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4. Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

Author

Wygrecka, Malgorzata, Birnhuber, Anna, Seeliger, Benjamin, Michalick, Laura, Pak, Oleg, Schultz, Astrid-Solveig, Schramm, Fabian, Zacharias, Martin, Gorkiewicz, Gregor, David, Sascha, Welte, Tobias, Schmidt, Julius J., Weissmann, Norbert, Schermuly, Ralph T., Barreto, Guillermo, Schaefer, Liliana, Markart, Philipp, Brack, Markus C., Hippenstiel, Stefan, Kurth, Florian, Sander, Leif E., Witzenrath, Martin, Kuebler, Wolfgang M., Kwapiszewska, Grazyna, and Preissner, Klaus T.

Published
2022
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5. Disease trajectories in interstitial lung diseases – data from the EXCITING-ILD registry

Author

Buschulte, Katharina, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Höffgen, Marc, additional, Maqhuzu, Phillen, additional, Schwarzkopf, Larissa, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Jürgen, additional, Karpavicius, Rainer, additional, Günther, Andreas, additional, Polke, Markus, additional, Höger, Philipp, additional, Somogyi, Vivien, additional, Lederer, Christoph, additional, Markart, Philipp, additional, and Kreuter, Michael, additional

Published
2024
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6. Hospitalisation patterns in interstitial lung diseases: data from the EXCITING-ILD registry

Author

Buschulte, Katharina, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Höffgen, Marc, additional, Maqhuzu, Phillen, additional, Schwarzkopf, Larissa, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Jürgen, additional, Karpavicius, Rainer, additional, Günther, Andreas, additional, Polke, Markus, additional, Höger, Philipp, additional, Somogyi, Vivien, additional, Lederer, Christoph, additional, Markart, Philipp, additional, and Kreuter, Michael, additional

Published
2024
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11. Covid-19 triage in the emergency department 2.0: how analytics and AI transform a human-made algorithm for the prediction of clinical pathways

Author

Bartenschlager, Christina C., Grieger, Milena, Erber, Johanna, Neidel, Tobias, Borgmann, Stefan, Vehreschild, Jörg J., Steinbrecher, Markus, Rieg, Siegbert, Stecher, Melanie, Dhillon, Christine, Ruethrich, Maria M., Jakob, Carolin E. M., Hower, Martin, Heller, Axel R., Vehreschild, Maria, Wyen, Christoph, Messmann, Helmut, Piepel, Christiane, Brunner, Jens O., Hanses, Frank, Römmele, Christoph, Spinner, Christoph, Ruethrich, Maria Madeleine, Lanznaster, Julia, Wille, Kai, Tometten, Lukas, Dolff, Sebastian, von Bergwelt-Baildon, Michael, Merle, Uta, Rothfuss, Katja, Isberner, Nora, Jung, Norma, Göpel, Siri, vom Dahl, Juergen, Degenhardt, Christian, Strauss, Richard, Gruener, Beate, Eberwein, Lukas, Hellwig, Kerstin, Rauschning, Dominic, Neufang, Mark, Westhoff, Timm, Raichle, Claudia, Akova, Murat, Jensen, Bjoern-Erik, Schubert, Joerg, Grunwald, Stephan, Friedrichs, Anette, Trauth, Janina, de With, Katja, Guggemos, Wolfgang, Kielstein, Jan, Heigener, David, Markart, Philipp, Bals, Robert, Stieglitz, Sven, Voigt, Ingo, Taubel, Jorg, and Milovanovic, Milena

Subjects
ddc:610
Abstract

The Covid-19 pandemic has pushed many hospitals to their capacity limits. Therefore, a triage of patients has been discussed controversially primarily through an ethical perspective. The term triage contains many aspects such as urgency of treatment, severity of the disease and pre-existing conditions, access to critical care, or the classification of patients regarding subsequent clinical pathways starting from the emergency department. The determination of the pathways is important not only for patient care, but also for capacity planning in hospitals. We examine the performance of a human-made triage algorithm for clinical pathways which is considered a guideline for emergency departments in Germany based on a large multicenter dataset with over 4,000 European Covid-19 patients from the LEOSS registry. We find an accuracy of 28 percent and approximately 15 percent sensitivity for the ward class. The results serve as a benchmark for our extensions including an additional category of palliative care as a new label, analytics, AI, XAI, and interactive techniques. We find significant potential of analytics and AI in Covid-19 triage regarding accuracy, sensitivity, and other performance metrics whilst our interactive human-AI algorithm shows superior performance with approximately 73 percent accuracy and up to 76 percent sensitivity. The results are independent of the data preparation process regarding the imputation of missing values or grouping of comorbidities. In addition, we find that the consideration of an additional label palliative care does not improve the results.

Published
2023

12. Consensus guideline on the interdisciplinary diagnosis of interstitial lung diseases

Author

Kreuter, Michael, Behr, Jürgen, Bonella, Francesco, Costabel, Ulrich, Gerber, Alexander, Hamer, Okka W., Heussel, Claus Peter, Jonigk, Danny, Krause, Andreas, Koschel, Dirk, Leuschner, Gabriela, Markart, Philipp, Nowak, Dennis, Pfeifer, Michael, Wälscher, Julia, Prasse, Antje, Winter, Hauke, Kabitz, Hans-Joachim, and Publica

Subjects
Pulmonary and Respiratory Medicine, Medizin
Abstract

ZusammenfassungDie Beurteilung von Patienten mit v. a. einer interstitiellen Lungenerkrankung (ILD) umfasst die Beurteilung klinischer, radiologischer und oft histopathologischer Daten. Da bislang noch keine dezidierten Empfehlungen für die Evaluation bei Verdacht auf eine ILD in Deutschland existierten, war es Ziel dieses interdisziplinären Konsensusstatements, eine praktische Orientierungshilfe für den klinischen Alltag in Bezug auf die interdisziplinäre Diagnostik der ILDs zu geben. Dazu gehören die umfassende klinisch-pneumologische und in vielen Fällen auch eine rheumatologische Beurteilung, radiologische Diagnostik sowie Probenentnahme zur histopathologischen Evaluation sowie die abschließende Diskussion im multidisziplinären Team.

Published
2023

13. Erratum: Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury

Author

Wygrecka, Malgorzata, primary, Wujak, Lukasz, additional, Markart, Philipp, additional, Kosanovic, Djuro, additional, Müller-Redetzky, Holger C., additional, Witzenrath, Martin, additional, Henneke, Ingrid, additional, Schermuly, Ralph T., additional, Seeger, Werner, additional, Schaefer, Liliana, additional, Kwapiszewska, Grazyna, additional, Marsh, Leigh M., additional, Baal, Nelli, additional, Hackstein, Holger, additional, Maat, Steven de, additional, and Maas, Coen, additional

Published
2022
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16. Neurological symptoms and complications in predominantly hospitalized COVID-19 patients: Results of the European multinational Lean European Open Survey on SARS-Infected Patients (LEOSS)

Author

Kleineberg, Nina N., Knauss, Samuel, Gülke, Eileen, Pinnschmidt, Hans O., Jakob, Carolin E. M., Lingor, Paul, Hellwig, Kerstin, Berthele, Achim, Höglinger, Günter, Fink, Gereon R., Endres, Matthias, Gerloff, Christian, Klein, Christine, Stecher, Melanie, Classen, Annika Y., Rieg, Siegbert, Borgmann, Stefan, Hanses, Frank, Haselberger, Martina, Merle, Uta, Dolff, Sebastian, Degenhardt, Christian, Jensen, Björn-Erik O., Vehreschild, Maria J. G. T., Erber, Johanna, Franke, Christiana, Warnke, Clemens, Spinner, Christoph, Lanzster, Julia, Jensen, Björn, Vehreschild, Maria, Hower, Martin, Rüthrich, Maria Madeleine, Rothfuss, Katja, Piepel, Christiane, Wyen, Christopf, Römmele, Christoph, Eberwein, Lukas, Käding, Kadja, Wille, Kai, Haake, Hendrik, Voigt, Ingo, Tometten, Lukas, Neufang, Mark, Jung, Norma, Schultheis, Beate, Raichle, Claudia, von Bergwelt-Baildon, Michael, Göpel, Siri, Strauß, Richard, Rauschning, Dominic, Isberner, Nora, Walter, Lorenz, Milovanovic, Mile, D'Hooghe, Marie, Grunwald, Stephan, Akova, Murat, Markart, Philipp, Grüner, Beate, Kielstein, Jan, Guggemos, Wolfgang, Trauth, Janina, Heigener, David, Beutel, Gernot, Gramatniece, Alise, de With, Katja, Bals, Robert, Friedrichs, Anette, Röseler, Stefani, Müller-Jörger, Gabriele, Ritter, Annika, Vehreschild, Jörg Janne, Pilgram, Lisa, Schons, Max, de Miranda, Susana Nunes, Schulze, Nick, Fuhrmann, Sandra, Claßen, Annika, Franke, Bernd, Praßer, Fabian, Lablans, Martin, and LEOSS Study Group

Subjects
medicine.medical_specialty, Nausea, medicine.medical_treatment, Medizin, Disease, SARS‐CoV‐2, COVID‐19, Internal medicine, medicine, Extracorporeal membrane oxygenation, Humans, Clinical significance, ddc:610, Stroke, business.industry, SARS-CoV-2, Headache, COVID-19, Neurodegenerative Diseases, Odds ratio, Original Articles, medicine.disease, Neurology, neurological manifestations, Delirium, Original Article, Neurology (clinical), medicine.symptom, Complication, business
Abstract

Background and purpose During acute coronavirus disease 2019 (COVID‐19) infection, neurological signs, symptoms and complications occur. We aimed to assess their clinical relevance by evaluating real‐world data from a multinational registry. Methods We analyzed COVID‐19 patients from 127 centers, diagnosed between January 2020 and February 2021, and registered in the European multinational LEOSS (Lean European Open Survey on SARS‐Infected Patients) registry. The effects of prior neurological diseases and the effect of neurological symptoms on outcome were studied using multivariate logistic regression. Results A total of 6537 COVID‐19 patients (97.7% PCR‐confirmed) were analyzed, of whom 92.1% were hospitalized and 14.7% died. Commonly, excessive tiredness (28.0%), headache (18.5%), nausea/emesis (16.6%), muscular weakness (17.0%), impaired sense of smell (9.0%) and taste (12.8%), and delirium (6.7%) were reported. In patients with a complicated or critical disease course (53%) the most frequent neurological complications were ischemic stroke (1.0%) and intracerebral bleeding (ICB; 2.2%). ICB peaked in the critical disease phase (5%) and was associated with the administration of anticoagulation and extracorporeal membrane oxygenation (ECMO). Excessive tiredness (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.20–1.68) and prior neurodegenerative diseases (OR 1.32, 95% CI 1.07–1.63) were associated with an increased risk of an unfavorable outcome. Prior cerebrovascular and neuroimmunological diseases were not associated with an unfavorable short‐term outcome of COVID‐19. Conclusion Our data on mostly hospitalized COVID‐19 patients show that excessive tiredness or prior neurodegenerative disease at first presentation increase the risk of an unfavorable short‐term outcome. ICB in critical COVID‐19 was associated with therapeutic interventions, such as anticoagulation and ECMO, and thus may be an indirect complication of a life‐threatening systemic viral infection., We retrospectively analyzed data from 6537 predominantly hospitalized COVID‐19 patients registered in the European multinational Lean European Open Survey on SARS‐Infected Patients (LEOSS) registry between January 2020 and February 2021. Common neurological symptoms were excessive tiredness (28.0%), headache (18.5%), nausea/emesis (16.6%), muscular weakness (17.0%), impaired sense of smell (9.0%) and taste (12.8%), and delirium (6.7%). Most frequent neurological complications were ischemic stroke (1.0%) and intracerebral bleeding (2.2%) in patients with a complicated or critical disease course. Excessive tiredness (odds ratio [OR] 1.42) and prior neurodegenerative disease (OR 1.32) were associated with an increased risk of an unfavorable outcome.

Published
2021

17. Altered fibrin clot structure contributes to thrombosis risk in severe COVID-19

Author

Wygrecka, Malgorzata, primary, Birnhuber, Anna, additional, Seeliger, Benjamin, additional, Michalick, Laura, additional, Pak, Oleg, additional, Schultz, Astrid-Solveig, additional, Schramm, Fabian, additional, Zacharias, Martin, additional, Gorkiewicz, Gregor, additional, David, Sascha, additional, Welte, Tobias, additional, Schmidt, Julius J., additional, Weissmann, Norbert, additional, Schermuly, Ralph T, additional, Barreto, Guillermo, additional, Schäfer, Liliana, additional, Markart, Philipp, additional, Brack, Markus C., additional, Hippenstiel, Stefan, additional, Kurth, Florian, additional, Sander, Leif E, additional, Witzenrath, Martin, additional, Kuebler, Wolfgang M., additional, Kwapiszewska, Grazyna, additional, and Preissner, Klaus T, additional

Published
2021
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18. Outcomes of patients with progressive fibrosing interstitial lung disease (PF-ILD) – data from a prospective ILD registry

Author

Kreuter, Michael, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Höffgen, Marc, additional, Maqhuzu, Phillen, additional, Schwarzkopf, Larisa, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Jürgen, additional, Karpavicius, Rainer, additional, Günther, Andreas, additional, Herth, Felix J. F., additional, and Markart, Philipp, additional

Published
2021
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22. S2K Guideline for Diagnosis of Idiopathic Pulmonary Fibrosis

Author

Behr, Jürgen, primary, Günther, Andreas, additional, Bonella, Francesco, additional, Dinkel, Julien, additional, Fink, Ludger, additional, Geiser, Thomas, additional, Geissler, Klaus, additional, Gläser, Sven, additional, Handzhiev, Sabin, additional, Jonigk, Danny, additional, Koschel, Dirk, additional, Kreuter, Michael, additional, Leuschner, Gabriela, additional, Markart, Philipp, additional, Prasse, Antje, additional, Schönfeld, Nicolas, additional, Schupp, Jonas Christian, additional, Sitter, Helmut, additional, Müller-Quernheim, Joachim, additional, and Costabel, Ulrich, additional

Published
2021
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23. Sex-specific Effect and Disconnect Between Plasma Levels of FXII and FXIIa-C1-esterase Inhibitor Complexes in Pneumonia

Author

Ehrlich, Kristin, primary, Wilhelm, Jochen, additional, Wolff, Jens-Christian, additional, Markart, Philipp, additional, Bein, Gregor, additional, Pak, Oleg, additional, Barreto, Guillermo, additional, Weissmann, Norbert, additional, Seeger, Werner, additional, Schaefer, Liliana, additional, Kuebler, Wolfgang, additional, and Wygrecka, Malgorzata, additional

Published
2020
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28. Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores

Author

Schnieder, Jennifer, primary, Mamazhakypov, Argen, additional, Birnhuber, Anna, additional, Wilhelm, Jochen, additional, Kwapiszewska, Grazyna, additional, Ruppert, Clemens, additional, Markart, Philipp, additional, Wujak, Lukasz, additional, Rubio, Karla, additional, Barreto, Guillermo, additional, Schaefer, Liliana, additional, and Wygrecka, Malgorzata, additional

Published
2020
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32. Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia.

Author

Ehrlich, Kristin, Wilhelm, Jochen, Markart, Philipp, Weisser, Heike, Wolff, Jens-Christian, Bein, Gregor, Pak, Oleg, Barreto, Guillermo, Weissmann, Norbert, Schramm, Fabian, Seeger, Werner, Schaefer, Liliana, Kuebler, Wolfgang M., and Wygrecka, Malgorzata

Subjects
COMMUNITY-acquired pneumonia, TREATMENT effectiveness, ALBUMINS, BLOOD coagulation, ESTRADIOL
Abstract

Sex-dependent differences in immunity and coagulation play an active role in the outcome of community-acquired pneumonia (CAP). Contact phase proteins act at the crossroads between inflammation and coagulation thus representing a point of convergence in host defense against infection. Here, we measured the levels of factor XII (FXII), FXIIa-C1 esterase inhibitor (C1INH) complexes, and high-molecular-weight kininogen (HK) in plasma of patients with CAP and correlated them to clinical disease severity. Levels of FXIIa-C1INH/albumin ratio were elevated, irrespective of sex, in plasma of patients with CAP (n = 139) as compared with age-matched donors (n = 58). No simultaneous decrease in FXII levels, indicating its consumption, was observed. Stratification by sex revealed augmented FXII levels in plasma of women with CAP as compared with sex-matched donors yet no apparent differences in men. This sex-specific effect was, however, attributable to lower FXII levels in female donors relative to men donors. Plasma estradiol levels mirrored those for FXII. Levels of HK/albumin ratio were decreased in CAP plasma as compared with donors, however, after stratification by sex, this difference was only observed in women and was related to higher HK/albumin values in female donors as opposed to male donors. Finally, strong negative correlation between plasma levels of HK/albumin ratio and CAP severity, as assessed by CRB65 score, in males and females was observed. Our study identifies sex-dependent differences in plasma levels of the contact phase proteins in elderly subjects that may contribute to specific clinical outcomes in CAP between men and women. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Treatment and survival diversities in different forms of ILD in Germany - EXCITING registry

Author

Kreuter, Michael, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Maqhuzu, Phillen, additional, Schwarzkopf, Larissa, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Jürgen, additional, Kauschka, Dagmar, additional, Günther, Andreas, additional, Herth, Felix J. F., additional, and Markart, Philipp, additional

Published
2019
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37. Nanomedical Relevance of the Intermolecular Interaction Dynamics—Examples from Lysozymes and Insulins

Author

Zhang, Ruiyan, primary, Zhang, Ning, additional, Mohri, Marzieh, additional, Wu, Lisha, additional, Eckert, Thomas, additional, Krylov, Vadim B., additional, Antosova, Andrea, additional, Ponikova, Slavomira, additional, Bednarikova, Zuzana, additional, Markart, Philipp, additional, Günther, Andreas, additional, Norden, Bengt, additional, Billeter, Martin, additional, Schauer, Roland, additional, Scheidig, Axel J., additional, Ratha, Bhisma N., additional, Bhunia, Anirban, additional, Hesse, Karsten, additional, Enani, Mushira Abdelaziz, additional, Steinmeyer, Jürgen, additional, Petridis, Athanasios K., additional, Kozar, Tibor, additional, Gazova, Zuzana, additional, Nifantiev, Nikolay E., additional, and Siebert, Hans-Christian, additional

Published
2019
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41. Outcome differences between idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD) - data from the EXCITING registry

Author

Kreuter, Michael, primary, Kabitz, Hans-Joachim, additional, Hagmeyer, Lars, additional, Hammerl, Peter, additional, Esselmann, Albert, additional, Wiederhold, Conrad, additional, Skowasch, Dirk, additional, Stolpe, Christoph, additional, Joest, Marcus, additional, Veitshans, Stefan, additional, Witt, Sabine, additional, Leidl, Reiner, additional, Hellmann, Andreas, additional, Pfeifer, Michael, additional, Behr, Juergen, additional, Guenther, Andreas, additional, Kauschka, Dagmar, additional, Herth, Felix J.F., additional, and Markart, Philipp, additional

Published
2018
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50. FXII promotes proteolytic processing of the LRP1 ectodomain

Author

Wujak, Lukasz, primary, Hesse, Christina, additional, Sewald, Katherina, additional, Jonigk, Danny, additional, Braubach, Peter, additional, Warnecke, Gregor, additional, Fieguth, Hans-Gerd, additional, Braun, Armin, additional, Lochnit, Günter, additional, Markart, Philipp, additional, Schaefer, Liliana, additional, and Wygrecka, Malgorzata, additional

Published
2017
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