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1. Rediscovery of penicillin of psychiatry: haloperidol decanoate

Author

Nazan Aydın, Hasan Mervan Aytaç, Esra Yazıcı, Doğan Yılmaz, Pınar Çetinay Aydın, Gökşen Yüksel Yalçın, Yücel Kadıoğlu, Cana Canbay, Merve Terzioğlu, Onur Şenol, Cavide Çakmak, and Aysel Özer

Subjects
schizophrenia, long-term antipsychotics, haloperidol decanoate, extrapyramidal side effects, metabolic side effects, adherence, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

BACKGROUND: Haloperidol has been used as an effective antipsychotic for many years and continues to be one of the first options in difficult patients who require parenteral therapy in the acute phase. However, the depot form is less preferred in the treatment of patients with non-adherence among these patients whose clinical stabilization has been achieved by using parenteral haloperidol in the acute phase. Therefore, updating the information about the side effects of the depot form of haloperidol, which is still an effective treatment option, will be useful in reconsidering the position of this medicine among new and different options. METHODS: A total of 54 schizophrenic patients with severe symptoms and poor adherence to treatment who were hospitalized and treated with depot haloperidol following an acute stabilization period were included in this study. First, the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-CV) was used to confirm the diagnosis, the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS) and Scale for the Assessment of Negative Symptoms (SANS) to assess the clinical severity and Global Assessment of Functioning (GAF) to assess the functionality. The Simpson-Angus Scale (SAS) was used to assess extrapyramidal side effects. With the exception of Visit 0, plasma haloperidol levels were measured at all visits. Also, measurements of waist circumference and weight, plasma fasting blood glucose, triglyceride, HDL, iron, haemoglobin (Hgb), prolactin (PRL) and HbA1c were also used for evaluation of the metabolic effects. RESULTS: Significant improvements were observed in the BPRS, SANS, SAPS scores in the long-term follow-up with the depot haloperidol treatment. While the dosage decreased over time, the plasma levels remained changed, and symptom improvement was maintained. No signs such as neuroleptic malignant syndrome or acute dystonia were observed and SAS scores were within acceptable limits during the treatment (μ = 1.40 ± 2.55). There is no statistically significant difference between measurements of the weight even there was a significant difference between three of the waist circumference values (p = 0.987). The first measurement of the waist circumference is statistically significantly higher than both the mid-measurement and the final measurement, interestingly (p = 0.002). When fasting blood glucose, triglyceride, HDL, iron, Hgb, PRL and HbA1c were measured at different times throughout the study, only prolactin levels increased significantly over time with the use of haloperidol (p

Published
2019
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2. Oral Research Presentations

Author

Hatice Gözde Akkın Gürbüz, Levent Turhan, Nilgun Şendil, Halim Ömer Kaşıkçı, Banu Salepçi, Derya Ipekcioglu, Canan Kuygun Karcı, Perihan Çam Ray, Ayşegül Yolga Tahiroğlu, Ayşe Avcı, Gonca Gül Çelik, Necmi Cekin, Nurdan Evliyaoğlu, Mehmet Alkanat, Hafize Özdemir, Egemen Akgün, Mehmet Emin Demirkol, Lut Tamam, Erman Esnafoglu, Doğa Sevinçok, Çağdaş Öykü Memiş, Bilge Doğan, Burcu Çakaloz, Ayşe Kutlu, Levent Sevinçok, Sema Nur Türkoğlu Dikmen, Yasir Şafak, Rıza Gökçer Tulacı, İlker Özdemir, Sema Baykara, Kübra Alban, Nazan Aydın, Hasan Mervan Aytaç, Doğan Yılmaz, Pınar Çetinay Aydın, Gökşen Yüksel Yalçın, Cana Canbay, Merve Terzioğlu, Aysel Özer, Ebru Altintas, Meryem Özlem Kütük, Ali Evren Tufan, Harika Gözükara Bağ, Güliz Şenormancı, Oya Güçlü, Cemil Çelik, Abdullah Bolu, Taner Öznur, Mehmet Sinan Aydın, Yusuf Tokgöz, Özcan Uzun, Sakır Gıca, Burç Çağrı Poyraz, Yağmur Sever Fidan, Hüseyin Güleç, Erdoğdu Akça, Mesut Yıldız, Zeynep Nur Demirok Akça, Yusuf Öztürk, Gonca Özyurt, Kadir Özdel, Gulcin Elboga, Muhammet Berkay Ozyurek, Abdullah Akgün, Ali Coşkun, Ayhan Bilgiç, Rukiye Çolak Sivri, İbrahim Kılınç, Ahmet İnal, Uğur Eray, Murat Acat, Arif Önder, Aslı Sürer Adanır, Canem Kavurma, Öznur Bilaç, Yakup Doğan, Rukiye Ay, Çağatay Uğur, Betül Gül Alıç, Mehmet Gündüz, Özlem Ünal, Ömer Uçur, Özlem Özcan, Hasret Karabulut Gül, Demet Sağlam Aykut, Ahmet Tiryaki, Filiz Civil Arslan, Gül Alkan Bülbül, Ömer Yolcu, Aysel Uysal, Esin Özatalay, Selma Cırrık, Esin Erdogan, Dursun Hakan Delibas, Hazan Tomar Bozkurt, Rukiye Tekdemir, Vefa Erbasan, Okan İmre, Memduha Aydın, Kürşat Altınbaş, Başak Karabucak, Halime Tuna Çak Esen, Sadriye Ebru Çengel Kültür, Remzi Karaokur, Songül Atasavun Uysal, Nurhan Erbil, Meltem Çiğdem Kirazlı, Tayfun Kara, Ajda Mutlu Mıhçıoğlu, Semra Yılmaz, İsmail Akaltun, Abdullah Atli, Zübeyir Can, Emine Füsun Akyüz Çim, Aslıhan Okan İbiloğlu, Nilfer Şahin, Hülya Ertekin, Zehra Başar Kocagöz, Adnan Özçetin, Ahmet Ataoğlu, Şengül Cangür, Safiye Bahar Ölmez, Neslihan Yazar, Halit Necmi Uçar, Duygu Murat, Şafak Eray, Yaşar Tanır, Hatice Altun, Mehmet Hanifi Tanyeri, Mehmet Emin Büyükokuroğlu, Pelin Tanyeri, Oguz Mutlu, Füruzan Yıldız Akar, Güner Ulak, Bekir Faruk Erden, Feyza Hatice Sevgen, Asiye Arıcı, Fethiye Kılıçaslan, Mehmet Fatih Erbay, Cengiz Darılmaz, Fikret Poyraz Çökmüş, Serra Yüzeren, Didem Sücüllüoğlu Dikici, Orkun Aydın, Pınar Ünal Aydın, Fatma Akdeniz, Siğnem Öztekin, Emine Özge Çöldür, Kuzeymen Balıkçı, Ertuğrul Köroğlu, Ömer Aydemir, Hüseyin Kara, Özgen Özçelik, Mehmet Murat Balcı, Mehmet Murat Kuloğlu, Talya Tomar, Fatma Taneli, Arzu Oran, Gülgün Yılmaz Ovalı, Gamze Yapça Kaypaklı, Özge Metin, Hakan Karaş, Halil Çetingök, Reşat İlişer, Elif Çarpar, Muzaffer Kaşer, Güneş Şayan Can, Gözde Ulaş, Ayşegül Ildız, Neslihan Emiroğlu, Emel Ada, Ayşegül Özerdem, Okan Imre, Oğuz Mutlu, Furuzan Yıldız Akar, Uğur Tekin, Ayşegül Satar, Ayşe Nur Aydın, Hatice Serpil Erermiş, Orhan Kocaman, Nihal Yurteri Çetin, Aynur Akay, Yüksel Sümeyra Karagöz, Özlem Doğan, Serenay Ülkar, Birim Günay Kılıç, Hacer Akgül Ceyhun, Esat Fahri Aydın, Tuba Ülkevan, Nilifer Gürbüzer, Hasan Cem Aykutlu, Işık Görker, Emel Özen, Evrim Aktepe, Mustafa Asım Aydın, Dudu Dilek Yavuz, Umut Karaaslan, Abdullah Karataş, Zehra Sancak, Erhan Eser, Mehmet Murat Demet, Mehmet Emrah Karadere, Ece Yazla Asafov, Halil İbrahim Ölçüm, Ayhan Algül, İbrahim Gündoğmuş, Fatih Hilmi Cetin, Hasan Ali Guler, Serhat Turkoglu, Bahar Keleş Çolpan, Elif Bayram, Funda Seher Özalp Ateş, Serap Tıraş Teber, Nagihan Saday Duman, Emel Sarı Gökten, Elif Nurgül Sungur, Melike Ceyhan Balcı Şengül, Ayşen Çetin Kardeşler, Yaşar Enli, Neslihan Kurtul, Cihan Aslan, Bahadır Konuşkan, Burçin Şener, Banu Anlar, Fatih Ünal, Bülent Devrim Akçay, Güray Koç, Sinan Yetkin, Serkan Bayad, Müge Elbir, Özge Alp Topbaş, Tuğba Kocabaş, Adem Aydın, Pelin Avcu Çelik, Deniz Argüz Çıldır, Aylin Özbek, Aybuke Tuğçe Mustan, Ayşe Sevgi Karadağ, Aysun Kalenderoğlu, Mehmet Hamdi Örüm, Murat Eren Özen, Oğuzhan Bekir Eğilmez, Dilek Bingöl Aydın, Bahri Elmas, Serhat Nasıroğlu, Engin Aydın, Öner Özdemir, Özcan Erel, Ülker Fedai, Mehmet Asoğlu, Rümeysa Yeni Elbay, Hasan Turan Karatepe, Celal Ulaşoğlu, Hamza Ayaydın, Berkan Şahin, Koray Karabekiroğlu, Abdullah Bozkurt, Miraç Barış Usta, Muazzez Aydın, Cansu Çobanoğlu, Yalçın Kahya, Dilara İnan, Ali Ercan Altınöz, Ferdi Köşger, Altan Eşsizoğlu, Mehmet Arslan, Ali Metehan Çalışkan, Duygu Göktaş, İkbal İnanlı, Saliha Çalışır, İbrahim Eren, Zeynep Baran Tatar, Erhan Kurt, Gokhan Unal, Feyza Aricioglu, Mustafa Esad Tezcan, Tuğba Kalyoncu, Fazilet Ergüvendi, Çigdem Yektaş, Recep Eroz, Gokhan Yurdakul, Mahmut Cakır, Mehmet Yalcin Tasmektepligil, Saliha Baykal, Mirac Barıs Usta, Melih Nuri Karakurt, Koray Karabekiroglu, Yasemin Yulaf, Funda Gümştaş, Sebla Gökçe, Yankı Yazgan, Doğa Sevincok, Tugba Kalyoncu, Fazilet Arkat Ergüvendi, İbrahim Yağcı, Sema Avcı, Yüksel Kıvrak, Alişan Burak Yaşar, Ceyhun Sayman, Serap Erdoğan Taycan, Yılmaz Çetinkaya, Anıl Gündüz, Hülya Tireli, Kemal Utku Yazici, Ipek Percinel Yazici, Pınar Aksu Kılıçle, Süleyman Gül, Ipek Percınel Yazici, Ayçin Darıcı Sümer, Esra Çöp, Duygu Bilgili, Müge Şahin, Gülser Şenses Dinç, Özlem Hekim, Emine Dibek Mısırlıoğlu, Funda Kurt, Zeynep Göker, Özden Üneri, Eray Atalay, İrem Yıldırım, Ali İnaltekin, Bengü Yücens, Vahap Ozan Kotan, Nihal Özkayar, Fatih Dede, Rabia Nazik Yüksel, Şenol Bayram, Zeynep Kotan, Erol Göka, Gökçe Nur Say, Merve Kalyoncu, Özlem Beğinoğlu, Bahadir Bilgin Basgoz, Semra Ince, Umut Safer, and İlker Tasci

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2018
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3. Outstanding Awards Brief Reports

Author

Ferhat Can Ardic, Samet Kose, Mustafa Solmaz, Filiz Kulacaoglu, Yasin Hasan Balcioglu, Emrah Yıldız, Gülçin Elboğa, Abdurrahman Altındağ, Mehmet Arslan, Ali Metehan Çalışkan, Duygu Göktaş, İkbal İnanlı, Saliha Çalışır, İbrahim Eren, Gokhan Unal, Feyza Aricioglu, Yasemin Yulaf, Funda Gümştaş, Sebla Gökçe, Yankı Yazgan, Çağdaş Öykü Memiş, Doğa Sevincok, Bilge Doğan, Ayşe Kutlu, Burcu Çakaloz, Levent Sevinçok, Tuğba Mutu, Esra Yazici, Derya Guzel, Atila Erol, Nazan Aydın, Hasan Mervan Aytaç, Doğan Yılmaz, Pınar Çetinay Aydın, Gökşen Yüksel Yalçın, Cana Canbay, Merve Terzioğlu, and Aysel Özer

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2018
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4. Case Reports Presentations

Author

Mustafa Dinçer, Cemil Çelik, Elif Ecem Helvalı, Şahin Bodur, Emine Tuğçe Akçaer, Serdar Süleyman Can, Görkem Karakaş Uğurlu, Sümeyye İslamoğlu, Semra Ulusoy Kaymak, Yasemin Taştorun, Oğuz Peker, Ali Çayköylü, Zehra Ece Soğucak, Aslı Sürer Adanır, Esin Özatalay, Arif Önder, Abdurrahman Erdem Başaran, Ayşen Bingöl, Berhan Akdağ, Murat İlhan Atagün, Yakup Doğan, Öznur Bilaç, Canem Kavurma, Gülseren Taşkıran, Aybike Erdem, Zehra Başar Kocagöz, Adnan Özçetin, Ahmet Ataoğlu, Merve Çavdar Toraman, Özgen Özçelik, Hüseyin Kara, Talya Tomar, Buket Cinemre, Yusuf Tokgöz, Taner Öznur, Abdullah Bolu, Özcan Uzun, İkbal İnanlı, Deniz Altunova, Ali Metehan Çalışkan, İbrahim Eren, Tüba Şerife Elmas, Yasemin Gökçenoğlu, Saliha Çalışır, Ali Baran Tanrıkulu, Şenay Yıldız Bozdoğan, Fatma Şahin, Ceren Çamur, İbrahim Gündoğmuş, Abdulkadir Karagöz, Ayhan Algül, Ebru Doneray, Ipek Percinel Yazici, Kemal Utku Yazici, Aslı Adanır, Yetiş Işıldar, Ebru Sağlam, Ayhan Bilgiç, Betül Akbaş, Çağla Çelikkol, Seher Serez Öztürrk, Hilal Seven, Dudu Demiröz, Seda Özbek, İsmet Esra Çiçek, Fatma Coşkun, Ömer Faruk Akça, Doğa Sevinçok, Çağdaş Öykü Memiş, Burcu Çakaloz, Bilge Çetin İlhan, Tuba Şerife Elmas, Azra Sehure Yaşar, Nafiye Yağlı, Osman Ak, Recep Başaran, Mehmet Murat Balcı, Mehmet Murat Kuloğlu, İbrahim Taş, Sehure Azra Yaşar, Mustafa Çağrı Yıldız, Ebru Çiftçi, Hasan Ali Guler, Ali Kandeger, Dilara Guler, Serhat Turkoglu, Önder Küçük, Ferhat Yaylacı, Handan Özek Erkuran, Betül Kurtses Gürsoy, Seher Serez Öztürk, Berrin Ünal, Gizem Aral, Evrim Özkorumak Karagüzel, Demet Sağlam Aykut, Filiz Civil Arslan, Ezgi Karagöz, Neslihan Emir İnaloğlu, Necati Uzun, Mutlu Muhammed Özbek, Mustafa Tolga Tunagür, Bilge Doğan, Levent Sevinçok, Abdullah Akgün, Kamil Nahit Özmenler, Tayfun Kara, İsmail Akaltun, Ayşe Erdoğan Kaya, Esra Yazıcı, Muhammed Nurullah Sezer, Çağlar Turan, Engin Sert, Yusuf Ezel Yıldırım, Pınar Çetinay Aydın, Sevilay Kunt, Tonguç Demir Berkol, Erman Esnafoglu, Öznur Adıgüzel, Serhat Tunc, Hamit Serdar Basbug, Selçuk Dalyan, Şermin Bilgen Ulgar, Hamza Ayaydın, Sema Bozbey, Merve Yazıcı, Çiğdem Yektaş, Enes Sarıgedik, Mehmet Asoğlu, Betül Uyar Ekmen, Hasan Akçalı, Cuma Taş, Cansu Mercan Işık, Belde Demirci, Seda Aybüke Sarı, Ayla Uzun Çiçek, Ezgi Eynalli, Ozge Metin, Perihan Cam Ray, Aysegul Yolga Tahiroglu, Gonca Gul Celik, Tuğçe Akçaer, Elif Merve Kurt, İbrahim Özkan Göncüoğlu, İsmail Ak, Merve Tsakir Chasan, Lut Tamam, Soner Çakmak, Mehmet Emin Demirkol, Erdem Örnek, Ayşe Sakallı Kani, Volkan Topçuoğlu, Rukiye Çolak Sivri, Nihal Yurteri Çetin, Merve Sertdemir, Emre Ürer, Gökçen İlçioğlu Ekici, Birim Günay Kılıç, Keziban Turgut, Canan Kuygun Karci, Ayse Avci, Azra Yaşar, Sümeyra Elif Kaplan, Hazal Muhsinoglu, Alper Zıblak, Ayşe Nur İnci Kenar, Cantekin Can, Canan Kuygun Karcı, Gamze Kutlu, Çağlar Soykan, Cansu Pınar Şen, Mehmet Fatih Ceylan, Selma Tural Hesapçıoğlu, Özden Şükran Öneri, Abdullah Karataş, Hatice Altun, Umut Karaaslan, Nurdan Kasar, Nilfer Şahin, Damla Balkan, Aslıhan Okan İbiloğlu, Abdullah Atli, Rabia Erdogan, Esra Yazici, Tugba Mutu, Ozlem Akcay Ciner, Ali Savas Cilli, Atila Erol, Esra Porgalı Zayman, Cengiz Darılmaz, İsmail Reyhani, Rıfat Karlıdağ, Kübra Yıldırım, Yunus Emre Dönmez, Serdar Karatoprak, Özlem Özcan, Ali Hakan Öztürk, Özden Şükran Üneri, Perihan Turhan Gürbüz, Mustafa Uğurlu, Özlem Doğan, Tahir Kurtuluş Yoldaş, Nuran Bilgen, Vesile Altınyazar, Muhammed Mutlu Özbek, Ebru Ulu, Esra Demirci, Sevgi Özmen, Ümit Haluk Yeşilkaya, Ozge Sahmelikoglu Onur, Omer Akay, Yasin Hasan Balcioglu, Fatih Oncu, Çiğdem Toklu Yalvaç, Ümit Işık, Erol Erkan, Mehmet Hamdi Örüm, Tezan Bildik, Mahmut Zabit Kara, Helin Yılmaz, Hasan Akın Tahıllıoğlu, Aysun Kalenderoğlu, Oğuzhan Bekir Eğilmez, Murat Eren Özen, Yaşar Kapıcı, Ümit Kılıçoğlu, Murad Atmaca, Gulgaz Karimova, Asiye Arıcı, Feyza Hatice Sevgen, Zehra Alğan, Fadime Dalboy, Mehmet Ak, Faruk Uğuz, Kübra Kılınç, Fatih Hilmi Çetin, Serhat Türkoğlu, Semra Yılmaz, İbrahim İbiloğlu, Mustafa Özkan, Osman Bertizlioğlu, Ece Merve Yazar, Ahmet Özercan, Mehmet Kemal Kuşçu, Muhammet Akbolat, Gazanfer Ekinci, İpek Midi, Fatih Mücahit Harmankaya, Adem Aydın, Neslihan Yazar, Busra Bahar Ataoğlu, Neşe Yorguner Küpeli, Necati Serkut Bulut, Kaan Kora, Cihad Yükselir, Serkan Zincir, Dilşad Yıldız Miniksar, Pelin Çon Bayhan, Faruk Pirinççioğlu, İsmail Karka, Meltem Göbelek, Öznur Akıl, Sümeyra Güngören, Deniz Deniz Özturan, Zeynep Bebek Yılmaz, Derya Deniz Kürekçi, Aykut Özturan, Mihriban Ünay, Hasan Mervan Aytaç, Nazan Aydın, Can Tuncer, Volkan Seneger, Burcu Bakar Kahraman, Selma Hilal Avcı, Hasan Turan Karatepe, Mehmet Arslan, Sıla Çalışkan, Yusuf Çokünlü, Zeynep Yücehan, Seher Serez Öztrük, Hatice Yardım Özayhan, Özlem Karakaya, Gökçen Turan, Burak Elbeyli Ahmet, Safiye Bahar Ölmez, Merve Çavdar, Evrim Aktepe, Pınar Aydoğan Avşar, Yakup Erdoğan, Özlem Beğinoğlu, Rümeysa Yeni Elbay, Hayriye Hızarcıoğlu Gülşen, Arzu Yılmaz, Yasemin İmrek, Mesut Sari, Büşra Pala, Yusuf Öztürk, Güler Göl, Mehmet Akif Cansız, Uğur Savcı, Berna Gündüz Çıtır, Hatice Aksu, Sema Çam Salihoğlu, Nurhak Çağatay Birer, Güler Özkula, Ercan Altınörs, Fatih Baz, Mesut Yıldız, Leyla Bozatlı, Hasan Cem Aykutlu, Işık Görker, Oğuzhan Sapdüzen, Çiçek Hocaoğlu, Alphan Anak, Mesut Yılmaz, Yeliz Doymaz, Ece Ayyıldız, Mehmet Baltacıoğlu, Selvi Ceran Kayıpmaz, Ali Ercan Altınöz, Arzu Oğuz, Sema Çam Salihoglu, Hacer Gizem Gerçek, Mehmet Ayhan Cöngöloğlu, Emre Subas, Selin Alkan, Suat Yalcin, Suleyman Donmezler, Sevilay Umut Kilinc, Burcu Hamurisci Yalcin, Guliz Ozgen, Ahmet Turkcan, Ayse Ceren Kaypak, Nese Yorguner Kupeli, Ali İnaltekin, İbrahim Yağcı, Yüksel Kıvrak, Emine Füsun Akyüz Çim, Leyla Delikanli, Mustafa Tuncturk, Oguz Bilal Karakus, Ali Guven Kılıcoglu, Gul Karacetin, Merve Okuyan, Halil İbrahim İvelik, Burak Okumuş, Rukiye Tekdemir, Memduha Aydın, Nihal Taştekin, Betül Kırşavoğlu, Murat Yalçın, Sibel Ayvaz, Ayşe Gülşah Kırımlı, Ayşegül Taşdelen Kul, Huda Pasli, Mine Ozkan, and Ferda Volkan

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2018
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5. Turkish Validity and Reliability Study of the ECT Perception and Knowledge Scale

Author

Yusuf Ezel Yıldırım, Pınar Çetinay Aydın, and Nalan Öztürk

Subjects
Psychiatry and Mental health, General Neuroscience, Research Article
Abstract

INTRODUCTION: Electroconvulsive Therapy (ECT) is an effective and safe treatment method used in the treatment of various psychiatric diseases. However, negative attitudes associated with ECT are common. This causes many negative consequences, from the treatment preference to treatment response and stigma. In this study, we aimed to carry out a validity-reliability analysis of the ECT Perception and Knowledge Scale (ECT-PK), which was developed to determine the perception and knowledge levels related to ECT, and adapt it to Turkish. METHOD: The Turkish adaptation of the ECT-PK was made using the translation-retranslation method. Our study included 50 patients with schizophrenia, 50 patients with bipolar disorder, 50 patients with major depression who met the remission criteria determined separately for each disorder, and 150 healthy controls.. To measure test-retest reliability, the scale was re-applied to 30 patients randomly selected from the patient group 14–21 days after the first application of the scale. RESULTS: In our study, a significant difference was found in both the patient and control groups in terms of the history of ECT application in the past and the status of accepting ECT application when recommended, and the perception and knowledge subscales of the ECT-PK. These results support the construct and criterion validity of the ECT-PK. Cronbach’s alpha coefficient was found to be 0.85 for the perception subscale and 0.78 for the knowledge subscale. The intra-class correlation coefficient used to evaluate the test-retest reliability was 0.86 for the perception scale and 0.83 for the knowledge subscale. CONCLUSION: It has been shown that the ECT-PK is a valid and reliable measurement tool that can be used to measure the perception and knowledge levels related to ECT in both clinical and non-clinical groups.

Published
2023

6. Memory deficits and frontal lobe syndrome associated with bilateral globus pallidus lesions in a patient with synthetic cannabinoid use

Author

Pınar Çetinay Aydın, Fatma Sibel Bayramoğlu, Tonguç Demir Berkol, and Merve Çukurova

Subjects
business.industry, lcsh:RC435-571, medicine.medical_treatment, Globus pallidus, Anatomy, nervous system diseases, frontal lobe syndrome, Psychiatry and Mental health, lcsh:Therapeutics. Psychotherapy, lcsh:RC475-489, Frontal lobe, nervous system, amnesia, synthetic cannabinoid use, lcsh:Psychiatry, medicine, Cannabinoid, business
Abstract

Major strategic functions of the basal ganglia are thought to involve the fine tuning and modulation of the activity of the most parts of the frontal cortex, control of the skeleto-motor and oculo-motor movements, and modulation of the limbic system and associative functions. In this case report, a patient with a 10-year history of synthetic cannabinoid use and bilateral symmetrical hyperintense lesions of the globus pallidus in T2 weighed images following head trauma is described in conjunction clinical signs of global amnesia, behavioral changes consistent with frontal lobe syndrome, and reduced affect display, without any movement disorders. To the best of our knowledge, this patients represents the first case who had bilateral globus pallidus lesions due to synthetic cannabinoid use together with frontal lobe syndrome-like clinical signs without movement disorder. This case report points out to the fact that synthetic cannabinoid use may lead to development of bilateral globus pallidus lesions, which may be associated with amnesia without movement disorder, suggesting that this clinical picture may have resulted from the interruption of pathways between the prefrontal cortex and basal ganglia.

Published
2018

7. Two Cases of Schizophrenia; The Relationship Between Cavum Septum Pellucidum and Clinical Course

Author

Pınar Çetinay Aydın, Engin Sert, Yusuf Ezel Yıldırım, Tonguç Demir Berkol, and Sevilay Kunt

Subjects
First episode, Pediatrics, medicine.medical_specialty, animal structures, business.industry, Schizophrenia (object-oriented programming), fungi, Neuropsychology, Disease, behavioral disciplines and activities, Lateral ventricles, medicine.anatomical_structure, parasitic diseases, mental disorders, medicine, Etiology, business, Cavum septum pellucidum, Septum pellucidum
Abstract

Septum pellucidum, which forms the medial wall of the lateral ventricles, consists of two laminates. Cavum septum pellucidum (CSP) is defined when there is a space between these laminae. In some MRI studies have shown a higher rate of large CSP in patients with schizophrenia than in normal subjects. Looking at the literature on psychiatric disorders, CSP has been shown to be most associated with schizophrenia. Large CSP supports the neurodevelopmental model, which is one of the etiological explanations of schizophrenia. In our study, two patients with a diagnosis of CSP are mentioned. One of our patients is a first episode of schizophrenia, and the other one chronic schizophrenia patient with a history of multi-drug resistance. The first episode of schizophrenia is consistent with the information available in the literature in terms of the severity of symptoms, weak-response to treatment, and insufficiency of neuropsychological tests. The apparent deficit of the chronic schizophrenia patient suggests that CSP has a neurodevelopmental model in the etiology of schizophrenia, as well as the duration of the disease and non-compliance with treatment. There is no study in the literature comparing the response to treatment with large CSP in schizophrenia. It is thought that investigation of response to treatment in future studies is important for demonstrating the effects of neurodevelopmental model on the treatment of psychiatric disorders.

Published
2019
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9. CNR2 rs2229579 and COMT Val158Met variants, but not CNR2 rs2501432, IL-17 rs763780 and UCP2 rs659366, contribute to susceptibility to substance use disorder in the Turkish population

Author

Selin Kurnaz, Ahmet Bulent Yazici, Ayse Feyda Nursal, Pinar Cetinay Aydin, Ayca Ongel Atar, Nazan Aydin, Zeliha Kincir, and Sacide Pehlivan

Subjects
substance use disorder, variant, pcr-rflp, comt, cnr2, ucp2, il-17, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

OBJECTIVE: Substance use disorders (SUD) are among the most important public health problems throughout the world. We investigated whether COMT (Val108/158Met), CNR2 (rs2501432 and rs2229579), UCP2 (rs659366), and IL-17 (rs763780) gene variants were associated with SUD and its clinical parameters in a Turkish population. METHODS: We conducted a case–control study among 136 subjects with SUD and 100 healthy controls. Six variants were analysed by the PCR-RFLP method. RESULTS: The CNR2 rs2229579 T/T genotype and T allele increased in SUD groups than controls while the C/C genotype and C allele were more prevalent in the control group compared to the SUD group (p = 0.000 and p = 0.001, respectively). The COMT Val108/158Met Val/Val genotype and Val allele were significantly associated with polysubstance abuse (p

Published
2019
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10. Possible association between DNA repair gene variants and cannabis dependence in a Turkish cohort: a pilot study

Author

Sacide Pehlivan, Ahmet Bulent Yazici, Nazan Aydin, Ayse Feyda Nursal, Selin Kurnaz, Ayca Ongel Atar, Ulgen Sever, Zeliha Kincir, Mustafa Pehlivan, and Pınar Cetinay Aydin

Subjects
Substance use disorder, cannabis, DNA repair, XRCC1, XRCC4, XPD, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

OBJECTIVE: Substance use disorder (SUD) has important effects on health and well-being. It is well known that genetic factors play a role in SUD. The purpose of this research was to investigate whether functional variants of DNA repair genes might be a risk factor for cannabis and/or synthetic cannabis dependence in a Turkish cohort. METHODS: In total, 131 patients with cannabis and/or synthetic dependence and 70 healthy controls were included in this case–control study. XRCC1 codon 399 (rs25487) and XRCC4 G1394 T (rs6869366), and XPD (rs13181) variants were determined by the polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). RESULTS: The XRCC1 rs25487 GG genotype and G allele were significantly lower in patients compared to controls (p = 0.005; p = 0.002, respectively). XRCC4 rs6869366 TT genotype and T allele were more common in patients compared to controls (p = 0.001, p = 0.001, respectively). It was found that patients with XPD rs13181 Lys/Gln had a significantly higher risk of cannabis dependence than control did (p = 0.00). The subjects carried XPD rs13181 Gln/Gln genotype had a 2.2-fold increased risk for cannabis dependence (p = 0.010). CONCLUSIONS: We demonstrated for the first time that DNA repair gene variants may alter individual vulnerability for SUD. This observation could be of further interest to researchers, as it could suggest new candidate genes, presumably crucial for the etiopathogenesis of the cannabis and/or synthetic cannabis dependence.

Published
2018
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11. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Özge Şahmelikoğlu Onur, Merve Çukurova, Sevda Bağ, Suat Yalçın, Cansu Çakır Şen, Çağatay Karşıdağ, Serdar Süleyman Can, Emine Tuğçe Akçaer, Ayşegül Taşdelen Kul, Mustafa İspir, Osman Bakkal, Ayhan Algül, Servet Ebrinç, Cihad Yükselir, Serkan Zincir, Pelin Öztürk, Bülent Karaahmetoğlu, Özlem Baş, Sema Ulukaya, Çağlar Soykan, Ali Çayköylü, Neslihan Yazar, Zehra Başar Kocagöz, Adnan Özçetin, Safiye Bahar Ölmez, Ahmet Ataoğlu, Yasin Hasan Balcioglu, Tonguc Demir Berkol, Filiz Ekim Cevik, Fatih Oncu, Guliz Ozgen, Dudu Demiröz, Hatice Yardım Özayhan, Hilal Seven, Mustafa Çağrı Yıldız, Recep Başaran, İbrahim Eren, Elif Özlem Canazlar, Levent Sevinçok, Bilge Doğan, Çağdaş Öykü Memiş, Ali Baran Tanrikulu, İkbal İnanli̇, Mustafa Çağri̇ Yi̇ldi̇z, Tuba Şerife Elmas, Ibrahim Eren, Şükrü Alperen Korkmaz, Cansu Pınar Şen, Mehmet Fatih Ceylan, Selma Tural Hesapçıoğlu, Burcu Bakar, Can Tuncer, Rümeysa Yeni Elbay, Aynur Görmez, Yusuf Tokgöz, Abdullah Bolu, Cemil Çelik, Özcan Uzun, Simge Seren Kirlioglu, Pinar Cetinay Aydin, Mustafa Uğurlu, Görkem Karakaş Uğurlu, Zuhal Koç, Nazlı Kapubağlı, Ömer Faruk Tuncer, Gülsen Ünlü, Esra Kabadayı Şahin, Zuhal Koç Apaydın, Semra Ulusoy Kaymak, Oğuz Peker, Bedriye Özkan, Ali Güven Kılıçoğlu, Gül Karaçetin, Zeynep Yücehan, Tuğba Şerife Elmas, Nafiye Yağlı, Bilge Çetin İlhan, Derya Adali Aker, Yiğit Kıvılcım, Mustafa Solmaz, Yeşim Ruhat Kutlu, Bahar Yeşil, Behice Han Almış, Başak Küçük, Cem Cerit, Burcu Sarici, Ayşe Ceren Kaypak, Erensu Baysak, Serhat Ergün, Mesut Yildiz, Aslihan Okan Ibiloglu, Abdullah Atli, Mehmet Asoglu, Mustafa Ozkan, Nursu Çakın Memik, Hatice Ünver, Özlem Yıldız Gündoğdu, Necati Uzun, Ömer Faruk Akça, Gizem Aral, Demet Sağlam Aykut, Özgür Maden, İbrahim Gündoğmuş, Fulya Gok, Seda Kiraz, Arif Cipil, Meliha Zengin Eroglu, Elvan Çiftçi, Zeynep Aslan, Melike Kevser Gül, Neslihan Taştepe, Esra Demirci, Sevgi Özmen, Hicran Doğru, Elif Karayağmurlu, Ali Karayağmurlu, Muhsine Göksu, Leyla Ezgi Tügen, Ayşe Burcu Ayaz, Ayşe Arman, Deniz Altunova, Murat İlhan Atagün, Ekrem Güldaş, Güler Göl, Uğur Savcı, Ali Evren Tufan, Seda Yıldırım Özbek, Süleyman Özbek, Hilal Uygur, Başak Demirel, İ. Esra Çiçek, Hüseyin Kara, Mehmet Murat Balcı, Servet Karaca, Mehmet Murat Kuloğlu, Hasan Mervan Aytaç, Mehmet Can Ger, Aslıhan Okan İbiloğlu, Mehmet Asoğlu, Ayşe Çakır, Ahmet Tiryaki, Gülşah Güçlü Çelme, Mehmet Hamid Boztaş, Fatma Sırmatel, Mucahid Erdogan, Cengiz Dayan, Hayrunisa Dilek Atakli, Gülşen Kartalcı, Ebru Yücel, Şükrü Kartalcı, Meliha Zengin Eroğlu, Arif Çipil, Mecit Çalışkan, Emine Cengiz Çavusoglu, Yusuf Özay Özdemir, Ebru Fındıklı, Berkan Şahin, Koray Karabekiroğlu, Mustafa Kurt, Doğa Sevinçok, Merve Sertdemir, Rukiye Ay, Nevzat Yılmaz, Sevcan Karakoç Demirkaya, Hatice Aksu, Hacer Gizem Gerçek, Gülser Karakoç, Ayşe Ender Altıntoprak, Hakan Coşkunol, Ipek Percinel Yazici, Kemal Utku Yazici, Kevser Altıntaş, Fulya Gök, Ferhat Yaylacı, Handan Özek Erkuran, Murat Eyüboğlu, Diğdem Göverti, Rabia Nazik Yüksel, Alper Bülbül, Makbule Çiğdem Aydemir, Erol Göka, Ilgaz Kınalı, Münevver Yıldırım Hacıoğlu, Burcu Sarıcı, Kemal Sayar, Hatice Doğan, Ömer Akay, Heecheol Kim, Hyunjoo Lee, Abdulkadir Karagöz, Hakan Kullakçı, Yasin Duman, Yusuf Çokünlü, Memduha Aydın, Ali Baran Tanrıkulu, İbrahım Eren, Hande Ayraler Taner, Burcu Akın Sarı, Çiğdem Yektaş, Nuran Demir Samurcu, Saliha Çalışır, Özalp Ekinci, Muhammet Emin Tan, Merve Kalınlı, Murat Kıyançiçek, Meltem Küçükdağ, Hasret Karabulut Gül, Emel Uysal, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Burak Karakök, Halime Tuna Çak, Pınar Kızılay Çankaya, İlkay Keleş Altun, Eren Abatan, Ali Metehan Çalışkan, Hatice Kübra Çakı, Burak Doğangün, Muhammed Tayyib Kadak, Mehmet Kefeli, Asiye Arıcı, Hatice Altun, Can Acıpayam, Pelin Çon Bayhan, Elif Nurgül Sungur, Ayşe Nur İnci Kenar, Sevde Afife Ersoy, Mehmet Gürkan Gürok, Sevler Yildiz, Tuba Korucu, Denizhan Danaci Keles, Murad Atmaca, Esra Hoşoğlu, Kübra Kılınç, Barış Şen, Erdem Örnek, Cengiz Çelebi, Ayşe Sakallı Kani, Ömer Yanartaş, Zeynep Şenkal, Yıldız Akvardar, Kaan Kora, Ümran Egilmez, Ali Kandeğer, Özkan Güler, Selcen Dogru Kösker, Elif Ates Budak, Zeliha Deveci Karasin, Mehmet Diyaddin Güleken, Mustafa Celik, Hande Yıldırım, Burçin Güler, Baybars Veznedaroğlu, Funda Lale, Halime Tuna Çak Esen, Göknur Haliloğlu, Nuran Ekinci, Gamze Özçürümez Bilgili, Volkan Seneger, Ümit Işık, Gonca Aşut, Elif Tatlıdil Yaylacı, Ömer Asan, Serkan Güneş, Ebru Çiftçi, Sehure Azra Yaşar, İkbal İnanlı, Sencan Sertçelik, Selma Hilal Avci, Alişan Burak Yaşar, Hasan Turan Karatepe, Melike Dönmez, Volkan Topçuoğlu, Ayhan Bilgiç, Volkan Doğru, Abdullah Bozkurt, Tuğba Kalyoncu, Deniz Argüz Çıldır, Can Beşer, Neşe Perdahlı Fiş, Şermin Bilgen Ulgar, Hamza Ayaydın, Hatice Takatak, Hamza Ayaydin, Cansu Çobanoğlu, Mahmut Müjdeci, Yusuf Yasin Gümüş, Betül Akbaş, Feyza Hatice Sevgen, Fatih Öncü, Nilfer Şahin, Damla Balkan, Fatma Coşkun, Savaş Yılmaz, Çağla Çelikkol, Ganime Dilek Emlik, Hüseyin Çaksen, Derya Arslan, Özden Arısoy, Ahmet Şair, Yaşan Bilge Şair, Dilek Sarı, Mustafa Ispir, Ayhan Algul, Vuslat Kara Ölmeztoprak, Esra Porgalı Zayman, Süheyla Ünal, Ali Hakan Öztürk, Başak Karabucak, Ebru Sadriye Çengel Kültür, Tuna Halime Çak Esen, İpek Fatma Özaktaç, Murat Altın, Ayşe Sena Sarıdoğan, Eser Buluş, Sevilay Güneş, Zehra Koyuncu, Rahime Hülya Bingöl, Mine Uzgel, Selahattin Ayas, Yüksel Kıvrak, Yiğit Şahbal, Kübra Kocagöz, Gamze Kutlu, Ali Baz, Mehmet Akif Cansız, Tugba Kalyoncu, Ebru Sağlam, Özlem Önen, Ayşe Kutlu, Ecenur Aydın Aşık, Şermin Yalın Sapmaz, Serpil Erermiş, Şahika Gülen Şişmanlar, İsmail Karka, Fethiye Kilicaslan, Ceren Enüstün Hürmeydan, Ozge Sahmelikoğlu Onur, Didem Nagehan Sarı, Bahar Kılıç, Elif Merve Kurt, İsmail Ak, Ali Emre Şevik, Ayşe Dilara Yalçın, Ümit Tural, Hilmi Yaşar, Münir Karaaslan, Fatih Kizilağaç, Taner Öznur, Ali̇ Baran Tanri̇kulu, Mustafa Çağri Yildiz, İkbal İnanli, Seher Serez Öztürk, Seda Özbek, İsmet Esra Çiçek, Rıfat Karlıdağ, Mustafa Akan, Lara Utku İnce, İsmail Reyhani, Dilek Çağlar Tetik, Ayşe Büyükaslan, Musa Yılanlı, Ender Cesur, Fatma Belger, Bürge Kabukçu Başay, Cansu Pinar Şen, Selma Tural Hesapcioglu, Gülşen Teksin, Nese Yorguner Kupeli, Serhat Ergun, Abdullah Atlı, Öznur Akıl, and Aslıhan Okan İbilioğlu

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2017
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12. Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome

Author

Yasin Hasan Balcioglu, Simge Seren Kirlioglu, and Pinar Cetinay Aydin

Subjects
Cannabinoids, Isaacs’ syndrome, neuromyotonia, opioids, substance use disorder, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Isaacs’ syndrome (IS) is an autoimmunological hyperexcitability syndrome of the peripheral motor nerves, manifesting with progressive muscle stiffness, involuntary continuous muscle twitching, muscle pain and cramping, sweating, and decreased reflexes. We report a 31-year-old man who was suffering from muscle twitches and stiffness in lower extremities and previously diagnosed with IS in his age of 16 through electrophysiological studies and the shown presence of autoantibodies against voltage-gated potassium channels. Without any adherence to the prescribed treatment, he had been using synthetic cannabinoids and opioids for 10 years. He admitted lessened complaints by using them. Current literature offered cannabinoid receptor agonists not only for symptomatic relief in IS, but also potential modulator effects on both potassium channels and autoimmunity. Opioids were also recognized with their analgesic and antispastic effects in the management of IS. This report aimed to discuss possible medicinal effects and therapeutic mechanisms of aforementioned psychoactive molecules on the symptomatology of IS.

Published
2018
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