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Introduction Despite the fact that buprenorphine is effective, well tolerated and due to its pharmacological profile a very safe drug, the impact of long-term buprenorphine substitution therapy on complex psychomotor and cognitive function predicting driving ability is not yet clear. Therefore, a prospective comparison between patients receiving sublingual buprenorphine and a control group of untreated, healthy volunteers was performed. Methods Treated and untreated subjects were matched for age and sex, with three control subjects selected for every buprenorphine patient. Patients using unreported drugs were included in the intention-to-treat (ITT) analysis; the remaining patients were analysed as the per-protocol (PP) group. The test battery comprised the assessment of: performance during stress, visual orientation, concentration, attention, vigilance and reaction time. The primary endpoint was defined as the sum of the relevant scores of the tests after z -transformation of the individual scores. Results 30 patients with sublingual buprenorphine treatment (7.7 ± 3.9 mg per day) were matched to 90 controls. 19 patients were excluded from the PP-analysis because of additional unreported drug intake. Significant non-inferiority could be demonstrated for the PP-group ( p p Conclusion Patients receiving a stable dose of sublingual buprenorphine showed no significant impairment of complex psychomotor or cognitive performance as compared to healthy controls. However intake of illicit drugs as well as the lack of social reliability are major problems in this specific patients group. Despite of the absence of a relevant impact of the drug on driving ability, those patients do not seem to be qualified for getting their driving license.

Mitarbeiterbindung ist im Moment in der Wahrnehmung der deutschen Unternehmen ein uberaus wichtiges Thema zur Zukunftssicherung (Deutsche Gesellschaft fur Personalfuhrung e. V. [DGFP], 2012). Allerdings wird die wissenschaftliche Literatur zu diesem Thema von vielen Unternehmen noch nicht ausreichend wahrgenommen. Dies hat zur Folge, dass gerade die Bedeutung der Fuhrungskraft bei der Mitarbeiterbindung noch nicht ausreichend innerbetrieblich betont wird. Vielmehr wird Mitarbeiterbindung als ein Thema des Human- Resources(HR)-Managements angesehen. Dass dies nicht sinnvoll ist, zeigt der folgende Artikel, indem er die Grunde fur Mitarbeiterbindung mit den handelnden Personengruppen, Fuhrungskraften beziehungsweise dem Personalwesen verbindet.