7 results on '"Oudmaijer, Christiaan A. J."'
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2. A nationwide assessment of hepatocellular adenoma resection:Indications and pathological discordance
- Author
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Haring, Martijn P D, Elfrink, Arthur K E, Oudmaijer, Christiaan A J, Andel, Paul C M, Furumaya, Alicia, de Jong, Nenke, Willems, Colin J J M, Huits, Thijs, Sijmons, Julie M L, Belt, Eric J T, Bosscha, Koop, Consten, Esther C J, Coolsen, Mariëlle M E, van Duijvendijk, Peter, Erdmann, Joris I, Gobardhan, Paul, de Haas, Robbert J, van Heek, Tjarda, Lam, Hwai-Ding, Leclercq, Wouter K G, Liem, Mike S L, Marsman, Hendrik A, Patijn, Gijs A, Terkivatan, Türkan, Zonderhuis, Babs M, Molenaar, Izaak Quintus, Te Riele, Wouter W, Hagendoorn, Jeroen, Schaapherder, Alexander F M, IJzermans, Jan N M, Buis, Carlijn I, Klaase, Joost M, de Jong, Koert P, de Meijer, Vincent E, Haring, Martijn P D, Elfrink, Arthur K E, Oudmaijer, Christiaan A J, Andel, Paul C M, Furumaya, Alicia, de Jong, Nenke, Willems, Colin J J M, Huits, Thijs, Sijmons, Julie M L, Belt, Eric J T, Bosscha, Koop, Consten, Esther C J, Coolsen, Mariëlle M E, van Duijvendijk, Peter, Erdmann, Joris I, Gobardhan, Paul, de Haas, Robbert J, van Heek, Tjarda, Lam, Hwai-Ding, Leclercq, Wouter K G, Liem, Mike S L, Marsman, Hendrik A, Patijn, Gijs A, Terkivatan, Türkan, Zonderhuis, Babs M, Molenaar, Izaak Quintus, Te Riele, Wouter W, Hagendoorn, Jeroen, Schaapherder, Alexander F M, IJzermans, Jan N M, Buis, Carlijn I, Klaase, Joost M, de Jong, Koert P, and de Meijer, Vincent E
- Abstract
Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (≥50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors (p = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre)malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio [aOR], 3.4; p < 0.01), male sex (aOR, 3.7; p = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis.
- Published
- 2023
3. Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity
- Author
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Oudmaijer, Christiaan A. J., van den Boogaard, Winnie M. C., Komninos, Daphne S. J., Verwaaijen, Emma J., van Santen, Hanneke M., Lilien, Marc R., Hoeijmakers, Jan H. J., Wijnen, Marc H. W., van den Heuvel-Eibrink, Marry M., Vermeij, Wilbert P., Oudmaijer, Christiaan A. J., van den Boogaard, Winnie M. C., Komninos, Daphne S. J., Verwaaijen, Emma J., van Santen, Hanneke M., Lilien, Marc R., Hoeijmakers, Jan H. J., Wijnen, Marc H. W., van den Heuvel-Eibrink, Marry M., and Vermeij, Wilbert P.
- Abstract
Childhood renal tumors account for around 6% of all childhood cancers and 90% of these cases are Wilms tumor. In Europe, the SIOP-RTSG approach is considered standard of care and has resulted in five-year survival rates of over 90%. Efforts to decrease toxicity are now being pursued. Short-term fasting (STF), a short but strong reduction in calorie-intake, is associated with improved fitness, enhanced coping with acute physical stress and a lower risk of age-associated diseases. STF temporarily reduces growth to boost resilience, maintenance, and defense-mechanisms, by which toxic side-effects of (oxidative) damage and inflammation are largely prevented. Renal surgery for Wilms tumor carries a risk of acute kidney injury (AKI) and pediatric patients that had an episode of AKI are at increased risk for developing chronic renal disease. STF could mitigate surgery-induced stress and could further improve outcomes. We aim to investigate the effect of STF on renal function recovery after renal tumor surgery by conducting a single-center, prospective, randomized, non-blinded, intervention study. Children diagnosed with a unilateral renal tumor and opting for curative treatment are eligible for inclusion. The main study objective is to investigate the potential decrease in occurrence of AKI due to STF. Secondary objectives include renal function recovery, child's wellbeing, physical functioning, and feasibility of and adherence to STF in children with cancer.
- Published
- 2022
4. Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity
- Author
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Kinderbewegingszorg patientenzorg, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Nefrologie, Zorgeenheid Kinderchirurgie Medisch, Zorg en O&O, Oudmaijer, Christiaan A J, van den Boogaard, Winnie M C, Komninos, Daphne S J, Verwaaijen, Emma J, van Santen, Hanneke M, Lilien, Marc R, Hoeijmakers, Jan H J, Wijnen, Marc H W, van den Heuvel-Eibrink, Marry M, Vermeij, Wilbert P, Kinderbewegingszorg patientenzorg, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Nefrologie, Zorgeenheid Kinderchirurgie Medisch, Zorg en O&O, Oudmaijer, Christiaan A J, van den Boogaard, Winnie M C, Komninos, Daphne S J, Verwaaijen, Emma J, van Santen, Hanneke M, Lilien, Marc R, Hoeijmakers, Jan H J, Wijnen, Marc H W, van den Heuvel-Eibrink, Marry M, and Vermeij, Wilbert P
- Published
- 2022
5. Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity
- Author
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Oudmaijer, Christiaan A. J., primary, Boogaard, Winnie M. C. van den, additional, Komninos, Daphne S. J., additional, Verwaaijen, Emma J., additional, Santen, Hanneke M. van, additional, Lilien, Marc R., additional, Hoeijmakers, Jan H. J., additional, Wijnen, Marc H. W., additional, Heuvel-Eibrink, Marry M. van den, additional, and Vermeij, Wilbert P., additional
- Published
- 2022
- Full Text
- View/download PDF
6. A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance.
- Author
-
Haring, Martijn P. D., Elfrink, Arthur K. E., Oudmaijer, Christiaan A. J., Andel, Paul C. M., Furumaya, Alicia, de Jong, Nenke, Willems, Colin J. J. M., Huits, Thijs, Sijmons, Julie M. L., Belt, Eric J. T., Bosscha, Koop, Consten, Esther C. J., Coolsen, Mariëlle M. E., van Duijvendijk, Peter, Erdmann, Joris I., Gobardhan, Paul, de Haas, Robbert J., van Heek, Tjarda, Hwai-Ding Lam, and Leclercq, Wouter K. G.
- Subjects
CONTRAST-enhanced magnetic resonance imaging ,PREOPERATIVE risk factors ,LIVER tumors ,LOGISTIC regression analysis - Abstract
Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50mm compared to HCAs = 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (=50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors (p = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre) malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50mm (adjusted odds ratio [aOR], 3.4; p < 0.01), male sex (aOR, 3.7; p = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance.
- Author
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Haring MPD, Elfrink AKE, Oudmaijer CAJ, Andel PCM, Furumaya A, de Jong N, Willems CJJM, Huits T, Sijmons JML, Belt EJT, Bosscha K, Consten ECJ, Coolsen MME, van Duijvendijk P, Erdmann JI, Gobardhan P, de Haas RJ, van Heek T, Lam HD, Leclercq WKG, Liem MSL, Marsman HA, Patijn GA, Terkivatan T, Zonderhuis BM, Molenaar IQ, Te Riele WW, Hagendoorn J, Schaapherder AFM, IJzermans JNM, Buis CI, Klaase JM, de Jong KP, and de Meijer VE
- Subjects
- Humans, Male, Adult, Middle Aged, Retrospective Studies, Magnetic Resonance Imaging methods, Adenoma, Liver Cell diagnostic imaging, Adenoma, Liver Cell surgery, Liver Neoplasms diagnostic imaging, Liver Neoplasms surgery, Carcinoma, Hepatocellular pathology
- Abstract
Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (≥50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors ( p = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre)malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio [aOR], 3.4; p < 0.01), male sex (aOR, 3.7; p = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc on behalf of the American Association for the Study of Liver Diseases.)
- Published
- 2022
- Full Text
- View/download PDF
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