Search

In this study, we will express the 2-crossed module of groups from a higher-dimensional categorical perspective. According to simplicial homotopy theory, a 2-crossed module is the Moore complex of a 2-truncated simplicial group. Therefore, the 2-crossed module is an algebraic homotopy model for the homotopy 3-types. Tricategories are a three-dimensional generalization of the bicategory concept. Any tricategory is triequivalent to the Gray category, where Gray is a category enriched over the monoidal category 2Cat equipped with the Gray tensor product. Briefly, a Gray category is a semi-strict 3-category for homotopy 3-types. Naturally, the tricategory perspective is used in homotopy theory. The 2-crossed module is associated with the concept of the Gray category. The aim of this study is to obtain a single object tricategory from any 2-crossed module of groups.

Introduction: The objective of the present study was to evaluate morphine consumption and pain scores 24 h postoperatively to compare the effects of a bilateral External Oblique Intercostal (EOI) block with those of a Modified Thoracoabdominal Nerve Block Trough Perichondrial Approach (M-TAPA) block in laparoscopic sleeve gastrectomy (LSG)., Methods: Fifty-eight patients aged between 18 and 65 years of with American Society of Anesthesiologists class II-III were included in this randomized, double-blinded study. Patients were assigned into two groups either EOI block or M-TAPA block. The primary outcome was cumulative morphine consumption within the first postoperative 24 h. Secondary outcomes were numerical rating scale (NRS) scores at rest and during activity, QoR-15 Patient Questionnaire scores, incidence of postoperative nausea and vomiting (PONV), number of patients requiring rescue analgesic and antiemetics drugs, and complications., Results: There was no statistically significant difference between the groups in terms of morphine consumption in the first 24 h (EOI block; 10.74 ± 3.94 mg vs. M-TAPA block; 11.67 ± 4.66 mg, respectively). In addition, no significant difference between the two groups in the NRS and PONV scores, total QoR-15 scores, and the number of patients requiring rescue analgesics and antiemetics., Conclusions: EOI block and M-TAPA block showed similar effectiveness for morphine consumption within 24 h postoperatively and in pain scores in LSG., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

This review assesses the efficacy of inhalation anesthetics and propofol in cardiac surgery, primarily focusing on their impact on myocardial protection and subsequent clinical outcomes. The review provides a concise summary of the current scientific information regarding the protective efects of inhalation anesthetics and propofol, particularly in the context of ischemia-reperfusion injury during cardiac surgery. The review delves into the mechanisms of action and discusses clinical studies comparing the 2 anesthetic strategies regarding mortality, complication rates, and length of hospital stay. Inhalation anesthetics exhibit cardioprotective properties through many mechanisms, such as preconditioning, scavenging of free radicals, and stabilizing mitochondria. Propofol demonstrates certain protective benefits but does not possess the preconditioning capability of inhalation medications. Clinical investigations yield contradictory findings, as several studies indicate enhanced outcomes with inhalation anesthetics, while others observe no substantial disparity between the 2 approaches. The cardioprotective efcacy of propofol against ischemia-reperfusion injury remains limited. While its inherent antioxidant properties ofer direct myocardial protection, propofol demonstrably lacks the preconditioning-mediated signaling pathways triggered by inhalation anesthetics. As a result, propofol's protective efect may be slightly inferior to preconditioning strategies, and its potential to inhibit organ-protective impact of other interventions needs further investigation. The question of which anesthetic approach ofers superior myocardial protection remains debatable. Current evidence is inconclusive, potentially due to patient heterogeneity, surgical complexity, and methodological limitations of existing studies. Future research, including pharmacogenetic studies and large, welldesigned, randomized controlled trials, are necessary to provide definitive guidance on anesthetic selection for optimal myocardial protection in cardiac surgery.

16S rRNA amplicon sequencing provides a relatively inexpensive culture-independent method for studying microbial communities. Although thousands of such studies have examined diverse habitats, it is difficult for researchers to use this vast trove of experiments when interpreting their own findings in a broader context. To bridge this gap, we introduce dbBact - a novel pan-microbiome resource. dbBact combines manually curated information from studies across diverse habitats, creating a collaborative central repository of 16S rRNA amplicon sequence variants (ASVs), which are assigned multiple ontology-based terms. To date dbBact contains information from more than 1000 studies, which include 1500000 associations between 360000 ASVs and 6500 ontology terms. Importantly, dbBact offers a set of computational tools allowing users to easily query their own datasets against the database. To demonstrate how dbBact augments standard microbiome analysis we selected 16 published papers, and reanalyzed their data via dbBact. We uncovered novel inter-host similarities, potential intra-host sources of bacteria, commonalities across different diseases and lower host-specificity in disease-associated bacteria. We also demonstrate the ability to detect environmental sources, reagent-borne contaminants, and identify potential cross-sample contaminations. These analyses demonstrate how combining information across multiple studies and over diverse habitats leads to better understanding of underlying biological processes., (© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Blood cysts of the heart are unusual primary cardiac tumor-like masses, which are usually located on the cardiac valves. These are very rare in adults, especially in a non-valvular location. Autosomal-dominant polycystic kidney disease (ADPKD) typically presents with multiple bilateral renal cysts, resulting in chronic kidney disease. Whilst many of the extra-renal manifestations of ADPKD are well-documented, associated cardiac masses are extremely rare: and cardiac blood cyst has not been reported in a patient with APKD to date. We present a 57-year man with a history of ADPKD and end-stage renal disease with a 2-cm-diameter right ventricular blood cyst, which was detected on multimodality imaging. Key words: Autosomal dominant polycystic kidney disease, Cardiac blood cyst, Extra-renal manifestations.

Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide. While HPV is responsible for low-grade benign lesions in the anogenital area such as condyloma acuminatum, it is also strongly associated with cervical, anal, vulvar/vaginal, and penile carcinomas. In addition to being an oncogenic virus, HPV causes a substantial socioeconomic burden due to the recurrence of benign lesions, the lack of a definitive treatment option that provides a complete cure, and the high cost of treatment. The global incidence of HPV infection is rising, especially among young and sexually active individuals; as a result, in recent years these infections have also become increasingly conspicuous in urology practice, both as incidental findings and primary complaints. The aim of this review is to evaluate the pathogenesis, diagnosis, and treatment modalities of HPV infections in light of the current literature from the urologist's perspective.

Organoid technologies have become a powerful emerging tool to model liver diseases, for drug screening, and for personalized treatments. These applications are, however, limited in their capacity to generate functional hepatocytes in a reproducible and efficient manner. Here, we generated and characterized the hepatic organoid (eHEPO) culture system using human induced pluripotent stem cell (iPSC)-derived EpCAM-positive endodermal cells as an intermediate. eHEPOs can be produced within 2 weeks and expanded long term (>16 months) without any loss of differentiation capacity to mature hepatocytes. Starting from patient-specific iPSCs, we modeled citrullinemia type 1, a urea cycle disorder caused by mutations in the argininosuccinate synthetase (ASS1) enzyme. The disease-related ammonia accumulation phenotype in eHEPOs could be reversed by the overexpression of the wild-type ASS1 gene, which also indicated that this model is amenable to genetic manipulation. Thus, eHEPOs are excellent unlimited cell sources to generate functional hepatic organoids in a fast and efficient manner., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)

Objective: To assess the awareness/knowledge of stroke risk factors and warning signs among caregivers of patients with or without stroke., Methods: The cross-sectional, descriptive and comparative study was conducted in the neurology clinic and polyclinic of a university hospital in Izmir, Turkey, from March to July 2014, and comprised primary caregivers of patients with stroke in group 1 and those of patients with no stroke in group 2. The subjects were screened and data was collected using the Participant Information Form and the Questionnaire Form About Stroke. Warning signs and symptoms of stroke were compared between the two sets of caregivers. SPSS 17was used for data analysis., Results: Of the 203 respondents, 105(52%) were in group 1 and 98(48%) in group 2. Group 1 had better awareness than group 2 (p<0.05). In group 1, weakness was the most commonly recognised warning sign 101(96.2%), whereas dyspnoea 41(39%), was the least commonly identified. There was no relationship of stroke knowledge with educational level and age (p>0.05 each). ., Conclusions: Caregivers had a moderate knowledge of some of the warning signs and risk factors about stroke.

This research experimentally investigates the treatment of authentic electroplating wastewater with high Cr(VI) content by electrocoagulation with the obtained sludge being reused as a raw material to produce inorganic pigments. A zero waste process is introduced to help conserve resources and to minimize environmental effects. The effects of operational parameters on electrocoagulation are determined in a batch stirred reactor using an iron electrode. The best performance was observed when a current density 20 mA/cm 2 , pH 2.4 and 0.05 M NaCl electrolyte were maintained. The initial Cr(VI) concentration of 1000 mg/L was almost completely abated (∼100%) at an energy cost of 2.68 kWh/m 3 , fulfilling the EPA guideline of 2.77 mg/L within a single step process. The sludge was characterized using XRD and XRF showing that the sludge is a rich source of iron and chromium and can be reused to produce value added ceramic pigments. Pigments prepared in this way appeared to be reddish brown and black color in transparent glaze and were also characterized using XRD and XRF. In this study, a zero waste process is successfully introduced with ∼100% Cr(VI) removal, with subsequent reuse of the resulting sludge., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Objectives: The aim of this study was to evaluate the effects of time elapsed since bleaching and different bleaching regimens on the microtensile bond strength of resin composite to enamel., Methodology: Forty flattened buccal enamel surfaces were divided into four groups: An unbleached (control) group and three bleaching groups. Control group specimens were not subjected to a bleaching regimen (Group 1), while those in the bleaching groups were bleached as follows: opalescence 10% (Group 2), whiteness perfect 16% (Group 3), and whiteness hydrogen peroxide 35% (Group 4). Thereafter, the bleached specimens were divided into three subgroups ( n = 4 teeth each) for restoration according to predetermined posttreatment time intervals (immediately, 1 week, and 2 weeks). Bonded specimens were then sectioned and subjected to μTBS testing. The data were analyzed using Kruskal-Wallis and Mann-Whitney U-tests at α = 0.05., Results: There was a significant difference in the μTBS of the resin composite to enamel in groups that were bonded immediately after bleaching and in the control group ( P < 0.05). Compared to the control group, the μTBS in Groups 2, 3, and 4 decreased significantly 1-week postbleaching ( P < 0.05). No significant difference in μTBS was observed between the bleached and unbleached groups 2 weeks after treatment ( P > 0.05)., Conclusions: Adhesive restorative procedures could not be performed immediately or after 1 week irrespective of the type or concentration of bleaching system used. Composite restorations on bleached enamel surfaces should be performed after an interval of at least 2 weeks., Competing Interests: There are no conflicts of interest.

The purpose of this study was to evaluate the efficiency of the Er:YAG laser and diamond bur cavity preparation on the marginal microleakage of Class V cavities. Group 1: bur preparation (bp) + Vertise Flow (VF); Group 2: laser preparation (lp) + VF; Group 3: bp + Adper Easy One (AEO) + Filtek Ultimate Flowable Composite (FUFC); Group 4: lp + AEO + FUFC; Group 5: bp + Clearfil S3 Bond (CSB) + Clearfil Majesty Flow (CMF); Group 6: lp + CSB + CMF. Data were analyzed by Kruskal-Wallis and Mann-Whitney U tests (p < .05). More microleakage was observed in cervical regions compared to occlusal regions in all groups (p < .05). No significant difference was observed among all groups in terms of occlusal and cervical surfaces, respectively (p > .05). The use of the Er:YAG laser for cavity preparation with different adhesive systems and flowable composites did not influence microleakage., (© 2016 Wiley Periodicals, Inc.)

Condyloma acuminata (CA) are warty lesions caused by human papilloma virus (HPV) that generally affect the external genitalia and mucocutaneous junctions. Involvement of the urinary tract is rare, and involvement of the urinary bladder is thought to be due to immunosuppression. A 30-year-old woman was diagnosed with urethral CA 12 months after renal transplantation. She underwent transurethral resection (TUR) of the urethral lesions. During the operation, multiple sessile warty lesions were found incidentally inside the bladder and were also removed by TUR. The patient's postoperative course was uneventful. Pathological examination confirmed that the lesions were CA. Multiplex real-time polymerase chain reaction was performed to confirm the HPV genotype and revealed type 45 HPV DNA. CA of the urethra are uncommon, and bladder involvement is extremely rare. This case is the first reported, to our knowledge, to involve HPV type 45 in bladder condyloma. TUR may be the preferred option for the management of CA in the urinary bladder., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

The purpose of this study was to compare total-etch, self-etch, and selective etching techniques on the marginal microleakage of Class V composite restorations prepared by Er:YAG laser and bur. Class V cavities prepared on both buccal and lingual surfaces of 30 premolars by Er:YAG laser or bur and divided into six groups. The occlusal margins were in enamel, and the cervical margins were in cementum. Group-1: bur preparation(bp)+Adper Single Bond 2 (ASB)+Filtek Z550 (FZ); Group-2: laser preparation(lp)+(ASB)+(FZ); Group-3: bp + Clearfil S3 Bond Plus (CSBP)+(FZ); Group-4: lp+(CSBP) (FZ); Group-5: bp + acid etching+(CSBP)+(FZ); Group-6: lp + acid etching+(CSBP)+(FZ). All teeth were stored in distilled water at 37°C for 24 hr, and then thermocycled 1000 times (5-55°C). Five teeth from each group were chosen for the microleakage investigation, and two teeth for the scanning electron microscope evaluation. Teeth which were prepared for the microleakage test were immersed in .5% methylene blue dye for 24 hr. After immersion, the teeth were sectioned and observed under a stereomicroscope for dye penetration. Data were analyzed using Kruskal-Wallis and Mann-Whitney U tests (p < .05). More microleakage was observed in the cervical regions compared to the occlusal regions in Groups 3, 5, and 6, respectively (p < .05). There is no statistically significant difference in Groups 1, 2, and 4, in terms of cervical regions versus occlusal regions (p > .05). No significant differences were observed among any groups in terms of occlusal and cervical surfaces, separately (p > .05). Different etching techniques did not influence microleakage of Class V restorations prepared by Er:YAG laser and bur., (© 2016 Wiley Periodicals, Inc.)

The purpose of this study was to investigate how two cavity-filling techniques affect microleakage in class II resin restorations prepared with Er:YAG laser and diamond bur. Standard MO and DO cavities were prepared in 20 extracted third molars, each randomly assigned to either Group-1 [Herculite XRV Ultra-bur-prepared cavity(bp)], Group-2 [Herculite XRV Ultra-laser-prepared cavity(lp)], Group-3 (SonicFill-(bp)], or Group-4 [SonicFill-(lp)]. For Groups 2 and 4, cavities were prepared by using an Er:YAG laser with a wavelength of 2.94 μm, output power of 200 mJ/pulse, and repetition rate of 20Hz. Teeth were restored with a one-step, self-etch adhesive material (OptiBond All-in-One), a nanohybrid composite (Herculite XRV Ultra), and a bulk-fill composite (SonicFill) according to the manufacturer's instructions. Five teeth from each group were chosen for microleakage investigation and two teeth for scanning electron microscope evaluation. Statistical analysis was performed by using Kruskal-Wallis test. Pair-wise comparisons were performed by Mann-Whitney U test with Bonferroni correction (p < 0.05). The statistical analysis of data revealed greater microleakage in cervical versus occlusal regions in all groups (P < 0.05). Group-2 yielded a higher degree of marginal leakage than Group-3 in terms of occlusal surfaces (p < 0.05). For cervical regions, a statistically significant difference was observed between Groups 2 and 3 as well as Groups 2 and 4 (p < 0.05). Group-3 exhibited significantly better marginal sealing than Group-1 in the cervical region (p < 0.05). The cavities prepared using an Er:YAG laser showed greater microleakage than those conventionally prepared using burs regardless of restorative material at both occlusal and cervical margins. SCANNING 38:389-395, 2016. © 2015 Wiley Periodicals, Inc., (© Wiley Periodicals, Inc.)

The purpose of this study was to compare different parameters of Er:YAG laser irradiations on the marginal microleakage of Class V resin composite restorations. A total of 45 extracted premolars were selected for the study. Class V cavities prepared on both buccal and lingual surfaces of teeth by Er:YAG laser or bur and divided into nine groups. The occlusal margins were in enamel and the cervical margins were in cementum. Group-1: bur preparation; Group-2: laser preparation (lp) (600 mJ/5 Hz); Group-3: lp (300 mJ/10 Hz); Group-4: lp (200 mJ/15 Hz); Group-5: lp (150 mJ/20 Hz); Group-6: lp (200 mJ/20 Hz); Group-7: lp (300 mJ/14 Hz); Group-8: lp (400 mJ/10 Hz); Group-9: lp (700 mJ/5 Hz). All teeth were stored in distilled water at 37°C for 24 h, then thermocycled 1,000 times (5-55°C). Five teeth from each group were chosen for the microleakage investigation and two teeth for the scanning electron microscope (SEM) evaluation. Teeth, which were prepared for the microleakage test were immersed in 0.5% methylene blue dye for 24 h. After immersing, the teeth were sectioned and observed under a stereomicroscope for dye penetration. Data were analyzed by Kruskal-Wallis and Mann-Whitney U tests (p < 0.05). More microleakage was observed in cervical regions compared to occlusal regions in all groups (p < 0.05) except for Group 6 (p > 0.05). No significant difference was observed among groups in terms of occlusal and cervical surfaces, separately (p > 0.05). It may be concluded that the cavities prepared by Er:YAG laser showed higher degree of microleakage than bur prepared at cervical regions. Different parameters of Er:YAG laser irradiations affected microleakage. SCANNING 38:434-441, 2016. © 2016 Wiley Periodicals, Inc., (© Wiley Periodicals, Inc.)

The purpose of this report is to present a rare case of a fused mandibular lateral incisor with supernumerary tooth with a follow-up for 18-months. A 35-year-old female patient was referred to our clinic with an extraoral sinus tract in the chin. The intraoral diagnosis revealed the fusion of her mandibular lateral incisors. Vitality pulp tests were negative for mandibular right central and lateral incisors. Radiographic examinations showed a fused tooth with two separate pulp chambers, two distinct roots, and two separate root canals. There were also periapical lesion of fused teeth and mandibular right central incisor, so endodontic treatment was carried out the related teeth. Radiographic examination revealed a complete healing of the lesion postoperatively at the end of 18-months. This paper reports the successful endodontic and restorative treatment of unilateral fused incisors. Because of the abnormal morphology of the crown and the complexity of the root canal system in fused teeth, treatment protocols require special attention.

Objective. The aim of this in vitro study was to evaluate the long-term fracture resistance of simulated human immature permanent teeth filled with BioAggregate™ (BA), mineral trioxide aggregate (MTA), and EndoSequence® Root Repair Material (ERRM). Material and Methods. 40 teeth, simulated to average root length of 13 ± 1 mm (Cvek's stage 3), were included in the study. The teeth were randomly divided into four groups: Group 1: DiaRoot® BA, Group 2: MTA-Plus™ (MTA-P), Group 3: MTA-Angelus (MTA-A), and Group 4: ERRM. The root canal filling materials were applied according to the manufacturers' instructions. After 24 months of incubation, the roots of the teeth were embedded in acrylic blocks and subjected to fracture testing. The resultant data were analyzed statistically by Kruskal-Wallis and Mann-Whitney U tests. Results. Mean (±SD) failure loads (MPa) were 20.46 ± 2.53 for BA, 18.88 ± 5.13 for MTA-P, 14.12 ± 1.99 for MTA-A, and 17.65 ± 4.28 for ERRM groups. BA group exhibited the highest and MTA-A group showed the lowest resistance to fracture. Significant differences in fracture resistance were found between the groups of BA and MTA-A (p < 0.001), MTA-P and MTA-A (p < 0.05), and ERRM and MTA-A (p < 0.05). Conclusion. Within the limitations of this study, data suggests that BA-filled immature teeth demonstrate higher fracture resistance than other groups at 24 months appearing to be the most promising material tested.

Purpose: The purpose of the study was to evaluate the postoperative sensitivity of posterior Class I composite restoration at short-term, restorated with two different all-in-one self-etch adhesives with or without surface sealant application., Materials and Methods: 44 restorations were inserted in 11 patients who required Class I restorations in their molars. Each patient received 4 restorations, thus four groups were formed; (1) G-Aenial Bond (GC, Japan); (2) Clearfil S3 Bond (Kuraray, Japan); (3) G-Aenial Bond+Fortify Plus (Bisco, USA), (4) Clearfil S3 Bond+Fortify Plus. Sensitivity was evaluated at 24h, 7, 15, and 30 days using cold air, ice, and pressure stimuli using a visual analog scale. Comparisons of continuous variables between the sensitivity evaluations were performed using the Friedman's One-Way Analysis of Variance with repeated measures test (p<0.05)., Results: The type of adhesive used and the application of a surface sealant had no significant effects in postoperative sensitivity (p>0.05). The use of Clearfil S3 Bond resulted in almost the same level of postoperative sensitivity as did the use of G-Aenial Bond. The highest sensitivity scores were observed for the surface sealant applied teeth without any statistical significance (p>0.05)., Conclusion: Self etch adhesives displayed postoperative sensitivity. The sensitivity scores slightly decreased at the end of 30 days (p>0.05). Surface sealant application did not result in a decrease in sensitivity scores for either dentin adhesives., Competing Interests: Conflict of interest: None declared.

The purpose of this report is to present a rare case of a maxillary lateral incisor exhibiting two separate root canals confirmed by cone-beam computed tomography (CBCT). A 65-year-old female patient with an esthetic complaint regarding her maxillary left lateral incisor was referred to our clinic. During a radiographical examination, an endodontically treated root canal and an extra root canal with an apical lesion were observed. The retreatment was performed. CBCT findings confirmed the root canal mophology of the maxillary left lateral with two distinct canals. We conclude that the CBCT imaging is an adjunctive tool for better assessment of complex root canal systems.