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Cytology slides are essential tools in diagnosing and staging cancer, but their analysis is time-consuming and costly. Foundation models have shown great potential to assist in these tasks. In this paper, we explore how existing foundation models can be applied to cytological classification. More particularly, we focus on low-rank adaptation, a parameter-efficient fine-tuning method suited to few-shot learning. We evaluated five foundation models across four cytological classification datasets. Our results demonstrate that fine-tuning the pre-trained backbones with LoRA significantly improves model performance compared to fine-tuning only the classifier head, achieving state-of-the-art results on both simple and complex classification tasks while requiring fewer data samples., Comment: 5 pages, 2 figures

Electrokinetic energy harvesting from evaporation-driven flows in porous materials has recently been the subject of numerous studies, particularly with the development of nanomaterials with high conversion efficiencies. The configuration in which the energy conversion element is located upstream of the element which passively drives the evaporative flow has rarely been studied. However, this configuration offers the possibility of increasing the harvested energy simply by increasing the evaporation surface area and/or the hydraulic resistance of the energy conversion element. In this work, we investigate this configuration with poly(dimethylsiloxane) (PDMS) chips playing the role of {\it artificial leaves} driving a pervaporation-induced flow through a polystyrene colloid plug in a submillimetre tube for the energy conversion. With an appropriate design of the venation of the PDMS leaves, we report the first experimental evidence of electrokinetic energy conversion from pervaporation-induced flows, which increases with the pervaporation area. We also provide new insights by demonstrating that this increase is limited by cavitation within the PDMS leaves, which occurs systematically as soon as the water pressure inside the leaf reaches $P_\text{leaf} \simeq 0$~bar. Whatever the cavitation threshold, this phenomenon imposes an intrinsic limit on this configuration, underlining the need for innovative strategies to improve the harvesting of electrokinetic energy by evaporation.

GPT-4o is an autoregressive omni model that accepts as input any combination of text, audio, image, and video, and generates any combination of text, audio, and image outputs. It's trained end-to-end across text, vision, and audio, meaning all inputs and outputs are processed by the same neural network. GPT-4o can respond to audio inputs in as little as 232 milliseconds, with an average of 320 milliseconds, which is similar to human response time in conversation. It matches GPT-4 Turbo performance on text in English and code, with significant improvement on text in non-English languages, while also being much faster and 50\% cheaper in the API. GPT-4o is especially better at vision and audio understanding compared to existing models. In line with our commitment to building AI safely and consistent with our voluntary commitments to the White House, we are sharing the GPT-4o System Card, which includes our Preparedness Framework evaluations. In this System Card, we provide a detailed look at GPT-4o's capabilities, limitations, and safety evaluations across multiple categories, focusing on speech-to-speech while also evaluating text and image capabilities, and measures we've implemented to ensure the model is safe and aligned. We also include third-party assessments on dangerous capabilities, as well as discussion of potential societal impacts of GPT-4o's text and vision capabilities.

We present new observations from CHEOPS and TESS to clarify the architecture of the planetary system hosted by the old Galactic thick disk star TOI-561. Our global analysis, which also includes previously published photometric and radial velocity data, incontrovertibly proves that TOI-561 is hosting at least four transiting planets with periods of 0.44 days (TOI-561 b), 10.8 days (TOI-561 c), 25.7 days (TOI-561 d), and 77.1 days (TOI-561 e) and a fifth non-transiting candidate, TOI-561f with a period of 433 days. The precise characterisation of TOI-561's orbital architecture is interesting since old and metal-poor thick disk stars are less likely to host ultra-short period Super-Earths like TOI-561 b. The new period of planet -e is consistent with the value obtained using radial velocity alone and is now known to be $77.14399\pm0.00025$ days, thanks to the new CHEOPS and TESS transits. The new data allowed us to improve its radius ($R_p = 2.517 \pm 0.045 R_{\oplus}$ from 5$\%$ to 2$\%$ precision) and mass ($M_p = 12.4 \pm 1.4 M_{\oplus}$) estimates, implying a density of $\rho_p = 0.778 \pm 0.097 \rho_{\oplus}$. Thanks to recent TESS observations and the focused CHEOPS visit of the transit of TOI-561 e, a good candidate for exomoon searches, the planet's period is finally constrained, allowing us to predict transit times through 2030 with 20-minute accuracy. We present an updated version of the internal structure of the four transiting planets. We finally performed a detailed stability analysis, which confirmed the long-term stability of the outer planet TOI-561 f., Comment: 13 pages, 10 Figures. Accepted on MNRAS. Updated the author list

Estimation algebras have been extensively studied in Euclidean space, where finite-dimensional estimation algebras form the foundation of the Kalman and Benes filters, and have contributed to the discovery of many other finite-dimensional filters. This work extends the theory of estimation algebras to filtering problems on Riemannian manifolds in continuous time. Our main result demonstrates that, with non-constant observation functions, the estimation algebra associated with the system on closed Riemannian manifolds is infinite-dimensional., Comment: 6 pages, submitted to IEEE Transaction on Automatic Control

Objectives: To identify a head acceleration event (HAE) severity measure associated with HIA1 removals in elite level rugby union. Methods: HAEs were recorded from 215 men and 325 women with 30 and 28 HIA1 removals from men and women, respectively. Logistical regression were calculated to identify if peak power, maximum principal strain (MPS) and or Head Acceleration Response Metric (HARM) were associated with HIA1 events compared to non-cases. Optimal threshold values were determined using the Youden Index. Area under the curve (AUC) were compared using a paired sample approach. Significant differences were set at p<0.05. Results: All three severity measures were associated with HIA1 removals in both the mens and womens game. Power performed greatest for HIA1 removals in both the mens and womens games, based on overall AUC, sensitivity, and specificity values. HARM and MPS were found to perform lower than PLA in the womens game based on AUC comparisons (p=0.006 and 0.001, respectively), with MPS performing lower than PAA (p=0.001). Conclusion: The findings progress our understanding of HAE measures associated with HIA1 removals. Peak power, a measure based on fundamental mechanics and commonly used in sports performance, may be a suitable HAE severity measure., Comment: 4 Tables, 2 Figures

Dengue virus (DENV) is a mosquito-borne virus with a significant human health concern. With 390 million infections annually and 96 million showing clinical symptoms, severe dengue can lead to life-threatening conditions like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The only FDA-approved vaccine, Dengvaxia, has limitations due to antibody-dependent enhancement (ADE), necessitating careful administration. The recent pre-approval of TAK-003 by WHO in 2024 highlights ongoing efforts to improve vaccine options. This review explores recent advancements in dengue vaccine development, emphasizing potential utility of mRNA-based vaccines. By examining current clinical trial data and innovations, we aim to identify promising strategies to address the limitations of existing vaccines and enhance global dengue prevention efforts., Comment: 16 pages, 1 figure, 1 table

We review and provide new proofs of results used to compare the efficiency of estimates generated by reversible MCMC algorithms on a general state space. We provide a full proof of the formula for the asymptotic variance for real-valued functionals on $\phi$-irreducible reversible Markov chains, first introduced by Kipnis and Varadhan. Given two Markov kernels $P$ and $Q$ with stationary measure $\pi$, we say that the Markov kernel $P$ efficiency dominates the Markov kernel $Q$ if the asymptotic variance with respect to $P$ is at most the asymptotic variance with respect to $Q$ for every real-valued functional $f\in L^2(\pi)$. Assuming only a basic background in functional analysis, we prove that for two $\phi$-irreducible reversible Markov kernels $P$ and $Q$, $P$ efficiency dominates $Q$ if and only if the operator $Q-P$, where $P$ is the operator on $L^2(\pi)$ that maps $f\mapsto\int f(y)P(\cdot,dy)$ and similarly for $Q$, is positive on $L^2(\pi)$, i.e. $\langle f,(Q-P)f\rangle\geq0$ for every $f\in L^2(\pi)$. We use this result to show that reversible antithetic kernels are more efficient than i.i.d. sampling, and that efficiency dominance is a partial ordering on $\phi$-irreducible reversible Markov kernels. We also provide a proof based on that of Tierney that Peskun dominance is a sufficient condition for efficiency dominance for reversible kernels. Using these results, we show that Markov kernels formed by randomly selecting other "component" Markov kernels will always efficiency dominate another Markov kernel formed in this way, as long as the component kernels of the former efficiency dominate those of the latter. These results on the efficiency dominance of combining component kernels generalises the results on the efficiency dominance of combined chains introduced by Neal and Rosenthal from finite state spaces to general state spaces., Comment: 27 pages

We investigate exact nonlinear waves on surfaces locally approximating the rotating sphere for two-dimensional inviscid incompressible flow. Our first system corresponds to a beta-plane approximation at the equator and the second to a gamma approximation, with the latter describing flow near the poles. We find exact wave solutions in the Lagrangian reference frame that cannot be written down in closed form in the Eulerian reference frame. The wave particle trajectories, contours of potential vorticity and Lagrangian mean velocity take relatively simple forms. The waves possess a non-trivial Lagrangian mean flow that depends on the amplitude of the waves and on a particle label that characterizes values of constant potential vorticity. The mean flow arises due to potential vorticity conservation on fluid particles. Solutions over the entire space are generated by assuming that the flow far from the origin is zonal and there is a region of constant potential vorticity between this zonal flow and the waves. In the gamma approximation a class of waves are found which, based on analogous solutions on the plane, we call Ptolemaic vortex waves. The mean flow of some of these waves resemble polar jet streams. Several illustrative solutions are used as initial conditions in the fully spherical rotating Navier-Stokes equations, where integration is performed via the numerical scheme presented in Salmon and Pizzo (2023). The potential vorticity contours found from these numerical experiments vary between stable permanent progressive form and fully turbulent flows generated by wave breaking.

Multi-agent human-robot co-manipulation is a poorly understood process with many inputs that potentially affect agent behavior. This paper explores one such input known as interaction force. Interaction force is potentially a primary component in communication that occurs during co-manipulation. There are, however, many different perspectives and definitions of interaction force in the literature. Therefore, a decomposition of interaction force is proposed that provides a consistent way of ascertaining the state of an agent relative to the group for multi-agent co-manipulation. This proposed method extends a current definition from one to four degrees of freedom, does not rely on a predefined object path, and is independent of the number of agents acting on the system and their locations and input wrenches (forces and torques). In addition, all of the necessary measures can be obtained by a self-contained robotic system, allowing for a more flexible and adaptive approach for future co-manipulation robot controllers., Comment: 11 pages, 19 figures, 4 tables, 3 equations, prepared for submission to transactions on haptics

We report the spectroscopic confirmation and fundamental properties of TOI-757 b, a mini-Neptune on a 17.5-day orbit transiting a bright star ($V = 9.7$ mag) discovered by the TESS mission. We acquired high-precision radial velocity measurements with the HARPS, ESPRESSO, and PFS spectrographs to confirm the planet detection and determine its mass. We also acquired space-borne transit photometry with the CHEOPS space telescope to place stronger constraints on the planet radius, supported with ground-based LCOGT photometry. WASP and KELT photometry were used to help constrain the stellar rotation period. We also determined the fundamental parameters of the host star. We find that TOI-757 b has a radius of $R_{\mathrm{p}} = 2.5 \pm 0.1 R_{\oplus}$ and a mass of $M_{\mathrm{p}} = 10.5^{+2.2}_{-2.1} M_{\oplus}$, implying a bulk density of $\rho_{\text{p}} = 3.6 \pm 0.8$ g cm$^{-3}$. Our internal composition modeling was unable to constrain the composition of TOI-757 b, highlighting the importance of atmospheric observations for the system. We also find the planet to be highly eccentric with $e$ = 0.39$^{+0.08}_{-0.07}$, making it one of the very few highly eccentric planets among precisely characterized mini-Neptunes. Based on comparisons to other similar eccentric systems, we find a likely scenario for TOI-757 b's formation to be high eccentricity migration due to a distant outer companion. We additionally propose the possibility of a more intrinsic explanation for the high eccentricity due to star-star interactions during the earlier epoch of the Galactic disk formation, given the low metallicity and older age of TOI-757., Comment: Accepted for publication in MNRAS; 26 pages, 14 figures, 6 tables

Medical imaging technologies have undergone extensive development, enabling non-invasive visualization of clinical information. The traditional review of medical images by clinicians remains subjective, time-consuming, and prone to human error. With the recent availability of medical imaging data, quantification have become important goals in the field. Radiomics, a methodology aimed at extracting quantitative information from imaging data, has emerged as a promising approach to uncover hidden biological information and support decision-making in clinical practice. This paper presents a review of the radiomic pipeline from the clinical neuroimaging perspective, providing a detailed overview of each step with practical advice. It discusses the application of handcrafted and deep radiomics in neuroimaging, stratified by neurological diagnosis. Although radiomics shows great potential for increasing diagnostic precision and improving treatment quality in neurology, several limitations hinder its clinical implementation. Addressing these challenges requires collaborative efforts, advancements in image harmonization methods, and the establishment of reproducible and standardized pipelines with transparent reporting. By overcoming these obstacles, radiomics can significantly impact clinical neurology and enhance patient care.

Among the thousands of exoplanets discovered to date, approximately a few hundred gas giants on short-period orbits are classified as "lonely" and only a few are in a multi-planet system with a smaller companion on a close orbit. The processes that formed multi-planet systems hosting gas giants on close orbits are poorly understood, and only a few examples of this kind of system have been observed and well characterised. Within the contest of multi-planet system hosting gas-giant on short orbits, we characterise TOI-1130 system by measuring masses and orbital parameters. This is a 2-transiting planet system with a Jupiter-like planet (c) on a 8.35 days orbit and a Neptune-like planet (b) on an inner (4.07 days) orbit. Both planets show strong anti-correlated transit timing variations (TTVs). Furthermore, radial velocity (RV) analysis showed an additional linear trend, a possible hint of a non-transiting candidate planet on a far outer orbit. Since 2019, extensive transit and radial velocity observations of the TOI-1130 have been acquired using TESS and various ground-based facilities. We present a new photo-dynamical analysis of all available transit and RV data, with the addition of new CHEOPS and ASTEP+ data that achieve the best precision to date on the planetary radii and masses and on the timings of each transit. We were able to model interior structure of planet b constraining the presence of a gaseous envelope of H/He, while it was not possible to assess the possible water content. Furthermore, we analysed the resonant state of the two transiting planets, and we found that they lie just outside the resonant region. This could be the result of the tidal evolution that the system underwent. We obtained both masses of the planets with a precision less than 1.5%, and radii with a precision of about 1% and 3% for planet b and c, respectively., Comment: 22 pages, 10 figures, Accepted for publication by Astronomy and Astrophysics

PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases.

Deep learning models for plant species identification rely on large annotated datasets. The PlantNet system enables global data collection by allowing users to upload and annotate plant observations, leading to noisy labels due to diverse user skills. Achieving consensus is crucial for training, but the vast scale of collected data makes traditional label aggregation strategies challenging. Existing methods either retain all observations, resulting in noisy training data or selectively keep those with sufficient votes, discarding valuable information. Additionally, as many species are rarely observed, user expertise can not be evaluated as an inter-user agreement: otherwise, botanical experts would have a lower weight in the AI training step than the average user. Our proposed label aggregation strategy aims to cooperatively train plant identification AI models. This strategy estimates user expertise as a trust score per user based on their ability to identify plant species from crowdsourced data. The trust score is recursively estimated from correctly identified species given the current estimated labels. This interpretable score exploits botanical experts' knowledge and the heterogeneity of users. Subsequently, our strategy removes unreliable observations but retains those with limited trusted annotations, unlike other approaches. We evaluate PlantNet's strategy on a released large subset of the PlantNet database focused on European flora, comprising over 6M observations and 800K users. We demonstrate that estimating users' skills based on the diversity of their expertise enhances labeling performance. Our findings emphasize the synergy of human annotation and data filtering in improving AI performance for a refined dataset. We explore incorporating AI-based votes alongside human input. This can further enhance human-AI interactions to detect unreliable observations.

A central problem in quantum information is determining quantum-classical boundaries. A useful notion of classicality is provided by the quasiprobability formulation of quantum theory. In this framework, a state is called classical if it is represented by a quasiprobability distribution that is positive, and thus a probability distribution. In recent years, the Kirkwood-Dirac (KD) distributions have gained much interest due to their numerous applications in modern quantum-information research. A particular advantage of the KD distributions is that they can be defined with respect to arbitrary observables. Here, we show that if two observables are picked at random, the set of classical states of the resulting KD distribution is a simple polytope of minimal size. When the Hilbert space is of dimension $d$, this polytope is of dimension $2d-1$ and has $2d$ known vertices. Our result implies, $\textit{e.g.}$, that almost all KD distributions have resource theories in which the free states form a small and simple set., Comment: 12 pages

Ribonucleic acids (RNA) are unique in that they can store genetic information, replicate and perform catalysis. Importantly, RNA molecules are highly dynamic, and thus determining the ensemble of conformations that they populate is crucial not only to elucidate their biological functions, but also for their potential use as therapeutic targets. Computational and experimental techniques provide complementary views on RNA dynamics, and their integration is fundamental to improve the accuracy of computations and the resolution of experiments. Recent exciting developments in this field, were discussed at the CECAM workshop ``RNA dynamics from experimental and computational approaches'', in Paris, June 26-28, 2023. This report outlines key `take-home' messages that emerged during this workshop from the presentations and discussions.

The James-Stein estimator is a biased estimator -- for a finite number of samples its expected value is not the true mean. The maximum-likelihood estimator (MLE), is unbiased and asymptotically optimal. Yet, when estimating the mean of $3$ or more normally-distributed random variables, the James-Stein estimator has a smaller total (expected) error than the MLE. We introduce the James-Stein estimator to the field of quantum metrology, from both the frequentist and Bayesian perspectives. We characterise the effect of quantum phenomena on the James-Stein estimator through the lens of quantum Gaussian sensing, the task of estimating the mean of an unknown multivariate quantum Gaussian state. We find that noiseless entanglement or coherence improves performance of the James-Stein estimator, but diminishes its advantage over the MLE. In the presence of noise, the James-Stein advantage is restored. Quantum effects can also boost the James-Stein advantage. We demonstrate this by investigating multivariate postselective metrology (generalised weak-value amplification), a strategy that uses quantum effects to measure parameters with imperfect detectors. Simply by post-processing measured data differently, our techniques reduce errors in quantum experiments.

We aim to constrain the internal structure and composition of HD 15337 b and c, two short-period planets situated on opposite sides of the radius valley, using new transit photometry and radial velocity data. We acquire 6 new transit visits with the CHaracterising ExOPlanet Satellite (CHEOPS) and 32 new radial velocity measurements from the High Accuracy Radial Velocity Planet Searcher (HARPS) to improve the accuracy of the mass and radius estimates for both planets. We reanalyse light curves from TESS sectors 3 and 4 and analyse new data from sector 30, correcting for long-term stellar activity. Subsequently, we perform a joint fit of the TESS and CHEOPS light curves, and all available RV data from HARPS and the Planet Finder Spectrograph (PFS). Our model fits the planetary signals, the stellar activity signal and the instrumental decorrelation model for the CHEOPS data simultaneously. The stellar activity was modelled using a Gaussian-process regression on both the RV and activity indicators. We finally employ a Bayesian retrieval code to determine the internal composition and structure of the planets. We derive updated and highly precise parameters for the HD 15337 system. Our improved precision on the planetary parameters makes HD 15337 b one of the most precisely characterised rocky exoplanets, with radius and mass measurements achieving a precision better than 2\% and 7\%, respectively. We are able to improve the precision of the radius measurement of HD 15337 c to 3\%. Our results imply that the composition of HD 15337 b is predominantly rocky, while HD 15337 c exhibits a gas envelope with a mass of at least $0.01\ M_\oplus$.Our results lay the groundwork for future studies, which can further unravel the atmospheric evolution of these exoplanets and give new insights into their composition and formation history and the causes behind the radius gap., Comment: 17 pages, including appendix

We report the results of radioactivity assays and heat leak calculations for a range of common cryogenic materials, considered for use in the QUEST-DMC superfluid 3He dark matter detector. The bolometer, instrumented with nanomechanical resonators, will be sensitive to energy deposits from dark matter interactions. Events from radioactive decays and cosmic rays constitute a significant background and must be precisely modelled, using a combination of material screening and Monte Carlo simulations. However, the results presented here are of wider interest for experiments and quantum devices sensitive to minute heat leaks and spurious events, thus we present heat leak per unit mass or surface area for every material studied. This can inform material choices for other experiments, especially if underground operation is considered where the radiogenic backgrounds will dominate even at shallow depths.

We show that under some conditions, two constructions of nearby cycles over general bases coincide. More specifically, we show that under the assumption of $\Psi$-factorizability, the constructions of unipotent nearby cycles over an affine space can be described using the theory of nearby cycles over general bases via the vanishing topos. In particular, this applies to nearby cycles of Satake sheaves on Beilinson-Drinfeld Grassmannians with parahoric ramification., Comment: 18 pages

Recent asteroseismic studies have revealed that the convective core of $\gamma$ Doradus stars rotates faster than their radiative interior. We study the development of differential rotation near the convective core to test angular momentum transport processes that are typically adopted in stellar evolution models. Models that only include the advection of angular momentum by meridional circulation and shear instabilities cannot reproduce current rotational constraints, irrespective of the initial conditions. The latest formulation of internal magnetic fields based on the Tayler instability is indeed able to reproduce the internal rotation rate of post-main sequence stars, however, it appears too efficient during the main sequence and has thus been disfavoured. A less efficient version of the same transport process can simultaneously reproduce the rotation rate of the convective core, the rotation rate in radiative regions as probed by gravity-modes, and the surface rotational velocities of $\gamma$ Doradus stars. Our work suggests that there are additional physical processes apart from internal magnetic fields at work in the stellar interiors of post-main sequence stars., Comment: Accepted for publication in Astronomy & Astrophysics. 5 pages, 7 figures

We have developed a poly(dimethylsiloxane) (PDMS) microfluidic chip to study the directional drying of a colloidal dispersion confined in a channel. Our measurements on a dispersion of silica nanoparticles once again revealed the phenomenology commonly observed for such systems: the formation of a porous solid with linear growth in the channel at short times, slowing down at longer times as the evaporation rate decreases. The growth of the solid is also accompanied by mechanical stresses that are released by the delamination of the solid from the channel walls and the formation of cracks. In addition to these observations, we report original measurements using hydrophilic filler in the PDMS formulation used (Sylgard-184). When the PDMS matrix is in contact with water, water molecules pool around these hydrophilic sites, resulting in the formation of microscopic water clusters whose size depends on the water potential $\psi$. In our work, we have used these water clusters to estimate the water potential profile in the channel as the porous solid grows. Using a transport model that also takes into account solid delamination in the channel, we then linked these water potential measurements to the hydraulic permeability of the porous solid. These measurements finally enabled us to show that the slowdown in the evaporation rate is due to the invasion of the porous solid by air/water nanomenisci at a critical capillary pressure $\psi_\text{cap}$.