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Law concerns every aspect of our lives. However, rarely do scholars investigate metaphors of law, let alone those used in Mandarin, to which smaller attention is devoted in metaphor studies if compared to English. In this study I investigated the word yuan冤, a Chinese word referring to immoral and illegal deeds such as ‘injustice, wrong, tort’, but also ‘vengeance’ and ‘bad luck’, to find the mappings it realises. Previous approaches to Chinese moral metaphors used a source-domain oriented approach, thus finding a limited set of mappings. In this study, I devised a method (MetaCoCoTaC) of finding metaphors at the word compound and collocate level starting from a monosyllabic target-domain word, yuan, that enabled me to find more and new source domains for INJUSTICE, including SOUND, FOOD, MOVEMENT, and ANIMAL. The findings of this research also enable us to account for the polysemy of the word yuan. Moreover, discrepancies with previous studies were discovered as to the way far more predictable domains, such as VERTICALITY and OBJECT, are actually used. Finally, some unique aspects of the Chinese morphology and the Chinese logographic script that are not systematically taken into consideration in relation to metaphor research were also addressed.

L’aide à distance constitue l’un des piliers les plus anciens des stratégies de prévention du suicide.

This study addresses the different types and implications of linguistic indeterminacy in Chinese law. It firstly draws on the studies of scholars of different disciplines, such as linguistics and philosophy of language, to provide a taxonomy of indeterminacy in language. It then provides examples of each type, highlighting the implications in law and legal interpretation. It uses linguistic data from various texts, such as statutory laws and judgements, and analyses them with various methods, including discourse analysis and corpus linguistics. This study argues that when the language of the law is indeterminate, the legal outcomes may be particularly uncertain. It suggests that although it is difficult to ascertain whether the degree of indeterminacy is higher in some languages more than in others, some linguistic mechanisms at the word-formation level in Chinese, such as portmanteaus and the modifier-modified structure, are remarkably ambiguous. When uncertain terms are in key parts of the law, the consequences may be more serious. The study of linguistic indeterminacy in Chinese has implications for the study of forensic linguistics, and Chinese studies in general.

Venous percutaneous transluminal angioplasty (vPTA) in patients with multiple sclerosis (MS) and chronic cerebrospinal venous insufficiency (CCSVI) have shown contradictory results. The aim of the study is to evaluate the efficacy of the procedure in a randomized wait list control study.

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Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-tyrosine catabolic pathway. We analysed DNA of 40 AKU patients enrolled for SONIA1, the first study in DevelopAKUre, and of 59 other AKU patients sent to our laboratory for molecular diagnostics. We identified 12 novel DNA variants: one was identified in patients from Brazil (c.557T>A), Slovakia (c.500C>T) and France (c.440T>C), three in patients from India (c.469+6T>C, c.650–85A>G, c.158G>A), and six in patients from Italy (c.742A>G, c.614G>A, c.1057A>C, c.752G>A, c.119A>C, c.926G>T). Thus, the total number of potential AKU-causing variants found in 380 patients reported in the HGD mutation database is now 129. Using mCSM and DUET, computational approaches based on the protein 3D structure, the novel missense variants are predicted to affect the activity of the enzyme by three mechanisms: decrease of stability of individual protomers, disruption of protomer-protomer interactions or modification of residues in the region of the active site. We also present an overview of AKU in Italy, where so far about 60 AKU cases are known and DNA analysis has been reported for 34 of them. In this rather small group, 26 different HGD variants affecting function were described, indicating rather high heterogeneity. Twelve of these variants seem to be specific for Italy.