discomfort for both tests were also analysed.ResultsThe intraclass correlation coefficients for CWRCE and ESWT were 0.56 [95% confidence interval (CI) 0.37-0.71] and 0.75 (95% CI 0.63-0.84). More patients were limited by breathing discomfort during the ESWT than during CWRCE, whereas more patients were limited by leg discomfort or breathing/leg discomfort during CWRCE than the ESWT (p

Published
2020

14. Impaired Sleep Quality in COPD Is Associated With Exacerbations The CanCOLD Cohort Study

Author

Shorofsky, Matthew, Bourbeau, Jean, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Tan, Wan C, Aaron, Shawn D, Sin, Don D, Road, Jeremy, Chapman, Kenneth R, O’Donnell, Denis E, Maltais, François, Hernandez, Paul, Walker, Brandie L, Marciniuk, Darcy, Kaminska, Marta, FitzGerald, J Mark, Sin, DD, Marciniuk, DD, O'Donnell, DE, Cowie, Robert, Aaron, Shawn, Maltais, F, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C, Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, and Clemens, Ron

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Prevention, Chronic Obstructive Pulmonary Disease, Lung, Sleep Research, Clinical Research, 6.1 Pharmaceuticals, Respiratory, Aged, Cohort Studies, Disease Progression, Dyspnea, Female, Health Services, Humans, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Sleep, Sleep Wake Disorders, Sputum, Time Factors, acute exacerbation of chronic bronchitis, COPD, sleep medicine, Canadian Respiratory Research Network, CanCOLD Collaborative Research group, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundCOPD increases susceptibility to sleep disturbances, which may in turn predispose to increased respiratory symptoms. The objective of this study was to evaluate, in a population-based sample, the relationship between subjective sleep quality and risk of COPD exacerbations.MethodsData were obtained from the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Participants with COPD who had completed 18 months of follow-up were included. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and a three-factor analysis. Symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) exacerbations were assessed. Association of PSQI with exacerbation rate was assessed by using negative binomial regression. Exacerbation-free survival was also assessed.ResultsA total of 480 participants with COPD were studied, including 185 with one or more exacerbations during follow-up and 203 with poor baseline sleep quality (PSQI score > 5). Participants with subsequent symptom-based exacerbations had higher median baseline PSQI scores than those without (6.0 [interquartile range, 3.0-8.0] vs 5.0 [interquartile range, 2.0-7.0]; P = .01), and they were more likely to have baseline PSQI scores > 5 (50.3% vs 37.3%; P = .01). Higher PSQI scores were associated with increased symptom-based exacerbation risk (adjusted rate ratio, 1.09; 95% CI, 1.01-1.18; P = .02) and event-based exacerbation risk (adjusted rate ratio, 1.10; 95% CI, 1.00-1.21; P = .048). The association occurred mainly in those with undiagnosed COPD. Strongest associations were with Factor 3 (sleep disturbances and daytime dysfunction). Time to symptom-based exacerbation was shorter in participants with poor sleep quality (adjusted hazard ratio, 1.49; 95% CI, 1.09-2.03).ConclusionsHigher baseline PSQI scores were associated with increased risk of COPD exacerbation over 18 months' prospective follow-up.

Published
2019

17. Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author

Brusselle, Guy, Corhay, Jean-Louis, Janssens, Eduard, Janssens, Wim, Leys, Mathias, Ferguson, Murdo, Fitzgerald, Mark, Maltais, François, Mayers, Irvin, McNeil, Shelly, Pek, Bonavuth, Bourdin, Arnaud, Boyer, Laurent, Couturaud, Francis, Dussart, Luc, Andreas, Stefan, Illies, Gabriele, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Blasi, Francesco, Centanni, Stefano, Papi, Alberto, Pomari, Carlo, Echave-Sustaeta, José Maria, Llorca Martínez, Eleuterio, Narejos Pérez, Silvia, Pascual-Guardia, Sergi, Pérez Vera, Mercè, Puente-Maestu, Luis, Terns Riera, Manuel, Anderson, William, Choudhury, Gourab, De-Soyza, Anthony, Saralaya, Dinesh, Wilkinson, Tom MA, Boscia III, Joseph, Chinsky, Kenneth, Dunn, Leonard, Erb, David, Fogarty, Charles, Downey, Herman Jackson, Kerwin, Edward, Kunz, Craig, Poling, Terry, Sellman, Richard, Sigal, Barry, Southard, John, Spangenthal, Selwyn, Tannous, Ziad, Testa, Marco, Casula, Daniela, Di Maro, Gennaro, Lattanzi, Maria, Moraschini, Luca, Schoonbroodt, Sonia, Tasciotti, Annaelisa, Arora, Ashwani K, and Wilkinson, Tom M A

Published
2022
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18. Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD: A Randomized, Placebo-Controlled, Crossover Trial

Author

Aaron, Shawn, Martin, James, Paré, Peter, Hogg, James, Carlsten, Christopher, Leipsic, Jonathon, Sin, Don, Tan, Wan, Guenette, Jordan, FitzGerald, Mark, Coxson, Harvey, Sadatsafavi, Mohsen, Marra, Carlo, Mayo, John, Proud, David, Leigh, Richard, Kozyrskyj, Anita, Quail, Jacqueline, Halayko, Andrew, Brownell, Marni, Parraga, Grace, Nair, Parameswaran, Stampfli, Martin, O’Byrne, Paul, Gupta, Samir, Zamel, Noe, Ratjen, Felix, Brooks, Dina, Gershon, Andrea, To, Teresa, Ungar, Wendy, Lougheed, Diane, O’Donnell, Denis, Thebaud, Bernard, Pakhale, Smita, Fergusson, Dean, Graham, Ian, Grimshaw, Jeremy, Vandemheen, Katherine, Van Dam, Anne, Benedetti, Andrea, Bourbeau, Jean, Lands, Larry, Jensen, Dennis, Landry, Jennifer, Blais, Lucie, Ducharme, Francine, Lemière, Catherine, Nuyt, Anne-Monique, Bossé, Yohan, Boulet, Louis-Philippe, Maltais, Francois, Doucet, Marieve, Hernandez, Paul, Syed, Nafeez, Ryu, Min Hyung, Dhillon, Satvir, Schaeffer, Michele R., Ramsook, Andrew H., Leung, Janice M., Ryerson, Christopher J., and Guenette, Jordan A.

Published
2022
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19. Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Junior, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Shorofsky, Matthew, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Aaron, Shawn D., Sin, Don D., O’Donnell, Denis E., Maltais, François, Walker, Brandie L., and Kaminska, Marta

Published
2019
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20. Effect of 12 weeks of once-daily tiotropium/olodaterol on exercise endurance during constant work-rate cycling and endurance shuttle walking in chronic obstructive pulmonary disease

Author

Maltais, François, O’Donnell, Denis, Iturri, Juan Bautista Gáldiz, Kirsten, Anne-Marie, Singh, Dave, Hamilton, Alan, Tetzlaff, Kay, Zhao, Yihua, and Casaburi, Richard

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Clinical Trials and Supportive Activities, Clinical Research, Chronic Obstructive Pulmonary Disease, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Respiratory, Administration, Inhalation, Adrenergic beta-2 Receptor Agonists, Adult, Aged, Benzoxazines, Bicycling, Bronchodilator Agents, Cholinergic Antagonists, Double-Blind Method, Drug Administration Schedule, Drug Combinations, Exercise Tolerance, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Recovery of Function, Time Factors, Tiotropium Bromide, Treatment Outcome, Vital Capacity, Walking, bronchodilator, constant work-rate cycling, COPD, endurance shuttle walking, olodaterol, tiotropium, Respiratory System
Abstract

BACKGROUND:The TORRACTO® study evaluated the effects of tiotropium/olodaterol versus placebo on endurance time during constant work-rate cycling and constant speed shuttle walking in patients with chronic obstructive pulmonary disease (COPD) after 12 weeks of treatment. METHODS:The effects of once-daily tiotropium/olodaterol (2.5/5 and 5/5 μg) on endurance time during constant work-rate cycle ergometry (CWRCE) after 6 and 12 weeks of treatment were compared with placebo in patients with COPD in a randomized, double-blind, placebo-controlled, parallel-group clinical trial. Endurance time during the endurance shuttle walk test (ESWT) after 6 and 12 weeks of treatment was also evaluated in a subset of patients. RESULTS:A total of 404 patients received treatment, with 165 participating in the ESWT substudy. A statistically significant improvement in endurance time during CWRCE was observed after 12 weeks (primary endpoint) with tiotropium/olodaterol 5/5 µg [14% ( p = 0.02)] but not with tiotropium/olodaterol 2.5/5 µg [9% ( p = 0.14)] versus placebo. In the ESWT substudy, a trend to improvement in endurance time during ESWT after 12 weeks (key secondary endpoint) was observed with tiotropium/olodaterol 5/5 µg [21% ( p = 0.055)] and tiotropium/olodaterol 2.5/5 µg [21% ( p = 0.056)] versus placebo. CONCLUSION:Tiotropium/olodaterol 5/5 µg improved endurance time during cycle ergometry versus placebo, with a strong tendency to also improve walking endurance time. [ ClinicalTrials.gov identifier: NCT01525615.].

Published
2018

22. Effects of combined tiotropium/olodaterol on inspiratory capacity and exercise endurance in COPD.

Author

O'Donnell, Denis E, Casaburi, Richard, Frith, Peter, Kirsten, Anne, De Sousa, Dorothy, Hamilton, Alan, Xue, Wenqiong, and Maltais, François

Subjects
Humans, Pulmonary Disease, Chronic Obstructive, Benzoxazines, Bronchodilator Agents, Drug Combinations, Inspiratory Capacity, Forced Expiratory Volume, Cross-Over Studies, Double-Blind Method, Nebulizers and Vaporizers, Exercise Tolerance, Adult, Aged, Middle Aged, Female, Male, Tiotropium Bromide, Pulmonary Disease, Chronic Obstructive, Respiratory System, Medical and Health Sciences
Abstract

Two replicate, double-blind, 6-week, incomplete-crossover studies (MORACTO 1 and 2) assessed the effects of tiotropium/olodaterol on inspiratory capacity and exercise endurance time in patients with moderate to severe chronic obstructive pulmonary disease.For each patient, four of five treatments were administered once daily for 6 weeks, with a 21-day washout between treatments: tiotropium/olodaterol 2.5/5 µg or 5/5 µg, tiotropium 5 µg, olodaterol 5 µg or placebo, all via the Respimat inhaler. Primary outcomes were inspiratory capacity prior to exercise and exercise endurance time during constant work-rate cycle ergometry to symptom limitation at 75% of peak incremental work rate after 6 weeks (2 h post-dose).295 and 291 patients were treated in MORACTO 1 and 2, respectively. Tiotropium/olodaterol 2.5/5 and 5/5 µg provided significant improvements in inspiratory capacity versus placebo and monotherapies (p

Published
2017

26. Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis

Author

Aaron, Shawn, Martin, James, Paré, Peter, Hogg, James, Carlsten, Christopher, Leipsic, Jonathon, Sin, Don, Tan, Wan, Guenette, Jordan, FitzGerald, Mark, Coxson, Harvey, Sadatsafavi, Mohsen, Marra, Carlo, Mayo, John, Proud, David, Leigh, Richard, Kozyrskyj, Anita, Quail, Jacqueline, Halayko, Andrew, Brownell, Marni, Parraga, Grace, Nair, Parameswaran, Stampfli, Martin, O’Byrne, Paul, Gupta, Samir, Zamel, Noe, Ratjen, Felix, Brooks, Dina, Gershon, Andrea, To, Teresa, Ungar, Wendy, Lougheed, Diane, O’Donnell, Denis, Thebaud, Bernard, Pakhale, Smita, Fergusson, Dean, Graham, Ian, Grimshaw, Jeremy, Vandemheen, Katherine, Van Dam, Anne, Benedetti, Andrea, Bourbeau, Jean, Lands, Larry, Jensen, Dennis, Landry, Jennifer, Blais, Lucie, Ducharme, Francine, Lemière, Catherine, Nuyt, Anne-Monique, Bossé, Yohan, Boulet, Louis-Philippe, Maltais, Francois, Doucet, Marieve, Hernandez, Paul, Selvanathan, Janannii, Aaron, Shawn D., Sykes, Jenna R., Vandemheen, Katherine L., FitzGerald, J. Mark, Ainslie, Martha, Field, Stephen K., McIvor, R. Andrew, Mayers, Irvin, Mulpuru, Sunita, Alvarez, Gonzalo G., and Mallick, Ranjeeta

Published
2020
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29. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement

Author

Puente-Maestu, Luis, Palange, Paolo, Casaburi, Richard, Laveneziana, Pierantonio, Maltais, François, Neder, J Alberto, O'Donnell, Denis E, Onorati, Paolo, Porszasz, Janos, Rabinovich, Roberto, Rossiter, Harry B, Singh, Sally, Troosters, Thierry, and Ward, Susan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Respiratory, Advisory Committees, Breath Tests, Carbon Dioxide, Dyspnea, Europe, Exercise Test, Exercise Tolerance, Humans, Hypertension, Pulmonary, Inspiratory Capacity, Outcome Assessment, Health Care, Oxygen Consumption, Pulmonary Disease, Chronic Obstructive, Pulmonary Medicine, Pulmonary Ventilation, Reproducibility of Results, Respiratory Tract Diseases, Societies, Medical, Walking, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology
Abstract

This document reviews 1) the measurement properties of commonly used exercise tests in patients with chronic respiratory diseases and 2) published studies on their utilty and/or evaluation obtained from MEDLINE and Cochrane Library searches between 1990 and March 2015.Exercise tests are reliable and consistently responsive to rehabilitative and pharmacological interventions. Thresholds for clinically important changes in performance are available for several tests. In pulmonary arterial hypertension, the 6-min walk test (6MWT), peak oxygen uptake and ventilation/carbon dioxide output indices appear to be the variables most responsive to vasodilators. While bronchodilators do not always show clinically relevant effects in chronic obstructive pulmonary disease, high-intensity constant work-rate (endurance) tests (CWRET) are considerably more responsive than incremental exercise tests and 6MWTs. High-intensity CWRETs need to be standardised to reduce interindividual variability. Additional physiological information and responsiveness can be obtained from isotime measurements, particularly of inspiratory capacity and dyspnoea. Less evidence is available for the endurance shuttle walk test. Although the incremental shuttle walk test and 6MWT are reliable and less expensive than cardiopulmonary exercise testing, two repetitions are needed at baseline. All exercise tests are safe when recommended precautions are followed, with evidence suggesting that no test is safer than others.

Published
2016

32. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Haynes, Nancy, Chuang, Junior, Zheng, Liyun, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Gupta, Nisha, Pinto, Lancelot, Li, Pei Zhi, Aaron, Shawn D., Marciniuk, Darcy D., Maltais, François, O'Donnell, Denis E., and Walker, Brandie L.

Published
2016
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35. Haemodynamic compensations for exercise tissue oxygenation in early stages of COPD: an integrated cardiorespiratory assessment study

Author

Richard, Ruddy, primary, Jensen, Dennis, additional, Touron, Julianne, additional, Frederic, Costes, additional, Mulliez, Aurélien, additional, Pereira, Bruno, additional, Filaire, Laura, additional, Marciniuk, Darcy, additional, Maltais, François, additional, Tan, Wan, additional, Bourbeau, Jean, additional, and Perrault, Hélène, additional

Published
2024
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36. Airway tree caliber heterogeneity and airflow obstruction among older adults

Author

Vameghestahbanati, Motahareh, primary, Kingdom, Leina, additional, Hoffman, Eric A., additional, Kirby, Miranda, additional, Allen, Norrina B., additional, Angelini, Elsa, additional, Bertoni, Alain, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Jacobs, David R., additional, Laine, Andrew, additional, Maltais, François, additional, Michos, Erin D., additional, Sack, Coralynn, additional, Sin, Don, additional, Watson, Karol E., additional, Wysoczanksi, Artur, additional, Couper, David, additional, Cooper, Christopher, additional, Han, MeiLan, additional, Woodruff, Prescott, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, Barr, R. Graham, additional, and Smith, Benjamin M., additional

Published
2024
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37. Assessing functional capacity in directly and remotely monitored home-based settings in individuals with chronic respiratory diseases: A protocol for a multinational validation study (Preprint)

Author

Bass, Alec, primary, Géphine, Sarah, additional, Martin, Mickaël, additional, Belley, Marianne, additional, Robic, Manon, additional, Fabre, Claudine, additional, Grosbois, Jean-Marie, additional, Dion, Geneviève, additional, Saey, Didier, additional, Chambellan, Arnaud, additional, and Maltais, François, additional

Published
2024
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38. Assessing functional capacity in directly and remotely monitored home-based settings: A protocol for a multinational validation study in individuals with chronic respiratory diseases (Preprint)

Author

Bass, Alec, primary, Géphine, Sarah, additional, Martin, Mickaël, additional, Belley, Marianne, additional, Robic, Manon, additional, Fabre, Claudine, additional, Grosbois, Jean-Marie, additional, Dion, Geneviève, additional, Saey, Didier, additional, Chambellan, Arnaud, additional, and Maltais, François, additional

Published
2024
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39. Normative Reference Equations for Breathlessness Intensity during Incremental Cardiopulmonary Cycle Exercise Testing

Author

Ekström, Magnus, primary, Li, Pei Zhi, additional, Lewthwaite, Hayley, additional, Bourbeau, Jean, additional, Tan, Wan C., additional, Schiöler, Linus, additional, Brotto, Andrew, additional, Stickland, Michael K., additional, Jensen, Dennis, additional, FitzGerald, J. Mark, additional, Sin, Don D., additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Aaron, Shawn, additional, Maltais, François, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Doiron, Dany, additional, Mancino, Palmina, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Benedetti, Andrea, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2024
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42. Clinical Implementation of Automated Oxygen Titration in a Tertiary Care Hospital.

Author

Bouchard, Pierre-Alexandre, Parent-Racine, Geneviève, Paradis-Gagnon, Cassiopée, Simon, Mathieu, Lacasse, Yves, Lellouche, François, and Maltais, François

Subjects
OXYGEN therapy equipment, CONTINUING education units, OXYGEN saturation, HUMAN services programs, RESEARCH funding, PATIENTS, STATISTICAL hypothesis testing, RESPIRATORY insufficiency, HOSPITAL admission & discharge, SCIENTIFIC observation, FISHER exact test, TERTIARY care, DESCRIPTIVE statistics, MANN Whitney U Test, LONGITUDINAL method, COMMERCIAL product evaluation, CLINICAL deterioration, INTENSIVE care units, NASAL cannula, ONE-way analysis of variance, VENTILATOR weaning, AUTOMATION, HOSPITAL health promotion programs, HYPEROXIA, DATA analysis software, LENGTH of stay in hospitals, HYPOXEMIA, HEALTH care teams
Abstract

BACKGROUND: When treating acute respiratory failure, both hypoxemia and hyperoxemia should be avoided. ... should be monitored closely and O2 flows adjusted accordingly. Achieving this goal might be easier with automated O2 titration compared with manual titration of fixed-flow O2. We evaluated the feasibility of using an automated O2 titration device in subjects treated for acute hypoxemic respiratory failure in a tertiary care hospital. METHODS: Health-care workers received education and training about oxygen therapy, and were familiarized with an automated O2 titration device (FreeO2,). A coordinator was available from 8:00 AM to 5:00 PM during weekdays to provide technical assistance. The ability of the device to maintain ... within the prescribed therapeutic window was recorded. Basic clinical information was recorded. RESULTS: Subjects were enrolled from November 2020 to August 2022. We trained 508 health-care workers on the use of automated O2 titration, which was finally used on 872 occasions in 763 subjects, distributed on the respiratory, COVID-19, and thoracic surgery wards, and in the emergency department. Clinical information could be retrieved for 609 subjects (80%) who were on the system for a median (interquartile range) of 3 (2-6) d, which represented 2,567 subject-days of clinical experience with the device. In the 82 subjects (14%) for whom this information was available, the system maintained ... within the prescribed targets 89% of the time. Ninety-six subjects experienced clinical deterioration as defined by the need to be transferred to the ICU and/or requirement of high flow nasal oxygen but none of these events were judged to be related to the O2 device. CONCLUSIONS: Automated O2 titration could be successfully implemented in hospitalized subjects with hypoxemic respiratory failure from various causes. This experience should foster further improvement of the device and recommendations for an optimized utilization. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Peripheral muscles

Author

Puente-Maestu, Luis, primary, Maltais, François, additional, Nyberg, André, additional, and Saey, Didier, additional

Published
2020
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45. Assessment of Limb Muscle Function

Author

Rabinovich, Roberto A., Bui, Kim-Ly, Nyberg, André, Saey, Didier, Maltais, François, Clini, Enrico, editor, Holland, Anne E., editor, Pitta, Fabio, editor, and Troosters, Thierry, editor

Published
2018
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47. Incorporating telemedicine into the integrated care of the COPD patient a summary of an interdisciplinary workshop held in Stresa, Italy, 7–8 September 2017

Author

Donner, Claudio F., Raskin, Jonathan, ZuWallack, Richard, Nici, Linda, Ambrosino, Nicolino, Balbi, Bruno, Blackstock, Felicity, Casaburi, Richard, Dreher, Michael, Effing, Tanja, Goldstein, Roger, Krishnan, Jerry, Lareau, Suzanne C., Make, Barry J., Maltais, Francois, Meek, Paula, Morgan, Michael, Pépin, Jean-Louis, Rabbito, Chiara, Rochester, Carolyn L., Silverman, Adam R., Singh, Sally, Spruit, Martijn A., Vitacca, Michele, and Williams, Loreen

Published
2018
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