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Alzheimer's disease (AD) is a significant neurological disorder characterized by progressive cognitive decline and memory loss. One essential task is understanding the molecular mechanisms underlying brain disorders of AD. Detecting biomarkers that contribute significantly to the classification of AD is an effective means to accomplish this essential task. However, most machine learning methods used to detect AD biomarkers require lengthy training and are unable to rapidly and effectively detect AD biomarkers. To detect biomarkers for AD accurately and efficiently, we proposed a novel approach using the Multi-Kernel Support Vector Machine (SVM) with Apriori algorithm to mine strongly associated feature sets from functional magnetic resonance imaging (fMRI) and gene expression profiles. Firstly, we downloaded the imaging data and genetic data of 121 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and transformed gene sequences into labeled sequences by encoding the four types of bases (A, T, C, and G) into distinct labels. Subsequently, we extracted the first 130 temporal sequences of brain regions and employed Pearson correlation analysis to construct "brain region gene pairs". The integration of these data allowed us to explore the correlations between genes and brain regions. To improve classification accuracy and feature selection, we applied the Apriori algorithm to the multi-kernel SVM, dynamically building feature combinations and continuously validating classification results. By iteratively generating frequent itemsets, we obtained important brain region gene pairs. Experimental results show the effectiveness of our proposed approach. The Multi-Kernel SVM with Apriori model achieves an accuracy of 92.9%, precision of 95%, and an F1 score of 95% in classifying brain region-gene pairs within the AD–Late mild cognitive impairment (AD-LMCI) group. The amygdala, BIN1, RPN2, and IL15 associated with AD have been identified and demonstrate potential in identifying potential pathogenic factors of AD. The selected brain regions and associated genes may serve as valuable biomarkers for early AD diagnosis and better understanding of the disease's molecular mechanisms. The integration of fMRI and gene data using the Multi-Kernel SVM–Apriori model holds great potential for advancing our knowledge of brain function and the genetic basis of neurological disorders. This approach provides a valuable tool for neuroscientists and researchers in the field of genomics and brain imaging studies. [ABSTRACT FROM AUTHOR]

This study aims to identify the difference in the mobilisation degree of RAP asphalt binder under three mixing techniques and its influences on the performance of recycled hot-mix asphalt mixture (HMA). Glass beads were selected to replace parts of fresh coarse aggregates, and to analyze the transfer of RAP binder using Fourier Transformation Infrared (FTIR) spectroscope analysis. Superpave Gyratory Compactor (SGC) and Hamburg Wheel-Track Device (HWTD) were used to evaluate the compaction property and the high-temperature performance of recycled HMA. Results showed that the relative percentage of reclaimed asphalt recovered (Rp) varied with the mixing techniques. The workability of recycled HMA is related to the mixing technique. The softer fresh asphalt binder is more capable of facilitating the mineral aggregates to form a stable skeleton structure. In addition, the transfer of RAP binder in recycled HMA may be an important factor influencing the skeleton structure. [ABSTRACT FROM AUTHOR]