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Your search keyword '"Nishiyama, Kaoru"' showing total 18 results
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18 results on '"Nishiyama, Kaoru"'

5. Possible Pseudo-progression of Non-small Cell Lung Carcinoma in a Patient With Clinical Hyper-progression Associated With Trousseau Syndrome Who Was Treated With Pembrolizumab: A Case Report

Author

SHIONOYA, YOSUKE, primary, HIROHASHI, YOSHIHIKO, additional, TAKAHASHI, HARUKA, additional, HASHIMOTO, MIDORI, additional, NISHIYAMA, KAORU, additional, TAKAKUWA, YASUNARI, additional, NAKATSUGAWA, MUNEHIDE, additional, KUBO, TERUFUMI, additional, KANASEKI, TAKAYUKI, additional, TSUKAHARA, TOMOHIDE, additional, and TORIGOE, TOSHIHIKO, additional

Published
2021
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11. Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation

Author

Ohkoshi, Yasuo, primary, Sato, Toyotaka, additional, Wada, Takayuki, additional, Fukushima, Yukari, additional, Murabayashi, Hiromi, additional, Takakuwa, Yasunari, additional, Nishiyama, Kaoru, additional, Honda, Hiroyuki, additional, Shiraishi, Tsukasa, additional, Kuronuma, Koji, additional, Takahashi, Hiroki, additional, Nakajima, Chie, additional, Suzuki, Yasuhiko, additional, and Yokota, Shin-ichi, additional

Published
2018
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14. Complete Genome Sequence of Multidrug-Resistant Streptococcus pneumoniae Serotype 19F Isolated from an Invasive Infection in Sapporo, Japan

Author

Sato, Toyotaka, primary, Ohkoshi, Yasuo, additional, Wada, Takayuki, additional, Fukushima, Yukari, additional, Murabayashi, Hiromi, additional, Takakuwa, Yasunari, additional, Nishiyama, Kaoru, additional, Shiraishi, Tsukasa, additional, Nakajima, Chie, additional, Suzuki, Yasuhiko, additional, and Yokota, Shin-ichi, additional

Published
2017
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17. De novo Hepatitis B Virus Reactivation during Treatment with an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in a Patient with Advanced Lung Cancer.

Author

Horibe R, Yokota M, Uemura K, Hashimoto M, Kawagishi N, and Nishiyama K

Subjects
Humans, Female, Aged, Adenocarcinoma drug therapy, Adenocarcinoma secondary, Fatal Outcome, Antineoplastic Agents therapeutic use, Antineoplastic Agents adverse effects, Adenocarcinoma of Lung drug therapy, Tyrosine Kinase Inhibitors, Indoles, Pyrimidines, Lung Neoplasms drug therapy, Hepatitis B virus genetics, Hepatitis B virus drug effects, Hepatitis B virus physiology, ErbB Receptors antagonists & inhibitors, Virus Activation drug effects, Protein Kinase Inhibitors therapeutic use, Protein Kinase Inhibitors adverse effects, Aniline Compounds therapeutic use, Aniline Compounds adverse effects, Acrylamides therapeutic use, Acrylamides adverse effects, Hepatitis B drug therapy, Hepatitis B complications
Abstract

A 71-year-old woman was treated with osimertinib for stage IV adenocarcinoma with epidermal growth factor receptor (EGFR) mutations. Treatment led to improvements in the primary tumor, multiple lung metastases, and multiple bone metastases. However, nine months later, she presented with marked liver dysfunction and jaundice. Chest and abdominal computed tomography did not show abnormal findings in the liver parenchyma or biliary system. However, blood tests were positive for hepatitis B surface antigen and hepatitis B virus DNA, suggesting hepatitis B virus reactivation. The patient died of liver failure despite treatment with steroids and antiviral drugs.

Published
2024
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18. Radical Resection for Second EGFR-mutated Primary Lung Cancer Following Immune Checkpoint Inhibitor Monotherapy for Stage IV Lung Adenocarcinoma.

Author

Horibe R, Hatakeyama T, Ishikawa T, Sawai T, Hashimoto M, Domen H, Takakuwa Y, Satoh M, and Nishiyama K

Subjects
Aged, ErbB Receptors genetics, Female, Humans, Immune Checkpoint Inhibitors, Lung, Mutation, Adenocarcinoma of Lung drug therapy, Adenocarcinoma of Lung genetics, Adenocarcinoma of Lung surgery, Lung Neoplasms drug therapy, Lung Neoplasms genetics, Lung Neoplasms surgery
Abstract

A 78-year-old woman with multiple lung nodules, epithelial growth factor receptor (EGFR) exon 20 insertion mutations, and diagnosed with advanced lung adenocarcinoma (cT4N3M1a, stage IVA), was referred to our hospital. She received immune checkpoint inhibitor (ICI) therapy. The therapy showed remarkable antitumor effects; only a single nodule remained in the right upper lobe. The nodule was diagnosed as adenocarcinoma through a biopsy. We subsequently performed right upper lobectomy for multiple primary lung cancer (MPLC). The surgical specimen contained EGFR exon 19 deletion mutations and not exon 20 insertion mutations.

Published
2022
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