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16 results on '"Noulet, Fanny"'

2. A mutual information-based in vivo monitoring of adaptive response to targeted therapies in melanoma

Author

Bugi-Marteyn, Aurore, Noulet, Fanny, Liaudet, Nicolas, and Merat, Rastine

Subjects
Quantitative Biology - Tissues and Organs
Abstract

The mechanisms of adaptive resistance to genetic-based targeted therapies of solid malignancies have been the subject of intense research. These studies hold great promise for finding co-targetable hub/pathways which in turn would control the downstream non-genetic mechanisms of adaptive resistance. Many such mechanisms have been described in the paradigmatic BRAF-mutated melanoma model of adaptive response to BRAF inhibition. Currently, a major challenge for these mechanistic studies is to confirm in vivo, at the single-cell proteomic level, the existence of dependencies between the co-targeted hub/pathways and their downstream effectors. Moreover, the drug-induced in vivo modulation of these dependencies needs to be demonstrated. Here, we implement such single-cell-based in vivo expression dependency quantification using immunohistochemistry (IHC)-based analyses of sequential biopsies in two xenograft models. These mimic phase 2 and 3 trials in our own therapeutic strategy to prevent the adaptive response to BRAF inhibition. In this mechanistic model, the dependencies between the targeted Li2CO3-inducible hub HuR and the resistance effectors are more likely time-shifted and transient since the minority of HuRLow cells, which act as a reservoir of adaptive plasticity, switch to a HuRHigh state as they paradoxically proliferate under BRAF inhibition. Nevertheless, we show that a copula/kernel density estimator (KDE)-based quantification of mutual information (MI) efficiently captures, at the individual level, the dependencies between HuR and two relevant resistance markers pERK and EGFR, and outperforms classic expression correlation coefficients. Ultimately, the validation of MI as a predictive IHC-based metric of response to our therapeutic strategy will be carried in clinical trials., Comment: 9 pages, 5 figures Corrected typos

Published
2021
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5. Data from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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6. Supplementary Figure 2 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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7. Supplementary Table 2 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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8. Supplementary Table 3 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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9. Supplementary Table 1 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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10. Supplementary Figure 1 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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11. Supplementary Figure 3 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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12. Supplementary Figure Legends 1-3 from Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma

Author

Janouskova, Hana, primary, Maglott, Anne, primary, Leger, David Y., primary, Bossert, Catherine, primary, Noulet, Fanny, primary, Guerin, Eric, primary, Guenot, Dominique, primary, Pinel, Sophie, primary, Chastagner, Pascal, primary, Plenat, François, primary, Entz-Werle, Natacha, primary, Lehmann-Che, Jacqueline, primary, Godet, Julien, primary, Martin, Sophie, primary, Teisinger, Jan, primary, and Dontenwill, Monique, primary

Published
2023
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16. Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties

Author

Jung, Alain C., primary, Ray, Anne-Marie, additional, Ramolu, Ludivine, additional, Macabre, Christine, additional, Simon, Florian, additional, Noulet, Fanny, additional, Blandin, Anne-Florence, additional, Renner, Guillaume, additional, Lehmann, Maxime, additional, Choulier, Laurence, additional, Kessler, Horst, additional, Abecassis, Joseph, additional, Dontenwill, Monique, additional, and Martin, Sophie, additional

Published
2015
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