7 results on '"Orla Flynn"'
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2. Evaluating the Impact of Low-Pathogenicity Avian Influenza H6N1 Outbreaks in United Kingdom and Republic of Ireland Poultry Farms during 2020
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Michael J. McMenamy, Robyn McKenna, Valerie B. Bailie, Ben Cunningham, Adam Jeffers, Kelly McCullough, Catherine Forsythe, Laura Garza Cuartero, Orla Flynn, Christina Byrne, Emily Connaghan, John Moriarty, June Fanning, Stephanie Ronan, Damien Barrett, Alice Fusaro, Isabella Monne, Calogero Terregino, Joe James, Alexander M. P. Byrne, Fabian Z. X. Lean, Alejandro Núñez, Scott M. Reid, Rowena Hansen, Ian H. Brown, Ashley C. Banyard, and Ken Lemon
- Subjects
low-pathogenicity avian influenza virus ,avian influenza virus subtype H6 ,H6N1 outbreaks ,impact of LPAIV ,Microbiology ,QR1-502 - Abstract
In January 2020, increased mortality was reported in a small broiler breeder flock in County Fermanagh, Northern Ireland. Gross pathological findings included coelomitis, oophoritis, salpingitis, visceral gout, splenomegaly, and renomegaly. Clinical presentation included inappetence, pronounced diarrhoea, and increased egg deformation. These signs, in combination with increased mortality, triggered a notifiable avian disease investigation. High pathogenicity avian influenza virus (HPAIV) was not suspected, as mortality levels and clinical signs were not consistent with HPAIV. Laboratory investigation demonstrated the causative agent to be a low-pathogenicity avian influenza virus (LPAIV), subtype H6N1, resulting in an outbreak that affected 15 premises in Northern Ireland. The H6N1 virus was also associated with infection on 13 premises in the Republic of Ireland and six in Great Britain. The close genetic relationship between the viruses in Ireland and Northern Ireland suggested a direct causal link whereas those in Great Britain were associated with exposure to a common ancestral virus. Overall, this rapidly spreading outbreak required the culling of over 2 million birds across the United Kingdom and the Republic of Ireland to stamp out the incursion. This report demonstrates the importance of investigating LPAIV outbreaks promptly, given their substantial economic impacts.
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- 2024
- Full Text
- View/download PDF
3. A qualitative exploration of migraine in students attending Irish Universities.
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Orla Flynn, Catherine Blake, and Brona M Fullen
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Medicine ,Science - Abstract
IntroductionThe complex neurological disorder of migraine is prevalent (19%) and burdensome in university students. Qualitative research exploring the lived experience of migraine in students has yet to be conducted.MethodsStudents clinically diagnosed with migraine were recruited (purposive sampling) from a sample of Irish third-level institutions for a one-time anonymized Zoom focus group or individual interview. Focus group questions were sent to participants in advance. Interviews were iterative. Participants were also invited to submit a drawing. The interviews were audio-recorded, transcribed, and sent to participants for triangulation. Reflexive thematic content analysis was undertaken, data was imported to Microsoft Excel, initial codes were generated, and themes and sub-themes were derived from the codes. The Standards for Reporting Qualitative Studies Checklist (S1 File) ensured study rigour.ResultsTwenty students from three Irish universities participated (mean age 23.8 years). The four key themes identified were (i) Migraine Characteristics, (ii) Migraine Self-Management, (iii) Migraine Clinical Management, and (iii) Migraine Impacts. Migraine was described as not just a headache but a debilitating sensory experience. A notable high level of self-management satisfaction indicated hopeful coping strategies. However, many participants said medications were ineffective and had side effects, and clinical management could be improved. Additionally, there was a marked academic and social impact of migraine, psychological issues abounded, and several participants worried about finances.ConclusionsMigraine is impactful in a cohort of students attending Irish third-level institutions, with students carrying a wide range of debilitating migraine burdens. Students demonstrate an attitude of resilience and determination despite these challenges. Migraine awareness and education campaigns on university campuses are warranted.
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- 2024
- Full Text
- View/download PDF
4. First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
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Aideen Kennedy, Louise Britton, Andrew W. Byrne, Christina Byrne, Mícheál Casey, Orla Flynn, Jose Maria Lozano, Ferdia Marnell, Maire McElroy, Neil Reid, Margaret Wilson, and William FitzGerald
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RHDV2 ,Endemic species ,Wildlife disease ,Hare coursing ,Calicivirus ,RT-PCR ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Rabbit haemorrhagic disease virus (RHDV) is a Lagovirus, a subgroup of the family Caliciviridae. RHDV2 is a variant first described in France in 2010, and has since spread globally. It has been reported in several Lagomorph species (rabbits, hares, and their relatives) as well as other mammals including voles and shrews. The disease has raised international concerns for its potential impact on population abundance trajectories, particularly as 25% of Lagomorphs are currently Red-Listed by the International Union for the Conservation of Nature (IUCN). The Irish hare (Lepus timidus hibernicus) is a subspecies of the mountain hare, L. timidus, and is endemic to Ireland, making it an Evolutionarily Significant Unit of intrinsic value. Case presentation The first case of RHDV2 was detected in a wild Irish hare in July 2019. The individual exhibited atypical neurological behaviour (running in circles) prior to death. On necropsy, pink tinged foam was seen in the trachea and congestion was noted in the lungs, but there was no evidence of haemorrhages in any other organ. Both the liver and spleen were tested by reverse transcription real time qPCR confirming high levels of RHDV2 RNA. Histopathology confirmed multifocal necrotising hepatitis. Conclusion The Irish hare is susceptible to RHDV2 infection. Further investigation is warranted to explore the clinical, epidemiological, and population biology implications.
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- 2021
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5. Influenza D Virus in Cattle, Ireland
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Orla Flynn, Clare Gallagher, Jean Mooney, Claire Irvine, Mariette Ducatez, Ben Hause, Guy McGrath, and Eoin Ryan
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influenza D virus ,viruses ,influenza ,cattle ,respiratory infections ,Ireland ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We detected influenza D virus in 18 nasal swab samples from cattle in Ireland that were clinically diagnosed with respiratory disease. Specimens were obtained from archived samples received for routine diagnosis during 2014–2016. Sequencing showed that viruses from Ireland clustered with virus sequences obtained in Europe within the D/swine/OK/1334/2011 clade.
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- 2018
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6. Migraine in university students: A systematic review and meta‐analysis
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Orla Flynn, Brona M. Fullen, and Catherine Blake
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Anesthesiology and Pain Medicine - Abstract
Migraine is a complex, neurobiological disorder usually presenting as a unilateral, moderate to severe headache accompanied by sensory disturbances. Migraine prevalence has risen globally, affecting 14% of individuals and 16% of students and carries many negative impacts in both cohorts. With no recent meta-analysis of global migraine prevalence or associated factors in students, this systematic review and meta-analysis were conducted.The review was registered with PROSPERO (CRD42020167927). Electronic databases (n = 12) were searched for cross-sectional studies (1988 to August 2021, IHS criteria). Ninety-two articles were meta-analysed and 103 were narratively reviewed. The risk of bias was assessed using an established tool.The risk of bias ranged from low to moderate. Migraine pooled prevalence (R-Studio) was demonstrated at 19% (95% CI, 16%-22%, p 0.001, I^2 98%): females 23% (95% CI, 19%-27%, p 0.001), males 12% (95% CI, 9%-15%, p 0.001). Gender (p 0.0001), geographical region (p = 0.01), migraine types (p = 0.0002) and prevalence timeframes (p = 0.02) may be influencing the substantial heterogeneity. Migraine triggers were primarily behavioural and environmental and treatments were predominantly pharmaceutical. Impacts ranged from academic performance impairment to psychological co-morbidities.This study offers the most comprehensive overview of migraine prevalence and associated factors in university students. Migraine prevalence in university students has increased and has many negative effects. Enhancing migraine recognition and management at university may have positive implications for an improved educational experience, as well as for the burden migraine currently incurs, both in university and beyond.This global systematic review and meta-analysis of 92 studies and narrative review of 103 studies provide the most comprehensive synthesis to date of migraine prevalence and associated factors in university students. Pooled prevalence has increased to 19%. The significant heterogeneity demonstrated is influenced by gender, geographical region, migraine type and prevalence timeframes. Students manage migraines primarily with pharmaceuticals. Further studies conducted in low and middle-income countries, following headache protocols and reporting frequency of treatment-seeking and medication usage are warranted.
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- 2022
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7. First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
- Author
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Mícheál Casey, William Fitzgerald, Louise Britton, Orla Flynn, Aideen Kennedy, Margaret Wilson, Jose Maria Lozano, Andrew W. Byrne, Neil Reid, Máire C. McElroy, Christina Byrne, and Ferdia Marnell
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animal diseases ,Veterinary medicine ,RT-PCR ,Zoology ,Case Report ,Population biology ,Subspecies ,Wildlife disease ,Virus ,Rabbit haemorrhagic disease ,Hare coursing ,RHDV2 ,SDG 3 - Good Health and Well-being ,Calicivirus ,SF600-1100 ,IUCN Red List ,General Veterinary ,biology ,biology.organism_classification ,veterinary(all) ,Lagovirus ,Endemic species ,Lepus timidus - Abstract
Background Rabbit haemorrhagic disease virus (RHDV) is a Lagovirus, a subgroup of the family Caliciviridae. RHDV2 is a variant first described in France in 2010, and has since spread globally. It has been reported in several Lagomorph species (rabbits, hares, and their relatives) as well as other mammals including voles and shrews. The disease has raised international concerns for its potential impact on population abundance trajectories, particularly as 25% of Lagomorphs are currently Red-Listed by the International Union for the Conservation of Nature (IUCN). The Irish hare (Lepus timidus hibernicus) is a subspecies of the mountain hare, L. timidus, and is endemic to Ireland, making it an Evolutionarily Significant Unit of intrinsic value. Case presentation The first case of RHDV2 was detected in a wild Irish hare in July 2019. The individual exhibited atypical neurological behaviour (running in circles) prior to death. On necropsy, pink tinged foam was seen in the trachea and congestion was noted in the lungs, but there was no evidence of haemorrhages in any other organ. Both the liver and spleen were tested by reverse transcription real time qPCR confirming high levels of RHDV2 RNA. Histopathology confirmed multifocal necrotising hepatitis. Conclusion The Irish hare is susceptible to RHDV2 infection. Further investigation is warranted to explore the clinical, epidemiological, and population biology implications.
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- 2021
- Full Text
- View/download PDF
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