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29 results on '"Nishio, Eiji"'

2. Cervical mucus can be used for metabolite screening in cervical cancer.

Author

Kawasaki, Rie, Kukimoto, Iwao, Tsukamoto, Tetsuya, Nishio, Eiji, Iwata, Aya, and Fujii, Takuma

Abstract

Approximately 660,000 women are diagnosed with cervical cancer annually. Current screening options such as cytology or human papillomavirus testing have limitations, creating a need to identify more effective ancillary biomarkers for triage. Here, we evaluated whether metabolomic analysis of cervical mucus metabolism could be used to identify biomarkers of cervical intraepithelial neoplasia (CIN) and cervical cancer. The case–control group consisted of 181 CIN, 69 squamous cell carcinoma (SCC) patients, and 48 healthy controls in the primary cohort. We undertook metabolomic analyses using ultra‐HPLC–tandem mass spectrometry. Univariate and multivariate analyses were carried out to profile metabolite characteristics, and receiver operating characteristic (ROC) analysis identified biomarker candidates. Five metabolites conferred the highest discriminatory power for SCC: oxidized glutathione (GSSG) (area under the ROC curve, 0.924; 95% confidence interval, 0.877–0.971), malic acid (0.914, 0.859–0.968), kynurenine (0.884, 0.823–0.945), GSSG/glutathione (GSH) (0.936, 0.892–0.979), and kynurenine/tryptophan (0.909, 0.856–0.961). Malic acid was the best marker for detection of CIN2 or worse (0.858, 0.793–0.922) and was a clinically useful metabolite. We confirmed the reproducibility of the results by validation cohort. Additionally, metabolomic analyses revealed eight pathways strongly associated with cervical neoplasia. Of these, only the tricarboxylic acid cycle was strongly associated with all CINs and cancer, indicating active energy production. Aberrant arginine metabolism by decreasing arginine and increasing citrulline might reduce tumor immunity. Changes in cysteine‐methionine and GSH pathways might drive the initiation and progression of cervical cancer. These results suggest that metabolic analysis can identify ancillary biomarkers and could improve our understanding of the pathophysiological mechanisms underlying cervical neoplasia. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Guideline for gynecological practice in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2023 edition

Author

Nishio, Eiji, primary, Ishitani, Ken, additional, Arimoto, Takahide, additional, Igarashi, Toshio, additional, Ishikawa, Tetsuya, additional, Iwase, Akira, additional, Ogawa, Mariko, additional, Ozawa, Nobuaki, additional, Kajiyama, Hiroaki, additional, Kawasaki, Kaoru, additional, Kudo, Risa, additional, Kumakiri, Jun, additional, Komura, Hiroko, additional, Komai, Kan, additional, Sato, Seiya, additional, Shinohara, Koichi, additional, Takahashi, Toshifumi, additional, Tanaka, Kyoko, additional, Tanebe, Kyoko, additional, Deguchi, Masashi, additional, Tozawa‐Ono, Akiko, additional, Nakashima, Akitoshi, additional, Nakatsuka, Mikiya, additional, Hayakawa, Satoshi, additional, Hirata, Tetsuya, additional, Fukuhara, Rie, additional, Miyakuni, Yasuka, additional, Miyazaki, Hiroaki, additional, Morisada, Tohru, additional, Kuwabara, Yoshimitsu, additional, Takenaka, Masataka, additional, Shozu, Makio, additional, Sugiura‐Ogasawara, Mayumi, additional, Maeda, Tsugio, additional, Yokoyama, Yoshihito, additional, and Fujii, Takuma, additional

Published
2024
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5. Progress and future prospect of the CRAFFT project for the next generation UHECR observatory

Author

Tameda Yuichiro, Tomida Takayuki, Ikeda Daisuke, Yamazaki Katsuya, Kim Jihyun, Nakamura Yuya, Kubota Yuto, Shibata Norimichi, Nishio Eiji, Murakami Miyato, Ishimoto Yasuki, Katayama Tomoki, and Kobayashi Yuga

Subjects
Physics, QC1-999
Abstract

The next generation of ultra-high energy cosmic ray observations will require large detector arrays to achieve large statistics. In order to realize next-generation large-scale detector arrays, the Cosmic Ray Air Fluorescence Fresnel lens Telescope (CRAFFT) project is developing a low-cost simple fluorescence detector (FD). The simple structure of the CRAFFT detector will reduce the cost to about 1/10 of the current FD. We also aim to realize a fully automated observation system. A prototype of the CRAFFT detector has been successfully used to detect cosmic ray air showers. Since the spatial resolution of the simple FD is rougher than that of the current FD, we are developing a new air shower reconstruction method using the waveform fitting method. In this presentation, we report the performance of the CRAFFT detector, detector optimization, and future prospect.

Published
2023
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9. Performance of an ancillary test for cervical cancer that measures miRNAs and cytokines in serum and cervical mucus.

Author

Fujii, Takuma, Nishio, Eiji, Tsukamoto, Tetsuya, Kukimoto, Iwao, and Iwata, Aya

Abstract

Currently, human papillomavirus tests and cytology are used to screen for cervical cancer. However, more accurate ancillary screening tests are needed. MicroRNAs (miRNAs) and cytokines are promising biomarkers that are aberrantly expressed in cervical cancer. Therefore, the potential of developing new screening markers based on the levels of miRNAs and cytokines in serum and local mucus samples from the same patients with cervical neoplasia was investigated. miRNA screening was performed by microarray and measurement using real‐time reverse‐transcriptase PCR. Cytokine were measured using multiplex bead assay, and changes in expressions were analyzed based on disease severity. As lesions progressed, miR‐20b‐5p, −155‐5p, −144‐3p, −451a, and −126‐3p expression levels were increased in mucus, and miR‐16‐5p, −223‐3p, and ‐451a expression levels were decreased in serum. Regarding cytokines, IL‐6, IL‐8, monocyte chemoattractant protein‐1, Eotaxin, interferon‐γ, and RANTES were increased, whereas granulocyte–colony‐stimulating factor (G‐CSF) was significantly decreased in mucus. miRNAs and cytokines in serum did not have high diagnostic accuracy. However, a combination of miR‐20b‐5p, ‐451a, ‐126‐3p, Eotaxin, as well as G‐CSF in mucus samples, had high diagnostic accuracy with an area under the receiver operating characteristic curve of 0.989 (0.979–0.999). Our results suggest that using mucus for this ancillary test is more beneficial than serum. [ABSTRACT FROM AUTHOR]

Published
2024
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14. UHECR arrival directions in the latest data from the original Auger and TA surface detectors and nearby galaxies

Author

di Matteo, Armando, primary, Anchordoqui, Luis A., additional, Bister, Teresa, additional, Biteau, Jonathan, additional, Caccianiga, Lorenzo, additional, de Almeida, Rogerio M., additional, Deligny, Olivier, additional, GIACCARI, Ugo, additional, Harari, Diego, additional, Kim, Jihyun, additional, Kuznetsov, Mikhail, additional, Maris, Ioana Codrina, additional, Rubtsov, Grigory, additional, Tinyakov, Petr, additional, Troitsky, Sergey, additional, Urban, Federico, additional, Abreu, Pedro, additional, Aglietta, Marco, additional, Albury, Justin M., additional, Allekotte, Ingomar, additional, Almela, Alejandro, additional, Alvarez-Muniz, Jaime, additional, Alves Batista, Rafael, additional, Anastasi, Gioacchino Alex, additional, Andrada, Belén, additional, Andringa, Sofia, additional, Aramo, Carla, additional, Araújo Ferreira, Paulo Ricardo, additional, Arteaga Velazquez, Juan Carlos, additional, Asorey, Hernán Gonzalo, additional, Assis, Pedro, additional, Avila, Gualberto, additional, Badescu, Alina Mihaela, additional, Bakalova, Alena, additional, Balaceanu, Alexandru, additional, Barbato, Felicia, additional, Barreira Luz, Ricardo Jorge, additional, Becker, Karl-Heinz, additional, Bellido, Jose A., additional, Berat, Corinne, additional, Bertaina, Mario Edoardo, additional, Bertou, Xavier, additional, Biermann, Peter L., additional, Binet, Virginia, additional, Bismark, Kathrin, additional, Blazek, Jiri, additional, Bleve, Carla, additional, Bohacova, Martina, additional, Boncioli, Denise, additional, Bonifazi, Carla, additional, Bonneau Arbeletche, Luan, additional, Borodai, Nataliia, additional, Botti, Ana Martina, additional, Brack, Jeffrey, additional, Bretz, Thomas, additional, Brichetto Orchera, P. Gabriel, additional, Briechle, Florian Lukas, additional, Buchholz, Peter, additional, Bueno, Antonio, additional, Buitink, Stijn, additional, Buscemi, Mario, additional, Büsken, Max, additional, Caballero-Mora, Karen S., additional, Canfora, Fabrizia, additional, Caracas, Ioana, additional, Carceller, Juan Miguel, additional, Caruso, Rossella, additional, Castellina, Antonella, additional, Catalani, Fernando, additional, Cataldi, Gabriella, additional, Cazon, Lorenzo, additional, Cerda, Marcos, additional, Chinellato, Jose Augusto, additional, Chudoba, Jiří, additional, Chytka, Ladislav, additional, Clay, Roger W, additional, Cobos Cerutti, Agustín, additional, Colalillo, Roberta, additional, Coleman, Alan, additional, Coluccia, Maria Rita, additional, Conceição, Rúben, additional, Condorelli, Antonio, additional, Consolati, Giovanni, additional, Contreras, Fernando, additional, Convenga, Fabio, additional, Correia dos Santos, Diego, additional, Covault, Corbin, additional, Dasso, Sergio, additional, Daumiller, Kai, additional, Dawson, Bruce R., additional, Day, Jarryd A., additional, de Jesús, Joaquín, additional, de Jong, Sijbrand J., additional, De Mauro, Giuseppe, additional, de Mello Neto, João, additional, De Mitri, Ivan, additional, de Oliveira, Jaime, additional, de Oliveira Franco, Danelise, additional, de Palma, Francesco, additional, de Souza, Vitor, additional, De Vito, Emanuele, additional, del Río, Mariano, additional, Deval, Luca, additional, Dobrigkeit, Carola, additional, D'Olivo, Juan Carlos, additional, Domingues Mendes, Luis Miguel, additional, dos Anjos, Rita Cassia, additional, dos Santos, Diego, additional, Dova, Maria Teresa, additional, Ebr, Jan, additional, Engel, Ralph, additional, Epicoco, Italo, additional, Erdmann, Martin, additional, Escobar, Carlos O., additional, Etchegoyen, Alberto, additional, Falcke, Heino, additional, Farmer, John, additional, Farrar, Glennys R., additional, Fauth, Anderson, additional, Fazzini, Norberto, additional, Feldbusch, Fridtjof, additional, Fenu, Francesco, additional, Fick, Brian, additional, Figueira, Juan Manuel, additional, Filipcic, Andrej, additional, Fitoussi, Thomas, additional, Fodran, Tomáš, additional, Freire, Martín Miguel, additional, Fuster, Alan, additional, Galea, Cristina, additional, Galelli, Claudio, additional, García, Beatriz, additional, García Vegas, Adrianna Luz, additional, Gemmeke, Hartmut, additional, Gesualdi, Flavia, additional, Gherghel-Lascu, Alexandru, additional, Ghia, Piera Luisa, additional, Giammarchi, Marco, additional, Glombitza, Jonas, additional, Gobbi, Fabian, additional, Gollan, Fernando, additional, Golup, Geraldina, additional, Gómez Berisso, Mariano, additional, Gómez Vitale, Primo F., additional, Gongora, Juan Pablo, additional, González, Juan Manuel, additional, Gonzalez, Nicolas Martin, additional, Goos, Isabel, additional, Gora, Dariusz, additional, Gorgi, Alessio, additional, Gottowik, Marvin, additional, Grubb, Trent D., additional, Guarino, Fausto, additional, Guedes, Germano, additional, Guido, Eleonora, additional, Hahn, Steffen, additional, Hamal, Petr, additional, Hampel, Matías Rolf, additional, Hansen, Patricia María, additional, Harvey, Violet M., additional, Haungs, Andreas, additional, Hebbeker, Thomas, additional, Heck, Dieter, additional, Hill, Gary C., additional, Hojvat, Carlos, additional, Hörandel, Jörg R., additional, Horvath, Pavel, additional, Hrabovsky, Miroslav, additional, Huege, Tim, additional, Insolia, Antonio, additional, Isar, Paula Gina, additional, Janecek, Petr, additional, Johnsen, Jeffrey A., additional, Jurysek, Jakub, additional, Kääpä, Alex, additional, Kampert, Karl-Heinz, additional, Karastathis, Nikolaos, additional, Keilhauer, Bianca, additional, Kemp, Julian, additional, Khakurdikar, Abha, additional, Kizakke Covilakam, Varada Varma, additional, Klages, Hans, additional, Kleifges, Matthias, additional, Kleinfeller, Jonny, additional, Köpke, Marcel, additional, Kunka, Norbert, additional, Lago, Bruno L., additional, Lang, Rodrigo Guedes, additional, Langner, Niklas, additional, Leigui de Oliveira, Marcelo Augusto, additional, Lenok, Vladimir, additional, Letessier-Selvon, Antoine, additional, Lhenry-Yvon, Isabelle, additional, Lo Presti, Domenico, additional, LOPES, Luis, additional, López, Rebeca, additional, Lu, Lu, additional, Luce, Quentin, additional, Machado Payeras, Allan, additional, Mancarella, Giovanni, additional, Mandat, Dusan, additional, Manning, Bradley C., additional, Manshanden, Julien, additional, Mantsch, Paul, additional, Marafico, Sullivan, additional, Mariazzi, Analisa, additional, Marsella, Giovanni, additional, Martello, Daniele, additional, Martinelli, Sara, additional, Martínez Bravo, Oscar, additional, Mastrodicasa, Massimo, additional, Mathes, Hermann-Josef, additional, Matthews, James, additional, Matthiae, Giorgio, additional, Mayotte, Eric, additional, Mazur, Peter, additional, Medina-Tanco, Gustavo, additional, Melo, Diego, additional, Menshikov, Alexander, additional, Merenda, Kevin-Druis, additional, Michal, Stanislav, additional, Micheletti, Maria Isabel, additional, Miramonti, Lino, additional, Mollerach, Silvia, additional, Montanet, François, additional, Morello, Carlo, additional, Mostafa, Miguel, additional, Müller, Ana L., additional, Muller, Marcio Aparecido, additional, Mulrey, Katharine, additional, Mussa, Roberto, additional, Muzio, Marco Stein, additional, Namasaka, Wilson M., additional, Nasr-Esfahani, Alina, additional, Nellen, Lukas, additional, Niculescu-Oglinzanu, Mihai, additional, Niechciol, Marcus, additional, Nitz, Dave, additional, Nosek, Dalibor, additional, Novotný, Vladimír, additional, Nozka, Libor, additional, Nucita, Achille, additional, Nunez, Luis A., additional, Palatka, Miroslav, additional, Pallotta, Juan, additional, Papenbreer, Philipp, additional, Parente, Gonzalo, additional, Parra, Alejandra, additional, Pawlowsky, Jannis, additional, Pech, Miroslav, additional, Pedreira, Francisco, additional, Pękala, Jan, additional, Pelayo, Rodrigo, additional, Peña-Rodríguez, Jesús, additional, Pereira Martins, Edyvania Emily, additional, Perez Armand, Johnnier, additional, Pérez Bertolli, Carmina, additional, Perlin, Matías, additional, Perrone, Lorenzo, additional, Petrera, Sergio, additional, Pierog, Tanguy, additional, Pimenta, Mário, additional, Pirronello, Valerio, additional, Platino, Manuel, additional, Pont, Bjarni, additional, Pothast, Mart, additional, Privitera, Paolo, additional, Prouza, Michael, additional, Puyleart, Andrew, additional, Querchfeld, Sven, additional, Rautenberg, Julian, additional, Ravignani, Diego, additional, Reininghaus, Maximilian, additional, Ridky, Jan, additional, Riehn, Felix, additional, Risse, Markus, additional, Rizi, Vincenzo, additional, Rodrigues de Carvalho, Washington, additional, Rodriguez Rojo, Jorge Rubén, additional, Roncoroni, Matías J., additional, Rossoni, Simone, additional, Roth, Markus, additional, Roulet, Esteban, additional, Rovero, Adrian, additional, Ruehl, Philip, additional, Saftoiu, Alexandra, additional, Salamida, Francesco, additional, Salazar, Humberto Ibarguen, additional, Salina, Gaetano, additional, Sanabria Gomez, Jose, additional, Sánchez, Federico Andrés, additional, Santos, Edivaldo Moura, additional, Santos, Eva, additional, Sarazin, Fred, additional, Sarmento, Raul, additional, Sarmiento-Cano, Christian, additional, Sato, Ricardo, additional, Savina, Pierpaolo, additional, Schäfer, Christoph M., additional, Scherini, Viviana, additional, Schieler, Harald, additional, Schimassek, Martin, additional, Schimp, Michael, additional, Schlüter, Felix, additional, Schmidt, David, additional, Scholten, Olaf, additional, Schovanek, Petr, additional, Schröder, Frank G., additional, Schröder, Sonja, additional, Schulte, Josina, additional, Sciutto, Sergio, additional, Scornavacche, Marina, additional, Segreto, Alberto, additional, Sehgal, Srijan, additional, Shellard, Ronald C., additional, Sigl, Guenter, additional, Silli, Gaia, additional, Sima, Octavian, additional, Smida, Radomir, additional, Sommers, Paul, additional, Soriano, Jorge F., additional, Souchard, Julien, additional, Squartini, Ruben, additional, Stadelmaier, Maximilian, additional, Stanca, Denis, additional, Stanič, Samo, additional, Stasielak, Jaroslaw, additional, Stassi, Patrick, additional, Streich, Alexander, additional, Suárez-Durán, Mauricio, additional, Sudholz, Tristan, additional, Suomijarvi, Tiina, additional, Supanitsky, A. Daniel, additional, Szadkowski, Zbigniew, additional, Tapia, Alex, additional, Taricco, Carla, additional, Timmermans, Charles, additional, Tkachenko, Olena, additional, Tobiska, Petr, additional, Todero Peixoto, Carlos J., additional, Tomé, Bernardo, additional, Torrès, Zoé, additional, Travaini, Andres, additional, Travnicek, Petr, additional, Trimarelli, Caterina, additional, Tueros, Matías, additional, Ulrich, Ralf, additional, Unger, Michael, additional, Vaclavek, Lukáš, additional, Vacula, Martin, additional, Valdés Galicia, Jose F., additional, Valore, Laura, additional, Varela, Enrique, additional, Vásquez-Ramírez, Adriana, additional, Veberic, Darko, additional, Ventura, Cynthia, additional, Vergara Quispe, Indira D., additional, Verzi, Valerio, additional, Vicha, Jakub, additional, Vink, Jacco, additional, Vorobiov, Serguei, additional, Wahlberg, Hernan, additional, Watanabe, Clara Keiko Oliveira, additional, Watson, Alan, additional, Weber, Marc, additional, Weindl, Andreas, additional, Wiencke, Lawrence, additional, Wilczyński, Henryk, additional, Wirtz, Marcus, additional, Wittkowski, David, additional, Wundheiler, Brian, additional, Yushkov, Alexey, additional, Zapparrata, Orazio, additional, Zas, Enrique, additional, Zavrtanik, Danilo, additional, Zavrtanik, Marko, additional, Zehrer, Lukas, additional, Abbasi, Rasha, additional, Abu-Zayyad, Tareq, additional, Allen, Monica, additional, Arai, Yuto, additional, Arimura, Ryuhei, additional, Barcikowski, Elliott, additional, Belz, John, additional, Bergman, Douglas, additional, Blake, Samuel, additional, Cady, Robert, additional, Cheon, ByongGu, additional, Chiba, Jyunsei, additional, Chikawa, Michiyuki, additional, Fujii, Toshihiro, additional, Fujisue, Kozo, additional, Fujita, Keitaro, additional, Fujiwara, Ryota, additional, Fukushima, Masaki, additional, Fukushima, Ryota, additional, Furlich, Greg, additional, Gonzalez, Ricardo, additional, Hanlon, William, additional, Hayashi, Motoki, additional, Hayashida, Naoaki, additional, Hibino, Kinya, additional, Higuchi, Ryo, additional, Honda, Ken, additional, Ikeda, Daisuke, additional, Inadomi, Taichi, additional, Inoue, Naoya, additional, Ishii, Takaaki, additional, Ito, Hirotaka, additional, Ivanov, Dmitri, additional, Iwakura, Hirokazu, additional, Iwasaki, Aoi, additional, Jeong, Hyoming, additional, Jeong, Soomin, additional, Jui, Charlie, additional, Kadota, Kenichi, additional, Kakimoto, Fumio, additional, Kalashev, Oleg, additional, Kasahara, Katsuaki, additional, Kasami, Saori, additional, Kawai, Hideyuki, additional, Kawakami, Saburo, additional, Kawana, Shingo, additional, Kawata, Katsumasa, additional, Kharuk, Ivan, additional, Kido, Eiji, additional, Kim, HangBae, additional, Kim, Jihee, additional, Kim, Min Hyo, additional, Kim, Sang Woo, additional, Kimura, Yusuke, additional, Kishigami, Shoichi, additional, Kubota, Yuto, additional, Kurisu, Shinnosuke, additional, Kuzmin, Vladim, additional, Kwon, Youngjoon, additional, Lee, Kwangho, additional, Lubsandorzhiev, BayarJon Paul, additional, Lundquist, Jon Paul, additional, Machida, Kazuhiro, additional, Matsumiya, Hiroyuki, additional, Matsuyama, Toshio, additional, Matthews, John, additional, Mayta, Rosa, additional, Minamino, Mayuko, additional, Mukai, Keijiro, additional, Myers, Isaac, additional, Nagataki, Shigehiro, additional, Nakai, Kei, additional, Nakamura, Ryo, additional, Nakamura, Toru, additional, Nakamura, Tomoyuki, additional, Nakamura, Yuya, additional, Nakazawa, Arata, additional, Nishio, Eiji, additional, Nonaka, Toshiyuki, additional, Oda, Hiroyuki, additional, Ogio, Shoichi, additional, Ohnishi, Munehiro, additional, Ohoka, Hideyuki, additional, Oku, Yuya, additional, Okuda, Takeshi, additional, Omura, Yugo, additional, Ono, Masaomi, additional, Onogi, Ryota, additional, Oshima, Akitoshi, additional, OZAWA, Shunsuke, additional, Park, Il Hung, additional, Potts, Matt, additional, Pshirkov, Maxim, additional, Remington, Jackson, additional, Rodriguez, Doug, additional, Ryu, Dongsu, additional, Sagawa, Hiroyuki, additional, Sahara, Ryosuke, additional, Saito, Yasunori, additional, Sakaki, Naoto, additional, Sako, Takashi, additional, Sakurai, Nobuyuki, additional, Sano, Kengo, additional, Sato, Koki, additional, Seki, Terutsugu, additional, Sekino, Koichi, additional, Shah, Priti, additional, Shibasaki, Yuma, additional, Shibata, Fumiya, additional, Shibata, Norimichi, additional, Shibata, Tatsunobu, additional, Shimodaira, Hideaki, additional, Shin, Bokkyun, additional, Shin, Heungsu, additional, Shinto, Daiki, additional, Smith, Jeremy, additional, Sokolsky, Pierre, additional, Sone, Naohiro, additional, Stokes, Ben, additional, Stroman, Tom, additional, Takagi, Yoshinori, additional, Takahashi, Yuichi, additional, Takamura, Mai, additional, Takeda, Masahiro, additional, Takeishi, Ryuji, additional, Taketa, Akimichi, additional, Takita, Masato, additional, Tameda, Yuichiro, additional, Tanaka, Hideki, additional, Tanaka, Koichi, additional, Tanaka, Manobu, additional, Tanoue, Yuta, additional, Thomas, Stanton, additional, Thomson, Gordon, additional, Tkachev, Igor, additional, Tokuno, Hisono, additional, Tomida, Taka, additional, Tsuda, Ryosuke, additional, Tsunesada, Yoshiki, additional, Uchihori, Yukio, additional, Udo, Shigeharu, additional, Uehama, Takafumi, additional, Wong, Tiffany, additional, Yada, Kohei, additional, Yamamoto, Mashu, additional, Yamazaki, Katsuya, additional, Yang, Jongmann, additional, Yashiro, Kenta, additional, Yoshida, Fugo, additional, Yoshioka, Tsubasa, additional, Zhezher, Yana, additional, and Zundel, Zach, additional

Published
2021
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15. UHECR mass composition from anisotropy of their arrival directions with the Telescope Array SD

Author

Kuznetsov, Mikhail, primary, Tinyakov, Peter, additional, Abbasi, Rasha, additional, Abu-Zayyad, Tareq, additional, Allen, Monica, additional, Arai, Yuto, additional, Arimura, Ryuhei, additional, Barcikowski, Elliott, additional, Belz, John, additional, Bergman, Douglas, additional, Blake, Samuel, additional, Cady, Robert, additional, Cheon, ByongGu, additional, Chiba, Jyunsei, additional, Chikawa, Michiyuki, additional, Fujii, Toshihiro, additional, Fujisue, Kozo, additional, Fujita, Keitaro, additional, Fujiwara, Ryota, additional, Fukushima, Masaki, additional, Fukushima, Ryota, additional, Furlich, Greg, additional, Gonzalez, Ricardo, additional, Hanlon, William, additional, Hayashi, Motoki, additional, Hayashida, Naoaki, additional, Hibino, Kinya, additional, Higuchi, Ryo, additional, Honda, Ken, additional, Ikeda, Daisuke, additional, Inadomi, Taichi, additional, Inoue, Naoya, additional, Ishii, Takaaki, additional, Ito, Hirotaka, additional, Ivanov, Dmitri, additional, Iwakura, Hirokazu, additional, Iwasaki, Aoi, additional, Jeong, Hyoming, additional, Jeong, Soomin, additional, Jui, Charlie, additional, Kadota, Kenichi, additional, Kakimoto, Fumio, additional, Kalashev, Oleg, additional, Kasahara, Katsuaki, additional, Kasami, Saori, additional, Kawai, Hideyuki, additional, Kawakami, Saburo, additional, Kawana, Shingo, additional, Kawata, Katsumasa, additional, Kharuk, Ivan, additional, Kido, Eiji, additional, Kim, HangBae, additional, Kim, Jihee, additional, Kim, Jihyun, additional, Kim, Min Hyo, additional, Kim, Sang Woo, additional, Kimura, Yusuke, additional, Kishigami, Shoichi, additional, Kubota, Yuto, additional, Kurisu, Shinnosuke, additional, Kuzmin, Vladim, additional, Kwon, Youngjoon, additional, Lee, Kwangho, additional, Lubsandorzhiev, BayarJon Paul, additional, Lundquist, Jon Paul, additional, Machida, Kazuhiro, additional, Matsumiya, Hiroyuki, additional, Matsuyama, Toshio, additional, Matthews, John, additional, Mayta, Rosa, additional, Minamino, Mayuko, additional, Mukai, Keijiro, additional, Myers, Isaac, additional, Nagataki, Shigehiro, additional, Nakai, Kei, additional, Nakamura, Ryo, additional, Nakamura, Toru, additional, Nakamura, Tomoyuki, additional, Nakamura, Yuya, additional, Nakazawa, Arata, additional, Nishio, Eiji, additional, Nonaka, Toshiyuki, additional, Oda, Hiroyuki, additional, Ogio, Shoichi, additional, Ohnishi, Munehiro, additional, Ohoka, Hideyuki, additional, Oku, Yuya, additional, Okuda, Takeshi, additional, Omura, Yugo, additional, Ono, Masaomi, additional, Onogi, Ryota, additional, Oshima, Akitoshi, additional, OZAWA, Shunsuke, additional, Park, Il Hung, additional, Potts, Matt, additional, Pshirkov, Maxim, additional, Remington, Jackson, additional, Rodriguez, Doug, additional, Rubtsov, Grigory, additional, Ryu, Dongsu, additional, Sagawa, Hiroyuki, additional, Sahara, Ryosuke, additional, Saito, Yasunori, additional, Sakaki, Naoto, additional, Sako, Takashi, additional, Sakurai, Nobuyuki, additional, Sano, Kengo, additional, Sato, Koki, additional, Seki, Terutsugu, additional, Sekino, Koichi, additional, Shah, Priti, additional, Shibasaki, Yuma, additional, Shibata, Fumiya, additional, Shibata, Norimichi, additional, Shibata, Tatsunobu, additional, Shimodaira, Hideaki, additional, Shin, Bokkyun, additional, Shin, Heungsu, additional, Shinto, Daiki, additional, Smith, Jeremy, additional, Sokolsky, Pierre, additional, Sone, Naohiro, additional, Stokes, Ben, additional, Stroman, Tom, additional, Takagi, Yoshinori, additional, Takahashi, Yuichi, additional, Takamura, Mai, additional, Takeda, Masahiro, additional, Takeishi, Ryuji, additional, Taketa, Akimichi, additional, Takita, Masato, additional, Tameda, Yuichiro, additional, Tanaka, Hideki, additional, Tanaka, Koichi, additional, Tanaka, Manobu, additional, Tanoue, Yuta, additional, Thomas, Stanton, additional, Thomson, Gordon, additional, Tkachev, Igor, additional, Tokuno, Hisono, additional, Tomida, Taka, additional, Troitsky, Sergey, additional, Tsuda, Ryosuke, additional, Tsunesada, Yoshiki, additional, Uchihori, Yukio, additional, Udo, Shigeharu, additional, Uehama, Takafumi, additional, Urban, Federico, additional, Wong, Tiffany, additional, Yada, Kohei, additional, Yamamoto, Mashu, additional, Yamazaki, Katsuya, additional, Yang, Jongmann, additional, Yashiro, Kenta, additional, Yoshida, Fugo, additional, Yoshioka, Tsubasa, additional, Zhezher, Yana, additional, and Zundel, Zach, additional

Published
2021
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16. Progress and future prospect of the CRAFFT project for the next generation UHECR observation

Author

Tameda, Yuichiro, primary, Kagitani, Takashi, additional, Shibata, Norimichi, additional, Nishio, Eiji, additional, Tomida, Takayuki, additional, Iwakura, Hirokazu, additional, Nakamura, Yuya, additional, Kubota, Yuto, additional, Kurisu, Shinnosuke, additional, Saito, Ryosuke, additional, Ikeda, Daisuke, additional, and Yamazaki, Katsuya, additional

Published
2021
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25. Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake.

Author

Hayashi T, Kumamoto K, Kobayashi T, Hou X, Nagao S, Harada N, Honda S, Shimono Y, and Nishio E

Abstract

Estrogen is synthesized throughout various tissues in the body, and its production is regulated by the rate-limiting enzyme aromatase (encoded by the Cyp19a1 gene). Notably, aromatase is also expressed in central nervous system cells, allowing for localized estrogen synthesis in regions such as the hypothalamus. Estrogens produced within these neurons are referred to as neuroestrogens. In this study, we investigated the role of neuroestrogens in the regulation of appetite through modulation of hypothalamic pathways in OVX, ArKO, and aromatase-restored mice. Estrogen suppresses appetite by influencing the expression of appetite-regulating peptides, including POMC and NPY, via MC4R. We explored the direct effects of neuroestrogens, independent from ovarian estrogen, on appetite suppression and the underlying molecular mechanisms. We monitored body weight and food intake and evaluated the expression of Cyp19a1, Mc4r, and other appetite-related genes. Our findings indicate that OVX and ArKO mice exhibited increased body weight and food consumption, which correlated with altered expression of Mc4r and Cyp19a1. Conversely, restoration of Cyp19a1 expression in a neuron specific manner significantly decreased food intake and increased Mc4r expression in the hypothalamus. Furthermore, neuroestrogens enhanced leptin responsiveness. Our results imply that neuroestrogens likely contribute to appetite regulation and may be relevant for body weight reduction., (© 2025 The Author(s). The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)

Published
2025
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26. Laparoscopic repair combined with hysteroscopy of cesarean section scar after cesarean scar pregnancy resulting in a live birth: A case report.

Author

Takada K, Nishio E, Kotani K, Kobayashi A, Owaki A, Noda Y, Ito M, Miyamura H, and Nishizawa H

Abstract

We report a case where a spontaneous pregnancy and delivery of a live baby were achieved after laparoscopic repair combined with hysteroscopy of the cesarean section scar secondary to treatment for a prior cesarian section scar pregnancy. [Case] 31 years old, three pregnancies, and one delivery. A spontaneous abortion. Her first child was delivered by elective cesarean section due to pelvic position (breech presentation). During her second pregnancy, she was diagnosed with cesarean section scar pregnancy and underwent dilation and curettage. Subsequently, a laparoscopic repair of the uterine scar was performed using hysteroscopy owing to thinning of the cesarean section scar area. At six months postoperative, she conceived spontaneously and delivered a live baby by elective cesarean section at 38 weeks 2 days gestation. Conclusion: Thus, laparoscopic repair combined with hysteroscopy of the uterine scar can be a useful treatment option for patients with uterine scarring secondary to cesarean section scar pregnancy.

Published
2025
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27. A case of kidney graft injury during cesarean section in a pancreas and kidney transplantation recipient.

Author

Aida N, Nishio E, Sekiya T, Aida N, Ito T, Kenmochi T, and Nishizawa H

Abstract

Although organ transplantation is becoming general practice, little is known about the safety of delivery. This is the first known case that describes injury to the kidney by the uterine fundal pressure maneuver during cesarean section in a pancreas and kidney transplant recipient. A 40-year-old pregnant woman (gravida 0, para 0) was referred to our clinic. She had undergone living donor kidney transplantation 11 years earlier and brain-dead donor pancreas transplantation 1 year earlier owing to type 1 diabetes. Cesarean section was indicated when the patient's blood pressure was 150/100 mmHg at 37 weeks. We pushed the uterine fundus during delivery of the infant, with our usual caution. Serum creatinine levels were 1.6-2.6 mg/dl postoperatively. As this elevation was considered to be due to kidney graft dysfunction, we performed computed tomography, which revealed a hematoma around the kidney graft. Fifteen days after the cesarean section, surgical removal of the hematoma was performed by the transplant surgery team. Following hematoma removal, the serum creatinine level decreased to <1.4 mg/dl. We present a case of kidney graft injury during cesarean section in a pancreas and kidney transplant recipient., Competing Interests: No potential conflicts of interest were reported by the authors.

Published
2025
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28. Comparing Injection Site Reactions of Aprepitant and Fosaprepitant in Gynecologic Cancer Chemotherapy.

Author

Nishibe-Toyosato S, Ando Y, Torii Y, Ichikawa R, Owaki A, Miyamura H, Nishio E, Matsuda H, Tsujii-Fujii N, Shimato-Isobe A, Mukaiji K, Ito K, Hayashi T, Fujii T, and Yamada S

Subjects
Humans, Female, Middle Aged, Aged, Adult, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Aprepitant administration & dosage, Genital Neoplasms, Female drug therapy, Morpholines administration & dosage
Abstract

Background/aim: The frequency rate of injection site reactions (ISR) due to fosaprepitant meglumine (Fos APR) has been shown to vary depending on the types of combined anticancer drug. This study aimed to elucidate the impact of Fos APR on ISR in patients receiving paclitaxel and carboplatin, with and without bevacizumab therapy (TC±Bev)., Patients and Methods: This study focused on patients with gynecologic cancer (n=93) who received TC±Bev administration at Fujita Health University Hospital from March 2016 to February 2020, and monitored up to six cycles. The patients were randomly assigned to the Fos APR group (n=47) and the Aprepitant (APR) group (n=46). Using Visual Infusion Phlebitis (VIP) scores, ISR was evaluated by comparing the VIP scores of all cycles using a linear mixed model. The risk factors that contribute to the occurrence of vascular pain throughout all cycles were also examined., Results: The VIP scores of all cycles showed a near significant intergroup difference (p=0.071). Factors that affected the development of vascular pain included Fos APR and age (p=0.027 and 0.049, respectively). Regarding age, patients aged <65 years had a higher risk. Four patients underwent a switch from the originally assigned neurokinin-1 receptor antagonist; in all of these cases, Fos APR was changed to APR for vascular pain., Conclusion: Fos APR may increase the risk for ISR associated with TC±Bev therapy for gynecological cancer., (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2024
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29. Rare recurrence of a multilocular cystic leiomyoma following myomectomy.

Author

Nishio E, Sakabe Y, and Fujii T

Abstract

Multilocular cystic leiomyomas rarely develop following myomectomy. To the best of our knowledge, there are no published reports on recurrent multilocular cystic leiomyoma following myomectomy. We here present such a case. A 45-year-old woman visited our outpatient clinic because of heavy vaginal bleeding. She underwent laparoscopic myomectomy for a solid mass in the uterine cavity. Subsequent pathological examination of the operative specimen revealed a tumour with well-demarcated borders and spindle cells arranged in intersecting fascicles. Seven days postoperatively, ultrasonography revealed a cystic lesion. Magnetic resonance imaging performed 28 months postoperatively revealed a large, well-defined, multilocular cystic mass that was homogeneously hyperintense on T2-weighted images on the exterior of the uterus. Abdominal hysterectomy was performed. On pathological examination of the operative specimen, she was found to have a leiomyoma with marked cystic degeneration. Incomplete excision of a multilocular cystic leiomyoma may result in recurrence in the form of a large cystic mass. Clinical differentiation between a multilocular cystic leiomyoma and an ovarian tumour may be difficult. Complete resection of a uterine multilocular cystic lesion prevents recurrence., Competing Interests: The authors have no potential conflicts of interest.

Published
2023
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