21 results on '"Merli Y"'
Search Results
2. Topical zinc oxide: an effective treatment option for erosive pustular dermatosis of the leg.
- Author
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Di Altobrando, A., Patrizi, A., Vara, G., Merli, Y., and Bianchi, T.
- Subjects
ZINC oxide ,LEG ,LOG-rank test ,COMPRESSION bandages ,ZINC sulfate - Abstract
Dear Editor, Erosive pustular dermatosis of the leg (EPDL) is a rare inflammatory cutaneous disease characterized by nonfollicular sterile pustules, erosions and crusts on an erythematous background.[1] EPDL generally affects the middle third of the leg, typically in elderly patients. Indeed, 10 out of 23 patients (43%) in the TC-only group relapsed, whereas four out of 28 patients (14%) treated with both TC and topical zinc oxide relapsed. On the basis of our results, topical zinc oxide may represent a valid, easy and cheap therapeutic strategy for maintenance therapy of EPDL, after TCs have achieved their anti-inflammatory role in the acute phase. [Extracted from the article]
- Published
- 2020
- Full Text
- View/download PDF
3. Sonographic features of vaccination granulomas in children with delayed‐type hypersensitivity to aluminum
- Author
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Andrea Sechi, Francesco Savoia, Yuri Merli, Annalisa Patrizi, Colombina Vincenzi, Iria Neri, Miriam Leuzzi, Ambra Di Altobrando, Francesca Besagni, Federico Tartari, Sechi A., Patrizi A., Vincenzi C., Savoia F., Tartari F., Leuzzi M., Di Altobrando A., Besagni F., Merli Y., and Neri I.
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Granuloma formation ,Physical examination ,Dermatology ,dermatitis-contact ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Route of administration ,0302 clinical medicine ,030225 pediatrics ,medicine ,Humans ,Hypersensitivity, Delayed ,Aluminum Compounds ,Ultrasonography ,Granuloma ,medicine.diagnostic_test ,business.industry ,Vaccination ,Infant ,lumps/bumps ,medicine.disease ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
In this article, we report the sonographic features of vaccination granulomas in three children sensitized to aluminum. Although the recognition of the vaccination granuloma relies on the clinical examination, misdiagnosis is frequent, leading to distressful procedures or prolonged antibiotic administration. In all our cases, sonography revealed a teardrop-shaped echogenic central structure, suggesting the deposition of aluminum crystals along the route of administration with consequent subcutaneous degenerative changes, and a surrounding hypoechoic cap, which reflects the changeable inflammatory reaction and the granuloma formation.
- Published
- 2019
- Full Text
- View/download PDF
4. Intralesional steroid treatment for the intermediate stage of retronychia: A pilot study
- Author
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Andrea Sechi, Aurora Alessandrini, Francesca Bruni, Yuri Merli, Bianca Maria Piraccini, Michela Starace, and Alessandrini A, Sechi A, Merli Y, Bruni F, Piraccini BM, Starace M.
- Subjects
medicine.medical_specialty ,Pilot Projects ,Dermatology ,Injections, Intralesional ,retronychia ,Intermediate stage ,Nail Diseases ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,intralesional injection ,medicine ,Humans ,new classification ,Stage (cooking) ,Paronychia ,Vas score ,intermediate stage ,business.industry ,General Medicine ,Nail plate ,medicine.disease ,Treatment period ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Nails ,030220 oncology & carcinogenesis ,Nail (anatomy) ,Intralesional steroid ,Female ,Steroids ,business - Abstract
Retronychia describes the proximal ingrowing of the nail plate. In the early stage, topical steroids are the gold standard therapy, while in the late stage surgical treatment is mandatory. We identified an intermediate severity stage of retronychia, where the topical treatment alone is ineffective and surgery is avoidable. Intralesional steroids turn the best treatment in these patients. A pilot study consisting of a 3-month treatment period and 9-month follow-up time was designed to evaluate the treatment outcome to intralesional steroid injections in patients affected by the intermediate-stage of toenail retronychia. The complete recovery of retronychia-associated nail abnormalities was observed in 27/28 recruited patients at the end of the treatment phase. Paronychia, nail plate discoloration, proximal nail fold (PNF) elevation, and discharge were reduced (P < .01) after one steroid administration, while nail regrowth became significant after two sessions. No significant difference in terms of clinical outcome was found, while pain VAS score and intra-operative pain evaluated with Wong-Baker faces scale were higher in the female group (P < .01). Limitation Lack of control group of patients. Despite its temporary effect, the intralesional triamcinolone injection is an effective, cheap, and safe treatment especially for the intermediate stage of retronychia.
- Published
- 2020
- Full Text
- View/download PDF
5. Topical zinc oxide: an effective treatment option for erosive pustular dermatosis of the leg
- Author
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Yuri Merli, Giulio Vara, A. Di Altobrando, Annalisa Patrizi, Tommaso Bianchi, Di Altobrando A., Patrizi A., Vara G., Merli Y., and Bianchi T.
- Subjects
medicine.medical_specialty ,Leg ,Skin Diseases, Vesiculobullous ,business.industry ,chemistry.chemical_element ,Dermatology ,Zinc ,Leg Dermatoses ,Erosive pustular dermatosis ,Topical zinc oxide ,chemistry ,Scalp Dermatoses ,Medicine ,Effective treatment ,Humans ,Zinc Oxide ,business - Published
- 2019
6. Blue toe syndrome: A challenging diagnosis
- Author
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Ambra Di Altobrando, Tommaso Bianchi, Federico Tartari, Yuri Merli, Michele Mirelli, Annalisa Patrizi, Tartari F., Altobrando A., Merli Y., Patrizi A., Mirelli M., and Bianchi T.
- Subjects
medicine.medical_specialty ,business.industry ,Blue Toe Syndrome ,Correspondence ,lcsh:Dermatology ,medicine ,MEDLINE ,Dermatology ,lcsh:RL1-803 ,Blue toe syndrome ,business - Abstract
“Blue toe syndrome” (BTS) refers to the acute onset of purple painful digits in the absence of evident trauma, cold-associated injury or disorders that induce generalized cyanosis. The term was used for the first time in 1976 by Komody, who underlined the vascular etiology of the disease and its possible diagnostic confirmation through angiography.[1,2] Indeed, BTS may occur from end-arterial occlusion, impaired venous outflow, and/or abnormal blood circulation. Peripheral microembolism with distal arterial occlusion is one of the most frequent underlying mechanisms of the disease and consists of disrupted material from ulcerated atheromatous plaques (atheromatous or cholesterol crystal emboli). The case described by us assumes significance because of an atypical clinical presentation of a peripheral embolism from an abdominal aortic aneurysm, hence necessitating a high index of suspicion to achieve the correct diagnosis..
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- 2019
- Full Text
- View/download PDF
7. Pyoderma Gangrenosum: A Retrospective Case Series of 44 Patients.
- Author
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Bardazzi F, Maltoni L, Clarizio G, Baracca MF, Loi C, Starace M, Merli Y, and Misciali C
- Abstract
Introduction: Pyoderma gangrenosum (PG) poses a significant dermatological challenge due to its rapidly evolving painful necrotic ulcerations. Understanding its multifaceted pathogenesis and diverse clinical presentation is crucial for effective management., Objectives: We aimed to analyze demographic characteristics, clinical manifestations, lesion distributions, systemic disease associations, therapeutic interventions, and patient outcomes in PG cases., Methods: Medical records from 2017 to 2023 of PG patients at IRCCS Sant'Orsola Malpighi Hospital, Bologna, Italy, were retrospectively analyzed. Inclusion criteria encompassed persistent ulcers with clinical and histological evidence of PG, excluding cases with alternative diagnoses or inadequate follow-up. Clinical evaluations, including pain assessment and lesion measurements, were conducted at diagnosis and follow-up visits., Results: A total of 44 patients were evaluated. Pain was a universal symptom, and tissue pathergy was documented in 28.6% of patients. Ulcerative PG was the most common subtype (88.1%). Associations with inflammatory bowel diseases (25%), rheumatoid arthritis (9.1%), and hematological diseases (17.2%) were noted. Lower limbs were frequently affected (63.6%). Treatment approaches included wound management, topical and systemic corticosteroids, and immunosuppressive therapy, with varying response rates., Conclusion: Advanced dressing and steroid therapy were pivotal in mild PG cases, while moderate-to-severe cases often associated with systemic diseases showed incomplete healing despite treatment, especially in patients with inflammatory bowel diseases and hematological disorders. This study contributes to the understanding of PG's complexities, suggesting the use of biological therapy as first line in moderate-to-severe PG.
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- 2024
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- View/download PDF
8. A rapidly growing ulcer: an atypical presentation of Merkel cell carcinoma.
- Author
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Clarizio G, Merli Y, Campana D, Corti B, Agostinelli C, and Pileri A
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- 2024
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9. Automated Prediction of Photographic Wound Assessment Tool in Chronic Wound Images.
- Author
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Curti N, Merli Y, Zengarini C, Starace M, Rapparini L, Marcelli E, Carlini G, Buschi D, Castellani GC, Piraccini BM, Bianchi T, and Giampieri E
- Subjects
- Humans, Image Processing, Computer-Assisted, Neural Networks, Computer, Photography, Artificial Intelligence, Benchmarking
- Abstract
Many automated approaches have been proposed in literature to quantify clinically relevant wound features based on image processing analysis, aiming at removing human subjectivity and accelerate clinical practice. In this work we present a fully automated image processing pipeline leveraging deep learning and a large wound segmentation dataset to perform wound detection and following prediction of the Photographic Wound Assessment Tool (PWAT), automatizing the clinical judgement of the adequate wound healing. Starting from images acquired by smartphone cameras, a series of textural and morphological features are extracted from the wound areas, aiming to mimic the typical clinical considerations for wound assessment. The resulting extracted features can be easily interpreted by the clinician and allow a quantitative estimation of the PWAT scores. The features extracted from the region-of-interests detected by our pre-trained neural network model correctly predict the PWAT scale values with a Spearman's correlation coefficient of 0.85 on a set of unseen images. The obtained results agree with the current state-of-the-art and provide a benchmark for future artificial intelligence applications in this research field., (© 2024. The Author(s).)
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- 2024
- Full Text
- View/download PDF
10. Effectiveness of Semi-Supervised Active Learning in Automated Wound Image Segmentation.
- Author
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Curti N, Merli Y, Zengarini C, Giampieri E, Merlotti A, Dall'Olio D, Marcelli E, Bianchi T, and Castellani G
- Subjects
- Humans, Image Processing, Computer-Assisted methods, Supervised Machine Learning, Ulcer, Neural Networks, Computer
- Abstract
Appropriate wound management shortens the healing times and reduces the management costs, benefiting the patient in physical terms and potentially reducing the healthcare system's economic burden. Among the instrumental measurement methods, the image analysis of a wound area is becoming one of the cornerstones of chronic ulcer management. Our study aim is to develop a solid AI method based on a convolutional neural network to segment the wounds efficiently to make the work of the physician more efficient, and subsequently, to lay the foundations for the further development of more in-depth analyses of ulcer characteristics. In this work, we introduce a fully automated model for identifying and segmenting wound areas which can completely automatize the clinical wound severity assessment starting from images acquired from smartphones. This method is based on an active semi-supervised learning training of a convolutional neural network model. In our work, we tested the robustness of our method against a wide range of natural images acquired in different light conditions and image expositions. We collected the images using an ad hoc developed app and saved them in a database which we then used for AI training. We then tested different CNN architectures to develop a balanced model, which we finally validated with a public dataset. We used a dataset of images acquired during clinical practice and built an annotated wound image dataset consisting of 1564 ulcer images from 474 patients. Only a small part of this large amount of data was manually annotated by experts (ground truth). A multi-step, active, semi-supervised training procedure was applied to improve the segmentation performances of the model. The developed training strategy mimics a continuous learning approach and provides a viable alternative for further medical applications. We tested the efficiency of our model against other public datasets, proving its robustness. The efficiency of the transfer learning showed that after less than 50 epochs, the model achieved a stable DSC that was greater than 0.95. The proposed active semi-supervised learning strategy could allow us to obtain an efficient segmentation method, thereby facilitating the work of the clinician by reducing their working times to achieve the measurements. Finally, the robustness of our pipeline confirms its possible usage in clinical practice as a reliable decision support system for clinicians.
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- 2022
- Full Text
- View/download PDF
11. Guselkumab for the treatment of psoriasis: a 60-week real-life multicenter retrospective experience.
- Author
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Bardazzi F, Viviani F, Merli Y, Di Lernia V, Peccerillo F, Conti A, Lasagni C, Tabanelli M, D'Adamio S, Di Nuzzo S, Cortellazzi C, and Filippi F
- Subjects
- Humans, Retrospective Studies, Antibodies, Monoclonal adverse effects, Severity of Illness Index, Double-Blind Method, Treatment Outcome, Psoriasis diagnosis, Psoriasis drug therapy, Biological Products therapeutic use
- Abstract
Background: Real-world data for guselkumab, the first interleukin-23 inhibitor approved to treat moderate-to-severe psoriasis, are scarce. This study represents the first 60-week, real-life, multicenter, retrospective experience to investigate the effectiveness, safety, tolerability, and drug retention of guselkumab in psoriatic patients., Research Design and Methods: Clinical information was collected at baseline and at weeks 12, 24, 36, 48, and 60., Results: The mean baseline Psoriasis Activity Severity Index (PASI) reduced from 14.2 to 3.1 at week 12 and decreased to around 0 at weeks 36, 48, and 60. PASI 75, PASI 90, and PASI 100 were 100%, 96.8%, and 83.9% at week 60, respectively. Multiple logistic regression analysis showed that neither body mass index >30, smoking, ≥3 comorbidities, difficult-to-treat areas, nor a failure to ≥2 prior biologic treatments significantly influenced PASI reduction (p > 0.05)., Conclusions: Our findings confirm guselkumab as an appropriate therapeutic option in routine clinical practice, especially when dealing with complex patients with comorbidities or previous failure to biologic treatments.
- Published
- 2022
- Full Text
- View/download PDF
12. Multiple mucoceles in an infant.
- Author
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Merli Y, Prisco A, and Neri I
- Subjects
- Humans, Infant, Retrospective Studies, Mucocele diagnosis, Mucocele surgery
- Published
- 2022
- Full Text
- View/download PDF
13. Hypericum and neem oil for dehisced post-surgical wounds: a randomised, controlled, single-blinded phase III study.
- Author
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Arena R, Strazzeri MG, Bianchi T, Peghetti A, Merli Y, Abbenante D, and Olivari D
- Subjects
- Glycerides, Humans, Pain, Silver therapeutic use, Surgical Wound Infection epidemiology, Terpenes, Wound Healing, Hypericum, Surgical Wound therapy
- Abstract
Objective: To evaluate the clinical efficacy of a hypericum and neem oil dressing, Primary Wound Dressing [ONE] (1PWD) (Kerecis AG, Switzerland), in a patient population with dehiscence of surgical wounds with critical colonisation/infection. Efficacy was defined as resolution of inflammatory/infective symptoms., Method: A randomised, controlled, single-blinded, parallel-arms phase III study was conducted comparing the experimental medication to silver-based dressings. All patients were evaluated at enrolment, on days 7, 14, 21 and 28. Improvement of inflammatory/infective symptoms was measured by detecting seven items of the Bates-Jensen Wound Assessment Tool (BWAT). Pain was assessed using the Numeric Rating Scale (NRS)., Results: The study enrolled 99 patients. Follow-up was completed in 49 patients in the experimental group and 48 patients in the control group. Overall BWAT evaluation demonstrated similar outcomes between the groups: t=0.23, p-value=0.81, 95% confidence interval (CI): -13.3-10.8. Furthermore, when evaluating the seven items of the BWAT relating to inflammatory signs, there was not a significant difference between the groups: t=0.38, p=0.35, 95% CI: -2.8-2.7. However, when an analysis using the NRS pain scale was performed, a statistically significant pain reduction was demonstrated in favour of the experimental group: t=7.8, p<0.0001, 95% CI: 2.918-4.8819., Conclusion: This randomised controlled trial confirmed the efficacy of 1PWD, an investigational product, in the management of surgical dehiscence with critical colonisation or infection, with the added benefit of significant pain reduction when compared with a silver-based dressing.
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- 2022
- Full Text
- View/download PDF
14. Psoriasis or sexually transmitted diseases?
- Author
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Bardazzi F, Viviani F, DI Altobrando A, Merli Y, Gaspari V, and Patrizi A
- Subjects
- Humans, Sexual Behavior, Psoriasis therapy, Sexually Transmitted Diseases epidemiology
- Published
- 2022
- Full Text
- View/download PDF
15. Nodular vasculitis during treatment with vedolizumab in a patient with ulcerative colitis.
- Author
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Abbenante D, Merli Y, Misciali C, Sacchelli L, and Bardazzi F
- Subjects
- Adult, Colitis, Ulcerative diagnosis, Humans, Male, Treatment Outcome, Antibodies, Monoclonal, Humanized therapeutic use, Colitis, Ulcerative drug therapy, Gastrointestinal Agents therapeutic use
- Published
- 2022
- Full Text
- View/download PDF
16. Digital necrosis: a dermatological manifestation of antisynthetase syndrome.
- Author
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DI Altobrando A, Tartari F, Patrizi A, Merli Y, Mulè R, and Bianchi T
- Subjects
- Autoantibodies, Humans, Necrosis, Myositis complications
- Published
- 2021
- Full Text
- View/download PDF
17. Ein derber Knoten am Kinn.
- Author
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Merli Y, Filippini A, Gurioli C, and Savoia F
- Published
- 2021
- Full Text
- View/download PDF
18. A firm nodule on the chin.
- Author
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Merli Y, Filippini A, Gurioli C, and Savoia F
- Subjects
- Chin, Humans, Skin Neoplasms diagnosis
- Published
- 2021
- Full Text
- View/download PDF
19. Intralesional steroid treatment for the intermediate stage of retronychia: A pilot study.
- Author
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Alessandrini A, Sechi A, Merli Y, Bruni F, Piraccini BM, and Starace M
- Subjects
- Female, Humans, Injections, Intralesional, Nails, Pilot Projects, Steroids, Treatment Outcome, Nail Diseases drug therapy, Paronychia
- Abstract
Retronychia describes the proximal ingrowing of the nail plate. In the early stage, topical steroids are the gold standard therapy, while in the late stage surgical treatment is mandatory. We identified an intermediate severity stage of retronychia, where the topical treatment alone is ineffective and surgery is avoidable. Intralesional steroids turn the best treatment in these patients. A pilot study consisting of a 3-month treatment period and 9-month follow-up time was designed to evaluate the treatment outcome to intralesional steroid injections in patients affected by the intermediate-stage of toenail retronychia. The complete recovery of retronychia-associated nail abnormalities was observed in 27/28 recruited patients at the end of the treatment phase. Paronychia, nail plate discoloration, proximal nail fold (PNF) elevation, and discharge were reduced (P < .01) after one steroid administration, while nail regrowth became significant after two sessions. No significant difference in terms of clinical outcome was found, while pain VAS score and intra-operative pain evaluated with Wong-Baker faces scale were higher in the female group (P < .01). Limitation Lack of control group of patients. Despite its temporary effect, the intralesional triamcinolone injection is an effective, cheap, and safe treatment especially for the intermediate stage of retronychia., (© 2020 Wiley Periodicals LLC.)
- Published
- 2020
- Full Text
- View/download PDF
20. Sonographic features of vaccination granulomas in children with delayed-type hypersensitivity to aluminum.
- Author
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Sechi A, Patrizi A, Vincenzi C, Savoia F, Tartari F, Leuzzi M, Di Altobrando A, Besagni F, Merli Y, and Neri I
- Subjects
- Female, Granuloma etiology, Humans, Hypersensitivity, Delayed etiology, Infant, Male, Ultrasonography, Aluminum Compounds adverse effects, Granuloma diagnostic imaging, Hypersensitivity, Delayed diagnosis, Vaccination adverse effects
- Abstract
In this article, we report the sonographic features of vaccination granulomas in three children sensitized to aluminum. Although the recognition of the vaccination granuloma relies on the clinical examination, misdiagnosis is frequent, leading to distressful procedures or prolonged antibiotic administration. In all our cases, sonography revealed a teardrop-shaped echogenic central structure, suggesting the deposition of aluminum crystals along the route of administration with consequent subcutaneous degenerative changes, and a surrounding hypoechoic cap, which reflects the changeable inflammatory reaction and the granuloma formation., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
21. Blue Toe Syndrome: A Challenging Diagnosis.
- Author
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Tartari F, Di Altobrando A, Merli Y, Patrizi A, Mirelli M, and Bianchi T
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2019
- Full Text
- View/download PDF
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