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3. Incidence and clinical implications of intraoperative bilateral internal thoracic artery graft conversion: Insights from the Arterial Revascularization Trial

Author

Ratnatunga, C., Westaby, S., Cook, J., Wallis, C., Wos, S., Jasinski, M., Widenka, K., Blach, A., Gocol, R., Hudziak, D., Zurek, P., Deja, M., Bachowski, R., Mrozek, R., Kargul, T., Domarardzki, W., Frackiewicz, J., Zamvar, V., Ezakadan, D., Buxton, B., Seevanayagam, S., Matalanis, G., Rosalion, A., Negri, J., Moten, S., Atkinson, V., Newcomb, A., Polidano, P., Pana, R., Gerbo, S., O'Keefe, P., von Oppell, U., Mehta, D., Azzu, A., Szafranek, A., Kulatilake, E., Evans, J., Martin, N., Banner, D., Trivedi, U., Forsyth, A., Hyde, J., Cohen, A., Lewis, M., Gardner, E., MacKenzie, A., Cooter, N., Joyce, E., Parker, J., Champney, F., Clark, S., Dark, J., Tocewicz, K., Pillay, T., Rowling, S., Adams-Hall, J., Bochenek, A., Cisowski, M., Bolkowski, M., Morawski, W., Guc, M., Krejca, M., Wilczynski, M., Duralek, A., Gerber, W., Skarysz, J., Shrestha, R., Swiech, W., Szmagala, P., Krzych, L., Pawlak, A., Kepa, K., Hasan, R., Keenan, D., Prendergast, B., Odom, N., McLaughlin, K., Cummings-Fosong, G., Mathew, C., Iles-Smith, H., Oomen, A., Desai, J., El-Gamel, A., John, L., Wendler, O., Andrews, M., Rance, K., Williams, R., Hogervorst, V., Gregory, J., Jessup, J., Knighton, A., Hoare, A., Ritchie, A., Choong, C., Nair, S., Jenkins, D., Large, S., Sudarshan, C., Barman, M., Dhital, K., Routledge, T., Rosengard, B., Munday, H., Rintoul, K., Jarrett, E., Lao-Sirieix, S., Wilkinson, A., Garner, L., Osmond, J., Holcombe, H., Cale, A., Griffin, S., Dickson, J., Spyt, T., Hickey, M., Sosnowski, A., Peek, G., Szostek, J., Hadjinikalaou, L., Logtens, E., Oakley, M., Leji, S., Gaer, J., Amrani, M., Dreyfus, G., Bahrami, T., de Robertis, F., Baig, K., Asimakopoulos, G., Vohra, H., Pai, V., Tadjkarimi, S., Soleimani, B., Stavri, G., Bull, G., Collappen, H., Sadowksi, J., Gaweda, B., Rudzinski, P., Stolinski, J., Konstanty-Kalandyk, J., Moraes, F., Moraes, C., Wanderley, J., Pepper, J., De Souza, A., Petrou, M., Trimlett, R., Morgan, T., Gavino, J., Wang, S.F., Chandrasekaran, V., Kanagasaby, R., Sarsam, M., Ryan, H., Billings, L., Ruddick, L., Achampong, A., Forster, E., Pawlaczyk, R., Siondalski, P., Rogowski, J., Roszak, K., Jarmoszewicz, K., Jagielak, D., Gafka, S., Mannam, G., Naguboyin, G., Rao Sajja, L., Dandu, B., Briffa, N., Braidley, P., Cooper, G., Allen, K., Sangha, G., Bridge, C., McMellon, H., Casabona, R., Actis Dato, G., Bardi, G., Del Ponte, S., Forsennati, P., Parisi, F., Punta, G., Flocco, R., Sansone, F., Zingarelli, E., Dihmis, W., Kuduvali, M., Prince, C., Rogers, H., McQuade, L., Anisimowicz, L., Bokszanski, M., Pawliszak, W., Kolakowski, J., Lau, G., Ogorzeja, W., Gumanska, I., Kulinski, P., Podesser, B., Trescher, K., Bernecker, O., Holzinger, C., Binder, K., Schor, I., Bergmann, P., Kassal, H., Motovova, B., Trehan, N., Meharwal, Z., Malhotra, R., Goel, M., Kumer, B., Bazaz, S., Bake, N., Singh, A., Mishka, Y., Gupta, R., Basumatary, S., Zembala, M., Szafron, B., Pacholewicz, J., Krason, M., Farmas, A., Wojarski, J., Zych, B., Szymanik, I., Kolwca, M., Mazur, W., Kurowicki, A., Zurek, S., Stacel, T., Jaworska, I., Sleight, P., Channon, K., Farrell, B., Stables, R., Vermes, G., Pearson, J., Pitman, M., Yusuf, S., Pocock, S., Julian, D., Treasure, T., Von Oppel, U., Kanagasabay, R., Collinson, J., Bakhai, A., O'Hanlon, R., Kotecha, D., Qureshi, K., Geisler, T., Manzano-Espinosa, L., Benedetto, Umberto, Altman, Douglas G., Flather, Marcus, Gerry, Stephen, Gray, Alastair, Lees, Belinda, and Taggart, David P.

Published
2018
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4. Extensive morphological and behavioural diversity among fourteen new and seven described species in Phytophthora Clade 10 and its evolutionary implications

Author

Jung, T., Milenković, I., Corcobado, T., Májek, T., Janoušek, J., Kudláček, T., Tomšovský, M., Nagy, Z.Á., Durán, A., Tarigan, M., Sanfuentes von Stowasser, E., Singh, R., Ferreira, M., Webber, J. F., Scanu, B., Chi, N. M., Thu, P. Q., Junaid, M., Rosmana, A., Baharuddin, B., Kuswinanti, T., Nasri, N., Kageyama, K., Hieno, A., Masuya, H., Uematsu, S., Oliva, J., Redondo, M., Maia, Cristiana, Matsiakh, I., Kramarets, V., O'Hanlon, R., Tomić, Ž., Brasier, C. M., Horta Jung, M., and Naturalis journals & series

Subjects
Gondwana, Ecology, Evolution, Laurasia, phylogeny, allopatric, radiation, Biogeography, Behavior and Systematics, sympatric, oomycete, Allopatric, biogeography, Ecology, Evolution, Behavior and Systematics
Abstract

During extensive surveys of global Phytophthora diversity 14 new species detected in natural ecosystems in Chile, Indonesia, USA (Louisiana), Sweden, Ukraine and Vietnam were assigned to Phytophthora major Clade 10 based on a multigene phylogeny of nine nuclear and three mitochondrial gene regions. Clade 10 now comprises three subclades. Subclades 10a and 10b contain species with nonpapillate sporangia, a range of breeding systems and a mainly soil-and waterborne lifestyle. These include the previously described P. afrocarpa, P. gallica and P. intercalaris and eight of the new species: P. ludoviciana, P. procera, P. pseudogallica, P. scandinavica, P. subarctica, P. tenuimura, P. tonkinensis and P. ukrainensis. In contrast, all species in Subclade 10c have papillate sporangia and are self-fertile (or homothallic) with an aerial lifestyle including the known P. boehmeriae, P. gondwanensis, P. kernoviae and P. morindae and the new species P. celebensis, P. chilensis, P. javanensis, P. multiglobulosa, P. pseudochilensis and P. pseudokernoviae. All new Phytophthora species differed from each other and from related species by their unique combinations of morphological characters, breeding systems, cardinal temperatures and growth rates. The biogeography and evolutionary history of Clade 10 are discussed. We propose that the three subclades originated via the early divergence of pre-Gondwanan ancestors > 175 Mya into water-and soilborne and aerially dispersed lineages and subsequently underwent multiple allopatric and sympatric radiations during their global spread.

Published
2022
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7. Extensive morphological and behavioural diversity among fourteen new and seven described species inPhytophthora Clade 10 and its evolutionary implications

Author

Jung, T., primary, Milenković, I., additional, Corcobado, T., additional, Májek, T., additional, Janoušek, J., additional, Kudláček, T., additional, Tomšovský, M., additional, Nagy, Z.Á., additional, Durán, A., additional, Tarigan, M., additional, Sanfuentes von Stowasser, E., additional, Singh, R., additional, Ferreira, M., additional, Webber, J.F., additional, Scanu, B., additional, Chi, N.M., additional, Thu, P.Q., additional, Junaid, M., additional, Rosmana, A., additional, Baharuddin, B., additional, Kuswinanti, T., additional, Nasri, N., additional, Kageyama, K., additional, Hieno, A., additional, Masuya, H., additional, Uematsu, S., additional, Oliva, J., additional, Redondo, M., additional, Maia, C., additional, Matsiakh, I., additional, Kramarets, V., additional, O'Hanlon, R., additional, Tomić, Ž., additional, Brasier, C.M., additional, and Horta Jung, M., additional

Published
2022
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9. Worldwide diversity of endophytic fungi and insects associated with dormant tree twigs

Author

Franić, I., Prospero, S., Adamson, K., Allan, E., Attorre, F., Auger-Rozenberg, M.A., Augustin, S., Avtzis, D., Baert, W., Barta, M., Bauters, K., Bellahirech, A., Boroń, P., Bragança, H., Brestovanská, T., Brurberg, M.B., Burgess, T., Burokienė, D., Cleary, M., Corley, J., Coyle, D.R., Csóka, G., Černý, K., Davydenko, K., de Groot, M., Diez, J.J., Doğmuş Lehtijärvi, H.T., Drenkhan, R., Edwards, J., Elsafy, M., Eötvös, C.B., Falko, R., Fan, J., Feddern, N., Fürjes-Mikó, Á., Gossner, M.M., Grad, B., Hartmann, M., Havrdova, L., Horáková, M.K., Hrabětová, M., Justesen, M.J., Kacprzyk, M., Kenis, M., Kirichenko, N., Kovač, M., Kramarets, V., Lacković, N., Lantschner, M.V., Lazarević, J., Leskiv, M., Li, H., Madsen, C.L., Malumphy, C., Matošević, D., Matsiakh, I., May, T.W., Meffert, J., Migliorini, D., Nikolov, C., O’Hanlon, R., Oskay, F., Paap, T., Parpan, T., Piškur, B., Ravn, H.P., Richard, J., Ronse, A., Roques, A., Ruffner, B., Sivickis, K., Soliani, C., Talgø, V., Tomoshevich, M., Uimari, A., Ulyshen, M., Vettraino, A.M., Villari, C., Wang, Y., Witzell, J., Zlatković, M., Eschen, R., Franić, I., Prospero, S., Adamson, K., Allan, E., Attorre, F., Auger-Rozenberg, M.A., Augustin, S., Avtzis, D., Baert, W., Barta, M., Bauters, K., Bellahirech, A., Boroń, P., Bragança, H., Brestovanská, T., Brurberg, M.B., Burgess, T., Burokienė, D., Cleary, M., Corley, J., Coyle, D.R., Csóka, G., Černý, K., Davydenko, K., de Groot, M., Diez, J.J., Doğmuş Lehtijärvi, H.T., Drenkhan, R., Edwards, J., Elsafy, M., Eötvös, C.B., Falko, R., Fan, J., Feddern, N., Fürjes-Mikó, Á., Gossner, M.M., Grad, B., Hartmann, M., Havrdova, L., Horáková, M.K., Hrabětová, M., Justesen, M.J., Kacprzyk, M., Kenis, M., Kirichenko, N., Kovač, M., Kramarets, V., Lacković, N., Lantschner, M.V., Lazarević, J., Leskiv, M., Li, H., Madsen, C.L., Malumphy, C., Matošević, D., Matsiakh, I., May, T.W., Meffert, J., Migliorini, D., Nikolov, C., O’Hanlon, R., Oskay, F., Paap, T., Parpan, T., Piškur, B., Ravn, H.P., Richard, J., Ronse, A., Roques, A., Ruffner, B., Sivickis, K., Soliani, C., Talgø, V., Tomoshevich, M., Uimari, A., Ulyshen, M., Vettraino, A.M., Villari, C., Wang, Y., Witzell, J., Zlatković, M., and Eschen, R.

Abstract

International trade in plants and climate change are two of the main factors causing damaging tree pests (i.e. fungi and insects) to spread into new areas. To mitigate these risks, a large-scale assessment of tree-associated fungi and insects is needed. We present records of endophytic fungi and insects in twigs of 17 angiosperm and gymnosperm genera, from 51 locations in 32 countries worldwide. Endophytic fungi were characterized by high-throughput sequencing of 352 samples from 145 tree species in 28 countries. Insects were reared from 227 samples of 109 tree species in 18 countries and sorted into taxonomic orders and feeding guilds. Herbivorous insects were grouped into morphospecies and were identified using molecular and morphological approaches. This dataset reveals the diversity of tree-associated taxa, as it contains 12,721 fungal Amplicon Sequence Variants and 208 herbivorous insect morphospecies, sampled across broad geographic and climatic gradients and for many tree species. This dataset will facilitate applied and fundamental studies on the distribution of fungal endophytes and insects in trees.

Published
2022

10. Extensive morphological and behavioural diversity among fourteen new and seven described species in Phytophthora Clade 10 and its evolutionary implications

Author

Jung T., Milenković I., Corcobado T., Májek T., Janoušek J., Kudláček T., Tomšovský M., Nagy Z.Á., Durán A., Tarigan M., Sanfuentes von Stowasser E., Singh R., Ferreira M., Webber J.F., Scanu B., Chi N.M., Thu P.Q., Junaid M., Rosmana A., Baharuddin B., Kuswinanti T., Nasri N., Kageyama K., Hieno A., Masuya H., Uematsu S., Oliva J., Redondo M., Maia C., Matsiakh I., Kramarets V., O'Hanlon R., Tomić Ž., Brasier C.M., Horta Jung M., Jung T., Milenković I., Corcobado T., Májek T., Janoušek J., Kudláček T., Tomšovský M., Nagy Z.Á., Durán A., Tarigan M., Sanfuentes von Stowasser E., Singh R., Ferreira M., Webber J.F., Scanu B., Chi N.M., Thu P.Q., Junaid M., Rosmana A., Baharuddin B., Kuswinanti T., Nasri N., Kageyama K., Hieno A., Masuya H., Uematsu S., Oliva J., Redondo M., Maia C., Matsiakh I., Kramarets V., O'Hanlon R., Tomić Ž., Brasier C.M., and Horta Jung M.

Published
2022

13. State of the World’s Plants and Fungi

Author

Antonelli, A., Smith, R. J., Fry, C., Simmonds, Monique S. J., Kersey, Paul J., Pritchard, H. W., Abbo, M. S., Acedo, C., Adams, J., Ainsworth A.M., Allkin B., Annecke W, Bachman S P, Bacon, K., Bárrios, S., Barstow, C., Battison, A., Bell, E., Bensusan, K., Bidartondo, M. I., Blackhall-Miles, R. J., Borrell, J. S., Brearley, F. Q., Breman, E., Brewer, R. F. A., Brodie, J., Cámara-Leret, R., Campostrini Forzza, R., Cannon, P., Carine, M., Carretero, J., Cavagnaro, T. R., E Cazar, M., Chapman, T., Cheek, M., Clubbe, C., Cockel, C., Collemare, J., Cooper, A., Copeland, A. I., Corcoran, M., Couch, C., Cowell, C., Crous, P., Da Silva, M., Dalle, G., Das, D., David, J. C., Davies, L., Davies, N., Canha, M. N., Lirio, E. J., Demissew, S., Diazgranados, M., Dickie, J., Dines, T., Douglas, B., Dröge, G., Dulloo, M. E., Fang, R., Farlow, A., Farrar, K., Fay, M. F., Felix, J., Forest, F., Forrest, L. L., Fulcher, T., Gafforov, Y., Gardiner, L. M., Gâteblé, G., Gaya, E., Benoit Geslin, Gonçalves, S. C., Gore, C. J. N., Govaerts, R., Gowda, B., Grace, O. M., Grall, A., Haelewaters, D., Halley, J. M., Hamilton, M. A., Hazra, A., Heller, T., Hollingsworth, P. M., Holstein, N., Howes, M. -J R., Hughes, M., Hunter, D., Hutchinson, N., Hyde, K., Iganci, J., Jones, M., Kelly, L. J., Kirk, P., Koch, H., Krisai-Greilhuber, I., Lall, N., Langat, M. K., Leaman, D. J., Leão, T. C., Lee, M. A., Leitch, I. J., Leon, C., Lettice, E., Lewis, G. P., Li, L., Lindon, H., Liu, J. S., Liu, U., Llewellyn, T., Looney, B., Lovett, J. C., Łukasz Łuczaj, Lulekal, E., Maggassouba, S., Valéry Malécot, Martin, C., Masera, O. R., Mattana, E., Maxted, N., Mba, C., Mcginn, K. J., Metheringham, C., Miles, S., Miller, J., Milliken, W., Moat, J., Moore, P. G. P., Morim, M. P., Mueller, G. M., Muminjanov, H., Negrão, R., Nic Lughadha, E., Nicolson, N., Niskanen, T., Nono Womdim, R., Noorani, A., Obreza, M., O’donnell, K., O’hanlon, R., M Onana, J., Ondo, I., Padulosi, S., Paton, A., Pearce, T., Pérez Escobar, O. A., Pieroni, A., Pironon, S., Prescott, T. A. K., Qi, Y. D., Qin, H., Quave, C. L., Rajaovelona, L., Razanajatovo, H., Reich, P. B., Rianawati, E., Rich, T. C. G., Richards, S. L., Rivers, M. C., Ross, A., Rumsey, F., Ryan, M., Ryan, P., Sagala, S., Sanchez, M. D., Sharrock, S., Shrestha, K. K., Sim, J., Sirakaya, A., Sjöman, H., Smidt, E. C., Smith, D., Smith, P., Smith, S. R., Sofo, A., Spence, N., Stanworth, A., Stara, K., Stevenson, P. C., Stroh, P., Suz, L. M., Tambam, B. B., Tatsis, E. C., Taylor, I., Thiers, B., Thormann, I., Trivedi, C., Twilley, D., Twyford, A. D., Ulian, T., Utteridge, T., Vaglica, V., Vásquez-Londoño, C., Victor, J., Viruel, J., Walker, B. E., Walker, K., Walsh, A., Way, M., Wilbraham, J., Wilkin, P., Wilkinson, T., Williams, C., Winterton, D., Wong, K. M., Woodfield-Pascoe, N., Woodman, J., Wyatt, L., Wynberg, R., Zhang, B. G., Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Royal Botanic Gardens (Kew), and Sfumato Foundation

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDE.ES]Environmental Sciences/Environmental and Society, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

20. Incidence and clinical implications of intraoperative bilateral internal thoracic artery graft conversion: Insights from the Arterial Revascularization Trial

Author

Benedetto, Umberto, primary, Altman, Douglas G., additional, Flather, Marcus, additional, Gerry, Stephen, additional, Gray, Alastair, additional, Lees, Belinda, additional, Taggart, David P., additional, Ratnatunga, C., additional, Westaby, S., additional, Cook, J., additional, Wallis, C., additional, Wos, S., additional, Jasinski, M., additional, Widenka, K., additional, Blach, A., additional, Gocol, R., additional, Hudziak, D., additional, Zurek, P., additional, Deja, M., additional, Bachowski, R., additional, Mrozek, R., additional, Kargul, T., additional, Domarardzki, W., additional, Frackiewicz, J., additional, Zamvar, V., additional, Ezakadan, D., additional, Buxton, B., additional, Seevanayagam, S., additional, Matalanis, G., additional, Rosalion, A., additional, Negri, J., additional, Moten, S., additional, Atkinson, V., additional, Newcomb, A., additional, Polidano, P., additional, Pana, R., additional, Gerbo, S., additional, O'Keefe, P., additional, von Oppell, U., additional, Mehta, D., additional, Azzu, A., additional, Szafranek, A., additional, Kulatilake, E., additional, Evans, J., additional, Martin, N., additional, Banner, D., additional, Trivedi, U., additional, Forsyth, A., additional, Hyde, J., additional, Cohen, A., additional, Lewis, M., additional, Gardner, E., additional, MacKenzie, A., additional, Cooter, N., additional, Joyce, E., additional, Parker, J., additional, Champney, F., additional, Clark, S., additional, Dark, J., additional, Tocewicz, K., additional, Pillay, T., additional, Rowling, S., additional, Adams-Hall, J., additional, Bochenek, A., additional, Cisowski, M., additional, Bolkowski, M., additional, Morawski, W., additional, Guc, M., additional, Krejca, M., additional, Wilczynski, M., additional, Duralek, A., additional, Gerber, W., additional, Skarysz, J., additional, Shrestha, R., additional, Swiech, W., additional, Szmagala, P., additional, Krzych, L., additional, Pawlak, A., additional, Kepa, K., additional, Hasan, R., additional, Keenan, D., additional, Prendergast, B., additional, Odom, N., additional, McLaughlin, K., additional, Cummings-Fosong, G., additional, Mathew, C., additional, Iles-Smith, H., additional, Oomen, A., additional, Desai, J., additional, El-Gamel, A., additional, John, L., additional, Wendler, O., additional, Andrews, M., additional, Rance, K., additional, Williams, R., additional, Hogervorst, V., additional, Gregory, J., additional, Jessup, J., additional, Knighton, A., additional, Hoare, A., additional, Ritchie, A., additional, Choong, C., additional, Nair, S., additional, Jenkins, D., additional, Large, S., additional, Sudarshan, C., additional, Barman, M., additional, Dhital, K., additional, Routledge, T., additional, Rosengard, B., additional, Munday, H., additional, Rintoul, K., additional, Jarrett, E., additional, Lao-Sirieix, S., additional, Wilkinson, A., additional, Garner, L., additional, Osmond, J., additional, Holcombe, H., additional, Cale, A., additional, Griffin, S., additional, Dickson, J., additional, Spyt, T., additional, Hickey, M., additional, Sosnowski, A., additional, Peek, G., additional, Szostek, J., additional, Hadjinikalaou, L., additional, Logtens, E., additional, Oakley, M., additional, Leji, S., additional, Gaer, J., additional, Amrani, M., additional, Dreyfus, G., additional, Bahrami, T., additional, de Robertis, F., additional, Baig, K., additional, Asimakopoulos, G., additional, Vohra, H., additional, Pai, V., additional, Tadjkarimi, S., additional, Soleimani, B., additional, Stavri, G., additional, Bull, G., additional, Collappen, H., additional, Sadowksi, J., additional, Gaweda, B., additional, Rudzinski, P., additional, Stolinski, J., additional, Konstanty-Kalandyk, J., additional, Moraes, F., additional, Moraes, C., additional, Wanderley, J., additional, Pepper, J., additional, De Souza, A., additional, Petrou, M., additional, Trimlett, R., additional, Morgan, T., additional, Gavino, J., additional, Wang, S.F., additional, Chandrasekaran, V., additional, Kanagasaby, R., additional, Sarsam, M., additional, Ryan, H., additional, Billings, L., additional, Ruddick, L., additional, Achampong, A., additional, Forster, E., additional, Pawlaczyk, R., additional, Siondalski, P., additional, Rogowski, J., additional, Roszak, K., additional, Jarmoszewicz, K., additional, Jagielak, D., additional, Gafka, S., additional, Mannam, G., additional, Naguboyin, G., additional, Rao Sajja, L., additional, Dandu, B., additional, Briffa, N., additional, Braidley, P., additional, Cooper, G., additional, Allen, K., additional, Sangha, G., additional, Bridge, C., additional, McMellon, H., additional, Casabona, R., additional, Actis Dato, G., additional, Bardi, G., additional, Del Ponte, S., additional, Forsennati, P., additional, Parisi, F., additional, Punta, G., additional, Flocco, R., additional, Sansone, F., additional, Zingarelli, E., additional, Dihmis, W., additional, Kuduvali, M., additional, Prince, C., additional, Rogers, H., additional, McQuade, L., additional, Anisimowicz, L., additional, Bokszanski, M., additional, Pawliszak, W., additional, Kolakowski, J., additional, Lau, G., additional, Ogorzeja, W., additional, Gumanska, I., additional, Kulinski, P., additional, Podesser, B., additional, Trescher, K., additional, Bernecker, O., additional, Holzinger, C., additional, Binder, K., additional, Schor, I., additional, Bergmann, P., additional, Kassal, H., additional, Motovova, B., additional, Trehan, N., additional, Meharwal, Z., additional, Malhotra, R., additional, Goel, M., additional, Kumer, B., additional, Bazaz, S., additional, Bake, N., additional, Singh, A., additional, Mishka, Y., additional, Gupta, R., additional, Basumatary, S., additional, Zembala, M., additional, Szafron, B., additional, Pacholewicz, J., additional, Krason, M., additional, Farmas, A., additional, Wojarski, J., additional, Zych, B., additional, Szymanik, I., additional, Kolwca, M., additional, Mazur, W., additional, Kurowicki, A., additional, Zurek, S., additional, Stacel, T., additional, Jaworska, I., additional, Sleight, P., additional, Channon, K., additional, Farrell, B., additional, Stables, R., additional, Vermes, G., additional, Pearson, J., additional, Pitman, M., additional, Yusuf, S., additional, Pocock, S., additional, Julian, D., additional, Treasure, T., additional, Von Oppel, U., additional, Kanagasabay, R., additional, Collinson, J., additional, Bakhai, A., additional, O'Hanlon, R., additional, Kotecha, D., additional, Qureshi, K., additional, Geisler, T., additional, and Manzano-Espinosa, L., additional

Published
2018
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21. Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial)

Author

Benedetto, Umberto, primary, Altman, Douglas G., additional, Gerry, Stephen, additional, Gray, Alastair, additional, Lees, Belinda, additional, Angelini, Gianni D., additional, Flather, Marcus, additional, Taggart, David P., additional, Ratnatunga, C., additional, Westaby, S., additional, Cook, J., additional, Wallis, C., additional, Wos, S., additional, Jasinski, M., additional, Widenka, K., additional, Blach, A., additional, Gocol, R., additional, Hudziak, D., additional, Zurek, P., additional, Deja, M., additional, Bachowski, R., additional, Mrozek, R., additional, Kargul, T., additional, Domarardzki, W., additional, Frackiewicz, J., additional, Zamvar, V., additional, Ezakadan, D., additional, Buxton, B., additional, Seevanayagam, S., additional, Matalanis, G., additional, Rosalion, A., additional, Negri, J., additional, Moten, S., additional, Atkinson, V., additional, Newcomb, A., additional, Polidano, P., additional, Pana, R., additional, Gerbo, S., additional, O'Keefe, P., additional, von Oppell, U., additional, Mehta, D., additional, Azzu, A., additional, Szafranek, A., additional, Kulatilake, E., additional, Evans, J., additional, Martin, N., additional, Banner, D., additional, Trivedi, U., additional, Forsyth, A., additional, Hyde, J., additional, Cohen, A., additional, Lewis, M., additional, Gardner, E., additional, MacKenzie, A., additional, Cooter, N., additional, Joyce, E., additional, Parker, J., additional, Champney, F., additional, Clark, S., additional, Dark, J., additional, Tocewicz, K., additional, Pillay, T., additional, Rowling, S., additional, Adams‐Hall, J., additional, Bochenek, A., additional, Cisowski, M., additional, Bolkowski, M., additional, Morawski, W., additional, Guc, M., additional, Krejca, M., additional, Wilczynski, M., additional, Duralek, A., additional, Gerber, W., additional, Skarysz, J., additional, Shrestha, R., additional, Swiech, W., additional, Szmagala, P., additional, Krzych, L., additional, Pawlak, A., additional, Kepa, K., additional, Hasan, R., additional, Keenan, D., additional, Prendergast, B., additional, Odom, N., additional, McLaughlin, K., additional, Cummings‐Fosong, G., additional, Mathew, C., additional, Iles‐Smith, H., additional, Oomen, A., additional, Desai, J., additional, El‐Gamel, A., additional, John, L., additional, Wendler, O., additional, Andrews, M., additional, Rance, K., additional, Williams, R., additional, Hogervorst, V., additional, Gregory, J., additional, Jessup, J., additional, Knighton, A., additional, Hoare, A., additional, Ritchie, A., additional, Choong, C., additional, Nair, S., additional, Jenkins, D., additional, Large, S., additional, Sudarshan, C., additional, Barman, M., additional, Dhital, K., additional, Routledge, T., additional, Rosengard, B., additional, Munday, H., additional, Rintoul, K., additional, Jarrett, E., additional, Lao‐Sirieix, S., additional, Wilkinson, A., additional, Garner, L., additional, Osmond, J., additional, Holcombe, H., additional, Cale, A., additional, Griffin, S., additional, Dickson, J., additional, Spyt, T., additional, Hickey, M., additional, Sosnowski, A., additional, Peek, G., additional, Szostek, J., additional, Hadjinikalaou, L., additional, Logtens, E., additional, Oakley, M., additional, Leji, S., additional, Gaer, J., additional, Amrani, M., additional, Dreyfus, G., additional, Bahrami, T., additional, de Robertis, F., additional, Baig, K., additional, Asimakopoulos, G., additional, Vohra, H., additional, Pai, V., additional, Tadjkarimi, S., additional, Soleimani, B., additional, Stavri, G., additional, Bull, G., additional, Collappen, H., additional, Sadowksi, J., additional, Gaweda, B., additional, Rudzinski, P., additional, Stolinski, J., additional, Konstanty‐Kalandyk, J., additional, Moraes, F., additional, Moraes, C., additional, Wanderley, J., additional, Pepper, J., additional, De Souza, A., additional, Petrou, M., additional, Trimlett, R., additional, Morgan, T., additional, Gavino, J., additional, Wang, S.F., additional, Chandrasekaran, V., additional, Kanagasaby, R., additional, Sarsam, M., additional, Ryan, H., additional, Billings, L., additional, Ruddick, L., additional, Achampong, A., additional, Forster, E., additional, Pawlaczyk, R., additional, Siondalski, P., additional, Rogowski, J., additional, Roszak, K., additional, Jarmoszewicz, K., additional, Jagielak, D., additional, Gafka, S., additional, Mannam, G., additional, Naguboyin, G., additional, Rao Sajja, L., additional, Dandu, B., additional, Briffa, N., additional, Braidley, P., additional, Cooper, G., additional, Allen, K., additional, Sangha, G., additional, Bridge, C., additional, McMellon, H., additional, Casabona, R., additional, Actis Dato, G., additional, Bardi, G., additional, Del Ponte, S., additional, Forsennati, P., additional, Parisi, F., additional, Punta, G., additional, Flocco, R., additional, Sansone, F., additional, Zingarelli, E., additional, Dihmis, W., additional, Kuduvali, M., additional, Prince, C., additional, Rogers, H., additional, McQuade, L., additional, Anisimowicz, L., additional, Bokszanski, M., additional, Pawliszak, W., additional, Kolakowski, J., additional, Lau, G., additional, Ogorzeja, W., additional, Gumanska, I., additional, Kulinski, P., additional, Podesser, B., additional, Trescher, K., additional, Bernecker, O., additional, Holzinger, C., additional, Binder, K., additional, Schor, I., additional, Bergmann, P., additional, Kassal, H., additional, Motovova, B., additional, Trehan, N., additional, Meharwal, Z., additional, Malhotra, R., additional, Goel, M., additional, Kumer, B., additional, Bazaz, S., additional, Bake, N., additional, Singh, A., additional, Mishka, Y., additional, Gupta, R., additional, Basumatary, S., additional, Zembala, M., additional, Szafron, B., additional, Pacholewicz, J., additional, Krason, M., additional, Farmas, A., additional, Wojarski, J., additional, Zych, B., additional, Szymanik, I., additional, Kolwca, M., additional, Mazur, W., additional, Kurowicki, A., additional, Zurek, S., additional, Stacel, T., additional, Jaworska, I., additional, Sleight, P., additional, Channon, K., additional, Farrell, B., additional, Stables, R., additional, Vermes, G., additional, Pearson, J., additional, Pitman, M., additional, Yusuf, S., additional, Pocock, S., additional, Julian, D., additional, Treasure, T., additional, Von Oppel, U., additional, Kanagasabay, R., additional, Collinson, J., additional, Bakhai, A., additional, O'Hanlon, R., additional, Kotecha, D., additional, Qureshi, K., additional, Geisler, T., additional, and Manzano‐Espinosa, L., additional

Published
2018
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27. P4510Prognostic value of cardiovascular magnetic resonance in the prediction of atrial fibrillation in hypertrophic cardiomyopathy (HCM)

Author

Liew, A., primary, Raphael, C.E., additional, Mitchell, F., additional, Kanaganayagam, G.S., additional, Di Pietro, E., additional, Newsome, S., additional, Cooper, R., additional, Gatehouse, P., additional, Vassiliou, V., additional, Pennell, D.J., additional, Frenneaux, M., additional, O'Hanlon, R., additional, and Prasad, S.K., additional

Published
2017
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28. P4502Risk factors for the development of heart failure in hypertrophic cardiomyopathy: a cardiovascular magnetic resonance study

Author

Raphael, C.E., primary, Mitchell, F., additional, Kanaganayagam, G.S., additional, Liew, A., additional, Di Pietro, E., additional, Vieira, M.S., additional, Newsome, S., additional, Vassiliou, V., additional, Ali, A., additional, Wong, B., additional, Sun, K., additional, O'Hanlon, R., additional, Pennell, D.J., additional, and Prasad, S.K., additional

Published
2017
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30. Global and regional cardiac function in lifelong endurance athletes with and without myocardial fibrosis.

Author

Eijsvogels, T.M.H., Oxborough, D.L., O'Hanlon, R., Sharma, S., Prasad, S., Whyte, G., George, K.P., Wilson, M.G., Eijsvogels, T.M.H., Oxborough, D.L., O'Hanlon, R., Sharma, S., Prasad, S., Whyte, G., George, K.P., and Wilson, M.G.

Abstract

Contains fulltext : 177745.pdf (Publisher’s version ) (Open Access), The aim of the present study was to compare cardiac structure as well as global and regional cardiac function in athletes with and without myocardial fibrosis (MF). Cardiac magnetic resonance imaging with late gadolinium enhancement was used to detect MF and global cardiac structure in nine lifelong veteran endurance athletes (58 +/- 5 years, 43 +/- 5 years of training). Transthoracic echocardiography using tissue-Doppler and myocardial strain imaging assessed global and regional (18 segments) longitudinal left ventricular function. MF was present in four athletes (range 1-8 g) and not present in five athletes. MF was located near the insertion points of the right ventricular free wall on the left ventricle in three athletes and in the epicardial lateral wall in one athlete. Athletes with MF demonstrated a larger end diastolic volume (205 +/- 24 vs 173 +/- 18 ml) and posterior wall thickness (11 +/- 1 vs 9 +/- 1 mm) compared to those without MF. The presence of MF did not mediate global tissue velocities or global longitudinal strain and strain rate; however, regional analysis of longitudinal strain demonstrated reduced function in some fibrotic regions. Furthermore, base to apex gradient was affected in three out of four athletes with MF. Lifelong veteran endurance athletes with MF demonstrate larger cardiac dimensions and normal global cardiac function. Fibrotic areas may demonstrate some co-localised regional cardiac dysfunction, evidenced by an affected cardiac strain and base to apex gradient. These data emphasize the heterogeneous phenotype of MF in athletes.

Published
2017

34. ORAL AB QUICK FIRE I1496Myocardial substrates underlyng early ventricular arrhythmias in st-elevation acute myocardial infarction: the role of cardiac magnetic resonance1416Cardiac magnetic resonance predicts atrial fibrillation occurrence in patients with hypertrophic cardiomyopathy1469T1 and T2 mapping cardiovascular magnetic resonance to monitor inflammatory activity in patients with myocarditis1480Impact of electronic coaching on cardiovascular risk reduction in a high-risk primary prevention population – A cardiovascular magnetic resonance sub-study1598Anatomical and functional evaluation of postinterventional pulmonary vein stenosis by magnetic resonance imaging1364Reduced infarct-adjacent wall thickening and impaired restperfusion in the area at risk of successfully reperfused acute myocardial infarction1580Correlation between circulating microRNA 29 and diffuse myocardial fibrosis, assessed by T1 mapping, in patients affected by non ischemic dilative cardiomyopathy1435Association of Smoking with Myocardial Injury and Clinical Outcome in Patients Undergoing Mechanical Reperfusion for ST-Elevation Myocardial Infarction1640Assessing the risk of late cardiotoxicity in low risk breast cancer survivors receiving contemporary anthracycline treatment: a 6 year 100 patient study1511Risk stratification in sarcoidosis: Incidence of cardiac sarcoidosis in individuals diagnosed with extra-cardiac disease by cardiovascular magnetic resonance1334Patterns of late gadolinium enhancement in Brugada syndrome1591Detailed Left Atrial Assessment in Anderson Fabry Disease1634Role of cardiac magnetic resonance in the diagnosis of ARVC/D mimics1321Comparison of transtlioracic ecliocardiography versus cardiac magnetic for implantable cardioverter defibrillator therapy in primary prevention strategy dilated cardiomyopathy patients: Table 1.

Author

Angela, Susana, primary, Camaioni, Claudia, primary, Bohnen, S., primary, Khanji, Mohammed Y., primary, Hilbert, Sebastian, primary, Goetschalckx, K., primary, Calvieri, C., primary, Reinstadler, Sebastian J., primary, Maestrini, Viviana, primary, James, S., primary, Bastiaenen, Rachel, primary, Reid, A. B., primary, Amadu, A.M., primary, Pontone, Gianluca, primary, Alberto, Cipriani, additional, Manuel, De Lazzari, additional, Federico, Marin, additional, Francesca, Prevedello, additional, Bendetta, Giorgi, additional, Giorgio, De Conti, additional, Giuseppe, Tarantini, additional, Luisa, Cacciavillani, additional, Emanuele, Bertaglia, additional, Domenico, Corrado, additional, Sabino, Iliceto, additional, Martina, Perazzolo Marra, additional, Morlon, Lucas, additional, Vergé, Marie-Philippe, additional, Jais, Pierre, additional, Roudaut, Raymond, additional, Laurent, François, additional, Lafitte, Stéphane, additional, Cochet, Hubert, additional, Réant, Patricia, additional, Radunski, U. K., additional, Lund, G. K., additional, Senel, M., additional, Avanesov, M., additional, Tahir, E., additional, Stehning, C., additional, Adam, G., additional, Blankenberg, S., additional, Muellerleile, K., additional, Balawon, Armida, additional, Boubertakh, Redha, additional, Petersen, Steffen E, additional, Spampinato, Ricardo, additional, Oebel, Sabrina, additional, Hindricks, Gerhard, additional, Bollmann, Andreas, additional, Jahnke, Cosima, additional, Paetsch, Ingo, additional, Bogaert, J., additional, Desmet, W., additional, Toth, A., additional, Merkely, B., additional, Janssens, S., additional, Claus, P., additional, Preda, M. B., additional, Perfetti, A., additional, Valaperta, R., additional, Secchi, F., additional, Fedele, F., additional, Martelli, F., additional, Lombardi, M., additional, Eitel, Charlotte, additional, Fuernau, Georg, additional, de Waha, Suzanne, additional, Desch, Steffen, additional, Mende, Meinhard, additional, Metzler, Bernhard, additional, Schuler, Gerhard, additional, Thiele, Holger, additional, Eitel, Ingo, additional, Mun, Hong Cheang, additional, Kotwinski, Paul, additional, Rosmini, Stefania, additional, Sanders, Julie, additional, Lloyd, Guy, additional, Dudley, J. Pennell, additional, Kellman, Peter, additional, Hugh, E. Montgomery, additional, Manisty, Charlotte, additional, James, C. Moon, additional, Waterhouse, D.F., additional, Murphy, T.M., additional, Kenny, C., additional, O'Hanlon, R., additional, Cox, Andrew T., additional, Wijeyeratne, Yanushi, additional, Colbeck, Nicholas, additional, Pakroo, Nadia, additional, Ahmed, Hammad, additional, Bunce, Nick, additional, Anderson, Lisa, additional, Prasad, Sanjay, additional, Sharma, Sanjay, additional, Behr, Elijah R., additional, Miller, C., additional, Jovanovic, A., additional, Woolfson, P., additional, Abidin, N., additional, Schmitt, M., additional, Rodrigues, J.C.L., additional, Dastidar, A. Ghosh, additional, Baritussio, A., additional, Lawton, C., additional, Venuti, G., additional, Meloni, G.B., additional, Conti, M., additional, Bucciarelli-Ducci, C., additional, Andreini, Daniele, additional, SoLbiati, Anna, additional, Guglielmo, Marco, additional, Mushtaq, Saima, additional, Baggiano, Andrea, additional, Beltrama, Virginia, additional, Rota, Cristina, additional, Guaricci, Andrea I., additional, and Pepi, Mauro, additional

Published
2016
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39. 56 Comparison of morbidity, mortality and cost impact of stage B and stage C heart failure underline the clinical and economic need for national heart failure prevention strategy

Author

James, S, primary, Waterhouse, D, additional, Murphy, T, additional, Kenny, C, additional, Wilkinson, M, additional, O’Connell, E, additional, Gallagher, J, additional, Watson, C, additional, O’Hanlon, R, additional, Ledwidge, M, additional, and McDonald, K, additional

Published
2015
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41. Assessment of the eradication measures applied to <italic>Phytophthora ramorum</italic> in Irish <italic>Larix kaempferi</italic> forests.

Author

O'Hanlon, R., Choiseul, J., Brennan, J. M., and Grogan, H.

Subjects
*PHYTOPHTHORA ramorum, *JAPANESE larch, *TREE disease & pest control, *TREE mortality, *PLANT disease epidemics
Abstract

Summary: Phytophthora ramorum is the causal agent of the sudden larch death epidemic in Ireland and the UK. Within the EU, it is a quarantine pathogen and eradication measures are required if it is detected in horticultural or forest environments. Eradication measures in forests include the clearance of susceptible tree hosts from the infected stand along with all host known to support pathogen sporulation within a 250‐m buffer zone of the infected stand. Between 2010 and 2016, these measures have affected over 18,000 ha of Larix kaempferi forests in Ireland and the UK, but the epidemic continues to spread. An assessment of the efficacy of the eradication measures has not been published to date. Here, we provide details of the detection frequency of P. ramorum from aerial (rainwater) and terrestrial (soil, watercourses, plant material) sources in three forest locations in Ireland that had significant areas of L. kaempferi affected by P. ramorum before their removal. Monitoring of six plots with differing infection and eradication management histories was carried out from September 2013 to 2015. Presence of P. ramorum was confirmed by plating plant material onto selective media, followed by morphological identification. Phytophthora ramorum was detected in 65 of 1283 samples, in all sample types and in 17 of the 20 months sampled. Only three of the 295 soil samples were positive for P. ramorum, with all of these coming from an area under perennial standing water. The most positive samples came from a plot where symptomatic Larix trees had not been removed and the findings occurred consistently over the 2‐year study. Plots where infected Larix had been removed were rarely positive for P. ramorum across all the sample types indicating a level of success from the eradication measures in reducing pathogen levels on the sites. [ABSTRACT FROM AUTHOR]

Published
2018
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42. In-vitro characterisation of the four lineages of Phytophthora ramorum.

Author

O'hanlon, R., Choiseul, J., Grogan, H., and Brennan, J.M.

Abstract

Phytophthora ramorum is a plant pathogen with a wide host range including many ornamental hosts and tree species. In Ireland and the UK P. ramorum is known to cause sudden larch death. There are four distinct genetic lineages of P. ramorum, with the fourth lineage (EU2) described in 2012 and only present in Northern Ireland and Scotland. In this work, experiments that compare all four lineages of P. ramorum using several phenotypic characters are described. A total of 166 isolates (EU1: 116, EU2: 40, NA1: 8, NA2: 2) from several EU countries and the United States and several hosts were amassed, and a selection of isolates were compared according to standard phenotypic tests. The EU1 and EU2 isolates tested were all A1 mating type. Regarding linear growth rate, we found the isolates ranked as follows EU2 > NA2 > EU1 > NA1, with all lineages growing fastest at 20 °C. The lineages ranked as NA2 > EU1 > EU2 > NA1 based on their in-vitro aggressiveness on detached wounded Rhododendron leaves, all lineages most aggressive at 20 °C. At 20 °C, we found that there was no significant difference between the EU1 and EU2 lineage based on their linear growth rate or in-vitro aggressiveness. Temperature, host ramet and P. ramorum lineage all had statistically significant effects on the observed aggressiveness of the isolates. From an experimental point of view, our results are broadly in agreement with other phenotypic studies of P. ramorum, finding variation between the lineages, but also variation within the lineages. From an applied perspective, our work on Rhododendron indicates that the EU1 and EU2 lineages pose similar levels of threat to plant health in Ireland and the UK, however, how these results transfer to other hosts (e.g. Larix kaempferi) needs more study. [ABSTRACT FROM AUTHOR]

Published
2017
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43. 56 The inferior vena cava – a reproducible and clinically useful tool in the monitoring and treatment of heart failure which deserves greater clinical prominence

Author

Barrett, M, Iacoviello, M, Monitillo, F, Grande, D, Rizzo, C, Patle, A, Fox, R, Campbell, P, O'Hanlon, R, and McDonald, K

Abstract

Background/IntroductionHeart Failure (HF) management has advanced, however hospitalisation rates and mortality remain high. Maintaining euvolaemia is key to preventing decompensation but can be challenging. The Inferior Vena Cava (IVC) is a pliable reservoir for circulating volume, and changes in its shape during respiratory cycles are recognized as markers of intravascular volume status, albeit not routinely used in HF management.PurposeTo assess the reproducibility and test the clinical utility of using the IVC as a marker of volume status in a chronic HF population as well as to track change in IVC metrics in response to volume removal.MethodsThis was a multicentre study conducted between St. Vincent’s University Hospital (SVUH) and St. Michael’s Hospital (SMH) in Dublin. Stable outpatients were enrolled in prospective fashion during routine scheduled heart failure visits to SMH. Reproducibility was measured by three repeated measurements of maximal IVC diameter (IVCd) and collapsibility index (CI) at 0, 1 and 24 hours. Recompensating HF patients were enrolled prospectively from attendances to SVUH emergency department with acute decompensated heart failure. IVC metrics after admission were followed daily for 48 hours and then at 14 days post-admission. Dialysis patients were enrolled from patients undergoing intermittent haemodialysis in SVUH for stable chronic kidney disease. IVC metrics were measured at commencement, midpoint and end of dialysis. Data collected were correlated with markers of volume overload including natriuretic peptide (BNP).ResultsA total of 60 patients were included, 40 in the stable cohort and 10 each in the dialysis and recompensating arms. Serial IVC measurements over 24 hours showed good reproducibility, with an average standard deviation around the mean of 1.3 mm for IVCd and 7% for CI. When examining the stable cohort, patients with a dilated or poorly collapsible IVC had a significantly higher N-terminal pro B-type NP (3682 pg/mL vs 490 pg/mL, p=0.015) and poorer glomerular filtration rate (55 ml/kg/min vs 69 ml/kg/min p=0.029). Patients in the dialysis arm had an overall IVCd reduction of >30% over the course of their treatment which correlated with a 15% rise in haematocrit. Patients in the recompensating arm experienced a 30% reduction in IVCd during inpatient treatment over 48 hours. This subsequently rose after discharge back to similar size as their IVCd at enrollment, potentially reflecting the fact that the first month post-discharge is where rehospitalisation rates are highest.Conclusion(s)Measurement of IVC metrics appears to reflect volume status as well as matching fluid shifts in response to dialysis and diuretics. Use of the IVC to more precisely maintain euvolaemia in volume-dependent patients may deserve greater attention as a therapeutic target.Abstract 56 Table 1Normal IVCd andIVCCIHigh IVCd or low IVCCIpvalueE/e’ 13 19 0.02 NTpro BNP (pg/mL) 3682 490 0.015 BNP (pg/mL) 652 329 0.013 eGFR (mL/kg/1.73 m2) 55 69 0.029

Published
2017
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44. 20 Characterizing durable targets for therapy in asymptomatic left ventricular diastolic dysfunction by sequential two-dimensional doppler-echocardiography and cardiac magnetic resonance imaging

Author

Voon, V, Waterhouse, D, Patle, A, Badabhagni, M, O’Hanlon, R, McDonald, K, and Ledwidge, M

Abstract

BackgroundTwo-dimensional Doppler-echocardiography (2 DE) remains the primary modality in assessing left ventricular diastolic dysfunction (LVDD) due to its widespread availability. In asymptomatic LVDD (ALVDD), the putative precursor of diastolic heart failure, 2 DE imaging of cardiac volume and mass has been reported to be prognostically significant. However, the consistency of such measures is not fully known with limited data on sequential imaging. We aimed to compare reproducibility of cardiac volumes and mass by sequential 2 DE against cardiac magnetic resonance imaging (CMR), the gold standard in evaluating volumes and mass, in patients with ALVDD.MethodsWe sub-analysed imaging data from a prospective randomized clinical study (EudraCT 2010-021664-16) evaluating the impact of chronic doxycycline therapy on cardiac remodeling in patients with ALVDD, using 2 DE and CMR. Both modalities were performed by independent blinded observers at baseline, 6 months and 12 months. Cardiac volumes and mass were indexed to body surface area at each timepoint for all patients. Pearson’s correlation was performed between measurements of both modalities at (baseline, 6 months, 12 months) respectively. Results were reported as mean ± SD.ResultsAll patients (n=48) had mean age 69.8 ± 8.5 years and ejection fraction (EF) 67 ± 7% at baseline. Sequential correlations in EF (0.20, 0.15, 0.34), p = 0.17, 0.32, 0.02 respectively; and left ventricular end-diastolic volume index (LVEDVi) (0.37 , 0.17 , 0.07), p = 0.01, 0.27, 0.65 respectively, were compared between both modalities. Modest but significant correlations were observed between 2 DE and CMR for left atrial volume index (LAVi) (0.39, 0.50, 0.45), left ventricular mass index (LVMi)(0.46, 0.30 , 0.45) and left ventricular end-systolic volume index (LVESVi) ( 0.43, 0.58 , 0.48 ); all p<0.05.Conclusion2 DE-measured EF and LVEDVi demonstrated a predominantly poor correlation with CMR. However, 2 DE demonstrated modest correlation in LAVI, LVMI and LVESVi. The reproducibility of these sequential measurements against CMR supports their use as durable targets for measuring impact of therapies for ALVDD.

Published
2017
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45. 14 The use of sacubitril/valsartan: a real world experience in a high volume specialist heart failure service

Author

Murray, G, Barrett, M, Earls, S, Hammond, M, Campbell, P, O’Hanlon, R, and McDonald, K

Abstract

IntroductionSacubitril/Valsartan is a novel therapy in the treatment of heart failure with reduced ejection fraction, demonstrating a lower cardiovascular mortality and heart failure hospitalisation rates compared to standard therapy. We analysed the additive value of sacubitril/valsartan therapy on a well-managed real world heart failure cohort. Specifically, we aimed to see if there was an appreciable reduction in markers of fibrosis and cardiovascular risk – N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and ST2, a soluble interleukin-2 receptor. We also qualitatively assessed change in diuretic therapy and subjective symptoms of wellness.MethodsAll patients commencing sacubitril/valsartan therapy over an 18-month period were included. Of note, patients had been stable on angiotensin axis blockade prior to commencement. Patients were commenced on sacubitril/valsartan at the lowest dose and titrated upwards to either the maximum dose or to maximum tolerated dose based on renal function, blood pressure and symptoms. Serum renal function, NT pro-BNP and ST2 were measured at baseline and after completion of titration of therapy. Differences in baseline and follow-up biomarkers were analysed using a paired student’s t-test. A pvalue of 0.05 or less indicated a significant change with therapy.Results131 patients were included during the observed time period. A total of 19 patients (14.5%) discontinued therapy due to intolerable side effects. Primary reasons for discontinuation of therapy included hypotension (n=10), gastrointestinal disturbances (n=4), hyperkalaemia (n=1) and others (n=4).[Figure]Figure 1 demonstrates the main reasons for discontinuation of sacubitril/valsartan as a result of adverse side effects.A total of 19 patients discontinued sacubitril/valsartan. Of patients tolerating therapy, 49 (43.8%) had a reduction in diuretic dose as compared to 3 (2.7%) requiring an increase. 49 patients (43.8%) self-reported a subjective improvement in heart failure symptoms as compared to 4 (3.6%) who reported deterioration in symptoms.Change in biomarkers in patients completing therapy were assessed by measuring pre and post treatment serum levels. Table 1 below demonstrates the affects sacubitril/valsartan therapy had on the analysed biomarkers.Abstract 14 Table 1 Average values for each biomarker pre and post treatment with sacubitril/valsartanConclusionThese data demonstrate the efficacy of sacubitril/valsartan in improving symptoms and biomarkers of cardiovascular risk whilst reducing the need for diuretic therapy in a real-world population. Reaassuringly, a strong signal was seen for reduction in NT pro-BNP. Intolerance to the novel therapy was low, although further experience with use of the agent may help avoid discontinuations in the future, especially where physicians may not consider reduction in diuretic dose during therapy to minimise side-effects

Published
2017
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46. Abstracts

Author

Treibel, Thomas A., Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Sayeed, Aatif, Maanja, Maren, Daya, Hussein Abu, Moon, James C., Wong, Timothy C., Schelbert, Erik B., Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, Schwitter, Juerg, Beigelman-Aubry, Catherine, Peguret, Nicolas, Stuber, Matthias, Delacoste, Jean, Belmondo, Bastien, Lovis, Alban, Simons, Julien, Long, Olivier, Grant, Kathleen, Berchier, Gregoire, Rohner, Chantal, Bonanno, Gabriele, Coppo, Simone, Ozsahin, Esat-Mahmut, Qanadli, Salah, Meuli, Reto, Bourhis, Jean, Ide, Seiko, Riesenkampff, Eugenie, Chiasson, David, Dipchand, Anne I., Kantor, Paul F., Chaturvedi, Rajiv R., Yoo, Shi-Joon, Grosse-Wortmann, Lars, Sandrini, C., Aquaro, GD, De Marchi, D, Ait Ali, L, Khraiche, D, Boddaert, N, Bonnet, D, Raimondi, F, Fridman, Yaron, Hackman, Brianne E., Kadakkal, Ajay, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Angela, Susana, Alberto, Cipriani, Manuel, De Lazzari, Federico, Marin, Francesca, Prevedello, Bendetta, Giorgi, Giorgio, De Conti, Giuseppe, Tarantini, Luisa, Cacciavillani, Emanuele, Bertaglia, Domenico, Corrado, Sabino, Iliceto, Martina, Perazzolo Marra, Camaioni, Claudia, Morlon, Lucas, Vergé, Marie-Philippe, Jais, Pierre, Roudaut, Raymond, Laurent, Francois, Lafitte, Stéphane, Cochet, Hubert, Réant, Patricia, Bohnen, S., Radunski, U. K., Lund, G. K., Senel, M., Avanesov, M., Tahir, E., Stehning, C., Adam, G., Blankenberg, S., Muellerleile, K., Khanji, Mohammed Y., Balawon, Armida, Boubertakh, Redha, Petersen, Steffen E, Hilbert, Sebastian, Spampinato, Ricardo, Oebel, Sabrina, Hindricks, Gerhard, Bollmann, Andreas, Jahnke, Cosima, Paetsch, Ingo, Goetschalckx, K., Bogaert, J., Desmet, W., Toth, A., Merkely, B., Janssens, S., Claus, P., Calvieri, C., Preda, M. B., Perfetti, A., Valaperta, R., Secchi, F., Fedele, F., Martelli, F., Lombardi, M., Reinstadler, Sebastian J., Eitel, Charlotte, Fuernau, Georg, de Waha, Suzanne, Desch, Steffen, Mende, Meinhard, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Maestrini, Viviana, Mun, Hong Cheang, Kotwinski, Paul, Rosmini, Stefania, Sanders, Julie, Lloyd, Guy, Dudley, J. Pennell, Kellman, Peter, Hugh, E. Montgomery, Manisty, Charlotte, James, C. Moon, James, S., Waterhouse, D.F., Murphy, T.M., Kenny, C., O'Hanlon, R., Bastiaenen, Rachel, Cox, Andrew T., Wijeyeratne, Yanushi, Colbeck, Nicholas, Pakroo, Nadia, Ahmed, Hammad, Bunce, Nick, Anderson, Lisa, Prasad, Sanjay, Sharma, Sanjay, Behr, Elijah R., Reid, A. B., Miller, C., Jovanovic, A., Woolfson, P., Abidin, N., Schmitt, M., Amadu, A.M., Rodrigues, J.C.L., Dastidar, A. Ghosh, Baritussio, A., Lawton, C., Venuti, G., Meloni, G.B., Conti, M., Bucciarelli-Ducci, C., Pontone, Gianluca, Andreini, Daniele, SoLbiati, Anna, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Rota, Cristina, Guaricci, Andrea I., Pepi, Mauro, Wang, Yufei, Joannic, David, Juillion, Patrick, Delassus, P., Monnet, Aurélien, Lalande, Alain, Fontaine, Jean-Francois, Zweerink, A, Allaart, CP, Wu, L, Kuijer, JPA, Beek, AM, Croisille, P, Clarysse, P, van Rossum, AC, Nijveldt, R, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Hammond-Haley, Matthew, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Garg, P., Hassell, M, Foley, J., Ripley, D.P., Dobson, L., Swoboda, P.P., Fent, G., Musa, T.A., Erhayiem, B., Haaf, P., Greenwood, J.P., Nijveldt, R., Westenberg, J.J.M., Geest, R.J.V.D., Plein, S., Rodrigues, Jonathan C L, Amadu, Antonio Matteo, Dastidar, Amardeep Ghosh, Szantho, Gergley, Lyen, Stephen, Godsave, Cattleya, Ratcliffe, Laura E K, Burchell, Amy E, Hart, Emma C, Hamilton, Mark C K, Nightingale, Angus K, Paton, Julian F R, Manghat, Nathan E, Bucciarelli-Ducci, Chiara, Hafyane, Tarik, Teixeira, Tiago, Greiser, Andreas, Mongeon, Francois Pierre, Haifa, Almutairi, Mohammed, Khanji, Redha, Boubertakh, Marc, Miquel, Steffen, Petersen, Greulich, S., Kitterer, D., Latus, J., Henes, J., Kurmann, R., Gloekler, S., Wahl, A., Buss, S., Katus, H., Bobbo, M., Lombardi, M., Braun, N., Alscher, M.D., Sechtem, U., Mahrholdt, H., Meloni, A., Neri, M.G., Preziosi, P., Grassedonio, E., Schicchi, N., Keilberg, P., Pulini, S., Facchini, E., Positano, V., Pepe, A., Nazir, Sheraz A., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Squire, Iain, Gershlick, Anthony, McCann, Gerry P., Stefan Biesbroek, P., Amier, Raquel P., Teunissen, Paul F.A., Robbers, Lourens F.H.J., Beek, Aernout M., van Rossum, Albert C., Hofman, Mark B.M., van Royen, Niels, Nijveldt, Robin, Arenja, Nisha, Riffel, Johannes H, Djiokou, Charly Noel, Andre, Florian, Fritz, Thomas, Halder, Manuel, Thomas, Zelniker, Korosoglou, Grigorios, Katus, Hugo A, Buss, Sebastian J, Kammerlander, Andreas A., Schwaiger, Marianne L., Duca, Franz, Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Sayeed, Aatif, Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Maanja, Maren, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Ricci, F., Barison, A., Todiere, G., Gaeta, R., Galllina, S., Emdin, M., De Caterina, R., Aquaro, G.D., Bernhardt, Peter, Buckert, Dominik, Dyckmanns, Nils, Rottbauer, Wolfgang, Meierhofer, Christian, Kühn, Andreas, Shehu, Nerejda, Müller, Jan, Stern, Heiko, Ewert, Peter, Fratz, Sohrab, Vogt, Manfred, Devos, Daniel G.H., De Groote, Katya, Babin, Danilo, Demulier, Laurent, Taeymans, Yves, Westenberg, Jos J., Van Bortel, Luc, Segers, Patrick, Achten, Eric, De Schepper, Jean, Rietzschel, Ernst, Ruecker, Beate, Geiger, Julia, Makki, Malek, Burkhardt, Barbara, Kellenberger, Christian J., Buechel, Emanuela R. Valsangiacomo, Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Kamphuis, Vivian P., Elbaz, Mohammed S.M., Kroft, Lucia J.M., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos J.M., Roest, Arno A.W., De Lazzari, Manuel, Cipriani, Alberto, Susana, Angela, Rizzo, Stefania, Giorgi, Benedetta, Carmelo, Lacognata, Bertaglia, Emanuele, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Marra, Martina Perazzolo, Basso, Cristina, Iliceto, Sabino, Nederend, I., Roest, A.A.W., van den Boogaard, P.J., ten Harkel, A.D.J., de Geus, J.C.N., Kroft, L.J.M., de Roos, A., Westenberg, J.J.M., Dux-Santoy, Lydia, Kale, Raquel, Teixido-Tura, Gisela, Maldonado, Giuliana, Huguet, Marina, Garcia-Dorado, David, Evangelista, Artur, Rodriguez-Palomares, Jose, Cavalcante, João L., Rijal, Shasank, Schindler, John T., Gleason, Thomas G., Lee, Joon S., Schelbert, Erik B., Rosmini, Stefania, Bulluck, Heerajnarain, Treibel, Thomas A, Bhuva, Anish, Abdel-Gadir, Amna, Culotta, Veronica, Merghani, Ahmed, Maestrini, Viviana, Herrey, Anna S, Kellman, Peter, Manisty, Charlotte, Moon, James C, Liu, B., Hayer, M.K., Baig, S., Shah, T., Rooney, S.J., Edwards, N.C., Steeds, R.P., Fent, G.J., Garg, P., Swoboda, P., Dobson, L.E., Musa, T.A., Foley, J.F., Haaf, P., Greenwood, J.P., Plein, S., Claessen, G., Schnell, F., Bogaert, J., Dymarkowski, S., Pattyn, N., Claus, P., Van Cleemput, J., Gerche, A. La, Heidbuchel, H., Behar, Jonathan, Toth, Daniel, Reiml, Sabrina, Panayiotou, Maria, Claridge, Simon, Jackson, Tom, Sohal, Manav, Webb, Jessica, O'Neill, Mark, Brost, Alexander, Mountney, Peter, Razavi, Reza, Rhode, Kawal, Rinaldi, Christopher Aldo, Oebel, S., Arya, A., Hilbert, S., Bollmann, A., Hindricks, G., Jahnke, C., Paetsch, I., Dinov, B., Baritussio, A., Perazzolo Marra, M., Ghosh Dastidar, A., Rodrigues, J., Zorzi, A., Susana, A., Scatteia, A., De Garate, E., Mattesi, G., Strange, J., Corrado, D., Bucciarelli-Ducci, C., Ranjit Arnold, J., Jerosch-Herold, Michael, Karamitsos, Theodoros D., Francis, Jane M., Bhamra-Ariza, Paul, Sarwar, Rizwan, Choudhury, Robin, Selvanayagam, Joseph B., Neubauer, Stefan, Tayal, Upasana, Scott, Andrew D, Wage, Rick, Ferreira, Pedro, Pennell, Dudley, Zhong, Xiaodong, Epstein, Fred, Firmin, David, Prasad, Sanjay, Kallifatidis, Alexandros, Prousalis, Anastasios, Mouratoglou, Sophia-Anastasia, Giannakoulas, George, Deligianni, Xenia, Bakaloudis, Michail, Magganaris, Nikolaos, Sianos, George, Karvounis, Haralampos, Santini, Francesco, Garg, P., Aziz, R., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Geest, R.J.V.D., Westenberg, J.J.M., Beitzke, D., Rasul, S., Wadsak, W., Mitterhauser, M., Nolz, R., Stelzmueller, M., Loewe, C., Hacker, M., Funk, Stephanie, Kermer, Josephine, Dogangüzel, Serkan, von Knobelsdorff-Brenkenhoff, Florian, Schulz-Menger, Jeanette, Kolker, Shimon, Weisz, Giora, Bogot, Naama, Halpern, Irit Hadas, Wolak, Arik, Rutz, Tobias, Ginami, Giulia, Piccini, Davide, Coppo, Simone, Vincenti, Gabriella, Stuber, Matthias, Schwitter, Jürg, Safdar, Komal S, Gao, Xuexin, Ambach, Stephanie, Taylor, Michal D, Moore, Ryan, Taylor, Robin J, Toro-Salazar, Olga, Jeffries, John L, Bartone, Cheryl, Raman, Subha V, Mazur, Wojciech, Valente, F., Rodriguez-Palomares, J.F., Gutierrez, L., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Alujas, M.T., Evangelista, A., Garcia-Dorado, D., Murdoch, R., Gandy, S., Nicholas, R., Houston, G., Martin, P., Muir, J., Matthew, S., Ramkumar, P. Guntur-, Cavin, I., Macaione, F., Barison, A., Pescetelli, I., Pali, F., Pizzino, F., Terrizzi, A., Di Lisi, D., Novo, G., Todiere, G., Assennato, P., Novo, S., Aquaro, G.D., Dastidar, Amardeep Ghosh, McAlindon, Elisa, Rodrigues, Jonathan, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Benny Lawton, Chris, Erdei, Tamas, Szantho, Gergely, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Pontone, Gianluca, Andreini, Daniele, Rota, Cristina, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Solbiati, Anna, Guaricci, Andrea I., Pepi, Mauro, Grigoratos, Chrysanthos, Bratis, Konstantinos, Henningson, Markus, Dell'Omodarme, Matteo, Puntmann, Valentina O., Nagel, Eike, Meloni, Antonella, Giunta, Nicola, Giuliano, Pietro, Neri, Maria Giovanna, Restaino, Gennaro, Renne, Stefania, Quota, Alessandra, Positano, Vincenzo, De Marchi, Daniele, Pepe, Alessia, Pedrotti, Patrizia, Campadello, Paola, Masciocco, Gabriella, Facchetti, Rita, Milazzo, Angela, Quattrocchi, Giuseppina, Giannattasio, Cristina, Frigerio, Maria, Roghi, Alberto, Rimoldi, Ornella, De Garate, Estefania, Ghosh Dastidar, Amardeep, Baritussio, Anna, Scatteia, Alessandra, Amadu, Antonio, Venuti, Giuseppe, Rodrigues, Jonathan C., Bucciarelli-Ducci, Chiara, Careri, Giulia, Castelvecchio, Serenella, Camporeale, Antonia, Secchi, Francesco, Menicanti, Lorenzo, Lombardi, Massimo, Kockova, R., Sedlacek, K., Wichterle, D., Sikula, V., Tintera, J., Sukupova, L., Kautznerova, D., Segetova, M., Praveckova, A., Langova, R., Kryze, L., El-Husseini, W., Kautzner, J., Oebel, S., Dinov, B., Arya, A., Hilbert, S., Sommer, P., Bollmann, A., Hindricks, G., Paetsch, I., Jahnke, C., Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Grigoratos, Chrysanthos, Liga, Riccardo, Bennatti, Elena, Barison, Andrea, Todiere, Giancarlo, Aquaro, Giovanni Donato, Dell'Omodarme, Matteo, Lombardi, Massimo, Emdin, Michele, Masci, Pier Giorgio, Barison, A, Ortalda, A, Todiere, G, Grigoratos, C, Vergaro, G, Mirizzi, G, Martini, N, De Marchi, D, Keilberg, P, Passino, C, Aquaro, GD, Emdin, M, Swoboda, Peter P, McDiarmid, Adam K, Erhayiem, Bara, Fent, Graham J, Dobson, Laura E, Garg, Pankaj, Musa, Tarique A, Foley, James R, Page, Stephen P, Greenwood, John P, Plein, Sven, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Fontana, Marianna, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Broncano, J., Luna, A., Noguerol, T. Martin –, Caro, P., Toro-Cebada, R., Gonzalez, J. Sanchez –, Desroche, L.M., Milleron, O., Safar, B., Lavie-Badie, Y., Millischer, D., Abtan, J., Jondeau, G., Bermejo, Zorba Blázquez, Cuesta, Emilio, Rosillo, Sandra O., Guzmán, Gabriela, Pinilla, Inmaculada, González, Óscar, Caro, Juan, Ponz, Inés, López, Teresa, Refoyo, Elena, Kozor, Rebecca, Nordin, Sabrina, Treibel, Thomas A, Rosmini, Stefania, Castelleti, Silvia, Fontana, Marianna, Captur, Gabriella, Steeds, Rick, Baig, Shanat, Manisty, Charlotte, Grieve, Stuart M, Figtree, Gemma A, Moon, James C, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, De Garate, Estefania, Singhal, Priyanka, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, Erdei, Tamas, Strange, Julian, Nightingale, Angus, Baumbach, Andreas, Johnson, Tom, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Lapinskas, Tomas, Bucius, Paulius, Fedaravicius, Augustinas P., Urbonaite, Laura, Stabinskaite, Agnieta, Zaliunas, Remigijus, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Grigoratos, Chrysanthos, Genovesi, Dario, Giorgetti, Assuero, Chiappino, Sara, Barison, Andrea, Vergaro, Giuseppe, Todiere, Giancarlo, Emdin, Michele, Marzullo, Paolo, Aquaro, Giovanni Donato, Ladeiras-Lopes, Ricardo, Turin-Moreira, Henrique, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Sampaio, Francisco, Ambale-Venkatesh, Bharath, Wu, Colin, Liu, Kiang, Bertoni, Alain, Ouyang, Pamela, Bluemke, David, Lima, João, Fent, GJ., Garg, P., Dobson, LE., Musa, TA., Foley, JF., Haaf, P., Greenwood, JP., Plein, S., Swoboda, PP., Abdul Rahman, E., Ismail, JR., Najme Khir, R., Lim, CW., Chua, N., Ibrahim, ZO., Zainal Abidin, HA., Mohd Arshad, MK., Kasim, SS., Rodrigues, Jonathan, Rooms, Ben, Hyde, Katie, Rohan, Stephen, Dastidar, Amardeep Ghosh, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nightingale, Angus, Paton, Julian, Manghat, Nathan, MacIver, David, Gibelli, Giuseppe, Demolli, Walter, Russo, Alessandra, Minoia, Chiara, Biasi, Salvatore, Mkrtchyan, Naira, Eltschkner, Christin, Christian, Meierhofer, Ewert, Peter, Martinoff, Stefan, Stern, Heiko, Fratz, Sohrab, Valinoti, Maddalena, Fabbri, Claudio, Mantovan, Roberto, Severi, Stefano, Corsi, Cristiana, Nyktari, E., Vassiliou, V., Arzanauskaite, M., Izgi, C., Lam, W., Prasad, S., Reindl, Martin, Reinstadler, Sebastian Johannes, Feistritzer, Hans-Josef, Klug, Gert, Mair, Johannes, Mayr, Agnes, Jaschke, Werner, Franz, Wolfgang-Michael, Metzler, Bernhard, Arnhold, K., Muehlberg, F., Fritschi, S., Funk, S., Prothmann, M., von Knobelsdorff-Brenkenhoff, F., Schulz-Menger, J., Lakhani, Zeeshan S. A., Mohan, B., karthik, G A., Raj, Vimal, Weir-McCall, Jonathan, Cassidy, Deirdre B, Belch, Jill JF, Gandy, Stephen J, Houston, Graeme, Lambert, Matthew A, Littleford, Roberta, Rowland, Janice, Struthers, Allan D, Khan, Faisel, Camaioni, Claudia, Salel, Marjorie, Hennig, Alexia, Corneloup, Olivier, Montaudon, Michel, Laurent, Francois, Cochet, Hubert, Kan, Rachel, Erhayiem, Bara, McDiarmid, Adam K., Garg, Pankaj, Dobson, Laura E., Musa, Tarique A., Ripley, David, Ajjan, Ramzi, Greenwood, John P., Plein, Sven, Swoboda, Peter P., Reinstadler, Sebastian J., Fuernau, Georg, Eitel, Charlotte, de Waha, Suzanne, Desch, Steffen, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Klug, Gert, Reindl, Martin, Mair, Johannes, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Feistritzer, Hans-Josef, Klug, Gert, Reinstadler, Sebastian Johannes, Reindl, Martin, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Festa, P., Cadoni, A., D'andrea, C., Costa, S., Keilberg, P., Lunardini, A., Ali, L. Ait, Ali, L. Ait, Aquaro, GD., Peritore, G., Ricci, F., De Marchi, D., Passino, C., Festa, P., Martínez, A. Tercero, Cuartero, J. Navarro, Soriano, J.G. Córdoba, Núñez, S. Calero, de Galarreta, T. Cros Ruiz, García, M. Villar, Page, J.C. Gallego, López, J.C. García, Ruiz, M. Barambio, Erdei, Tamas, Rodrigues, Jonathan C., McIntyre, Bethannie, Dastidar, Amardeep Ghosh, Burchell, Amy E., Ratcliffe, Laura, Hart, Emma C., Paton, Julian F., Hamilton, Mark, Nightingale, Angus K., Manghat, Nathan E., Orii, Makoto, Tanimoto, Takashi, Ota, Shingo, Nishiguchi, Tsuyoshi, Tsujioka, Hiroto, Kuroi, Akio, Yamano, Takashi, Matsuo, Yoshiki, Ino, Yasushi, Kitabata, Hironori, Kubo, Takashi, Tanaka, Atsushi, Hozumi, Takeshi, Akasaka, Takashi, Sousa, Alexandra, Pinho, Teresa, Canedo, Paulo, Lopes, Luís, Azevedo, Olga, Madureira, António, Belo, Adriana, Cardoso, José Silva, Machado, José Carlos, Martins, Elisabete, Brzozowska-Czarnek, Agata, Urbanik, Andrzej, Brzozowska-Czarnek, Agata, Urbanik, Andrzej, Rakowski, Tomasz, Agudo-Quílez, P., Pozo-Osinalde, E., Viliani, D., Olivera, MJ., Caballero, P., Jiménez-Borreguero, LJ., Alfonso, F., Carrabba, Nazario, Angeloni, Giulia, Migliorini, Angela, Valenti, Renato, Parodi, Guido, Antoniucci, David, Almeida-Morais, Luís, Galrinho, Ana, Moura-Branco, Luísa, Tavares-Jalles, Nuno, António, Marta, Abreu, João, Timóteo, Ana Teresa, Pinto-Teixeira, Pedro, Aguiar-Rosa, Sílvia, Rodrigues, Inês, Modas-Daniel, Pedro, Cruz-Ferreira, Rui, Bica, R., Dobre, D., Stanciu, S., Acatrinei, E., Nour, A., Stefan, L., Calistru, P., Rajewska-Tabor, J., Pyda, M., Janus, M., Siniawski, A., Rajewska-Tabor, J., Pyda, M., Janus, M., Siniawski, A., Shaheen, Sameh Mohamed, Elhammady, Walid Abdel-Azim, Ahmed, Mohamed Ismail, Abdel-Hakim, Ahmed Samir, Allam, Lamyaa Elsayed, Helal, Ayman Mohamed, Inage, Akio, Mizuno, Naokazu, Inage, Akio, Mizuno, Naokazu, TEIS, Albert, JUNCÀ, Gladys, ARCE, Javier, ARMARIO, David, Cescau, Arthur, Logeart, Damien, Gelen, Barnabas, Derumeaux, Genevie`ve, Vicaut, Eric, Mercadier, Jean-Jacques, Sirol, Marc, Cipriani, Alberto, De Lazzari, Manuel, Susana, Angela, Zorzi, Alessandro, Baritussio, Anna, Siciliano, Mariachiara, Marinato, Martina, Prevedello, Francesca, Giorgi, Benedetta, Vezzaro, Roberto, Corrado, Domenico, Marra, Martina Perazzolo, von Roeder, M., Rommel, K.-P., Kowallick, J.T., Blazek, S., Fengler, K., Lotz, J., Hasenfuß, G., Lücke, Ch., Gutberlet, M., Schuler, G., Schuster, A., Lurz, Ph., Mahmoud, Ahmad A., Rifaie, Osama, Samir, Ahmed, Allam, Lamyaa, Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, She, Hoi Lam, Roest, Arno A.W., van den Boogaard, Pieter J., Calkoen, Emmeline E., van der Geest, Rob J., Hazekamp, Mark G., de Roos, Albert, Westenberg, Jos J.M., Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Bainbridge, G., Garg, P., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Charalambos, Max, Rodrigues, Jonathan, Burchell, Amy, Dastidar, Amardeep Ghosh, BSc(Hons), Laura Ratcliffe, Hart, Emma, Hamilton, Mark, Paton, Julian, Nightingale, Angus, Manghat, Nathan, Muñoz, Begoña Igual, Monserrat, Adrian, gonzalez, Alicia Maceira, Tuset, Luis, Miro, Vicente, Hernandiz, Amparo, Fernandez, Rubén, Sauri, Asunción, Sepúlveda, Pilar, Diez, Jose Luis, Montero, Anastasio, Contaldi, Carla, Imbriaco, Massimo, Alcidi, Gianmarco, Ponsiglione, Andrea, Santoro, Ciro, Puglia, Marta, Barbuto, Luigi, Cuocolo, Alberto, Trimarco, Bruno, Galderisi, Maurizio, Muñoz, Begoña Igual, Sanchez, Elena, Plaza, Diego, sanchis, Pilar Sepúlveda, Gonzalez, Alicia Maceira, Hernandiz, Amparo, Miro, Vicente, vazquez, Alex, Diez, Jose Luis, Martinez, Luis, Montero, Anastasio, Muñoz, B. Igual, Alfredo, Hernandez Caballero, Diana, Domingo Valero, Alicia, Maceira Gonzalez, Jordi, Estornell Erill, Jose, Valera martinez Francisco, Alejandro, Vazquez Sanchez, Anastasio, Montero Argudo, Mochula, O.V., Shelkovnikova, T.A., Popov, S.V., Lukyanenok, P.I., Shelupanov, A.A., Oferkin, A.I., Bakhmet'eva, T.A., Ussov, W.Yu., van den Bosch, Harrie CM., Westenberg, Jos JM., Setz-Pels, Wikke, Kersten, Erik, Tielbeek, Alexander, Duijm, Lucien EM., Post, Johannes, Teijink, Joep A.W., de Roos, Albert, Frick, M., Kirschfink, A., Mühler, E., Marx, N., Hövels-Gürich, H., Gert, Klug, Hans-Josef, Feistritzer, Sebastian, Reinstadler, Martin, Reindl, Benjamin, Seidner, Agnes, Mayr, Sylvana, Müller, Bernhard, Metzler, Fawal, aSara E., Zidan, aMamdouh, Webb, Jessica, Holub, Ondrej, Clough, Rachel, Carr-White, Gerald, Razavi, Reza, Sinkus, Ralph, Maksimova, A.S., Bobrikova, E.E., Bukhovets, I.L., Plotnikov, M.P., Rogovskaya, Yu.V., Rebenkova, M.S., Usov, W.Yu., Mayr, Agnes, Klug, Gert, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Reindl, Martin, Metzler, Bernhard, Kremser, Christian, Schocke, Michael, Winter, M.M., Pluchinotta, F.R., Giusti, G., Secchi, F., Piazza, L., Carminati, M., Chessa, M., Bokma, J.P., Bouma, B.J., Mulder, B.J., Lombardi, M., Katia, Menacho, Thomas, Treibel, Rebecca, Kozor, Heeraj, Bulluck, James, Moon, Charlotte, Manisty, Sztajzel, Juan, Bertron, Fabienne, Papavassiliu, Theano, Oezkan, Sueheyla, Lossnitzer, Dirk, Schoenberg, Stefan O., Borggrefe, Martin, Doesch, Christina, Baig, S., Edwards, NC., Liu, B., Hayer, MK., Dawson, CH., Geberhiwot, T., Steeds, RP., Shehu, N., Stern, H., Mkrtchyan, N., Meierhofer, C., Martinoff, S., Ewert, P., Fratz, S., Pais, João, Picarra, Bruno, Santos, Ana Rita, Guerreiro, Rui, Congo, Kisa Hyde, Carvalho, João, Neves, David, Aguiar, José, Vinco, Giulia, Fischer, Kady, Labelle, Chantal, Gelineau, Sylvie, Farkas, Sandra, Lebel, Julie, Friedrich, Matthias G., Webb, Jessica, Villa, Adriana, Bekri, Imane, Shome, Joy, Teall, Tom, Di Giovine, Gabriella, Sammut, Eva, Carr-White, Gerald, Al-Fakih, Khaled, Chiribiri, Amedeo, Kamphuis, Vivian P., Roest, Arno AW., Kroft, Lucia JM., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos JM., Elbaz, Mohammed SM., Bensaoud, M., Soufiani, A., Barahioui, H., Bayi, A., Fellat, N., Benjelloun, H., Tazi, Z., Abawi, Masieh, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Musa, TA., Uddin, A., Dobson, LE., Swoboa, PP., Garg, P., Fent, GJ., Foley, JRJ., Malkin, CJ., Plein, S., Blackman, DJ., Greenwood, JP., Yun, Chun-Ho, Bezerra, Hiram G., Richmond, C., Dobson, LE., Swoboda, PP., Musa, TA., Foley, JF., Garg, P., Haaf, P., Fent, GJ., Plein, S., Greenwood, JP., Meloni, Antonella, Gamberini, Maria Rita, Neri, Maria Giovanna, Cuccia, Liana, D'Ascola, Domenico Giuseppe, Tudisca, Chiara, Vinci, Valentina, Positano, Vincenzo, Pepe, Alessia, Meloni, Antonella, Borgna-Pignatti, Caterina, Del Vecchio, Giovanni Carlo, Romeo, Maria Antonietta, Gamberini, Maria Rita, Bonetti, Federico, Neri, Maria Giovanna, Missere, Massimiliano, Salvatori, Cristina, Pepe, Alessia, Dobson, LE., Musa, TA., Uddin, A., Fairbairn, TA., Bebb, OJ., Swoboda, PP., Haaf, P., Foley, J., Garg, P., Fent, GJ., Malkin, CJ., Blackman, DJ., Plein, S., Greenwood, JP., Schneeweis, C., Eckert, J., Tröbs, M., Magedanz, A., Schmidt, M., Voigtländer, T., Schmermund, A., Achenbach, S., Foley, JRJ., Dobson, LE., Musa, TA., Swoboda, PP., Garg, P., Fent, GF., Haaf, P., Malkin, CJ., Blackman, DJ., Plein, S., Greenwood, JP., Matthew, S., McCall, J. Weir, Gandy, S.J., Milne, W.G., Houston, J.G, Meloni, A., Ricchi, P., Spasiano, A., Neri, MG., Vallone, A., Resta, MC., Righi, R., Keilberg, P., Santamaria, V., Positano, V., Pepe, A., Henein, Michael Y., Bengrid, Tarek, Nicoll, Rachel, Zhao, Ying, Johansson, Bengt, Schmermund, Axel, Barbanti, Marco, Cascone, Irene, Miccichè, Eligio, Buccheri, Sergio, Immè, Sebastiano, Pilato, Gerlando, Tamburino, Claudia, Patanè, Martina, Gulino, Simona, Todaro, Denise, Salerno, Tatiana, Garretto, Valeria, Privitera, Gianbattista, Capodanno, Davide, Tamburino, Corrado, Manna, Alessio La, Vincenti, Gabriella, Masci, Pier-Giorgio, Rutz, Tobias, De Blois, Jonathan, Schwitter, Juerg, Monney, Pierre, Paelinck, Bernard P., Vandendriessche, Tom, De Bock, Dina, Parizel, Paul M., Rodrigus, Inez E., Claeys, Marc J., Leone, D., Tosello, F., Bruno, G., Avenatti, E., Faletti, R., Ravera, A, Veglio, F., Milan, A., Meloni, A., Maggio, A., Leto, F., Pitrolo, L., De Marchi, D., Positano, V., Neri, MG., Pepe, A., Pizzino, F., Meloni, A., Terrizzi, A., Aquaro, GD., Neri, MG., Spasiano, A., Serra, M., Allò, M., Keilberg, P., Positano, V., Di Bella, G., Zito, C., Pepe, A., Saunders, Laura, Stewart, Neil J., Hammerton, Charlotte, Capener, David, Puntmann, Valentina O, Graves, Martin J., Kiely, David G., Wild, Jim M., Swift, Andrew J., Macaione, F., Meloni, A., Barison, A., Neri, MG., Positano, V., Salvatore, N., Assennato, P., Pepe, A., Kammerlander, Andreas A., Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Duca, Franz, Knechtelsdorfer, Klaus, Wiesinger, Matthias, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Haberka, Maciej, Sosnowski, Maciej, Gasior, Zbigniew, Aslam, Sajid, El-Hamamsy, Ismail, SM, Francois-Pierre Mongeon, Bethke, Anne, Eritsland, Jan, Shanmuganathan, Limalanathan, Abdelnoor, Mikael, Andersen, Geir Øystein, Kløw, Nils Einar, Hoffmann, Pavel, Bouhzam, Najime, Caudron, Jérôme, Tron, Christophe, Camacho, Carlos Rodriguez, Cribier, Alain, Dacher, Jean Nicolas, Eltchaninoff, Hélène, Foley, JRJ., Garg, P., Musa, TA., Dobson, LE., Swoboda, PP., Fent, GJ., Haaf, P., Plein, S., Greenwood, JP., Heck, Siri Lagethon, Gulati, Geeta, Von Knobelsdorff-Brenkenhoff, Florian, Storas, Tryggve Holck, Schulz-Menger, Jeanette, Hoffmann, Pavel, Omland, Torbjørn, Kermer, J., Traber, J., Utz, W., Hennig, P., Menza, M., Jung, B., Greiser, A., Kuijer, J., Barckow, P., von Knobelsdorff-Brenkenhoff, F., Töpper, A., Schulz-Menger, J, Malanchini, Giovanni, Moscatelli, Sara, Di Giovine, Gabriella, Balzarini, Luca, Del Corral, Maria Pia, Gasparini, Gabriele, Montini, Orsola, Monti, Lorenzo, Aquaro, Giovanni Donato, Briatico, Alessandra, Toia, Patrizia, Barison, Andrea, Ait-Ali, Lamia, Midiri, Massimo, Cotroneo, Antonio Raffaele, Festa, Pierluigi, Aquaro, G.D., Pizzino, F., Terrizzi, A., Todiere, G., Grigoratos, C., Barison, A., Di Bella, G., Igual-Muñoz, Begoña, de Carranza, María Jose Sancho-Tello, Maceira-Gonzalez, Alicia, Buendía-Fuentes, Francisco, Estornell-Erill, Jordi, Cano-Perez, Oscar, Montero, Anastasio, Igual, Begoña, Sanz, Jorge, Maceira, Alicia, Miro, Vicente, Minguez, Ana Bel, Guillen, Manuel Perez, Lopez, Raquel, Vazquez, Alex, Diez, Jose Luis, rené, Oscar, sepúlveda, Pilar, argudo, Anastasio Montero, Roy, Clotilde, Slimani, Alisson, Amzulescu, Mihaela, de Ravenstein, Christophe de Meester, Pasquet, Agnès, Vancraeyenest, David, Vanoverschelde, Jean-Louis, Gerber, Bernhard, Pouleur, Anne-Catherine, Scatteia, Alessandra, Rodrigues, Jonathan, Lyen, Stephen, De Gerate, Estefania, Baritussio, Anna, Dastidar, Amardeep Ghosh, Maceira, Alicia, Pennell, Dudley, Bucciarelli-Ducci, Chiara, Katulska, Katarzyna, Kociemba, Anna, Rajewska-Tabor, Justyna, Janus, Magdalena, Siniawski, Andrzej, Stajgis, Marek, Pyda, Małgorzata, Brzostowicz, Tomasz, Brzostowicz, Marta, Gibbs, TGJ, Villa, AD, Sammut, E, Mullen, G, Ganeshan, B, Chiribir, A, Singh, Anvesha, McCann, Gerry P, Investigators, the PRIMID-AS, Le, Thu-Thao, Su, Boyang, Cai, Jiasheng, Han, Yiying, Tan, Ru San, Cook, Stuart A, Chin, Calvin WL, Scatteia, Alessandra, Vollema, E. Mara, Leung, Melissa, Marsan, Nina Ajmone, Baritussio, Anna, De Garate, Estefania, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, Bax, Jeroen J, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Baritussio, A., De Garate, E., Dastidar, A. Ghosh, Ahmed, N., Scatteia, A., Rodrigues, J., Lawton, C., Thomas, Glyn, Duncan, Edward, Cripps, Tim, Diab, Ihab, Bucciarelli-Ducci, C., Treibel, TA., Fontana, M., Kozor, R., Macrae, R., Malcolmson, JW., Menacho, KD., Scully, PR., Lawrence, DR., Sheikh, AM., Herrey, AS., Manisty, C., Moon, JC., Hinojar, R., Golfin, C. Fernandez, Portugal, JC., Esteban, A., Megias, A., Gomez, A. Gonzalez, Rincon, LM., Nacher, JJ. Jimenez, Zamorano, JL., Valente, F., Gutierrez, L., Maldonado, G., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Allujas, MT., Evangelista, A., Garcia-Dorado, D., Rodriguez-Palomares, JF., Fratz, Sohrab, Belker, Kristina, Naumann, Susanne, Martinoff, Stefan, Stern, Heiko, Shehu, Nerejda, Mkrtchyan, Naira, Meierhofer, Christian, Eicken, Andreas, Ewert, Peter, Hilbert, Sebastian, Weber, Alexander, Oebel, Sabrina, Hindricks, Gerhard, Jahnke, Cosima, Paetsch, Ingo, van der Palen, RLF., Roest, AAW., van den Boogaard, PJ., Blom, NA., de Roos, A., Westenberg, JJM., Piatti, Filippo, Sturla, Francesco, Pirola, Selene, Votta, Emiliano, Nesteruk, Igor, Lombardi, Massimo, Corte, Alessandro Della, Bissell, Malenka, Caiani, Enrico Gianluca, Redaelli, Alberto, Berlot, B., Golfin, C. Fernandez, Hinojar, R., Esteban, A., Mendez, MA Fernandez, Megias, A., Gomez, A. Gonzalez, García, A., Alonso, G., Marco, A., Casas, E., Nacher, JJ. Jimenez, Zamorano, JL., Baggi, Chiara, Piatti, Filippo, Sturla, Francesco, Votta, Emiliano, Pluchinotta, Francesca, Lombardi, Massimo, Redaelli, Alberto, Hinojar, R., Golfin, C. Fernandez, Esteban, A., Mendez, MA Fernandez, Megias, A., Gonzalez Gomez, A., García, A., Alonso, G., Marco, A., Nacher, JJ. Jimenez, Zamorano, JL., McAlindon, Elisa, Dastidar, Amardeep, Bucciarelli-Ducci, Chiara, McAlindon, Elisa, Littlejohns, Ben, Suleiman, Saadeh, Baumbach, Andreas, Bucciarelli-Ducci, Chiara, McAlindon, Elisa, Vizzi, Vincenzo, Baumbach, Andreas, Bucciarelli-Ducci, Chiara, Tanaka, Kaoru, Fierens, Yves, Nijs, Jan, De Mey, Johan, Lai, Peng, Raeymaekers, Hubert, Elbaz, Mohammed S.M., Toger, Johannes, Heiberg, Einar, Westenberg, Jos J., Solana, Ana Beatriz, Hafalir, Fatih, Ghedin, Piero, Lai, Peng, Shimakawa, A., Anja, C., Fratz, Sohrab, McGill, Laura-Ann, Ferreira, Pedro, Scott, Andrew D, Nielles-Vallespin, Sonia, Giannakidis, Archontis, J Kilner, Philip, Gatehouse, Peter D, de Silva, Ranil, Firmin, David N, Pennell, Dudley J, Merten, Constanze, Beurich, Hans-Wilko, Zachow, Dirk, El-Mawardy, Mohamed, Abdel-Wahab, Mohamed, Richardt, Gert, Merten, Constanze, Beurich, Hans-Wilko, Zachow, Dirk, Abdel-Wahab, Mohamed, El-Mawardy, Mohamed, Tölg, Ralph, Richardt, Gert, De Garate, Estefania, Biglino, Giovanni, Aileen, Wilson, Dodd, James, Bucciarelli-Ducci, Chiara, Salinas, GL. Alonso, Gómez, A. González, Hinojar, R., Golfín, C. Fernández, Esteban, A., del Castillo, A. Marco, Monteagudo, J., Izco, M. Pascual, Megías, A., Martín, A. García, Nacher, JJ. Jiménez, Zamorano, JL, Dastidar, Amardeep Ghosh, Carpenter, Alexander, Rodrigues, Jonathan, Palazzuoli, Alberto, Wilson, Catherine, Kestenbaum, Samantha, Baritussio, Anna, Baumbach, Andreas, Nightingale, Angus, Bucciarelli-Ducci, Chiara, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, Szantho, Gergely, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Lawton, Chris Benny, Erdei, Tamas, Manghat, Nathan, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Pais, João, Picarra, Bruno, Santos, Ana Rita, Guerreiro, Rui, Congo, Kisa Hyde, Carvalho, João, Neves, David, and Aguiar, José

Abstract

Objectives: Myocardial fibrosis in noninfarcted myocardium is emerging as a principal phenotype of vulnerability to adverse events such as mortality and hospitalization for heart failure (HHF), but its optimal noninvasive measurement remains uncertain despite consistently robust histologic validation data for extracellular volume fraction (ECV). We therefore compared ECV, native T1, post contrast T1, the gadolinium contrast partition coefficient (lambda), and the presence of nonischemic scar in their associations with mortality and HHF outcomes. Method: To quantify of myocardial fibrosis, we performed T1 mapping (MOLLI) in basal and mid short axis slices with cardiovascular magnetic resonance (CMR) before contrast and 12-30 minutes post contrast bolus in 1185 consecutive patients without amyloidosis, hypertrophic or stress cardiomyopathy. We assessed associations with outcomes using Kaplan-Meier plots and chi square values from univariable Cox regression models. All standard T1 mapping parameters were obtained: native and post contrast myocardial T1, the partition coefficient lambda, and ECV. ECV = (1-hematocrit) · [ΔR1myocardium]/[ΔR1bloodpool], where R1 = 1/T1 Late gadolinium enhancement imaging with phase sensitive reconstruction identified nonischemic scar. Results: Over a median of 1.7 years, 111 individuals experienced events after CMR: 55 HHF events and 74 deaths. ECV yielded better separation of Kaplan-Meier curves in a dose dependent fashion (Figure) and also stronger associations with the combined endpoint of death or HHF. The ECV chi square (77.3, p < 0.001) was at least twice as large as the Native T1 chi square (37.5, p < 0.001), the lambda chi square (34.8, p < 0.001) and nonischemic scar (chi square = 20.5, p<0.001). Post-contrast T1 was not associated with outcomes, even when adjusting further for time after contrast bolus, renal function, and patient weight (chi square <3, p >0.10). Conclusion: Analogous to histologic previously published validation data, quantitative ECV myocardial fibrosis measures associated with outcomes far stronger than other surrogate measures outcome measures such as native T1, post contrast T1 and nonischemic scar on LGE images. These data suggest that ECV is the noninvasive metric of choice to measure myocardial fibrosis. Figure. Kaplan-Meier Plots for T1 mapping parameters.

Published
2016
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47. A minority's agency: class, confession, and the quandaries of Muslim India, 1947-c. 1977

Author

Anil, P and O'Hanlon, R

Subjects
History, Cultural history, Political Science, Social history
Abstract

This thesis sets out to recover the agency of a wide range of Indian Muslim actors—elite and subaltern, secular and clerical, activist and apolitical—to illuminate the history of the world’s largest religious minority. Bringing the unity of the Muslim experience of postcolonial India from 1947 to c. 1977 under a single focus, it both generalises about the Indian Muslim condition and comments more broadly on the character of Indian democracy. The six chapters here tell of another India, as it were, one quite at variance with the exnominated account of the ‘world’s largest democracy’. Despite its best intentions, the Congress regime that ruled uninterruptedly through the period under study here appears, by turns, illiberal, intolerant, and undemocratic. Minority rights were at a discount. India’s Muslims, I document, had to contend with discrimination in the services, an electoral system that deprived them of commensurate representation, riots in which they accounted for most of the fatalities, a securitisation regime in the borderlands that dispossessed and disenfranchised them, and, a fortiori, an unresponsive leadership. Indeed, what I have called an ‘ashraf betrayal’ is the Ariadne’s thread running through the thesis. Steering between the Scylla of Islamophobia and the Charybdis of capitulation, the Muslim political elite plumped for depoliticisation and juridification. Muslim politics came to be identified with a set of elite symbols—the hajj subsidy, Urdu, Aligarh Muslim University, Muslim personal law, wasiqadari pensions, waqf income—that had little bearing on the lives of ordinary Muslims, shaped by discrimination, disadvantage, and deindustrialisation. There was no room for trade unions, mass protests, anti-discrimination legislation, and subaltern solidarity in this version of Muslim politics. The corollary was a jurisprudential habit of mind, the singular investment in two holy books, the Quran and the Constitution. ‘Muslim politics’ in postcolonial India, I conclude, has been a politics manqué.

Published
2022

48. Political ideas of B.G. Tilak: colonialism, self and Hindu nationalism

Author

Oak, A., Kanungo, P.R., Wickramasinghe, N.K., Velde, H. te, O'Hanlon, R., Bedner, A.W., Blarel, N.R.J.B, and Leiden University

Subjects
Intellectual, History, Indian, Theory, Colonialism, Political
Abstract

De primaire focus van dit proefschrift is het onderzoeken van de politieke ideeën van BG Tilak (1856-1920), de congres-extremistische leider van de Indiase nationalistische beweging en, in het proces, de politieke en intellectuele geschiedenis van Maharashtra en India te reconstrueren tijdens de late 19e en begin 20e eeuw. Deze dissertatie daagt de oudere stijlfiguur uit die Tilak binnen de reikwijdte van de meerderheid van de hindoe-nationalistische politiek plaatst. Het plaatst zijn sociale conservatisme in de heersende sociale overtuigingen van en liturgische lezingen aangeboden door de laat 19e-eeuwse Marathi openbare intellectuelen. De belangrijkste agenda van Tilak was de creatie van een gecollectiviseerd en geradicaliseerd hindoe-zelf, geponeerd tegen het Britse kolonialisme. Zijn creatieve versmelting van moderne westerse historische exegese met Sanskriet kennissystemen in het pleiten voor hoge oudheid voor de Arische beschaving worden onderzocht. Zijn commentaar op de Bhagavad Gītā bood een infusie van ethische principes in massaal politiek activisme. Tilak slaagde erin om provinciale parochialisme ten opzichte van pan-nationale identiteiten te verminderen. Ten slotte stelt dit proefschrift dat het nationalistische ideaal van Tilak beperkt was tot Svarājya of Zelfbeschikking voor India binnen het Britse Gemenebest.

Published
2022

49. Between the courts of Lahore and Windsor: Anglo-Indian relations and the re-making of royalty in the nineteenth century

Author

Atwal, R, O'Hanlon, R, Taylor, M, and Devji, F

Abstract

This thesis examines the political and social worldview of British and Indian royalty during the nineteenth century. Rather than viewing them as mere 'ornamental' figureheads, it seeks to highlight and scrutinise the ideas held by monarchs (sovereign or deposed) about empire and the role of royalty, as well as considering how their attempts at implementing such ideas can complicate existing narratives about the relative influence and authority of this group. Above all, this thesis breaks new ground by adopting a transnational approach in its study of such royal ideas and endeavours. Ruling dynasties, monarchs and courts have long been part of an interconnected, if rarefied, world encompassing Europe and Asia, though this is not adequately reflected in the historiography on the nineteenth century. This is despite the ironic fact that in that century, many royal houses were brought closer together than ever before, through the impact of growing global empires, and advancing communications and transportation networks. The first direct meetings between British and Indian royalty took place during this period, in the early 1850s, and are closely examined here. Based on a core case-study of the longstanding relationship between the Punjabi and British dynasties of Maharajah Ranjit Singh and Queen Victoria, and using a wide variety of textual and material sources, this thesis captures royal perspectives of their status and role in an evolving world, alongside considering how British and Indian royalty directly or indirectly influenced one another. This study effectively de-centres the British imperial official as the primary agent in Anglo-Indian elite encounters, and goes further to demonstrate that whether in the case of the connections between royal personages, or in the ties between ‘monarchy, nation and empire’, the capability for royal agency to shape the nature of such relationships evolved over time and was a consistently contested matter.

Published
2017

50. Beyond famines: wartime state, society, and politicization of food in colonial India, 1939 – 1945

Author

Sarkar, A and O'Hanlon, R

Subjects
Second World War, Famines, Food Studies, History, South Asian History, Modern Indian History, Communal Politics
Abstract

This thesis explores the origin of one of the most engrossing concerns of the post-colonial Indian state, that is, its extensive, intricate, and expensive feeding arrangements for the civilians. It tracks the colonial origin of the post-colonial welfare state, of which state-management of food is one of the most publicized manifestations. This thesis examines the intervention of the late colonial British state in food procurement and distribution in India during the Second World War, and various forms of such intervention, such as the introduction of food rationing and food austerity laws. It argues that the war necessitated actions on the part of the colonial state to secure food supplies to a vastly expanded British Indian Army, to the foreign Allied troops stationed in India, and to the workers employed in war-industries. The thesis brings forth the constitutional and political predicaments that deprived the colonial central government’s food administration of success. It further reveals how the bitter bargaining about food imports into India between the Government of India and the War Cabinet in Britain hampered the state efforts to tackle the food crisis. By discussing the religious and cultural codes vis-à-vis food consumption that influenced government food policies, this thesis has situated food in the historiography of consumption in colonial India. In addition to adopting a political approach to study food, it has also applied sociological treatment, particularly while dealing with how the wartime scarcity, and consequent austerity laws, forced people to accept novel consumption cultures. It also contributes to the historiography of ‘everyday state’. Through its wartime intervention in everyday food affairs, the colonial state that had been distant and abstract in the perception of most common households, suddenly became a reality to be dealt with in everyday life within the domestic site. Thus, the macro state penetrated micro levels of existence. The colonial state now even developed elaborate food surveillance to gather intelligence about violation of food laws. This thesis unravels the responses of some of the political and religious organizations to state intervention in quotidian food consumption. Following in this vein, through a study of the political use of famine-relief in wartime Bengal, it introduces a new site to the study of communal politics in India, namely, propagation of Hindu communal politics through distribution of food by the Hindu Mahasabha party. Further, it demonstrates how the Muslim League government’s failure to prevent the Great Bengal Famine of 1943-44 was politically used by the Mahasabha to oppose the League’s emerging demand for the creation of Pakistan.

Published
2017

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