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145 results on '"Mosavat, Arman"'

14. Novel insights into human T‐lymphotropic virus type‐1 (HTLV‐1) pathogenesis‐host interactions in the manifestation of HTLV‐1‐associated myelopathy/tropical spastic paraparesis.

Author

Ahmadi Ghezeldasht, Sanaz, Mosavat, Arman, and Rezaee, Seyed Abdolrahim

Abstract

Human T‐lymphotropic virus type‐1 (HTLV‐1) was the first discovered human oncogenic retrovirus, the etiological agent of two serious diseases have been identified as adult T‐cell leukaemia/lymphoma malignancy and HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neuro‐myelopathy. Despite more than 40 years of molecular, histopathological and immunological studies on HTLV‐1‐associated diseases, the virulence and pathogenicity of this virus are yet to be clarified. The reason why the majority of HTLV‐1‐infected individuals (∼95%) remain asymptomatic carriers is still unclear. The deterioration of the immune system towards oncogenicity and autoimmunity makes HTLV‐1 a natural probe for the study of malignancy and neuro‐inflammatory diseases. Additionally, its slow worldwide spreading has prompted public health authorities and researchers, as urged by the WHO, to focus on eradicating HTLV‐1. In contrast, neither an effective therapy nor a protective vaccine has been introduced. This comprehensive review focused on the most relevant studies of the neuro‐inflammatory propensity of HTLV‐1‐induced HAM/TSP. Such an emphasis on the virus‐host interactions in the HAM/TSP pathogenesis will be critically discussed epigenetically. The findings may shed light on future research venues in designing and developing proper HTLV‐1 therapeutics. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Immigrating and vicinity are not risk factors in the prevalence and transmission rate of human T-lymphotropic virus type 1: A Survey in an endemic region of Iran and Afghan refugees

Author

Mahdifar, Maryam, primary, Akbari-Eidgahi, Mohammad Reza, additional, Mosavat, Arman, additional, Pourreza, Alireza, additional, Akbarin, Mohammad Mehdi, additional, Valizadeh, Narges, additional, Rezaee, Seyed Abdolrahim, additional, and Rafatpanah, Houshang, additional

Published
2023
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23. Molecular insight into the study of adult T-cell leukemia/lymphoma (ATLL): Ten-year studies on HTLV-1 associated diseases in an endemic region

Author

Ashrafi, Fereshteh, primary, Rahimzada, Masooma, additional, Parandi, Mahsa, additional, Mirhosseini, Ali, additional, Mashkani, Baratali, additional, Ahmadi Ghezeldasht, Sanaz, additional, Soltani, Ararsh, additional, Rafatpanah, Houshang, additional, Mosavat, Arman, additional, and Abdolrahim Rezaee, Seyed, additional

Published
2022
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28. Immigrating and Vicinity are Not Risk Factors in the Prevalence and Transmission Rate of HTLV-1: A Survey in an Endemic Region of Iran and Afghan Refugees

Author

Mahdifar, Maryam, primary, Akbari-Eidgahi, Mohammad Reza, additional, Mosavat, Arman, additional, Pourreza, Alireza, additional, Akbarin, Mohammad Mehdi, additional, Valizadeh, Narges, additional, Sarbaz, Masoumeh, additional, Kiani, Behzad, additional, Rezaee, Seyed Abdolrahim, additional, and Rafatpanah, Houshang, additional

Published
2022
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31. TAX and HBZ: hFc Ɣ 1 proteins as targets for passive immunotherapy.

Author

Akbarin, Mohammad Mehdi, Rafatpanah, Houshang, Soleimanpour, Saman, Amini, Abbas Ali, Arian, Amirali, Mosavat, Arman, and Rezaee, Seyed Abdolrahim

Subjects
SYNTAXINS, RECOMBINANT proteins, HUMORAL immunity, CHIMERIC proteins, PICHIA pastoris
Abstract

Objective(s): Human T leukemia virus type one (HTLV-1) causes two life-threatening diseases in around five percent of infected subjects, a T cell malignancy and a neurodegenerative disease. TAX and HBZ are the main virulence agents implicated in the manifestation of HTLV-1-associated diseases. Therefore, this study aims to produce these HTLV-1 factors as recombinant Fc fusion proteins to study the structures, their immunogenic properties as vaccines, and their capability to produce specific neutralization antibodies. Materials and Methods: TAX and HBZ sequences were chosen from the NCBI-nucleotide database, then designed as human Fc chimers and cloned into Pichia pastoris. Produced proteins were purified by HiTrap affinity chromatography and subcutaneously injected into rabbits. Rabbit Abs were purified by batch chromatography, and their neutralization activities for the HTLV-1-infected MT-2 cell line were assessed. Furthermore, the protective abilities of recombinant proteins were evaluated in Tax or HBZ immunized rabbits by MT-2 cell line inoculation and measurement of HTLV-1-proviral load. Results: Specific Abs against Tax and HBZ can eliminate 2 million MT-2 cells in 1/1000 dilution in vitro. In challenging assays, the immunization of the animals using Tax or HBZ had no protective activity as HTLV-1 PVL was still positive. Conclusion: The result suggests that recombinant TAX and HBZ: hFcγ1 proteins can produce a proper humoral immune response. Therefore, they could be considered a passive immunotherapy source for HTLV-1-associated diseases, while total TAX and HBZ proteins are unsuitable as HTLV-1 vaccine candidates. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Prevalence and Associated Risk Factors of HTLV-1 and Co-infections of Blood-Borne Viruses in Birjand, Iran’s Eastern Border

Author

Yousefi, Masoud, primary, Sharifzadeh, Gholam Reza, additional, Ebrahimzadeh, Azadeh, additional, Azarkar, Zohreh, additional, Namaei, Mohammad Hasan, additional, Azarkar, Ghedsiyeh, additional, Ahmadi Ghezeldasht, Sanaz, additional, Rezaee, Rahim, additional, Valizadeh Zare, Najmeh, additional, Mosavat, Arman, additional, and Ziaee, Masood, additional

Published
2020
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36. Combination of auraptene and arsenic trioxide induces apoptosis and cellular accumulation in the subG1 phase in adult T-cell leukemia cells.

Author

Kazemi, Mohaddeseh, Kouhpeikar, Hamideh, Delbari, Zahra, Khodadadi, Faeze, Gerayli, Sina, Iranshahi, Mehrdad, Mosavat, Arman, Rassouli, Fatemeh Behnam, and Rafatpanah, Houshang

Subjects
ADULT T-cell leukemia, CELL survival, CELL cycle, ARSENIC trioxide, APOPTOSIS, CD44 antigen, FLOW cytometry, COUMARINS
Abstract

Objective(s): Despite advances in the treatment of adult T-cell leukemia/lymphoma (ATLL), the survival rate of this malignancy remains significantly low. Auraptene (AUR) is a natural coumarin with broad-spectrum anticancer activities. To introduce a more effective therapeutic strategy for ATLL, we investigated the combinatorial effects of AUR and arsenic trioxide (ATO) on MT-2 cells. Materials and Methods: The cells were treated with different concentrations of AUR for 24, 48, and 72 hr, and viability was measured by alamarBlue assay. Then, the combination of AUR (20 µg/ml) and ATO (3 µg/ml) was administrated and the cell cycle was analyzed by PI staining followed by flow cytometry analysis. In addition, the expression of NF-κB (REL-A), CD44, c-MYC, and BMI-1 was evaluated via qPCR. Results: Assessment of cell viability revealed increased toxicity of AUR and ATO when used in combination. Our findings were confirmed by accumulation of cells in the sub G1 phase of the cell cycle and significant down-regulation of NF-κB (REL-A), CD44, c-MYC, and BMI-1. Conclusion: Obtained findings suggest that combinatorial use of AUR and ATO could be considered for designing novel chemotherapy regimens for ATLL. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Mycobacterium tuberculosisand host interactions in the manifestation of tuberculosis

Author

Abbasnia, Shadi, Hashem Asnaashari, Amir Mohammad, Sharebiani, Hiva, Soleimanpour, Saman, Mosavat, Arman, and Rezaee, Seyed Abdolrahim

Abstract

The final step of epigenetic processes is changing the gene expression in a new microenvironment in the body, such as neuroendocrine changes, active infections, oncogenes, or chemical agents. The case of tuberculosis (TB) is an outcome of Mycobacterium tuberculosis(M.tb) and host interaction in the manifestation of active and latent TB or clearance. This comprehensive review explains and interprets the epigenetics findings regarding gene expressions on the host-pathogen interactions in the development and progression of tuberculosis. This review introduces novel insights into the complicated host-pathogen interactions, discusses the challengeable results, and shows the gaps in the clear understanding of M.tbbehavior. Focusing on the biological phenomena of host-pathogen interactions, the epigenetic changes, and their outcomes provides a promising future for developing effective TB immunotherapies when converting gene expression toward appropriate host immune responses gradually becomes attainable. Overall, this review may shed light on the dark sides of TB pathogenesis as a life-threatening disease. Therefore, it may support effective planning and implementation of epigenetics approaches for introducing proper therapies or effective vaccines.

Published
2024
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38. Prediction of HCV load using genotype, liver biomarkers, and clinical symptoms by a mathematical model in patients with HCV infection

Author

Basharkhah, Samira, primary, Sabet, Faezeh, additional, Ghezeldasht, Sanaz Ahmadi, additional, Mosavat, Arman, additional, Jahantigh, Hamid Reza, additional, Barati, Elham, additional, Shamsian, Khosrow, additional, Saleh‐Moghaddam, Masoud, additional, Sharebyani, Hiva, additional, Hassannia, Tahereh, additional, and Shamsian, Seyed Ali Akbar, additional

Published
2019
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41. Assessment of HCV viral load, genotype, liver biomarkers and clinical symptoms: Developing a mathematical model for prediction of HCV load

Author

Basharkhah, Samira, primary, Sabet, Faezeh, additional, Jahantightigh, Hamid Reza, additional, Ghezeldasht, Sanaz Ahmadi, additional, Mosavat, Arman, additional, Barati, Elham, additional, Shamsian, Khosrow, additional, Moghaddam, Masoud Saleh, additional, Sharebyani, Hiva, additional, Hassannia, Tahereh, additional, and Shamsian, Seyed Ali Akbar, additional

Published
2019
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48. High prevalence of blaCMYAmpC beta-lactamase in ESBL co-producing Escherichia coliand Klebsiellaspp. clinical isolates in the northeast of Iran

Author

Rizi, Kobra Salimiyan, Mosavat, Arman, Youssefi, Masoud, Jamehdar, Saeid Amel, Ghazvini, Kiarash, Safdari, Hadi, Amini, Yousef, and Farsiani, Hadi

Abstract

•A total of 55.8% of E. coli and Klebsiellaspp. isolates were identified as putative ESBL-producers.•A total16.7% of ESBL producing E. coliand Klebsiellaspp. were positive for plasmid-borne AmpC genes.•blaCMY-type was the most frequent genotype of pAmpC among ESBL producing E. coliand Klebsiellaspp.

Published
2020
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50. Fc-based delivery system enhances immunogenicity of a tuberculosis subunit vaccine candidate consisting of the ESAT-6:CFP-10 complex

Author

Farsiani, Hadi, primary, Mosavat, Arman, additional, Soleimanpour, Saman, additional, Sadeghian, Hamid, additional, Akbari Eydgahi, Mohammad Reza, additional, Ghazvini, Kiarash, additional, Sankian, Mojtaba, additional, Aryan, Ehsan, additional, Jamehdar, Saeid Amel, additional, and Rezaee, Seyed Abdolrahim, additional

Published
2016
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