Search

The rise of digital libraries has transformed the way academic writing in the English language is conducted. This article explores the multifaceted impacts of digital libraries on English language academic writing, focusing on accessibility, the breadth of resources, citation practices, and the enhancement of writing quality. By providing scholars with an extensive and diverse collection of resources, digital libraries have made academic research more inclusive and efficient. This paper evaluates both the positive and negative effects of digital libraries, analyzing how these platforms have contributed to the evolution of writing practices, research methodologies, and knowledge dissemination in academic settings. The findings suggest that digital libraries play a pivotal role in enhancing the quality of academic writing but also raise concerns about plagiarism and information overload. [ABSTRACT FROM AUTHOR]

Through an analysis of the play, the article seeks to demonstrate that Aimé Césaire’s A Tempest is a “reinscription” of Shakespeare’s The Tempest as “a drama of rebellion.” It is told from the point of view of “the loser”, Caliban, the “colonized”, who confronts and defies Prospero who has usurped the island and deprived him of his patrimony. He demands his freedom and refuses to accept the “hegemonic europocentric vision of the universe.” Césaire “demythifie[s]” Prospero who is not the benign Magus figure of traditional criticism but the “prototypical colonizer,” a despot, “the complete totalitarian.” The paper argues that, although he never mentions him, Césaire is influenced by George Lamming’s radical reading of Shakespeare’s play through “colonial” and “national” lenses, a reading that anticipates that of Stephen Greenblatt and the New Historicists and pre-empts the question of “linguistic colonialism” which is so crucial to them. While the colonial paradigm has featured in recent discussions of the plays and Césaire and Lamming have been grouped together, the article analyzes and applies Lamming’s reading to both Shakespeare and Césaire and provides a fresh reading of both. The article also goes beyond the argument of Greenblatt and the New Historicists. A Tempest ends equivocally, on a questioning note, and Lamming observes that the Epilogue in The Tempest leaves the latter work, too, somewhat open-ended, a point that is taken up and discussed. The article in conclusion gives a significant, new interpretation, of the titles of the two plays which ties up with and highlights the theme of colonialism which is the focus of both plays.

Objectives: Volatile organic compounds (VOCs) are a type of pollutant that causes health risks and can be present in both indoor and outdoor environments. VOCs originate mainly from solvents and chemicals used at home or in offices and also from vehicle emissions. The current research work was aimed at the detection and quantification of VOCs indoor and outdoor at Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, India. Material and Methods: Air was drawn through an adsorbent tube with a pump at a steady flow rate (100 mL min-1) for an hour to gather samples using the active sampling approach. Thermal desorption in combination with a gas chromatography (GC) analyzer was used to estimate the levels of hazardous VOCs, namely benzene, toluene, ethylbenzene, m-xylene, p-xylene, and o-xylene (BTEX) compounds. Results: VOCs were analyzed using the GC-mass spectroscopy technique. The finding shows the levels of BTEX as benzene (0.05-0.11 µg/m³), toluene (0.44-1.27 µg/m³), ethylbenzene (0.012-0.03 µg/m³), m-xylene (0.009-0.027 µg/m³), p-xylene (0.007-0.025 µg/m³), and o-xylene (0.003-0.019 µg/m³) compounds. Conclusion: The BTEX levels were observed to be well below the maximum acceptable limit. VOC emissions can be reduced by making process changes or by installing air pollution control equipment. [ABSTRACT FROM AUTHOR]

Progression through the G1 phase of the cell cycle is the most highly regulated step in cellular division. We employed a chemogenetic approach to discover novel cellular networks that regulate cell cycle progression. This approach uncovered functional clusters of genes that altered sensitivity of cells to inhibitors of the G1/S transition. Mutation of components of the Polycomb Repressor Complex 2 rescued proliferation inhibition caused by the CDK4/6 inhibitor palbociclib, but not to inhibitors of S phase or mitosis. In addition to its core catalytic subunits, mutation of the PRC2.1 accessory protein MTF2, but not the PRC2.2 protein JARID2, rendered cells resistant to palbociclib treatment. We found that PRC2.1 (MTF2), but not PRC2.2 (JARID2), was critical for promoting H3K27me3 deposition at CpG islands genome-wide and in promoters. This included the CpG islands in the promoter of the CDK4/6 cyclins CCND1 and CCND2, and loss of MTF2 lead to upregulation of both CCND1 and CCND2. Our results demonstrate a role for PRC2.1, but not PRC2.2, in antagonizing G1 progression in a diversity of cell linages, including chronic myeloid leukemia (CML), breast cancer, and immortalized cell lines.

Objective This article is meant to spark interest in readers of the rich experiences that Academic Dentistry can offer as a career pathway for dentists. Opportunities have evolved in the last 20 years making it more appealing financially full-time or it can be a compatible hybrid with other pathways such as private or corporate dentistry, public health, community clinic dentistry, or research.Methods Each of the five authors came to Academic Dentistry at different stages and from diverse expectations in their professional lives. These disparate histories are presented to provide a full and rich perspective on Academic Dentistry. Both challenges and rewards in academic are discussed.Conclusions Academic Dentistry, whether entered early or late in one’s professional life, or in combination with another pathway, may provide opportunity for renewal of one’s interest and enjoyment in the dental profession. With many individuals choosing to stay in the workforce longer, academics may increase longevity of career as well. With data indicating the actual shortage of dental faculty and the continuing expansion among dental schools, opportunities to join academics are available.

Objective: This study aimed to systematically review the effect of lithium on orthodontic tooth movement (OTM). Methods: The focus question was “does lithium have an effect on OTM?” A systematic search was conducted using indexed databases and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. The quality assessment of the selected studies was performed according to the systematic review center for laboratory animal experimentation. Results: Five of the initially identified 656 articles fulfilled the eligibility criteria and were selected for this review. The studies reported that lithium administration lowered the rate of OTM by inducing a reduction in the number of osteoclasts and possibly inhibiting osteoclastogenesis. These studies further showed an increase in bone density and bone volume by promoting the Wnt/ß-catenin signaling pathway and osteoblastogenesis. It was also noted that lithium reduced orthodontically induced root resorption during experimental OTM. Further, standardized studies are warranted to understand the impact of lithium in OTM. Overall, the risk of bias for 3 studies was very high, high in 1 study, and moderate in 1 study. Conclusion: On an experimental level in animals, lithium decreased the rate of OTM during the active treatment phase by increasing bone density and bone volume and reducing root resorption. In addition, lithium may enhance alveolar bone formation during orthodontic retention. Clinically, this may impact the orthodontic treatment duration in patients receiving lithium, and further studies are needed to understand the true impact of lithium on OTM.

For centuries, women have been thrown into a pattern that dictates them to replicate the behaviour of the generations of women under male dominance. They have been made to believe that they are incapable of receiving respect or fair treatment from a male society. They are the dull and insignificant shadows of men, mistaking servitude for idealism. They slide into nothingness and cower in their fears and insecurities. These terrorized and oppressed women experience their moments of spark to snap their ties with the repressive customs and render themselves a refreshing transformation to rewrite their identity. They muster their courage to get self-sufficient and build a world of strength in and around them to rise above prejudices and stigmas. This paper explores the rough journey of a woman, who breaks the stereotypes designated by the self-indulgent men,and finds her bold self in her pursuit of identity and freedom in Manju Kapur’s A Married Woman. [ABSTRACT FROM AUTHOR]

Cloud Computing provides high performance, accessibility and low cost for data storing and sharing, provides a better consumption of resources. Cloud service providers compromise an abstraction of infinite storage space for clients to mass data. However, security concerns are the main constraints as we now outsource the storage of data possibly sensitive to cloud providers. To preserve data privacy, a mutual approach is to encrypt data files before the clients upload the encrypted data into the cloud. Data confidentiality becomes the main concern in outsourcing client data to cloud storage and it is also essential for an access control mechanism to prevent data mistreatment within the organization. There is no system designed for secure and efficient data sharing especially for dynamic groups in the cloud. Therefore we propose a secure data sharing scheme by using Role based Access Control (RBAC) and Elliptical Curve Cryptography (ECC) for frequently changed groups and anonymous access. RBAC provides flexible controls and database management by having users mapped to roles and roles mapped to privileges on data objects. ECC based encryption scheme incorporates the cryptographic approaches. ECC with RBAC provides anonymous access control, thereby to address the privacy in data as well as the user identity. If the group member is revoked, this system provides automatic generation of new public key of existing group and distributed to the group, which eliminate the need to encrypt the data again with this new key therefore any user in the group can access the data in the cloud, which is not accessible by the revoked users. Thus the proposed method provides privacy and data confidentiality in cloud. [ABSTRACT FROM AUTHOR]

The article focuses on an encounter with Shakespeare in an unusual place, a novel set in medieval India, where Shakespeare is viewed and assessed by an Indian audience, by Indian listeners, through principles of classical Indian art and thought. Such an encounter creates a sense of incongruity, an incongruity that is cultural, philosophical and aesthetic, but at the same time leads to startling perspectives and new and fresh insights. The novel does not privilege one culture over another but the listeners do and we have a brilliant piece of comic writing where the humour derives from the one-sidedness of their perceptions, their “occidentalism”, their easy assumption of the superiority of their belief system over the “other”. The Silver Pilgrimage thus provides not only a stimulating perspective on two Shakespearean tragedies from the point of view of Sanskrit poetics and Indian thought, but also a gentle expose of the limitations of this point of view, and the cultural chauvinism that lies behind it.

The pain of occipital neuralgia (ON) is thought to be secondary to trauma or injury to the occipital nerve at any point along the course of the nerve. ON may also be caused by an infectious process (herpes zoster) or compression of the nerve. The patient, in this case, presented to our clinic with complaints of occipital pain and rash and swelling of the right lower jaw. One week before presenting to our clinic, the patient developed severe pain in the first division of the trigeminal region with erythema and vesicles. A blood test showed a remarkably high antibody titer for varicella–zoster virus (VZV). The patient was prescribed oral valacyclovir (Valtrex®) (3000 mg/day), which resulted in the complete remission of the rash and blisters in the occipital region. This highlights the importance of considering neuroanatomy of the trigeminal region and cervical nerve.

The objective of this article is to review the role of the dentist in the early diagnosis of pediatric obstructive sleep apnea (OSA) and to provide an in-depth review of the best evidence-based practices available to treat and/or to refer these patients for intervention. Material and methods: A narrative review was performed using indexed data bases (PubMed, Medline, EMBASE, OVID, Scopus and Cochrane) up to year 2020, and approximately 1000 articles were reviewed. The articles included were those with the best information provided. Results: Detailed review of the literature suggests that the role of the dentist has been redefined owing to their expertise in the orofacial region. Every patient consulting a dental practice is not merely a dental patient; he/she also requires a comprehensive medical review. The role of the dentist is pivotal in pediatric patients once diagnosed with OSA; as the patients grow, growth modification can be achieved, and future management will be easier. Initiating dental treatments during growth can benefit patients two-fold, saving them from malocclusion, and intervening in orofacial structural growth can help to avoid cumbersome treatments, such as CPAP and various surgeries. Proper diagnosis and management of systemic illnesses can prevent compromised quality of life, delays in treatment, morbidity and, in some cases, mortality.

Catheter-associated Urinary Tract Infection (CAUTI) is a common healthcare-related infection occurring in patients admitted for various ailments. Approximately 80% of hospital acquired Urinary Tract Infections (UTIs) are catheter associated. The purpose of the current research was to find out the level of knowledge, attitude and practice on prevention of CAUTI among healthcare professionals working in tertiary care hospital. A descriptive study was done among 95 health care working in tertiary care hospital in Chennai. The researchers administered standard questionnaire and statistically explored the knowledge, attitude, and practice levels about prevention of CAUTI among the participants. Among 95 participants, 28.4% and 71.6% of the individuals had moderately adequate knowledge and adequate knowledge about CAUTI. About 4.2% of the participants had unfavourable, 88.4% had moderately favourable and 7.4% had favourable attitude towards prevention of CAUTI. About 4.2% of the individuals had moderately adequate and 95.8% had adequate practice towards the prevention of CAUTI. There was significant correlation between attitude and practice. The professional experience of the participants showed statistically significant association with the level of practice among the demographic variables. In our present study, we found out that health care professionals had adequate knowledge, attitude, and practice on prevention of CAUTI. Medical education programs, frequent auditing with a checklist about catheter care must be conducted to maintain the achieved knowledge and practice levels.

High‐affinity antigen‐specific B cells are generated within specialized structures, germinal centers (GCs), inside lymphoid organs. In GCs, follicular dendritic cells (FDCs) present antigens on their membrane surface to cognate B cells, inducing rapid proliferation and differentiation of the B cells toward antibody‐secreting cells. The FDC's fluid membrane surface allows B cells to “pull” the antigens into clusters and internalize them, a process that frequently involves tearing off and internalizing FDC membrane fragments. To study this process ex vivo, liposomal membranes are used as the antigen‐presenting FDC‐like fluid lipid surface to activate B cells. In a fully synthetic in vitro GC model (sGC), which uses the microbead‐based presentation of the CD40 Ligand and a cytokine cocktail to mimic T follicular helper cell signals to B cells, liposomes presenting a model antigen mimic effectively engage B cell receptors (BCRs) and induce greater BCR clustering compared to soluble antigens, resulting in rapid antigen internalization and proliferation of the B cells. B cells showed GC‐like reactions and undergo efficient IgG1 class‐switching. Taken together, the results suggest that fluid membrane‐bound antigen induces a strong GC response and provides a novel synthetic in vitro system for studying GC biology in health and diseases, and for expanding therapeutic B cells ex vivo.

Banana fiber is a natural bast fiber which has wide range of uses in handicraft product developments such as mat, rope and twines, but only 10% of its pseudo stem is being used for making products and remaining is waste or used as fertilizer. As it has a property like weatherproof, UV protection (because of lignin content), moisture absorption, anti-oxidant and bio degradable etc., it can be used to make variety of products that help farmers economically and have wide scope to create new market. Recent studies have indicated banana fiber possesses a lot of advantageous physical and chemical properties which can be used a very good raw material for the textile and packaging industry. [ABSTRACT FROM AUTHOR]

Myogenous temporomandibular disorder (TMD) is the most common type of nonodontogenic pain. The diagnosis is often elusive since diagnosing such conditions often requires a more comprehensive patient assessment. At present, there is no simple one-step diagnostic test to help render a definitive diagnosis of myogenous TMD pain. The twin-block injection can serve as a diagnostic aid to facilitate diagnosis of such myogenous TMD. The twin-block injection blocks the innervation to both the temporalis and masseter muscles, the two most common sources of referred pain to the teeth. This article reviews the twin-block technique along with a case report illustrating its potential role in the diagnosis and management of myogenous TMD pain of masseteric and temporalis origin.

Orofacial pain can often be the chief complaint of many systemic disorders. Cysticercosis involving the lateral pterygoids may cause limitation of mouth opening and may mimic clinical symptoms of a temporomandibular disorder. A 37-year-old female presented with 1-month-old complaint of limited mandibular range of motion. She reported a similar episode a year earlier and was diagnosed with a temporomandibular joint disorder by her primary dentist. Comprehensive intra- and extra-oral examinations were performed, which revealed a limitation of mouth opening accompanied by mild limitation of contralateral excursion. A magnetic resonance imaging revealed a ring-enhancing lesion within the left pterygoid muscle suggestive of cysticercosis. The patient was referred to her primary care physician for further treatment and given physical therapy (stretching exercises) to improve mouth opening. One week later, she developed lesions in the arm and trunk. Further ultrasound imaging of the abdomen and the forearms confirmed the diagnosis of cysticercosis. She was treated with albendazole, physiotherapy, joint stabilization appliance, and had eventual complete recovery. This case emphasizes the importance of diagnosis of a systemic condition that may have serious implications, if untreated, and the importance of a comprehensive evaluation, workup, and multidisciplinary management.

Purpose: The purpose of this study was to compare and correlate sagittal condylar guidance determined by intraoral gothic arch tracing method and panoramic radiograph in edentulous patients. Materials and Methods: Twelve completely edentulous patients were selected by the inclusion and exclusion criteria. Conventional steps in the fabrication of complete denture till jaw relation were carried out. Intraoral gothic arch tracing and protrusive interocclusal records were obtained for each patient. Protrusive interocclusal record was used to program the Hanau Wide-Vue semi-adjustable articulator, thus obtaining the sagittal condylar guidance angle. Using RadiAnt DICOM software, on the orthopantomogram obtained for each patient in the study, two reference lines were drawn. The Frankfort's horizontal plane and the mean curvature line (joining the most superior and the inferior points on the glenoid fossa curvature) were drawn. The mean curvature line was extended to intersect the Frankfort's horizontal plane, thus obtaining the radiographic sagittal condylar guidance angle. The condylar guidance angles obtained by these two methods were compared and subjected to paired t-test. Results: There was no statistically significant difference between the sagittal condylar guidance angles obtained between right and left sides with intraoral gothic arch tracing and radiographic methods (P = 0.107 and 0.07, respectively). Conclusion: Within the limitations of this study, it was concluded that the protrusive condylar guidance angles obtained by panoramic radiograph may be used for programming semi-adjustable articulators.

Background: The CXCR4/SDF-1α axis plays a vital role in the retention of stem cells within the bone marrow and downstream activation of cell survival signaling pathways. LY2510924, a second generation CXCR4, showed significant anti-leukemia activity in a murine AML model.Methods: We conducted a phase I study to determine the safety and toxicity of LY2510924, idarubicin and cytarabine (IA) combination therapy in relapsed/refractory (R/R) AML. Eligible patients were 18–70 years of age receiving up to salvage 3 therapy. A peripheral blood absolute blast count of < 20,000/μL was required for inclusion. LY2510924 was administered daily for 7 days followed by IA from day 8. Two dose escalation levels (10 and 20 mg) were evaluated, with a plan to enroll up to 12 patients in the phase I portion.Results: The median age of the enrolled patients (n = 11) was 55 years (range, 19–70). Median number of prior therapies was 1 (1–3). Six and five patients were treated at dose-levels “0” (10 mg) and “1” (20 mg), respectively. Only one patient experiencing a dose limiting toxicity (grade 3 rash and myelosuppression). Three and one complete responses were observed at dose-levels “0” and “1,” respectively; the overall response rate (ORR) was 36% (4 of 11 patients). A ≥ 50% decrease in CXCR4 mean fluorescence intensity was observed in 4 of 9 patients by flow cytometry, indicating incomplete suppression of CXCR4-receptor occupancy.Conclusions: The combination of LY2510924 with IA is safe in R/R AML. Dose-escalation to a 30 mg LY2510924 dose is planned to achieve complete blockade of CXCR4 receptor occupancy, followed by expansion phase at the recommended phase 2 dose-level.

Introduction Gemcitabine, a cytotoxic drug, is used to treat a variety of solid tumors, such as pancreatic, lung, and breast malignancies. The efficiency rates for gemcitabine have decreased due to an increase in genetic instability. The association between gene polymorphisms and the efficacy of gemcitabine therapy may be better known by understanding the intricacies of genetics that target a few or more genes in drug-targeting metabolic pathways. Moreover, several studies have documented differences in the therapeutic response among various ethnicities to gemcitabine chemotherapy. Therefore, the purpose of this study was to determine the normative frequencies of gene polymorphisms linked to the metabolic pathway of gemcitabine ( DCK -360C>G (80143932), SLC29A1 -201A>G (760370), SLC29A1 +913C>T (9394992), SLC29A3 +4967C>A (10999776)) in Southern part of Indian healthy population and compared it with the 1000 genome population. In addition, the association of the above single nucleotide polymorphisms (SNPs) with lung cancer susceptibility was also evaluated. Methods The present study used real-time polymerase chain reaction (RT-PCR) for performing genotyping in 184 healthy participants as well as 123 South Indian patients with lung cancer. The frequencies of alleles and genotypes of the aforementioned genetic variants were in Hardy-Weinberg equilibrium (p > 0.05). Results The minor allele frequencies (MAF) of the SNPs DCK -360C>G (80143932), SLC29A1 -201A>G (760370), SLC29A1 +913C>T (9394992), SLC29A3 +4967C>A (10999776) were 3.8%, 17.7%, 27.7%, 29.3% respectively in healthy population. The MAF of the SNPs, DCK -360C>G (80143932), SLC29A1 -201A>G (760370), SLC29A1 +913C>T (9394992), SLC29A3 +4967C>A (10999776) in lung cancer patients was 2%, 15%, 23.2%, and 24.4% respectively. A trend toward a protective effect against lung cancer was observed with SLC29A1 +913C>T (9394992). Conclusion The observed frequencies of alleles and genotypes in the South Indian population were significantly different as compared to the 1000 genome population. In the present study, an association of SLC29A1 rs9394992 C>T between lung cancer patients and healthy subjects showed a trend toward protective effect against lung cancer risk. There was no association found between the other studied SNPs and lung cancer risk., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Institute Ethics Committee (Human Studies), JIPMER, Puducherry, India issued approval JIP/IEC/2014/4/310. This is to certify that the project no. JIP/IEC/2014/4/310 has been approved by the Institute Ethics Committee (Human Studies), JIPMER, Puducherry, India, at the meeting held on 27.06.2014. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, T et al.)

Introduction: The cancer burden is rising every year. Lung cancer is one of the most common cancers and non-small cell lung cancer is the most common type. Chemotherapy based on platinum drugs and third-generation nucleoside anti-metabolites such as gemcitabine are used widely. Gemcitabine has a complex metabolic pathway, with many mechanisms contributing to its cytotoxicity. Derangements in the metabolic pathway genes contribute to drug resistance and toxicity with this drug. Association studies including these genetic polymorphisms in the metabolic pathway, clinical outcomes, and cancer risk reported inter-individual differences. Thus, the aim of this study was to ascertain the role of these genetic variants in South Indian cancer patients treated with gemcitabine-based therapy., Methods: The study was done with 184 healthy volunteers for frequency establishment and 123 cancer patients were treated with gemcitabine-based chemotherapy for response and toxicity assessment. The participants were aged 18-65 years and resided in the southern states of India. DNA extraction was done from the leukocyte fraction of the blood by phenol-chloroform extraction procedures and genotyping was done by reverse transcription-polymerase chain reaction (RT-PCR) techniques to identify DNA repair gene polymorphisms. Tumor response was determined using Response evaluation criteria in solid tumors (RECIST) guidelines and toxicity using Common Terminology Criteria for Adverse Events (CTCAE), version 4.03. The patients were followed up for survival analysis., Results: The minor allele frequency of the single nucleotide polymorphism (SNP) NRF2-617 C>A (rs6721961) in the healthy population was 12.8%. SNPs were in Hardy-Weinberg equilibrium (p>0.05). Gender-based differences were not observed with the studied SNP in the healthy population and the lung cancer patients. These frequencies of NRF2 were found to be similar when compared to EUR (European) and all the South Asian subpopulations. They are significantly divergent compared to AFR (African), AMR (American), and EAS (East Asian) populations. The minor allele frequency in cancer patients was found to be 14.2% and the lung cancer risk with the SNP studied could not be detected. There was no association found with the response, toxicity, and survival among lung cancer patients., Conclusion: NRF2, being a multifaced molecule, did not show a significant association with lung cancer risk, response, and toxicity in patients with gemcitabine-based chemotherapy., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institute Ethics Committee (Human Studies), JIPMER, Puducherry, India issued approval JIP/IEC/2014/4/310 dated June 27, 2014. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Devika et al.)

Objectives: Nerve injury may lead to pain and sensory changes such as dysesthesia and paresthesia. Quantitative sensory testing (QST) is a psychophysical testing method used to quantify nerve damage and monitor its recovery. Duloxetine is used in the management of neuropathic pain conditions, but its effect on taste recovery has not been previously reported., Case Representation: A 65-year-old female, presented to the orofacial pain clinic, with a chief complaint of a burning sensation on the tongue, taste changes and a feeling of tightness beneath the tongue for five months. She reported that the complaints began subsequent to a complicated dental extraction during which she experienced trauma to the tongue. Patient was advised to take duloxetine 60 mg in divided doses three times daily. The assessment and monitoring of the recovery pattern were performed using QST. Electrical taste detection (mediated by chorda tympani) and electrical detection/tingling thresholds were performed at periodic intervals for up to a year following the nerve injury in the chorda tympani and lingual nerve territory. The patient reported complete recovery in taste sensation with duloxetine and this correlated with the QST results. QST documented at the end of one year revealed the electrical taste detection threshold and electrical detection threshold return to near normal values., Conclusions: QST may be a useful diagnostic tool to assess and monitor lingual and chorda tympani nerve injuries. Duloxetine may aid in the recovery of the taste changes following lingual and chorda tympani nerve injury., (© 2020 Khan Junad et al., published by De Gruyter, Berlin/Boston.)