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OBJECTIVES: To establish the epidemiological, clinical and mycological characteristics of tinea corporis at the Mycology Service of the Centro Dermatológico Pascua, Mexico City, from January 1956 to December 2019. MATERIALS AND METHODS: A retrospective, cross-sectional and descriptive study of patients with clinical mycosis diagnosis. RESULTS: 56,729 patients were included; 30,235 were confirmed by direct microscopy KOH examination and/or mycological culture; 3590 were tinea of the body. Tinea corporis accounted for the third place among dermatophytoses (11.8%); more frequent in adults (64.3%). The most common evolution was from 1 to 3 months (30.8%). It mainly involved the trunk (49.1%), face and neck (31.1%). The direct microscopy KOH examination was positive in 91% of cases, compared to the 75.4% positive cultures. There were 52.3% Trichophyton rubrum, 22.3% Microsporum canis, 16.8% Trichophyton tonsurans, 4.2% Trichophyton mentagrophytes, 1.7% Trichophyton concentricum, 1.1% Nannizzia gypsea (previously known as Microsporum gypseum), 1% Epidermophyton floccosum, 0.2% Trichophyton violaceum and 0.1% Microsporum audouinii. CONCLUSIONS: Tinea corporis takes third place among dermatophytoses, with a prevalence of 6.3%. Trichophytic ringworm had a clear preponderance over microsporic one. Direct microscopic KOH examination is more sensitive for confirming diagnosis than culture. Due to these results were obtained in a referral center, they reflect the behavior of these dermatophytoses in Mexico. [ABSTRACT FROM AUTHOR]

Moniletrhix is an uncommon hair shaft disease with autosomal dominant inheritance, incomplete penetrance and variable expressivity. The term monilethrix derives from monile (Latin) and thrix (Greek) meaning "hair necklace". This entity takes its name because the clinical resemblance of the hair to a string of beads, changes that can be seen with trichoscopy. It is characterized by periodic thinning of the hair shaft resulting in brittle, short and dry hair. We present the case of a 4-year-old girl, with family history of monilethrix in her father, a grandmother and a great grandfather. [ABSTRACT FROM AUTHOR]

Background: Sporotrichosis is a chronic fungal infection caused by the Sporothrix schenckii complex, is characterized by the presence of granulomas of epithelioid, tuberculoid or foreign body composed of histiocytes surrounding a central area of neutrophils that contribute to the non-specific immune system. Neutrophils are in lactoferrin which exerts a protective action against fungi and yeasts, attributing the antifungal effect to its ability to sequester an atom of Fe+2 or Fe+3, and they can also join to Cu+2, Zn+2 and Mn+ ions. There is evidence that lactoferrin activity increases blood neutrophil phagocytic activity of NK cells, the number of cells progenitors of neutrophils in the blood and the production of gamma interferon; it is able to display antimicrobial activity on a broad spectrum of pathogens among including: bacteria, yeasts, fungi, protozoa and viruses. Objective: To demonstrate the presence of lactoferrin in Sporothrix sp yeasts present on the histological sections of patients with cutaneous sporotrichosis. Material and method: A retrospective study in which 11 biopsies of patients with diagnosis of cutaneous sporotrichosis attended at Dermatological Center Ladislao de la Pascua and General Hospital Dr. Manuel Gea González, both in Mexico City, were included. Two cuts were made by biopsy, one for the realization of the technique of PAS and the other for the marking of the lactoferrin. We used the commercial kit Cell and Tissue Staining Kit, Goat Kit HRP-AEC System (catalog no. CTS009) R&D Systems, and the primary antibody that was used was the IgG polyclonal anti-human lactoferrin made in goat by Santa Cruz Biotechnology laboratories. Results: We found the presence of lactoferrin on yeasts of Sporothrix sp, previously observed by the reaction of PAS in the studied sections of the 11 patients, already diagnosed with sporotrichosis. Conclusion: It was found lactoferrin present in the specific granules of polymorphonuclear neutrophils attached to the yeasts of the Sporothrix schenckii complex, engaged in kidnapping of ions Fe+2 and Fe+3 function, trying to prevent the development and proliferation of this fungus in the cutaneous sporotrichosis. [ABSTRACT FROM AUTHOR]