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Your search keyword '"Naohiro, Okitsu"' showing total 4 results
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4 results on '"Naohiro, Okitsu"'

1. Comparative Survey of Children and Adults with Japanese Cedar Pollinosis Using a Self-written Questionnaire on Sublingual Immunotherapy in Clinical Practice

Author

Teruyuki Sato, Nobuo Ohta, Atsushi Yuta, Yukiko Ogawa, Takahiro Suzuki, Fumi Shoji, Naoya Noguchi, Naohiro Suzuki, Chikashi Kusakari, Kunitsugu Tabata, Eikan Kaku, Naohiro Okitsu, Jun Hasegawa, Yoshihiro Shibahara, Seiichiro Nakabayashi, Naoki Inamura, Yoshiyuki Ohi, Yoshitaka Takanashi, Jun Suzuki, Mitsuru Sugawara, Kazuhiro Nomura, Yukio Katori, and Yoshitaka Okamoto

Published
2022
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2. Practical Study of Immunotherapy in Patients with Japanese Cedar Pollinosis Using a Questionnaire. Comparison between Sublingual Immunotherapy and Subcutaneous Immunotherapy in the Third Season

Author

Yoshihiro Shibahara, Yoshitaka Okamoto, Kazuhiro Nomura, Yusuke Kusano, Ph D.Yukiko Ogawa, Mitsuru Sugawara, Shiori Kitaya, Eikan Kaku, Nobuo Ohta, Seiichiro Nakabayashi, Yoshiyuki Ohi, Naoki Inamura, Atsushi Yuta, Yukio Katori, Naoya Noguchi, Fumi Shoji, Jun Suzuki, Chikashi Kusakari, Jun Hasegawa, Naohiro Okitsu, Kunitsugu Tabata, Naohiro Suzuki, and Yoshitaka Takanashi

Subjects
medicine.medical_specialty, Otorhinolaryngology, business.industry, medicine.medical_treatment, medicine, Subcutaneous immunotherapy, In patient, Sublingual immunotherapy, Cedar pollinosis, Immunotherapy, business, Dermatology
Published
2021
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3. Impact of the Seven-valent Pneumococcal Conjugate Vaccine on Acute Otitis Media in Japanese Children: Emergence of Serotype 15A Multidrug-resistant Streptococcus pneumoniae in Middle Ear Fluid Isolates

Author

Hisakazu Yano, Sadahiro Ichimura, Yukio Katori, Masahiro Shimojima, Hajime Kanamori, Risako Kakuta, Shiro Endo, Hiroshi Hidaka, Daiki Ozawa, Shinya Inomata, Mitsuo Kaku, Naohiro Okitsu, and Miho Ogawa

Subjects
Microbiology (medical), Serotype, Male, Heptavalent Pneumococcal Conjugate Vaccine, Acute otitis media, Drug resistance, Microbial Sensitivity Tests, medicine.disease_cause, Serogroup, complex mixtures, Pneumococcal conjugate vaccine, Pneumococcal Infections, Microbiology, stomatognathic system, Japan, Drug Resistance, Multiple, Bacterial, Streptococcus pneumoniae, otorhinolaryngologic diseases, medicine, Prevalence, Humans, Serotyping, business.industry, Infant, Anti-Bacterial Agents, Vaccination, Multiple drug resistance, Otitis Media, Infectious Diseases, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Middle ear fluid, business, medicine.drug
Abstract

Streptococcus pneumoniae is one of the most common bacteria causing acute otitis media (AOM). In Japan, a 7-valent pneumococcal conjugate vaccine (PCV7) was introduced for voluntary vaccination of children in 2010, and it became a recommended vaccination in April 2013. We surveyed the serotypes and antimicrobial susceptibility profile of S. pneumoniae isolates obtained from the middle ear fluid of Japanese children with AOM.Between April and September 2013, a total of 176 S. pneumoniae isolates were obtained from the middle ear fluid of children aged 0-3 years with AOM. Isolates were collected from various regions of Japan. Minimum inhibitory concentrations were measured by the broth microdilution method. Serotyping was performed by observing the Quellung reaction.Although 45.5% of the strains were susceptible to penicillin G, 42.6% were penicillin-intermediate strains and 11.9% were penicillin-resistant strains. Serotype 19A (27.3%), serotype 15A (14.2%) and serotype 3 (11.9%) showed a high frequency. Although PCV7 types only accounted for 4.5% of all strains, 44.9% were PCV13 types and 55.1% were non-PCV types. Serotype 15A strains were 100% nonsusceptible to penicillin G and all of these strains showed multidrug resistance. Serotype 15A was frequent in children up to 1 year old.After this research was completed, PCV7 was switched to a PCV13 that also contained serotype 3 and serotype 19A. We need to consider the possibility that serotype 15A, which is not included in PCV13, may increase and cause intractable AOM in the future.

Published
2015

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