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1. Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial

Author

Aboulafia, David, Advani, Ranjana, Alpdogan, Onder, Ando, Kiyoshi, Arcaini, Luca, Baldini, Luca, Bellam, Naresh, Bartlett, Nancy, Belada, David, Yehuda, Dina Ben, Benedetti, Fabio, Borchman, Peter, Bordessoule, Dominique, Brice, Pauline, Briones, Javier, Caballero, Dolores, Carella, Angelo Michele, Chang, Hung, Cheong, June Weon, Cho, Seok-Goo, Choi, Ilseung, Choquet, Sylvain, Colita, Andrei, Congui, Angela Giovanna, D'amore, Francesco, Dang, Nam, Davison, Kelly, de Guibert, Sophie, Brown, Peter de Nully, Delwail, Vincent, Demeter, Judit, di Raimondo, Francesco, Do, Young Rok, Domingo, Eva, Douvas, Michael, Dreyling, Martin, Ernst, Thomas, Fanale, Michelle, Fay, Keith, Feldman, Tatyana, Ferrero, Silvia Fernandez, Flinn, Ian Winchester, Forero-Torres, Andres, Fox, Christopher, Friedberg, Jonathan, Fukuhara, Noriko, Garcia-Marco, Jose, Cruz, Jorge Gayoso, Codina, Jose Gomez, Gressin, Remy, Grigg, Andrew, Gurion, Ronit, Christensen, Jacob Haaber, Haioun, Corinne, Hajek, Roman, Hanel, Mathias, Hatake, Kiyohiko, Hensen, Robert, Horowitz, Netanel, Horwitz, Steven, Huttmann, Andreas, Illes, Arpad, Illidge, Tim, Ishizawa, Kenichi, Islas-Ohlmayer, Miguel, Jacobsen, Eric, Janakiram, Murali, Jurczak, Wojciech, Kaminski, Mark, Kato, Koji, Kim, Won Seog, Kirgner, Ilya, Iyer, Swaminathan, Kuo, Ching-Yuan, Lazaroiu, Mihaela Cornelia, Du, Katell Le, Lee, Jong-Seok, LeGouill, Steven, Lennard, Anne, LaRosee, Paul, Levi, Itai, Link, Brian, Maisonneuve, Herve, Maruyama, Dai, Mayer, Jiri, McCarty, John, McKay, Pam, Minami, Yosuke, Mocikova, Heidi, Morra, Enrica, Morschhauser, Franck, Munoz, Javier, Nagai, Hirokazu, O'Connor, Owen, Opat, Stephen, Pettengell, Ruth, Pezzutto, Antonio, Pfreundschuh, Michael, Pluta, Andrzej, Porcu, PierLuigi, Pro, Barbara, Quach, Hang, Rambaldi, Alessandro, Renwick, William, Reyes, Ruben, Izquierdo, Antonia Rodriguez, Rossi, Giuseppe, Ruan, Jia, Rusconi, Chiara, Salles, Gilles, Santoro, Armando, Sarriera, Jose, Savage, Kerry, Shibayama, Hirohiko, Shustov, Andrei, Suh, Cheolwon, Sureda, Anna, Tanimoto, Mitsune, Taniwaki, Masafumi, Tilly, Herve, Tobinai, Kensei, Trneny, Marek, Trumper, Lorenz, Tsukamoto, Norifumi, Tsukasaki, Kunihiro, Vitolo, Umberto, Walewski, Jan, Weidmann, Eckhart, Wilhelm, Martin, Witzens-Harig, Mathias, Yacoub, Abdulraheem, Yamamoto, Kazuhito, Yeh, Su-Peng, Yoon, Sung-Soo, Yuen, Sam, Yun, Hwan Jung, Zain, Jasmine, Zinzani, Pier Luigi, O'Connor, Owen A, Bartlett, Nancy L, Domingo-Domenech, Eva, Illés, Árpád, Hüttmann, Andreas, Savage, Kerry J, Hua, Zhaowei, Little, Meredith, Rao, Shangbang, Woolery, Joseph, Manley, Thomas, and Trümper, Lorenz more...

Published
2019
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2. Frontline bortezomib, rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in transplantation-ineligible patients with newly diagnosed mantle cell lymphoma: final overall survival results of a randomised, open-label, phase 3 study

Author

Van Hoof, Achiel, Sheliga, Adriana, Teixeira, Adriana, Tomita, Akihiro, Rocafiguera, Albert Oriol, Suvorov, Alexander, Kuzmin, Alexy, Khojasteh, Ali, Mezlini, Amel, Golenkov, Anatoly, Bosly, Andre, Belch, Andrew, Van De Velde, Ann, Illes, Árpád, Mukhopadhyay, Ashis, Meddeb, Balkis, De Prijck, Bernard, Garichochea, Bernardo, Undar, Bulent, Gabarrón, Caballero, Cao, Carmen, Souza, Carmino, Farber, Charles, Won Suh, Cheol, Burcoveanu, Cristina Ileana, Cebotaru, Cristina Ligia, Truica, Cristina-Ligia, Maruyama, Dai, Belada, David, Ben Yehuda, Dina, Udovitsa, Dmitry, Dolores, Morra, Enrica, Späth-Schwalbe, Ernst, Gonzalez-Barca, Eva, Osmanov, Evgenii, Capote, Francisco Javier, Offner, Fritz, Cardenas, Galvez, Heß, Georg, Manikhas, Georgii, Babu, Govind, Rekhtman, Grigoriy, Rossi, Guiseppe, Marques, Herlander, Bumbea, Horia, Wang, Huaqing, Huang, Huiqiang, Choi, Ilseung, Bulavina, Irina, Lysenko, Irina, Avivi, Irit, Kryachok, Iryna, Zaucha, Jan Maciej, Novak, Jan, Díaz, Joaquín, Demeter, Judit, Alexeeva, Julia, Zhu, Jun, Vilchevskaya, Kateryna, Ishizawa, Kenichi, Mauricio, Kenny, Tobinai, Kensei, Ando, Kiyoshi, Abdulkadryrov, Kudrat, Shih, Lee-Yung, Kuzina, Lyudmila, Gumus, Mahmut, De Wit, Maike, Capra, Marcelo, Marques, Margarida, Golubeva, Marina, Ojeda-Uribe, Mario, Kyselyova, Maryna, Taniwaki, Masafumi, Federico, Massimo, Crump, Michael, Baccarani, Michele, Ogura, Michinori, Egyed, Miklós, Udvardy, Miklos, Kurosawa, Mitsutoshi, Uike, Naokuni, Khuageva, Nuriet, Shpilberg, Ofer, Gladkov, Oleg, Samoilova, Olga, Serduk, Olga, Santi, Patricia, Zachee, Pierre, Kaplan, Polina, Stoia, Razvan, Gressin, Remy, Arranz, Reyes, Greil, Richard, Grosicki, Sebastian, Cancelado, Sergio, Nair, Sreejith, Le Gouill, Steven, Van Steenweghen, Steven, Yoon, Sung-Soo, Chuncharune, Suporn, Scheider, Tatiana, Shimoyama, Tatsu, Liu, Ting, Kinoshita, Tomohiro, Uchida, Toshiki, Bunworasate, Udomsak, Vitolo, Umberto, Pavlov, Viacheslav, Phooshkooru, Vijay Rao, Lima, Vladimir, Merkulov, Vladimir, Nawarawong, Weerasak, Hong, Xiaonan, Ke, Xiaoyan, Terui, Yasuhito, Tee Goh, Yeow, Maeda, Yoshiharu, Shi, Yuankai, Dunaev, Yuri, Lorie, Yurii, Wang, Zhao, Shen, Zhixiang, Borbenyi, Zita, Gasztonyi, Zoltán, Masliak, Zvenyslava, Robak, Tadeusz, Jin, Jie, Pylypenko, Halyna, Verhoef, Gregor, Siritanaratkul, Noppadol, Drach, Johannes, Raderer, Markus, Mayer, Jiri, Pereira, Juliana, Tumyan, Gayane, Okamoto, Rumiko, Nakahara, Susumu, Hu, Peter, Appiani, Carlos, Nemat, Sepideh, and Cavalli, Franco more...

Published
2018
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3. Prognostic value of end-of-induction PET response after first-line immunochemotherapy for follicular lymphoma (GALLIUM): secondary analysis of a randomised, phase 3 trial

Author

Hertzberg, Mark, Grigg, Andrew, Cannell, Paul, Quach, Hang, Opat, Stephen, Tam, Constantine, Marlton, Paula, Janssens, Ann, Offner, Fritz, Van eygen, Koen, Sangha, Randeep, Mckay, Pam, Wilson, Jonathan, Van Der Jagt, Richard, Roitman, Daryl, Trneny, Marek, Mayer, Jiri, Le Du, Katell, Solal-Celigny, Philippe, Cartron, Guillaume, Foussard, Charles, Frickhofen, Norbert, Schmidt, Peter, Graeven, Ullrich, Gaska, Tobias, Schlag, Rudolf, Sökler, Martin, Prange-Krex, Gabriele, Florschütz, Axel, Lindemann, Hans-Walter, Schimmelpfennig, Christoph, Tonndorf, Solveig, Hänel, Mathias, Hess, Georg, Schalk, Enrico, Hütten, Heiko, Doelken, Gottfried, Pfreundschuh, Michael, Keller, Ulrich, Herold, Michael, Forstpointner, Roswitha, Vehling-Kaiser, Ursula, Hoffmann, Martin, Borbenyi, Zita, Udvardy, Miklos, Demeter, Judit, Rambaldi, Alessandro, Morra, Enrica, Massimo, Federico, Majolino, Ignazio, Balzarotti, Monica, Semenzato, Gianpietro, Canales Albendea, Miguel Angel, Peñalver Parraga, Francisco Javier, Soler Campos, Alfonso, Sancho Cia, Juan Manuel, Marquez Navarro, Jose Antonio, Grande Garcia, Carlos, Nilsson-Ehle, Herman, Mccarthy, Helen, Pocock, Chris, Sadullah, Shalal, Malladi, Ram, Radford, John, Kanfer, Ed, Kruger, Anton, Culligan, Dominic, Dyer, Martin, Pettengell, Ruth, Seymour, John, Gribben, John, Al-Ismail, Saad, Al-Refaie, Faris, Blesing, Norbert, Macnamara, Christopher, O'callaghan, Ann, Haynes, Andrew, Follows, George, Johnson, Roderick, Cunningham, David, Bowles, Kristian, Collins, Graham, Gallop-Evans, Eve, Robinson, Stephen, Subash, Chezhian, Bailey, James, Holden, Viran, Neidhart, Jeffrey, De Oliveira, Moacyr, Tezcan, Haluk, Kim, Kevin, Kambhampati, Suman, Lanier, Keith, Mcclean, John, Tobinai, Kensei, Hatake, Kiyohiko, Ogura, Michinori, Uchida, Toshiki, Ando, Kiyoshi, Kinoshita, Tomohiro, Höhler, Thomas, Stauder, Heribert, Kirsch, Andreas, Koenigsmann, Michael, Kremers, Stephan, Illmer, Thomas, Witzens-Harig, Mathias, La Roseé, Paul, Dürig, Jan, Kneba, Michael, Hensel, Manfred, Fuxius, Stefan, Bergmann, Lothar, Hübel, Kai, Buske, Christian, Marks, Reinhard, Wulf, Gerald, Lerchenmueller, Christian, Schmits, Rudolf, Reinwald, Mark, Lengfelder, Eva, Scott, Fiona, Chou, Takaaki, Taniwaki, Masafumi, Yoshida, Isao, Ishizawa, Kenichi, Uike, Naokuni, Uoshima, Nobuhiko, Kamitsuji, Yuri, Iida, Shinsuke, Ohmine, Ken, Nosaka, Kisato, Ide, Kazuhiko, Ishikawa, Takayuki, Desjardins, Pierre, Finn, Nicholas, Zhu, Jun, Li, Wei, Yu, Li, Ren, Hanyun, Shi, Yuan Kai, Wu, Gang, Hong, Xiaonan, Zhang, Qingyuan, Feng, Jifeng, Zhan, Rong, Lin, Tongyu, Leppa, Sirpa, Costello, Regis, Tempescul, Adrian, Sanhes, Laurence, Tournilhac, Olivier, Kirchen, Heinz, Hebart, Holger, Weide, Rudolf, Jentsch-Ullrich, Kathleen, Avivi, Irit, Nagler, Arnon, Gurion, Ronit, Shpilberg, Ofer, Leoni, Pietro, Baldini, Luca, Samoylova, Olga, Myasnikov, Alexandr, Tan, Tran-Der, Chang, Hung, Kumagai, Kyoya, Tsukamoto, Norifumi, Tsukasaki, Kunihiro, Beatty, Patrick, Usui, Noriko, Izutsu, Koji, Murayama, Tohru, Ichinohe, Tatsuo, Kubo, Kohmei, Ishida, Fumihiro, Beck, J. Thaddeus, Griesinger, Frank, Osmanov, Dzhelil, Dakhil, Shaker, Clavert, Aline, Maruyama, Dai, Terui, Yasuhito, Yamamoto, Kazuhito, Eigendorff, Ekkehard, Kobayashi, Tsutomu, Ichikawa, Satoshi, Choi, Ilseung, Wada, Katsuya, Kikukawa, Yoshitaka, Matsuoka, Masao, Yoshino, Takayuki, Minami, Yosuke, Trotman, Judith, Barrington, Sally F, Belada, David, Meignan, Michel, MacEwan, Robert, Owen, Carolyn, Ptáčník, Václav, Rosta, András, Fingerle-Rowson, Günter R, Zhu, Jiawen, Nielsen, Tina, Sahin, Deniz, Hiddemann, Wolfgang, Marcus, Robert E, and Davies, Andrew more...

Published
2018
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6. Treatment recommendations from the Eighth International Workshop on Waldenström's Macroglobulinemia

Author

Leblond, Véronique, Kastritis, Efstathios, Advani, Ranjana, Ansell, Stephen M., Buske, Christian, Castillo, Jorge J., García-Sanz, Ramón, Gertz, Morie, Kimby, Eva, Kyriakou, Charalampia, Merlini, Giampaolo, Minnema, Monique C., Morel, Pierre, Morra, Enrica, Rummel, Mathias, Wechalekar, Ashutosh, Patterson, Christopher J., Treon, Steven P., and Dimopoulos, Meletios A. more...

Published
2016
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7. The influence of disease and comorbidity risk assessments on the survival of MDS and oligoblastic AML patients treated with 5-azacitidine: A retrospective analysis in ten centers of the “Rete Ematologica Lombarda”

Author

Molteni, Alfredo, Riva, Marta, Borin, Lorenza, Bernardi, Massimo, Pelizzari, Anna Maria, Freyrie, Alessandra, Porta, Matteo Della, Nichelatti, Michele, Ravano, Emanuele, Quaresmini, Giulia, Mariotti, Jacopo, Caramazza, Domenica, Ubezio, Marta, Guarco, Simona, Gigli, Federica, Greco, Rosa, Cairoli, Roberto, and Morra, Enrica more...

Published
2016
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10. Clonal architecture of CXCR4 WHIM-like mutations in Waldenström Macroglobulinaemia

Author

Xu, Lian, Hunter, Zachary R., Tsakmaklis, Nicholas, Cao, Yang, Yang, Guang, Chen, Jie, Liu, Xia, Kanan, Sandra, Castillo, Jorge J., Tai, Yu-Tzu, Zehnder, James L., Brown, Jennifer R., Carrasco, Ruben D., Advani, Ranjana, Sabile, Jean M., Argyropoulos, Kimon, Lia Palomba, M., Morra, Enrica, Trojani, Alessandra, Greco, Antonino, Tedeschi, Alessandra, Varettoni, Marzia, Arcaini, Luca, Munshi, Nikhil M., Anderson, Kenneth C., and Treon, Steven P. more...

Published
2016
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12. Post-remission intensive treatment after induction chemotherapy is feasible in selected elderly patients with acute myeloid leukemia and age ≥75 years: A retrospective analysis of the Rete Ematologica Lombarda

Author

Bernardi, Massimo, Zappasodi, Patrizia, Fracchiolla, Nicola, Marbello, Laura, Todisco, Elisabetta, Pagani, Chiara, Carrabba, Matteo, Rossi, Marianna, Guidotti, Francesca, Mancini, Valentina, Santoro, Armando, Borlenghi, Erika, Ciceri, Fabio, Morra, Enrica, and Rossi, Giuseppe more...

Published
2015
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13. Autologous stem cell transplantation with in vivo purged progenitor cells shows long-term efficacy in relapsed/refractory follicular lymphoma

Author

Arcaini, Luca, Morello, Lucia, Tucci, Alessandra, Rusconi, Chiara, Ladetto, Marco, Rattotti, Sara, Bonfichi, Maurizio, Bottelli, Chiara, Gabutti, Cristina, Bernasconi, Paolo, Varettoni, Marzia, Gotti, Manuel, Troletti, Daniela, Guerrera, Maria Luisa, Fiaccadori, Valeria, Sciarra, Roberta, Ferretti, Virginia Valeria, Alessandrino, Emilio Paolo, Rossi, Giuseppe, and Morra, Enrica more...

Published
2015
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15. Transmembrane Receptors, Cytoskeleton and Cell Cycle Genes Were Progressively Deregulated in the Bone Marrow CD19+ and CD138+ Cells of Patientswwith Waldenstrom's Macroglolubinemia (WM) Vs. Subjects with IgM Monoclonal Gammopathy of Undetermined Significance Igmmgus Vs. Healthy Subjects

Author

Trojani, Alessandra, primary, Tedeschi, Alessandra, additional, Frustaci, Annamaria Maria, additional, Deodato, Marina, additional, Bossi, Luca Emanuele, additional, Di Camillo, Barbara, additional, Montillo, Marco, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2019
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16. Progressive Down Regulation of JAK-STAT, Cell Cycle, and ABC Transporter Genes in CD34+/Lin- Cells of Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients at Diagnosis Vs. 12 Months of Nilotinib Treatment Vs. Healthy Subjects

Author

Trojani, Alessandra, primary, Pungolino, Ester, additional, Rossi, Giuseppe, additional, D'adda, Mariella, additional, Bossi, Luca Emanuele, additional, Baruzzo, Giacomo, additional, Di Camillo, Barbara, additional, Perego, Alessandra, additional, Turrini, Mauro, additional, Elena, Chiara, additional, Borin, Lorenza Maria, additional, Iurlo, Alessandra, additional, Malato, Simona, additional, Spina, Francesco, additional, Latargia, Maria Luisa, additional, Spedini, Pierangelo, additional, Artale, Salvatore, additional, Anghilieri, Michela, additional, Carraro, Maria Cristina, additional, Bucelli, Cristina, additional, De Canal, Gabriella, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2019
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17. Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment

Author

Trojani, Alessandra, primary, Pungolino, Ester, additional, Dal Molin, Alessandra, additional, Lodola, Milena, additional, Rossi, Giuseppe, additional, D’Adda, Mariella, additional, Perego, Alessandra, additional, Elena, Chiara, additional, Turrini, Mauro, additional, Borin, Lorenza, additional, Bucelli, Cristina, additional, Malato, Simona, additional, Carraro, Maria Cristina, additional, Spina, Francesco, additional, Latargia, Maria Luisa, additional, Artale, Salvatore, additional, Spedini, Pierangelo, additional, Anghilieri, Michela, additional, Di Camillo, Barbara, additional, Baruzzo, Giacomo, additional, De Canal, Gabriella, additional, Iurlo, Alessandra, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2019
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18. Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

Author

Lodola Milena, Morra Enrica, Giacomo Baruzzo, Anghilieri Michela, Carraro Maria Cristina, Lorenza Borin, Elena Chiara, Pungolino Ester, Rossi Giuseppe, Artale Salvatore, Gabriella De Canal, Turrini Mauro, Spina Francesco, Bucelli Cristina, Trojani Alessandra, D'adda Mariella, Malato Simona, Perego Alessandra, Iurlo Alessandra, Spedini Pierangelo, Alessandra Dal Molin, Cairoli Roberto, Maria Luisa Latargia, Trojani, A, Pungolino, E, Rossi, G, D'Adda, M, Lodola, M, Dal Molin, A, Baruzzo, G, Perego, A, Turrini, M, Elena, C, Borin, L, Iurlo, A, Malato, S, Spina, F, Latargia, M, Spedini, P, Artale, S, Anghilieri, M, Cristina, C, Bucelli, C, De Canal, G, Morra, E, and Cairoli, R more...

Subjects
Oncology, education.field_of_study, medicine.medical_specialty, business.industry, Immunology, Population, CD34, Myeloid leukemia, Cell Biology, Hematology, Cell cycle, Biochemistry, Gene expression profiling, medicine.anatomical_structure, Nilotinib, Internal medicine, medicine, Bone marrow, Stem cell, education, business, medicine.drug
Abstract

Introduction Chronic myeloid leukemia (CML) is a stem cell disease characterized by the constitutive activity of the oncoprotein BCR-ABL that activates multiple signal transduction pathways. Tyrosine-kinase inhibitor (TKI) nilotinib successfully inhibits the activation and the proliferative function of BCR-ABL in patients with CP-CML. Despite the success of nilotinib, some patients become refractory suggesting the presence of a population of Philadelphia positive (Ph+) quiescent stem cells escaping the drug activity. Thus, the molecular mechanisms underlying CML remain poorly understood. In this study, we enrolled 87 CP-CML patients (Pungolino et. al. Am J Hematol. 2018). Samples were collected on the behalf of the Rete Ematologica Lombarda (REL) the PhilosoPhi34 study (EudraCT: 2012-005062-34), which included 15 centers from Italy. We undertook gene expression profiling (GEP) of selected bone marrow (BM) CD34+/lin- cells of 80 patients at diagnosis vs. the same patients after 12 months of nilotinib to investigate gene expression changes induced by the treatment. Methods We isolated CD34+/lin- cells from BM samples in 87 patients at diagnosis whereas the same cells were also selected from 80/87 patients after 3, 6 and 12 months of nilotinib (Trojani et. al. Cancer Biomark. 2017). BM mononuclear cells (MNCs) as well as BM CD34+/lin- cells of all 80 CML patients were counted at diagnosis and during the treatment with nilotinib (at 3, 6, and 12 months, respectively). Standard FISH tested isolated BM CD34/lin- cells for the 87 patients at diagnosis, and for 80/87 patients after 3, 6 and 12 months of nilotinib treatment, respectively. Therefore, we performed GEP analyses of selected BM CD34+/lin- cells of 80/87 patients at diagnosis vs. the same patients after 12 months of nilotinib treatment. Then, we executed bioinformatic preprocessing and correction for batch effects on raw microarray data. Finally, we conducted differential expression analysis and significantly perturbed genes were subjected to functional clustering. Results We observed a wide variability of the number of BM MNCs as well as the number of the BM CD34+/lin- cells among the 80 CP-CML patients at diagnosis and after 3, 6 and 12 months of nilotinib for each patient (Table 1). Figure 1 showed that the number of the BM CD34+/lin- cells dramatically decreased between the diagnosis and after 3 as well as 6 months of nilotinib. We noticed that the BM CD34+/lin- cells slightly increased between 6 and 12 months of nilotinib which might be caused by the gradual repopulation of the normal CD34+/lin- cells in the bone marrow as FISH results suggested. FISH analysis detected CD34+/lin- Ph+ cells in 87 CP-CML patients at diagnosis. No positive Ph+ nuclei were detected on CD34+/lin- cells of 79/80 patients after 12 months of treatment (to categorize a sample as negative, at least 200 nuclei were examined). All of these 79 patients achieved at least complete cytogenetic response. 1/80 patient relapsed at 12 months. We conducted GEP analyses on 78 subjects because, due to experimental issues, two patients were not considered for differential expression analyses, as the microarray CEL files of the 12 months' samples were corrupted and missed probe intensities for most of the probes. GEP analyses determined 2,959 significantly differently expressed probes between diagnosis and after 12 months of nilotinib treatment. Functional clustering identified some pathways significantly enriched between diagnosis and 12 months of nilotinib. Among these pathways, we found that ABCC4, ABCC5, and ABCD3 genes associated with ATP-binding cassette (ABC) transporters were up regulated at diagnosis. GEP results highlighted that 26 genes belonging to cell cycle, mitosis, DNA damage and repair were over expressed at diagnosis. Moreover, GEP data demonstrated that JAK-STAT signaling pathway was deregulated: JAK2, IL7, STAM, PIK3CA, PTPN11, RAF1, SOS1 were over expressed whereas IL22RA1 was under expressed at diagnosis vs. 12 months of nilotinib, respectively. Conclusions In summary, we reported that BM CD34+/lin- cells from CP-CML patients after 12 months of nilotinib were characterized by changes of expression of genes involved in cell cycle checkpoints and mitosis, ABC transporters genes that pump drugs outside form the cells, and JAK-STAT signaling pathway genes responsible for the proliferation, differentiation and cell survival in CML. Disclosures Rossi: Teva: Membership on an entity's Board of Directors or advisory committees; Sanofi: Membership on an entity's Board of Directors or advisory committees; Abbvie: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees; Jazz: Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria; Mundipharma: Honoraria; BMS: Honoraria; Sandoz: Honoraria; Gilead: Membership on an entity's Board of Directors or advisory committees; Amgen: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Janssen: Membership on an entity's Board of Directors or advisory committees; Roche: Membership on an entity's Board of Directors or advisory committees. more...

Published
2018

19. Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial

Author

Horwitz, Steven, primary, O'Connor, Owen A, additional, Pro, Barbara, additional, Illidge, Tim, additional, Fanale, Michelle, additional, Advani, Ranjana, additional, Bartlett, Nancy L, additional, Christensen, Jacob Haaber, additional, Morschhauser, Franck, additional, Domingo-Domenech, Eva, additional, Rossi, Giuseppe, additional, Kim, Won Seog, additional, Feldman, Tatyana, additional, Lennard, Anne, additional, Belada, David, additional, Illés, Árpád, additional, Tobinai, Kensei, additional, Tsukasaki, Kunihiro, additional, Yeh, Su-Peng, additional, Shustov, Andrei, additional, Hüttmann, Andreas, additional, Savage, Kerry J, additional, Yuen, Sam, additional, Iyer, Swaminathan, additional, Zinzani, Pier Luigi, additional, Hua, Zhaowei, additional, Little, Meredith, additional, Rao, Shangbang, additional, Woolery, Joseph, additional, Manley, Thomas, additional, Trümper, Lorenz, additional, Aboulafia, David, additional, Alpdogan, Onder, additional, Ando, Kiyoshi, additional, Arcaini, Luca, additional, Baldini, Luca, additional, Bellam, Naresh, additional, Bartlett, Nancy, additional, Yehuda, Dina Ben, additional, Benedetti, Fabio, additional, Borchman, Peter, additional, Bordessoule, Dominique, additional, Brice, Pauline, additional, Briones, Javier, additional, Caballero, Dolores, additional, Carella, Angelo Michele, additional, Chang, Hung, additional, Cheong, June Weon, additional, Cho, Seok-Goo, additional, Choi, Ilseung, additional, Choquet, Sylvain, additional, Colita, Andrei, additional, Congui, Angela Giovanna, additional, D'amore, Francesco, additional, Dang, Nam, additional, Davison, Kelly, additional, de Guibert, Sophie, additional, Brown, Peter de Nully, additional, Delwail, Vincent, additional, Demeter, Judit, additional, di Raimondo, Francesco, additional, Do, Young Rok, additional, Domingo, Eva, additional, Douvas, Michael, additional, Dreyling, Martin, additional, Ernst, Thomas, additional, Fay, Keith, additional, Ferrero, Silvia Fernandez, additional, Flinn, Ian Winchester, additional, Forero-Torres, Andres, additional, Fox, Christopher, additional, Friedberg, Jonathan, additional, Fukuhara, Noriko, additional, Garcia-Marco, Jose, additional, Cruz, Jorge Gayoso, additional, Codina, Jose Gomez, additional, Gressin, Remy, additional, Grigg, Andrew, additional, Gurion, Ronit, additional, Haioun, Corinne, additional, Hajek, Roman, additional, Hanel, Mathias, additional, Hatake, Kiyohiko, additional, Hensen, Robert, additional, Horowitz, Netanel, additional, Horwitz, Steven, additional, Huttmann, Andreas, additional, Illes, Arpad, additional, Ishizawa, Kenichi, additional, Islas-Ohlmayer, Miguel, additional, Jacobsen, Eric, additional, Janakiram, Murali, additional, Jurczak, Wojciech, additional, Kaminski, Mark, additional, Kato, Koji, additional, Kirgner, Ilya, additional, Kuo, Ching-Yuan, additional, Lazaroiu, Mihaela Cornelia, additional, Du, Katell Le, additional, Lee, Jong-Seok, additional, LeGouill, Steven, additional, LaRosee, Paul, additional, Levi, Itai, additional, Link, Brian, additional, Maisonneuve, Herve, additional, Maruyama, Dai, additional, Mayer, Jiri, additional, McCarty, John, additional, McKay, Pam, additional, Minami, Yosuke, additional, Mocikova, Heidi, additional, Morra, Enrica, additional, Munoz, Javier, additional, Nagai, Hirokazu, additional, O'Connor, Owen, additional, Opat, Stephen, additional, Pettengell, Ruth, additional, Pezzutto, Antonio, additional, Pfreundschuh, Michael, additional, Pluta, Andrzej, additional, Porcu, PierLuigi, additional, Quach, Hang, additional, Rambaldi, Alessandro, additional, Renwick, William, additional, Reyes, Ruben, additional, Izquierdo, Antonia Rodriguez, additional, Ruan, Jia, additional, Rusconi, Chiara, additional, Salles, Gilles, additional, Santoro, Armando, additional, Sarriera, Jose, additional, Savage, Kerry, additional, Shibayama, Hirohiko, additional, Suh, Cheolwon, additional, Sureda, Anna, additional, Tanimoto, Mitsune, additional, Taniwaki, Masafumi, additional, Tilly, Herve, additional, Trneny, Marek, additional, Trumper, Lorenz, additional, Tsukamoto, Norifumi, additional, Vitolo, Umberto, additional, Walewski, Jan, additional, Weidmann, Eckhart, additional, Wilhelm, Martin, additional, Witzens-Harig, Mathias, additional, Yacoub, Abdulraheem, additional, Yamamoto, Kazuhito, additional, Yoon, Sung-Soo, additional, Yun, Hwan Jung, additional, and Zain, Jasmine, additional more...

Published
2019
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20. Jak-2 and Nfkbia Gene Expression Play a Strategic Role in Chronic Myeloid Leukemia (CML) Molecular Response during Early Nilotinib Treatment: The PhilosoPhi34 Data

Author

Pungolino, Ester, primary, D'adda, Mariella, additional, Trojani, Alessandra, additional, Perego, Alessandra, additional, Elena, Chiara, additional, Iurlo, Alessandra, additional, Malato, Simona, additional, Turrini, Mauro, additional, De Canal, Gabriella, additional, Borin, Lorenza, additional, Lodola, Milena, additional, Caramella, Marianna, additional, Artale, Salvatore, additional, Spina, Francesco, additional, Latargia, Maria Luisa, additional, Anghilieri, Michela, additional, Spedini, Pierangelo, additional, Carraro, Mariacristina, additional, Di Camillo, Barbara, additional, Gramegna, Doriana, additional, Pioltelli, Maria Luisa, additional, Rossi, Giuseppe, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2018
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21. Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

Author

Trojani, Alessandra, primary, Pungolino, Ester, additional, Rossi, Giuseppe, additional, D'adda, Mariella, additional, Lodola, Milena, additional, Dal Molin, Alessandra, additional, Baruzzo, Giacomo, additional, Perego, Alessandra, additional, Turrini, Mauro, additional, Elena, Chiara, additional, Borin, Lorenza Maria, additional, Iurlo, Alessandra, additional, Malato, Simona, additional, Spina, Francesco, additional, Latargia, Maria Luisa, additional, Spedini, Pierangelo, additional, Artale, Salvatore, additional, Anghilieri, Michela, additional, Maria Cristina, Carraro, additional, Bucelli, Cristina, additional, De Canal, Gabriella, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2018
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22. Combining Imatinib-Following-Nilotinib Treatment in First Line Therapy for Chronic Phase Chronic Myeloid Leukemia. Update from the PhilosoPhi34 Study at 24 Months of Follow-up

Author

Pioltelli, Maria Luisa, primary, Pungolino, Ester, additional, D'adda, Mariella, additional, Elena, Chiara, additional, Borin, Lorenza Maria, additional, Perego, Alessandra, additional, Iurlo, Alessandra, additional, Trojani, Alessandra, additional, Turrini, Mauro, additional, Caramella, Marianna, additional, Spedini, Pierangelo, additional, Malato, Simona, additional, Spina, Francesco, additional, Artale, Salvatore, additional, Carraro, Mariacristina, additional, Orofino, Nicola, additional, Anghilieri, Michela, additional, Farina, Mirko, additional, Latargia, Maria Luisa, additional, Rossi, Giuseppe, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2018
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23. Prognostic value of end-of-induction PET response after first-line immunochemotherapy for follicular lymphoma (GALLIUM): secondary analysis of a randomised, phase 3 trial

Author

Trotman, Judith, primary, Barrington, Sally F, additional, Belada, David, additional, Meignan, Michel, additional, MacEwan, Robert, additional, Owen, Carolyn, additional, Ptáčník, Václav, additional, Rosta, András, additional, Fingerle-Rowson, Günter R, additional, Zhu, Jiawen, additional, Nielsen, Tina, additional, Sahin, Deniz, additional, Hiddemann, Wolfgang, additional, Marcus, Robert E, additional, Davies, Andrew, additional, Hertzberg, Mark, additional, Grigg, Andrew, additional, Cannell, Paul, additional, Quach, Hang, additional, Opat, Stephen, additional, Tam, Constantine, additional, Marlton, Paula, additional, Janssens, Ann, additional, Offner, Fritz, additional, Van eygen, Koen, additional, Sangha, Randeep, additional, Mckay, Pam, additional, Wilson, Jonathan, additional, Van Der Jagt, Richard, additional, Roitman, Daryl, additional, Trneny, Marek, additional, Mayer, Jiri, additional, Le Du, Katell, additional, Solal-Celigny, Philippe, additional, Cartron, Guillaume, additional, Foussard, Charles, additional, Frickhofen, Norbert, additional, Schmidt, Peter, additional, Graeven, Ullrich, additional, Gaska, Tobias, additional, Schlag, Rudolf, additional, Sökler, Martin, additional, Prange-Krex, Gabriele, additional, Florschütz, Axel, additional, Lindemann, Hans-Walter, additional, Schimmelpfennig, Christoph, additional, Tonndorf, Solveig, additional, Hänel, Mathias, additional, Hess, Georg, additional, Schalk, Enrico, additional, Hütten, Heiko, additional, Doelken, Gottfried, additional, Pfreundschuh, Michael, additional, Keller, Ulrich, additional, Herold, Michael, additional, Forstpointner, Roswitha, additional, Vehling-Kaiser, Ursula, additional, Hoffmann, Martin, additional, Borbenyi, Zita, additional, Udvardy, Miklos, additional, Demeter, Judit, additional, Rambaldi, Alessandro, additional, Morra, Enrica, additional, Massimo, Federico, additional, Majolino, Ignazio, additional, Balzarotti, Monica, additional, Semenzato, Gianpietro, additional, Canales Albendea, Miguel Angel, additional, Peñalver Parraga, Francisco Javier, additional, Soler Campos, Alfonso, additional, Sancho Cia, Juan Manuel, additional, Marquez Navarro, Jose Antonio, additional, Grande Garcia, Carlos, additional, Nilsson-Ehle, Herman, additional, Mccarthy, Helen, additional, Pocock, Chris, additional, Sadullah, Shalal, additional, Malladi, Ram, additional, Radford, John, additional, Kanfer, Ed, additional, Kruger, Anton, additional, Culligan, Dominic, additional, Dyer, Martin, additional, Pettengell, Ruth, additional, Seymour, John, additional, Gribben, John, additional, Al-Ismail, Saad, additional, Al-Refaie, Faris, additional, Blesing, Norbert, additional, Macnamara, Christopher, additional, O'callaghan, Ann, additional, Haynes, Andrew, additional, Follows, George, additional, Johnson, Roderick, additional, Cunningham, David, additional, Bowles, Kristian, additional, Collins, Graham, additional, Gallop-Evans, Eve, additional, Robinson, Stephen, additional, Subash, Chezhian, additional, Bailey, James, additional, Holden, Viran, additional, Neidhart, Jeffrey, additional, De Oliveira, Moacyr, additional, Tezcan, Haluk, additional, Kim, Kevin, additional, Kambhampati, Suman, additional, Lanier, Keith, additional, Mcclean, John, additional, Tobinai, Kensei, additional, Hatake, Kiyohiko, additional, Ogura, Michinori, additional, Uchida, Toshiki, additional, Ando, Kiyoshi, additional, Kinoshita, Tomohiro, additional, Höhler, Thomas, additional, Stauder, Heribert, additional, Kirsch, Andreas, additional, Koenigsmann, Michael, additional, Kremers, Stephan, additional, Illmer, Thomas, additional, Witzens-Harig, Mathias, additional, La Roseé, Paul, additional, Dürig, Jan, additional, Kneba, Michael, additional, Hensel, Manfred, additional, Fuxius, Stefan, additional, Bergmann, Lothar, additional, Hübel, Kai, additional, Buske, Christian, additional, Marks, Reinhard, additional, Wulf, Gerald, additional, Lerchenmueller, Christian, additional, Schmits, Rudolf, additional, Reinwald, Mark, additional, Lengfelder, Eva, additional, Scott, Fiona, additional, Chou, Takaaki, additional, Taniwaki, Masafumi, additional, Yoshida, Isao, additional, Ishizawa, Kenichi, additional, Uike, Naokuni, additional, Uoshima, Nobuhiko, additional, Kamitsuji, Yuri, additional, Iida, Shinsuke, additional, Ohmine, Ken, additional, Nosaka, Kisato, additional, Ide, Kazuhiko, additional, Ishikawa, Takayuki, additional, Desjardins, Pierre, additional, Finn, Nicholas, additional, Zhu, Jun, additional, Li, Wei, additional, Yu, Li, additional, Ren, Hanyun, additional, Shi, Yuan Kai, additional, Wu, Gang, additional, Hong, Xiaonan, additional, Zhang, Qingyuan, additional, Feng, Jifeng, additional, Zhan, Rong, additional, Lin, Tongyu, additional, Leppa, Sirpa, additional, Costello, Regis, additional, Tempescul, Adrian, additional, Sanhes, Laurence, additional, Tournilhac, Olivier, additional, Kirchen, Heinz, additional, Hebart, Holger, additional, Weide, Rudolf, additional, Jentsch-Ullrich, Kathleen, additional, Avivi, Irit, additional, Nagler, Arnon, additional, Gurion, Ronit, additional, Shpilberg, Ofer, additional, Leoni, Pietro, additional, Baldini, Luca, additional, Samoylova, Olga, additional, Myasnikov, Alexandr, additional, Tan, Tran-Der, additional, Chang, Hung, additional, Kumagai, Kyoya, additional, Tsukamoto, Norifumi, additional, Tsukasaki, Kunihiro, additional, Beatty, Patrick, additional, Usui, Noriko, additional, Izutsu, Koji, additional, Murayama, Tohru, additional, Ichinohe, Tatsuo, additional, Kubo, Kohmei, additional, Ishida, Fumihiro, additional, Beck, J. Thaddeus, additional, Griesinger, Frank, additional, Osmanov, Dzhelil, additional, Dakhil, Shaker, additional, Clavert, Aline, additional, Maruyama, Dai, additional, Terui, Yasuhito, additional, Yamamoto, Kazuhito, additional, Eigendorff, Ekkehard, additional, Kobayashi, Tsutomu, additional, Ichikawa, Satoshi, additional, Choi, Ilseung, additional, Wada, Katsuya, additional, Kikukawa, Yoshitaka, additional, Matsuoka, Masao, additional, Yoshino, Takayuki, additional, and Minami, Yosuke, additional more...

Published
2018
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24. Nilotinib induced bone marrow CD34+/lin-Ph+ cells early clearance in newly diagnosed CP-chronic myeloid leukemia

Author

Pungolino, Ester, primary, Rossi, Giuseppe, additional, De Canal, Gabriella, additional, Trojani, Alessandra, additional, D'adda, Mariella, additional, Perego, Alessandra, additional, Orlandi, Ester Maria, additional, Lunghi, Francesca, additional, Turrini, Mauro, additional, Borin, Lorenza, additional, Iurlo, Alessandra, additional, Latargia, Maria Luisa, additional, Carraro, Maria Cristina, additional, Spina, Francesco, additional, Lodola, Milena, additional, Artale, Salvatore, additional, Anghilieri, Michela, additional, Spedini, Pierangelo, additional, Cantoni, Silvia, additional, Di Camillo, Barbara, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2018
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27. Wide-transcriptome analysis and cellularity of bone marrow CD34+/lin- cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs. 12 months of first-line nilotinib treatment

Author

Trojani, Alessandra, primary, Pungolino, Ester, additional, Rossi, Giuseppe, additional, D’Adda, Mariella, additional, Lodola, Milena, additional, Camillo, Barbara Di, additional, Perego, Alessandra, additional, Turrini, Mauro, additional, Orlandi, Ester, additional, Borin, Lorenza, additional, Iurlo, Alessandra, additional, Malato, Simona, additional, Spina, Francesco, additional, Latargia, Maria Luisa, additional, Lanza, Francesco, additional, Artale, Salvatore, additional, Anghilieri, Michela, additional, Carraro, Maria Cristina, additional, Canal, Gabriella De, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2017
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28. Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia : A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia

Author

Castillo, Jorge J, Garcia-Sanz, Ramon, Hatjiharissi, Evdoxia, Kyle, Robert A, Leleu, Xavier, McMaster, Mary, Merlini, Giampaolo, Minnema, Monique C, Morra, Enrica, Owen, Roger G, Poulain, Stephanie, Stone, Marvin J, Tam, Constantine, Varettoni, Marzia, Dimopoulos, Meletios A, Treon, Steven P, Kastritis, Efstathios, Castillo, Jorge J, Garcia-Sanz, Ramon, Hatjiharissi, Evdoxia, Kyle, Robert A, Leleu, Xavier, McMaster, Mary, Merlini, Giampaolo, Minnema, Monique C, Morra, Enrica, Owen, Roger G, Poulain, Stephanie, Stone, Marvin J, Tam, Constantine, Varettoni, Marzia, Dimopoulos, Meletios A, Treon, Steven P, and Kastritis, Efstathios more...

Published
2016

29. Treatment recommendations from the Eighth International Workshop on Waldenström's Macroglobulinemia

Author

MS Hematologie, Regenerative Medicine and Stem Cells, Infection & Immunity, Leblond, Véronique, Kastritis, Efstathios, Advani, Ranjana, Ansell, Stephen M, Buske, Christian, Castillo, Jorge J, García-Sanz, Ramón, Gertz, Morie, Kimby, Eva, Kyriakou, Charalampia, Merlini, Giampaolo, Minnema, Monique C, Morel, Pierre, Morra, Enrica, Rummel, Mathias, Wechalekar, Ashutosh, Patterson, Christopher J, Treon, Steven P, Dimopoulos, Meletios A, MS Hematologie, Regenerative Medicine and Stem Cells, Infection & Immunity, Leblond, Véronique, Kastritis, Efstathios, Advani, Ranjana, Ansell, Stephen M, Buske, Christian, Castillo, Jorge J, García-Sanz, Ramón, Gertz, Morie, Kimby, Eva, Kyriakou, Charalampia, Merlini, Giampaolo, Minnema, Monique C, Morel, Pierre, Morra, Enrica, Rummel, Mathias, Wechalekar, Ashutosh, Patterson, Christopher J, Treon, Steven P, and Dimopoulos, Meletios A more...

Published
2016

30. Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia

Author

MS Hematologie, Regenerative Medicine and Stem Cells, Infection & Immunity, Castillo, Jorge J, Garcia-Sanz, Ramon, Hatjiharissi, Evdoxia, Kyle, Robert A, Leleu, Xavier, McMaster, Mary, Merlini, Giampaolo, Minnema, Monique C, Morra, Enrica, Owen, Roger G, Poulain, Stephanie, Stone, Marvin J, Tam, Constantine, Varettoni, Marzia, Dimopoulos, Meletios A, Treon, Steven P, Kastritis, Efstathios, MS Hematologie, Regenerative Medicine and Stem Cells, Infection & Immunity, Castillo, Jorge J, Garcia-Sanz, Ramon, Hatjiharissi, Evdoxia, Kyle, Robert A, Leleu, Xavier, McMaster, Mary, Merlini, Giampaolo, Minnema, Monique C, Morra, Enrica, Owen, Roger G, Poulain, Stephanie, Stone, Marvin J, Tam, Constantine, Varettoni, Marzia, Dimopoulos, Meletios A, Treon, Steven P, and Kastritis, Efstathios more...

Published
2016

31. Transcriptome Analysis Identified Significant Differences in Gene Expression Variability Between WM and IgM-MGUS BM B Cell Clones

Author

Trojani, Alessandra, primary, Lodola, Milena, additional, Tedeschi, Alessandra, additional, Greco, Antonino, additional, Di Camillo, Barbara, additional, Sanavia, Tiziana, additional, Frustaci, Anna Maria, additional, Mazzucchelli, Maddalena, additional, Villa, Chiara, additional, Boselli, Daniela, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2016
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32. The REL-Protocol PhilosoPhi34 - an Open Label, Single Arm, Phase II Study of Nilotinib 300 Mg BID in Newly Diagnosed Chronic Phase Chronic Myeloid Leukaemia (CML) Patients - Confirms Early Clearance of Bone Marrow CD34+/Lin-Ph+ Cells

Author

Pungolino, Ester, primary, De Canal, Gabriella, additional, D'adda, Mariella, additional, Perego, Alessandra, additional, Turrini, Mauro, additional, Orlandi, Ester Maria, additional, Trojani, Alessandra, additional, Borin, Lorenza, additional, Iurlo, Alessandra, additional, Latargia, Maria Luisa, additional, Malato, Simona, additional, Carraro, Maria Cristina, additional, Brusorio, Stefania, additional, Elena, Chiara, additional, Spina, Francesco, additional, Lodola, Milena, additional, Artale, Salvatore, additional, Anghilieri, Michela, additional, Bucelli, Cristina, additional, Pioltelli, Maria Luisa, additional, Cantoni, Silvia, additional, Rossi, Giuseppe, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2016
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33. Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia

Author

Castillo, Jorge J., primary, Garcia‐Sanz, Ramon, additional, Hatjiharissi, Evdoxia, additional, Kyle, Robert A., additional, Leleu, Xavier, additional, McMaster, Mary, additional, Merlini, Giampaolo, additional, Minnema, Monique C., additional, Morra, Enrica, additional, Owen, Roger G., additional, Poulain, Stephanie, additional, Stone, Marvin J., additional, Tam, Constantine, additional, Varettoni, Marzia, additional, Dimopoulos, Meletios A., additional, Treon, Steven P., additional, and Kastritis, Efstathios, additional more...

Published
2016
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34. Clonal architecture ofCXCR4WHIM-like mutations in Waldenström Macroglobulinaemia

Author

Xu, Lian, primary, Hunter, Zachary R., additional, Tsakmaklis, Nicholas, additional, Cao, Yang, additional, Yang, Guang, additional, Chen, Jie, additional, Liu, Xia, additional, Kanan, Sandra, additional, Castillo, Jorge J., additional, Tai, Yu-Tzu, additional, Zehnder, James L., additional, Brown, Jennifer R., additional, Carrasco, Ruben D., additional, Advani, Ranjana, additional, Sabile, Jean M., additional, Argyropoulos, Kimon, additional, Lia Palomba, M., additional, Morra, Enrica, additional, Trojani, Alessandra, additional, Greco, Antonino, additional, Tedeschi, Alessandra, additional, Varettoni, Marzia, additional, Arcaini, Luca, additional, Munshi, Nikhil M., additional, Anderson, Kenneth C., additional, and Treon, Steven P., additional more...

Published
2015
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35. The Clonal Architecture of CXCR4mutations in Waldenstrom's Macroglobulinemia Shows Highly Variable Subclonal Distribution, and Multiple Mutations within Individual Patients Indicative of Targeted Genomic Instability

Author

Xu, Lian, primary, Hunter, Zachary, additional, Tsakmaklis, Nicholas, additional, Cao, Yang, additional, Yang, Guang, additional, Chen, Jie, additional, Liu, Xia, additional, Kanan, Sandra, additional, Castillo, Jorge J, additional, Tai, Yu-Tzu, additional, Zehnder, James L., additional, Brown, Jennifer R., additional, Carrasco, Ruben D., additional, Advani, Ranjana H, additional, Argyropoulos, Kimon V., additional, Palomba, M. Lia, additional, Morra, Enrica, additional, Trojani, Alessandra, additional, Greco, Antonino, additional, Tedeschi, Alessandra, additional, Varettoni, Marzia, additional, Arcaini, Luca, additional, Munshi, Nikhil C., additional, Anderson, Kenneth C, additional, and Treon, Steven P, additional more...

Published
2015
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36. Long Term Toxicity and Follow-up of Waldenstrom´s Macroglobulinemia Patients after Salvage Treatment with Fludarabine Cyclophosphamide Rituximab or Bendamustine and Rituximab

Author

Tedeschi, Alessandra, primary, Picardi, Paola, additional, Goldaniga, Maria Cecilia, additional, Margiotta Casaluci, Gloria, additional, Benevolo, Giulia, additional, Ferrero, Simone, additional, Varettoni, Marzia, additional, Baratè, Claudia, additional, Gini, Guido, additional, Visco, Carlo, additional, Motta, Marina, additional, Belsito Petrizzi, Valeria, additional, Zaja, Francesco, additional, Ravelli, Erica, additional, Gentile, Massimo, additional, Frustaci, Anna Maria, additional, Orsucci, Lorella, additional, Morra, Enrica, additional, Gaidano, Gianluca, additional, and Cairoli, Roberto, additional more...

Published
2015
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37. GEP Analyses of Bone Marrow CD34+/Lin- Cells of Chronic Phase CML Patients at Diagnosis Identified Different Sets of Genes Associated to the Molecular Response after 3 and 6 Months of First-Line Nilotinib Treatment

Author

Trojani, Alessandra, primary, Pungolino, Ester, additional, Lodola, Milena, additional, Di Camillo, Barbara, additional, D'Adda, Mariella, additional, Perego, Alessandra, additional, Turrini, Mauro, additional, Elena, Chiara, additional, Iurlo, Alessandra, additional, Buccelli, Cristina, additional, Malato, Simona, additional, Spina, Francesco, additional, Latargia, Maria Luisa, additional, Lanza, Francesco, additional, Pauli, Sergio, additional, Anghilieri, Michela, additional, Carraro, Maria Cristina, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2015
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38. REL-Protocol PhilosoPhi34: An Open Label, Single Arm, Phase II Study of Nilotinib 300 Mg BID in Newly Diagnosed Chronic Phase Chronic Myeloid Leukaemia Patients, to Study the Disappearance of CD34+/Lin-Ph+ Cells from Bone Marrow during Treatment. Preliminary Data

Author

Pungolino, Ester, primary, Rossi, Giuseppe, additional, Mura, Maria Angela, additional, Perego, Alessandra, additional, Orlandi, Ester Maria, additional, Turrini, Mauro, additional, Borin, Lorenza, additional, Capucci, Maria Adele, additional, Iurlo, Alessandra, additional, Trojani, Alessandra, additional, D'Adda, Mariella, additional, Spina, Francesco, additional, De Canal, Gabriella, additional, Pioltelli, Maria Luisa, additional, Latargia, Maria Luisa, additional, Pauli, Sergio, additional, Elena, Chiara, additional, Brusorio, Stefania, additional, Lanza, Francesco, additional, Malato, Simona, additional, Anghilieri, Michela, additional, Carraro, Maria C, additional, Morra, Enrica, additional, and Cairoli, Roberto, additional more...

Published
2015
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40. Abstract 5491: Sequential use of first and second generation TKIs are effective on prolonged overall survival in elderly population affected by Ph+ acute lymphoblastic leukemia: the GIMEMA experience

Author

Sartor, Chiara, primary, Papayannidis, Cristina, additional, Piciocchi, Alfonso, additional, Vitale, Antonella, additional, Iacobucci, Ilaria, additional, Soverini, Simona, additional, Lollini, Pier Luigi, additional, Di Raimondo, Francesco, additional, Paolini, Stefania, additional, Bonifacio, Massimiliano, additional, Carella, Angelo Michele, additional, Cazzola, Mario, additional, Cuneo, Antonio, additional, Leoni, Pietro, additional, Luppi, Mario, additional, Morra, Enrica, additional, Specchia, Giorgina, additional, Elia, Loredana, additional, Foà, Robin, additional, Baccarani, Michele, additional, and Martinelli, Giovanni, additional more...

Published
2015
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41. Gene Expression Profiling and Cellularity of Bone Marrow CD34+/Lin- Cells of Patients with Chronic-Phase Chronic Myeloid Leukemia at Diagnosis Vs. 12 Months of First-Line Nilotinib Treatment

Author

Trojani, Alessandra, Pungolino, Ester, Rossi, Giuseppe, D'Adda, Mariella, Lodola, Milena, Di Camillo, Barbara, Perego, Alessandra, Turrini, Mauro, Orlandi, Ester Maria, Borin, Lorenza Maria, Iurlo, Alessandra, Malato, Simona, Spina, Francesco, Latargia, Maria Luisa, Lanza, Francesco, Artale, Salvatore, Anghilieri, Michela, Maria Cristina, Carraro, Bucelli, Cristina, De Canal, Gabriella, Morra, Enrica, and Cairoli, Roberto more...

Published
2017
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42. Preliminary Experience of Imatinib after Nilotinib in the First Line Treatment of Chronic Myeloid Leukemia

Author

Pungolino, Ester, D'adda, Mariella, Perego, Alessandra, Orlandi, Ester Maria, Turrini, Mauro, Borin, Lorenza Maria, Iurlo, Alessandra, Artale, Salvatore, Latargia, Maria Luisa, Anghilieri, Michela, Malato, Simona, Trojani, Alessandra, Spina, Francesco, Maria Cristina, Carraro, Pioltelli, Maria Luisa, Elena, Chiara, Bucelli, Cristina, Spedini, Pierangelo, Rossi, Giuseppe, Morra, Enrica, and Cairoli, Roberto more...

Published
2017
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43. Bendamustine and rituximab combination is safe and effective as salvage regimen in Waldenström macroglobulinemia

Author

Tedeschi, Alessandra, primary, Picardi, Paola, additional, Ferrero, Simone, additional, Benevolo, Giulia, additional, Margiotta Casaluci, Gloria, additional, Varettoni, Marzia, additional, Baratè, Claudia, additional, Motta, Marina, additional, Gini, Guido, additional, Goldaniga, Maria Cecilia, additional, Visco, Carlo, additional, Zaja, Francesco, additional, Belsito Petrizi, Valeria, additional, Ravelli, Erika, additional, Gentile, Massimo, additional, Urbano, Marina Aurora, additional, Franceschetti, Silvia, additional, Ghione, Paola, additional, Orsucci, Lorella, additional, Frustaci, Anna Maria, additional, Gaidano, Gianluca, additional, Vitolo, Umberto, additional, and Morra, Enrica, additional more...

Published
2015
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44. Jak-2and Nfkbia Gene Expression Play a Strategic Role in Chronic Myeloid Leukemia (CML) Molecular Response during Early Nilotinib Treatment: The PhilosoPhi34 Data

Author

Pungolino, Ester, D'adda, Mariella, Trojani, Alessandra, Perego, Alessandra, Elena, Chiara, Iurlo, Alessandra, Malato, Simona, Turrini, Mauro, De Canal, Gabriella, Borin, Lorenza, Lodola, Milena, Caramella, Marianna, Artale, Salvatore, Spina, Francesco, Latargia, Maria Luisa, Anghilieri, Michela, Spedini, Pierangelo, Carraro, Mariacristina, Di Camillo, Barbara, Gramegna, Doriana, Pioltelli, Maria Luisa, Rossi, Giuseppe, Morra, Enrica, and Cairoli, Roberto more...

Abstract

BackgroundTargeted therapy with Tyrosine-Kinase-Inhibitors (TKIs) totally modified the course of treatment of Chronic Myeloid Leukemia (CML). The objectives and the needs of treatment have been modified during the last years and the discontinuation of therapy is now a feasible aim. However, a lot of biological data acquired in the last twenty years, showed that degree and mechanisms of Leukemic Stem Cells (LSCs) clearance during TKI treatment are not clearly established as well as the predictive criteria for a stable and prolonged Treatment Free Remission (TFR). The multicentre, prospective, single-arm PhilosoPhi34 study (EudraCT: 2012-005062-34) was designed by the Rete Ematologica Lombarda (REL), to verify the in-vivo activity and time-course of first-line Nilotinib (NIL) therapy on Bone Marrow (BM) CD34+/lin-Ph+ cells clearance. An exploratory Gene Expression Profiling (GEP) study of CD34+/lin- cells at diagnosis and at 12 months (mos) of treatment, for the first 30 evaluable pts, was included. Preliminary GEP data suggested a correlation between different NFKBIAexpression at diagnosis and at 12 mos and the achievement of a deeper Molecular Response (MR) (Pungolino et al, AJH 2018). more...

Published
2018
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45. Lymphomas associated with chronic hepatitis C virus infection: A prospective multicenter cohort study from the Rete Ematologica Lombarda (REL) clinical network.

Author

Rattotti S, Ferretti VV, Rusconi C, Rossi A, Fogazzi S, Baldini L, Pioltelli P, Balzarotti M, Farina L, Ferreri AJM, Laszlo D, Speziale V, Varettoni M, Sciarra R, Morello L, Tedeschi A, Frigeni M, Defrancesco I, Zerbi C, Flospergher E, Nizzoli ME, Morra E, and Arcaini L more...

Subjects
Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Follow-Up Studies, Humans, Italy epidemiology, Male, Middle Aged, Prospective Studies, Survival Rate, Hepacivirus, Hepatitis C, Chronic diagnosis, Hepatitis C, Chronic drug therapy, Hepatitis C, Chronic mortality, Interferons administration & dosage, Lymphoma, Non-Hodgkin diagnosis, Lymphoma, Non-Hodgkin drug therapy, Lymphoma, Non-Hodgkin mortality
Abstract

Chronic hepatitis C virus (HCV) infection is related with an increased risk of non-Hodgkin lymphomas (NHL). In indolent subtypes, regression of NHL was reported after HCV eradication with antiviral therapy (AT). In 2008 in Lombardy, a region of Northern Italy, the "Rete Ematologica Lombarda" (REL, Hematology Network of Lombardy-Lymphoma Workgroup) started a prospective multicenter observational cohort study on NHL associated with HCV infection, named "Registro Lombardo dei Linfomi HCV-positivi" ("Lombardy Registry of HCV-associated non-Hodgkin lymphomas"). Two hundred fifty patients with a first diagnosis of NHL associated with HCV infection were enrolled; also in our cohort, diffuse large B cell lymphoma (DLBCL) and marginal zone lymphoma (MZL) are the two most frequent HCV-associated lymphomas. Two thirds of patients had HCV-positivity detection before NHL; overall, NHL was diagnosed after a median time of 11 years since HCV survey. Our data on eradication of HCV infection were collected prior the recent introduction of the direct-acting antivirals (DAAs) therapy. Sixteen patients with indolent NHL treated with interferon-based AT as first line anti-lymphoma therapy, because of the absence of criteria for an immediate conventional treatment for lymphoma, had an overall response rate of 90%. After a median follow-up of 7 years, the overall survival (OS) was significantly longer in indolent NHL treated with AT as first line (P = 0.048); this confirms a favorable outcome in this subset. Liver toxicity was an important adverse event after a conventional treatment in 20% of all patients, in particular among DLBCL, in which it is more frequent the coexistence of a more advanced liver disease. Overall, HCV infection should be consider as an important co-pathology in the treatment of lymphomas and an interdisciplinary approach should be always considered, in particular to evaluate the presence of fibrosis or necroinflammatory liver disease., (© 2019 John Wiley & Sons, Ltd.) more...

Published
2019
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