1. PD-1 and PD-L1 expression in cardiac transplantation.
- Author
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Bishawi M, Bowles D, Pla MM, Oakes F, Chiang Y, Schroder J, Milano C, and Glass C
- Subjects
- Humans, Lymphocyte Activation, T-Lymphocytes, B7-H1 Antigen metabolism, Heart Transplantation, Programmed Cell Death 1 Receptor metabolism
- Abstract
Programmed death-ligand 1 (PD-L1), a transmembrane protein and member of the CD28 T cell family is associated with lymphocyte activation.
1 PD-L1 expression is upregulated on activated antigen presenting cells such as monocytes, myeloid and dendritic cells.2 When bound to its cognate receptor programmed cell death (PD-1), inhibition of immune responses including downregulation of T cell proliferation occurs.3 Mechanistically, such inhibition would be hypothetically favorable in the setting of a transplanted organ undergoing allograft rejection. However, there is a paucity of data addressing the role of PD-L1 and PD-1 expression in the human transplanted heart., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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