10 results on '"Masanori Tanahashi"'
Search Results
2. Skin capillary extraction technique based on independent component analysis and Frangi filter using videomicroscopy
- Author
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Masaru Sugahara, Akihiko Oharazawa, Masaki Ogino, and Masanori Tanahashi
- Subjects
Ground truth ,Microscopy, Video ,Materials science ,Steady state (electronics) ,Capillary action ,Image processing ,Dermatology ,Filter (signal processing) ,01 natural sciences ,Independent component analysis ,Capillaries ,010309 optics ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Sørensen–Dice coefficient ,0103 physical sciences ,Image Processing, Computer-Assisted ,medicine ,Humans ,Algorithms ,Skin ,Blood vessel ,Biomedical engineering - Abstract
Background Videomicroscopy can be used to observe skin capillaries easily and non-invasively. In this study, we develop an algorithm that can handle skin regions by combining color component separation methods as pre-processing based on blood vessel extraction filtering. Materials and methods Images of skin on the inner upper arm were acquired using videomicroscopy. An algorithm using independent component analysis (ICA) and the Frangi filter was constructed, and capillary regions were extracted. The capillary blood vessel extraction images were compared with ground truth to verify accuracy. An evaluation of the physiological responses of skin exposed to carbon dioxide (CO2 ) water, local heating, and methyl nicotinate was performed to test blood vessels with different mechanisms of action and layer depth. Results Based on a comparison with ground truth images, a Dice coefficient of 0.82 was calculated. In examining physiological responses to stimuli on the skin, it was found that exposure to CO2 for 2 minutes significantly increased the capillary area compared with the steady state. Conclusion An algorithm to extract capillaries from skin images using ICA and the Frangi filter method was proposed. Results suggest that this algorithm can quantitatively analyze physiological changes in capillaries on the skin surface.
- Published
- 2020
3. Cover Image
- Author
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Akihiko Oharazawa, Masaki Ogino, Masaru Sugahara, and Masanori Tanahashi
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Dermatology - Published
- 2020
4. Dry skin conditions are related to the recovery rate of skin temperature after cold stress rather than to blood flow
- Author
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Masanori Tanahashi, Kayoko Iwata, Tomoko Nomura, Yuko Higaki, Yasuko Yoshida-Amano, and Yoshinori Sugiyama
- Subjects
Adult ,Male ,Adolescent ,Physiology ,Dermatology ,Electric Capacitance ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Stress, Physiological ,Dry skin ,medicine ,Stratum corneum ,Homeostasis ,Humans ,Aged ,Skin ,Leg ,Transepidermal water loss ,integumentary system ,Resting state fMRI ,business.industry ,Age Factors ,Water ,Blood flow ,Anatomy ,Middle Aged ,Thermoregulation ,Water Loss, Insensible ,Cold Temperature ,Cheek ,medicine.anatomical_structure ,Regional Blood Flow ,Arm ,Dryness ,Female ,Seasons ,medicine.symptom ,Skin Temperature ,business ,030217 neurology & neurosurgery ,Body Temperature Regulation - Abstract
Background Cutaneous blood flow plays an important role in the thermoregulation, oxygen supply, and nutritional support necessary to maintain the skin. However, there is little evidence for a link between blood flow and skin physiology. Therefore, we conducted surveys of healthy volunteers to determine the relationship(s) between dry skin properties and cutaneous vascular function. Methods Water content of the stratum corneum, transepidermal water loss, and visual dryness score were investigated as dry skin parameters. Cutaneous blood flow in the resting state, the recovery rate (RR) of skin temperature on the hand after a cold-stress test, and the responsiveness of facial skin blood flow to local cooling were examined as indices of cutaneous vascular functions. The relationships between dry skin parameters and cutaneous vascular functions were assessed. Results The RR correlated negatively with the visual dryness score of skin on the leg but correlated positively with water content of the stratum corneum on the arm. No significant correlation between the resting state of blood flow and dry skin parameters was observed. In both the face and the body, deterioration in skin dryness from summer to winter was significant in subjects with low RR. The RR correlated well with the responsiveness of facial skin blood flow to local cooling, indicating that the RR affects systemic dry skin conditions. Conclusions These results suggest that the RR but not blood flow at the resting state is associated with dry skin conditions and is involved in skin homeostasis during seasonal environmental changes.
- Published
- 2016
5. Particle Simulation of Skin Basal Layer Formation
- Author
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Katsuya Nagayama, Takeshi Kurihara, Yasuko Amano, and Masanori Tanahashi
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0301 basic medicine ,Particle Model ,Particle simulation ,Particle model ,Anatomy ,Biology ,Skin Formation ,Computational simulation ,03 medical and health sciences ,Basal (phylogenetics) ,030104 developmental biology ,medicine.anatomical_structure ,Biophysics ,medicine ,Epidermis ,Numerical Simulation ,Layer (electronics) - Abstract
There has been increasing concern regarding the cosmetic aspects of skin in recent years. Computational simulation can be useful in understanding the mechanism underlying skin formation. The bottom of the epidermis is called the basal layer and is very undulation. In this study, we focus on the basal layer formation. We created a particle model, which forms an undulation basal layer and regenerates the basal layer formation by numerical simulation. At first, two-dimensional basal layer formation without epidermal turnover was simulated. The results showed film shape changes and the stability, as a layer in the process of long-time with an increase and decrease of basal cells. Next, the model was applied to three-dimensional basal layer formation with epidermal turnover. As the structure of the basal layer was deformed, the upper structure of the epidermis comprising the cells divided from the basal layer also became irregular. The simulation results accurately represented and reproduced the three-dimensional basal layer formation and epidermis turnover process., 2nd Conference on Advances in Prevention and Treatment of Cancer (CAPTC 2016), March 18-20, 2016, Los Angeles, USA
- Published
- 2016
6. Ingestion of Coffee Polyphenols Improves a Scaly Skin Surface and the Recovery Rate of Skin Temperature after Cold Stress: A Randomized, Controlled Trial
- Author
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Yoshinori Sugiyama, Sachie Ueda, Yuko Higaki, Masanori Tanahashi, and Kayoko Iwata
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Adult ,medicine.medical_specialty ,Patient Dropouts ,Erythema ,Visual analogue scale ,Surface Properties ,Medicine (miscellaneous) ,Coffea ,Gastroenterology ,Severity of Illness Index ,law.invention ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Double-Blind Method ,Japan ,Re-Epithelialization ,law ,Stress, Physiological ,Internal medicine ,Dry skin ,Immersion ,Ultraviolet light ,Medicine ,Ingestion ,Humans ,Cold Injury ,Skin ,Nutrition and Dietetics ,integumentary system ,business.industry ,Plant Extracts ,Polyphenols ,Blood flow ,Hand ,Blood pressure ,Regional Blood Flow ,Dietary Supplements ,Seeds ,Female ,medicine.symptom ,business ,Skin Temperature ,030217 neurology & neurosurgery ,Dermatitis, Exfoliative - Abstract
Coffee polyphenols (CPPs) derived from coffee beans have beneficial effects on blood pressure and vascular endothelial function. In addition, CPPs suppress ultraviolet light induced erythema. However, the effects of CPPs on dry skin and cutaneous vascular function have not been clarified. We investigated the effects of CPPs on dry skin and the recovery rate (RR) of skin temperature after a cold-stress test as a measure of vascular function in subjects with visible scaliness in a double-blind, placebo-controlled, randomized study. The subjects were divided into two groups, the CPP group and the Placebo group. In the CPP group, the subjects ingested a beverage containing 297.8 mg CPPs every day for 4 wk. The degree of skin dryness was assessed quantitatively using a Visioscan to evaluate skin scaliness and smoothness. A subjective evaluation using a visual analog scale (VAS) of skin smoothness was also used. As a result, the scaliness and smoothness of cheek skin was significantly improved after 4 wk in the CPP group compared to the Placebo group. The improvements of the VAS score on 'skin smoothness' and the RR were also observed in the CPP group but the difference was not statistically significant. However, when the CPP group was divided into subgroups of high RR and low RR, the improvement of the RR was significant in the low RR subgroup. In conclusion, our results suggest that CPPs improve skin scaliness and play a role in cutaneous blood flow regulation after cold stress.
- Published
- 2017
7. 3D Numerical Simulation of Epidermal Skin Turnover Process Using a Particle Model
- Author
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Masanori Tanahashi, Yasuko Amano, Katsuya Nagayama, and Takahiro Uehara
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Particle Model ,Materials science ,integumentary system ,Computer simulation ,Particle model ,media_common.quotation_subject ,Skin Formation ,Cosmetics ,Computational simulation ,Scientific method ,Research studies ,Numerical Simulation ,Biological system ,media_common - Abstract
Skin is the largest organ of the human body. In recent years, concern regarding the cosmetics area has increased, and research studies on anti-aging therapy or cosmetics have been rapidly conducted. Skin cells are not only changing its shape but also its physical properties during the epidermal skin turnover process. Computational simulation can be useful in further understanding the mechanisms of skin formation. We propose a particle model that can handle complex biological phenomena, including cell interactions and is a suitable method for simulating skin formation. The particle model was applied to simulate three-dimensional skin formation accompanied by proliferation and cornification of skin cells. The simulation results represented and reproduced the epidermal skin turnover phenomenon.
- Published
- 2015
8. Relationships between transepidermal water loss, cutaneous microcirculatory function and autonomic nervous activity
- Author
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Takatoshi Murase, Masanori Tanahashi, Yasuko Yoshida-Amano, Yoshinori Sugiyama, Kayoko Iwata, Tomoko Nomura, Kenichiro Yoshida, and Akihiko Fujii
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Adult ,Male ,Aging ,medicine.medical_specialty ,Pharmaceutical Science ,Dermatology ,030204 cardiovascular system & hematology ,Autonomic Nervous System ,Microcirculation ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Colloid and Surface Chemistry ,Body Water ,Diabetes mellitus ,Internal medicine ,Drug Discovery ,medicine ,Stratum corneum ,Diabetes Mellitus ,Heart rate variability ,Humans ,Pathological ,Skin barrier function ,Balance (ability) ,Skin ,Transepidermal water loss ,integumentary system ,Chemistry ,Raynaud Disease ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Chemistry (miscellaneous) ,Anesthesia ,Cardiology - Abstract
Objective Several studies have shown that a deterioration of skin properties, an impaired cutaneous microcirculation function and an imbalance of autonomic nervous activity are observed in smokers and in patients with diabetes mellitus or Raynaud's phenomenon. These observations suggest that skin properties are associated with cutaneous microcirculatory function and autonomic nervous activity in pathological conditions. However, there is no published evidence to support the concept that these two functions have any relationship with skin properties even in healthy subjects. In order to investigate the hypothesis that these properties are related, we conducted a survey of healthy adult subjects to investigate the relationships between cutaneous microcirculatory function and autonomic nervous activity and skin properties. Methods The hydration of the stratum corneum and transepidermal water loss (TEWL) were investigated as skin properties, and the responsiveness of skin blood flow (SkBF) to local warming was examined as an index of cutaneous microcirculatory function in 19 healthy adult male subjects. Electrocardiograms were monitored for 24 hours and heart rate variability was analyzed as indices of autonomic nervous activity, as low frequency power (LF: 0.04-0.15 Hz), high frequency power (HF: 0.15–0.40 Hz) and as a ratio of low-to-high frequency power (LF/HF) as indices of autonomic nervous activity; HF for parasympathetic activity, LF/HF for sympathovagal balance. The relationships between those indices were then analyzed. Results A moderate negative correlation was found between TEWL and the relative maximum rate of increases in the responsiveness of SkBF on local warming. A moderate positive and a moderate negative correlation were observed between TEWL and LF/HF or HF, respectively. Moreover, a moderate negative and a moderate positive correlation were shown between the responsiveness of SkBF and LF/HF or HF, respectively. The hydration of the stratum corneum showed no correlations with any indices of microcirculation or autonomic nervous activity. Conclusion These results indicate that skin barrier function, cutaneous microcirculatory function and autonomic nervous activity are mutually associated in healthy adults. This article is protected by copyright. All rights reserved.
- Published
- 2016
9. Relationships between transepidermal water loss, cutaneous microcirculatory function and autonomic nerve activity
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Kayoko Iwata, Tomoko Nomura, Kenichiro Yoshida, Yoshinori Sugiyama, Yasuko Amano, Masanori Tanahashi, Akihiko Fujii, and Takatoshi Murase
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medicine.medical_specialty ,Transepidermal water loss ,Autonomic nerve ,business.industry ,Internal medicine ,medicine ,Cardiology ,Dermatology ,business ,Molecular Biology ,Biochemistry - Published
- 2017
10. The recovery rate of skin temperature after cold stress but not blood flow in a resting state is related to dry skin conditions
- Author
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Masanori Tanahashi, Kayoko Iwata, Tomoko Nomura, Yasuko Amano, Yoshinori Sugiyama, and Yuko Higaki
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Resting state fMRI ,business.industry ,Skin temperature ,Dermatology ,Blood flow ,Biochemistry ,Animal science ,Recovery rate ,Dry skin ,Medicine ,medicine.symptom ,business ,Molecular Biology ,Cold stress - Published
- 2017
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