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Abstract Background Early tumor shrinkage (ETS) has been identified as a promising imaging biomarker for patients undergoing immunotherapy for several cancer entities. This study aimed to validate the potential of ETS as an imaging biomarker for patients undergoing immunotherapy for hepatocellular carcinoma (HCC). Methods We screened all patients with HCC that received immunotherapy as the first or subsequent line of treatment at our tertiary care center between 2016 and 2021. ETS was defined as the reduction in the sum of the sizes of target lesions, between the initial imaging and the first follow-up. The ETS was compared to the radiologic response, according to the modified response evaluation criteria in solid tumors (mRECIST). Furthermore, we evaluated the influence of ETS on overall survival (OS), progression-free survival (PFS), and the alpha-fetoprotein (AFP) response. Results The final analysis included 39 patients with available cross-sectional imaging acquired at the initiation of immunotherapy (baseline) and after 8–14 weeks. The median ETS was 5.4%. ETS was significantly correlated with the response according to mRECIST and with the AFP response. Patients with an ETS ≥10% had significantly longer survival times after the first follow-up, compared to patients with

Cells of the pulmonary vasculature show a hyperproliferative phenotype in pulmonary arterial hypertension (PAH), thus contributing to the disease pathogenesis. Here the authors show that cyclin-dependent kinases are overactivated in PAH, and that their pharmacological inhibition attenuates the disease in two independent rodent models

A vivid discussion revolves around the role of the human mind in the quantum measurement process. While some authors argue that conscious observation is a necessary element to achieve the transition from quantum to classical states during measurement (Wigner, 1963), some go even further and propose a more active influence of the human mind on the probabilities of quantum measurement outcomes (e.g. Atmanspacher, Römer, & Walach, 2002; Penrose & Hameroff, 2011). This proposition was tested in micro-psychokinesis (micro-Pk) research were intentional observer effects on quantum random number generators (RNGs) were investigated. In the studies presented here we extended this line of research and tested the impact unconscious goals on micro-Pk. Our focus was cigarette addiction as an unconscious drive and hypothesized that regular cigarette smokers would influence the outcome of a quantum RNG that determined whether the participant was going to see a smoking-related or a neutral picture. Study 1 revealed strong evidence for micro-Pk (BF = 66.06) supporting the H1. As expected, no deviation from chance was found with non-smokers. In Study 2, a pre-registered highly powered replication attempt, failed to reproduce this result and showed strong evidence for H0 (BF = 11.07). When the data from both studies are combined a remarkable change in effect across time (resembling a combination of appearance followed by decline) can be seen only in the smoker’s subsample. Appearance-and-decline effects were absent in the non-smokers sample and in a simulation. Based on von Lucadou’s Model of Pragmatic Information we suggest that (micro-)Pk effects follow a systematic pattern comparable to a dampened harmonic oscillation. This concept may shed new light on past and future Pk research.