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2. Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population

Author

Pan, Hongxu, Liu, Zhenhua, Ma, Jinghong, Li, Yuanyuan, Zhao, Yuwen, Zhou, Xiaoxia, Xiang, Yaqin, Wang, Yige, Zhou, Xun, He, Runcheng, Xie, Yali, Zhou, Qiao, Yuan, Kai, Xu, Qian, Sun, Qiying, Wang, Junling, Yan, Xinxiang, Zhang, Hainan, Wang, Chunyu, Lei, Lifang, Liu, Weiguo, Wang, Xuejing, Ding, Xuebing, Wang, Tao, Xue, Zheng, Zhang, Zhentao, Chen, Ling, Wang, Qing, Liu, Yonghong, Tang, Jiayu, Zhang, Xuewei, Peng, Shifang, Wang, Chaodong, Ding, Jianqing, Liu, Chunfeng, Wang, Lijuan, Chen, Haibo, Shen, Lu, Jiang, Hong, Wu, Xinyin, Tan, Hongzhuan, Luo, Dan, Xiao, Shuiyuan, Chen, Xiang, Tan, Jieqiong, Hu, Zhengmao, Chen, Chao, Xia, Kun, Zhang, Zhuohua, Foo, Jia Nee, Blauwendraat, Cornelis, Nalls, Mike A., Singleton, Andrew B., Liu, Jun, Chan, Piu, Zheng, Houfeng, Li, Jinchen, Guo, Jifeng, Yang, Jian, and Tang, Beisha

Published
2023
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6. Construction of Ideological and Political Education Innovation and Development Platform of Colleges and Universities Based on Big Data Technology under the Concept of Green Ecological Development

Author

Hao Wenjia, Zeng Honghu, and Pan Hongxu

Subjects
association rules, collaborative filtering algorithms, course recommendation methods, personalized instruction, 97m50, Mathematics, QA1-939
Abstract

This paper combines association rules and collaborative filtering algorithms to build a course recommendation method that considers personalized learning characteristics on the innovative development platform of Civic and Political Education in colleges and universities. The related algorithms in the association rules are used to visualize and analyze the association of the 10 main contents of the Civic and Political courses and give the combination of the contents of the Civic and Political courses. By analyzing the mastery and interest of students on the platform, we push the combination of courses that meet the personalized needs of students according to their knowledge, ability and interest. The constructed personalized teaching platform is used in actual teaching, and the application of association rules in course analysis and personalized push function is analyzed to prove the effectiveness of the platform. The impact of the platform on teaching is evaluated by comparing the students’ performance under platform learning to that under traditional teaching. The results show that the average scores of the Civics course content of group D1 are all above 80, and the significance value of the difference between group D1 and D2 is 4.21% < less than 5%, indicating that there is an obvious achievement difference between the two groups. In the recommended course content of Student 2, the score of the combination course A4 and A7 was 8.2158, and the learning interest rating was 17.326, which was 0.769 higher than the sum of the interest ratings of the two courses alone.

Published
2024
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16. PAM-SA hydrogel driving membrane with a cross-linked network structure for high stretchability.

Author

Wang, Junyao, Chen, Yansong, Liu, Huan, Lang, Tianhong, Hou, Qi, Wang, Rui, Cui, Bowen, Quan, Jingran, Pan, Hongxu, Yang, Hanbo, Xu, Jianxin, and Liu, Yahao

Subjects
FORCE density, DOPING agents (Chemistry), ELASTIC modulus, TENSILE strength, ARTIFICIAL muscles
Abstract

The hydrogel actuated membrane in this paper is highly stretchable while having an electrically responsive output force. At a doping level of 0.6 g SA, the elongation at break of the hydrogel-driven membrane reached 3117% and the output force density reached 16.49 mN/g. In addition, the elastic modulus, tensile strength, and specific capacitance of the driving membrane reached the maximum values of 29.05 kPa, 907.24 kPa, and 452.8 mF/g at SA doping content of 0.75 g. [ABSTRACT FROM AUTHOR]

Published
2024
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18. A self-healing artificial muscle was realized by fitting the electrode membrane with the self-healing actuating membrane with a folded structure

Author

Wang, Junyao, primary, Chen, Yansong, additional, Wang, Jing, additional, Liu, huan, additional, Lang, tianhong, additional, Hou, Qi, additional, Pan, Hongxu, additional, Yang, Hanbo, additional, Xu, Jianxin, additional, Liu, Yahao, additional, Wang, Baoliang, additional, Wang, rui, additional, Cui, bowen, additional, and Quan, Jingran, additional

Published
2023
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21. GGC expansions in NOTCH2NLC contribute to Parkinson disease and dopaminergic neuron degeneration.

Author

Liu, Qiong, Chen, Juan, Xue, Jin, Zhou, Xun, Tian, Yun, Xiao, Qiao, Huang, Wen, Pan, Yongcheng, Zhou, Xiaoxia, Li, Jian, Zhao, Yuwen, Pan, Hongxu, Wang, Yige, He, Runcheng, Xiang, Yaqin, Tu, Tian, Xu, Qian, Sun, Qiying, Tan, Jieqiong, and Yan, Xinxiang

Subjects
DOPAMINERGIC neurons, NEURODEGENERATION, PARKINSON'S disease, NERVE fibers, SUBSTANTIA nigra, CEREBELLUM degeneration, SPINOCEREBELLAR ataxia, DOPAMINE receptors
Abstract

Background and purpose: The role of GGC repeat expansions within NOTCH2NLC in Parkinson's disease (PD) and the substantia nigra (SN) dopaminergic neuron remains unclear. Here, we profile the NOTCH2NLC GGC repeat expansions in a large cohort of patients with PD. We also investigate the role of GGC repeat expansions within NOTCH2NLC in the dopaminergic neurodegeneration of SN. Methods: A total of 2,522 patients diagnosed with PD and 1,085 health controls were analyzed for the repeat expansions of NOTCH2NLC by repeat‐primed PCR and GC‐rich PCR assay. Furthermore, the effects of GGC repeat expansions in NOTCH2NLC on dopaminergic neurons were investigated by using recombinant adeno‐associated virus (AAV)‐mediated overexpression of NOTCH2NLC with 98 GGC repeats in the SN of mice by stereotactic injection. Results: Four PD pedigrees (4/333, 1.2%) and three sporadic PD patients (3/2189, 0.14%) were identified with pathogenic GGC repeat expansions (larger than 60 GGC repeats) in the NOTCH2NLC gene, while eight PD patients and one healthy control were identified with intermediate GGC repeat expansions ranging from 41 to 60 repeats. No significant difference was observed in the distribution of intermediate NOTCH2NLC GGC repeat expansions between PD cases and controls (Fisher's exact test p‐value = 0.29). Skin biopsy showed P62‐positive intranuclear NOTCH2NLC‐polyGlycine (polyG) inclusions in the skin nerve fibers of patient. Expanded GGC repeats in NOTCH2NLC produced widespread intranuclear and perinuclear polyG inclusions, which led to a severe loss of dopaminergic neurons in the SN. Consistently, polyG inclusions were presented in the SN of EIIa‐NOTCH2NLC‐(GGC)98 transgenic mice and also led to dopaminergic neuron loss in the SN. Conclusions: Overall, our findings provide strong evidence that GGC repeat expansions within NOTCH2NLC contribute to the pathogenesis of PD and cause degeneration of nigral dopaminergic neurons. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Evaluation of the role of FMR1 CGG repeat allele in Parkinson’s disease from the Chinese population

Author

Chen, Juan, primary, Zhao, Yuwen, additional, Zhou, Xun, additional, Xue, Jin, additional, Xiao, Qiao, additional, Pan, Hongxu, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Li, Jian, additional, Zhu, Liping, additional, Zhou, Zhou, additional, Yang, Yang, additional, Xu, Qian, additional, Sun, Qiying, additional, Yan, Xinxiang, additional, Tan, Jieqiong, additional, Li, Jinchen, additional, Guo, Jifeng, additional, Duan, Ranhui, additional, Tang, Beisha, additional, Yu, Qiao, additional, and Liu, Zhenhua, additional

Published
2023
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23. ATP10B variants in Parkinson’s disease: a large cohort study in Chinese mainland population

Author

Zhao, Yuwen, Pan, Hongxu, Wang, Yige, Zeng, Qian, Fang, Zhenghuan, He, Runcheng, Xu, Kun, Zhou, Xiaoxia, Zhou, Xun, Zhou, Zhou, Li, Yanghong, Deng, Penghui, Xu, Yinghui, Xu, Qian, Sun, Qiying, Li, Bin, Zhao, Guihu, Lei, Lifang, Zhang, Hainan, Wang, Chunyu, Tan, Jieqiong, Yan, Xinxiang, Shen, Lu, Jiang, Hong, Li, Jinchen, Guo, Jifeng, Tang, Beisha, and Liu, Zhenhua

Published
2021
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24. Genetic analysis of dystonia-related genes in Parkinson's disease

Author

Wang, Yige, primary, Zhao, Yuwen, additional, Pan, Hongxu, additional, Zeng, Qian, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Zhou, Zhou, additional, Xu, Qian, additional, Sun, Qiying, additional, Tan, Jieqiong, additional, Yan, Xinxiang, additional, Li, Jinchen, additional, Guo, Jifeng, additional, Tang, Beisha, additional, Yu, Qiao, additional, and Liu, Zhenhua, additional

Published
2023
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27. Screen-printed highly stretchable and stable flexible electrodes with a negative Poisson's ratio structure for supercapacitors

Author

Xu, Jianxin, primary, Li, Yang, additional, Wang, Junyao, additional, Liu, Huan, additional, Hou, Qi, additional, Wang, Rui, additional, Lang, Tianhong, additional, Cui, Bowen, additional, Pan, Hongxu, additional, Chen, Yansong, additional, Quan, Jingran, additional, Yang, Hanbo, additional, Li, Lixiang, additional, and Liu, Yahao, additional

Published
2023
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28. Screen-printed highly sensitive and anisotropic strain sensors with asymmetrical inner concave honeycomb cross-conducting structure for health monitoring of medical electrophysiological signals

Author

Wang, Junyao, primary, Li, Lixiang, additional, Liu, Huan, additional, Hou, Qi, additional, Lang, Tianhong, additional, Wang, Rui, additional, Cui, Bowen, additional, Xu, Jianxin, additional, Yang, Hanbo, additional, Liu, Yahao, additional, Pan, Hongxu, additional, Chen, Yansong, additional, and Quan, Jingran, additional

Published
2023
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29. A structural design and decoupling method of a flexible capacitive pressure sensor for measuring spatial force

Author

Liu, Huan, primary, Pan, Hongxu, additional, Wang, Jing, additional, Wang, Junyao, additional, Hou, Qi, additional, Wang, Rui, additional, Lang, Tianhong, additional, Cui, Bowen, additional, Xu, Jianxin, additional, Quan, Jingran, additional, Yang, Hanbo, additional, Chen, Yansong, additional, Liu, Yahao, additional, Li, Lixiang, additional, and Liu, Ming, additional

Published
2023
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32. Subtyping of early-onset Parkinson’s disease using cluster analysis: A large cohort study

Author

Zhou, Zhou, primary, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Zhao, Yuwen, additional, Pan, Hongxu, additional, Wu, Juan, additional, Xu, Qian, additional, Chen, Yase, additional, Sun, Qiying, additional, Wu, Xinyin, additional, Zhu, Jianping, additional, Wu, Xuehong, additional, Li, Jianhua, additional, Yan, Xinxiang, additional, Guo, Jifeng, additional, Tang, Beisha, additional, Lei, Lifang, additional, and Liu, Zhenhua, additional

Published
2022
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35. Genetic Analysis of Six Transmembrane Protein Family Genes in Parkinson’s Disease in a Large Chinese Cohort

Author

Zhao, Yuwen, primary, Zhang, Kailin, additional, Pan, Hongxu, additional, Wang, Yige, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Xu, Qian, additional, Sun, Qiying, additional, Tan, Jieqiong, additional, Yan, Xinxiang, additional, Li, Jinchen, additional, Guo, Jifeng, additional, Tang, Beisha, additional, and Liu, Zhenhua, additional

Published
2022
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37. Profiling the Genome-Wide Landscape of Short Tandem Repeats by Long-Read Sequencing

Author

Liu, Zhenhua, Zhao, Guihu, Xiao, Yuhui, Zeng, Sheng, Yuan, Yanchun, Zhou, Xun, Fang, Zhenghuan, He, Runcheng, Li, Bin, Zhao, Yuwen, Pan, Hongxu, Wang, Yige, Yu, Guoliang, Peng, I-Feng, Wang, Depeng, Meng, Qingtuan, Xu, Qian, Sun, Qiying, Yan, Xinxiang, Shen, Lu, Jiang, Hong, Xia, Kun, Wang, Junling, Guo, Jifeng, Liang, Fan, Li, Jinchen, and Tang, Beisha

Subjects
Genetics, Molecular Medicine, Genetics (clinical)
Abstract

Background: Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases and the regulation of gene expression. Long-read sequencing (LRS) offers a potential solution to genome-wide STR analysis. However, characterizing STRs in human genomes using LRS on a large population scale has not been reported.Methods: We conducted the large LRS-based STR analysis in 193 unrelated samples of the Chinese population and performed genome-wide profiling of STR variation in the human genome. The repeat dynamic index (RDI) was introduced to evaluate the variability of STR. We sourced the expression data from the Genotype-Tissue Expression to explore the tissue specificity of highly variable STRs related genes across tissues. Enrichment analyses were also conducted to identify potential functional roles of the high variable STRs.Results: This study reports the large-scale analysis of human STR variation by LRS and offers a reference STR database based on the LRS dataset. We found that the disease-associated STRs (dSTRs) and STRs associated with the expression of nearby genes (eSTRs) were highly variable in the general population. Moreover, tissue-specific expression analysis showed that those highly variable STRs related genes presented the highest expression level in brain tissues, and enrichment pathways analysis found those STRs are involved in synaptic function-related pathways.Conclusion: Our study profiled the genome-wide landscape of STR using LRS and highlighted the highly variable STRs in the human genome, which provide a valuable resource for studying the role of STRs in human disease and complex traits.

Published
2022

39. Performance Comparison of Computational Methods for the Prediction of the Function and Pathogenicity of Non-Coding Variants

Author

Wang, Zheng, primary, Zhao, Guihu, additional, Li, Bin, additional, Fang, Zhenghuan, additional, Chen, Qian, additional, Wang, Xiaomeng, additional, Luo, Tengfei, additional, Wang, Yijing, additional, Zhou, Qiao, additional, Li, Kuokuo, additional, Xia, Lu, additional, Zhang, Yi, additional, Zhou, Xun, additional, Pan, Hongxu, additional, Zhao, Yuwen, additional, Wang, Yige, additional, Wang, Lin, additional, Guo, Jifeng, additional, Tang, Beisha, additional, Xia, Kun, additional, and Li, Jinchen, additional

Published
2022
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40. GWAS of PD in Chinese

Author

潘宏旭(Pan Hongxu)

Subjects
Monoisolate, Medical, Variation
Abstract

Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson's disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify genetic variants associated with PD in the Chinese population, we performed a GWAS using whole-genome sequencing (WGS) in 1,972 cases and 2,478 controls, and a replication study in a total of 8,209 cases and 9,454 controls.

Published
2022
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43. Genetic landscape of human mitochondrial genome using whole-genome sequencing

Author

Wang, Yijing, primary, Zhao, Guihu, additional, Fang, Zhenghuan, additional, Pan, Hongxu, additional, Zhao, Yuwen, additional, Wang, Yige, additional, Zhou, Xun, additional, Wang, Xiaomeng, additional, Luo, Tengfei, additional, Zhang, Yi, additional, Wang, Zheng, additional, Chen, Qian, additional, Dong, Lijie, additional, Huang, Yuanfeng, additional, Zhou, Qiao, additional, Xia, Lu, additional, Li, Bin, additional, Guo, Jifeng, additional, Xia, Kun, additional, Tang, Beisha, additional, and Li, Jinchen, additional

Published
2021
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44. Characteristics of Autonomic Dysfunction in Parkinson’s Disease: A Large Chinese Multicenter Cohort Study

Author

Zhou, Zhou, primary, Zhou, Xiaoting, additional, Zhou, Xiaoxia, additional, Xiang, Yaqin, additional, Zhu, Liping, additional, Qin, Lixia, additional, Wang, Yige, additional, Pan, Hongxu, additional, Zhao, Yuwen, additional, Sun, Qiying, additional, Xu, Qian, additional, Wu, Xinyin, additional, Yan, Xinxiang, additional, Guo, Jifeng, additional, Tang, Beisha, additional, and Liu, Zhenhua, additional

Published
2021
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45. Performance Comparison of Computational Prediction Methods for the Function and Pathogenicity of Non-coding Variants

Author

Wang, Zheng, primary, Zhao, Guihu, additional, Li, Bin, additional, Fang, Zhenghuan, additional, Chen, Qian, additional, Wang, Xiaomeng, additional, Luo, Tengfei, additional, Wang, Yijing, additional, Zhou, Qiao, additional, Li, Kuokuo, additional, Xia, Lu, additional, Zhang, Yi, additional, Zhou, Xun, additional, Pan, Hongxu, additional, Zhao, Yuwen, additional, Wang, Yige, additional, Wang, Lin, additional, Guo, Jifeng, additional, Tang, Beisha, additional, Xia, Kun, additional, and Li, Jinchen, additional

Published
2021
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47. The Chinese Parkinson's Disease Registry (CPDR): Study Design and Baseline Patient Characteristics.

Author

Zhou, Xiaoxia, Liu, Zhenhua, Zhou, Xiaoting, Xiang, Yaqin, Zhou, Zhou, Zhao, Yuwen, Pan, Hongxu, Xu, Qian, Chen, Yase, Sun, Qiying, Wu, Xinyin, Tan, Hongzhuan, Li, Bin, Yuan, Kai, Xie, Yali, Liao, Weihua, Hu, Shuo, Zhu, Jianping, Wu, Xuehong, and Li, Jianhua

Abstract

Background: There is a lack of large multicenter Parkinson's disease (PD) cohort studies and limited data on the natural history of PD in China. Objectives: The objective of this study was to launch the Chinese Parkinson's Disease Registry (CPDR) and to report its protocol, cross‐sectional baseline data, and prospects for a comprehensive observational, longitudinal, multicenter study. Methods: The CPDR recruited PD patients from 19 clinical sites across China between January 2018 and December 2020. Clinical data were collected prospectively using at least 17 core assessment scales. Patients were followed up for clinical outcomes through face‐to‐face interviews biennially. Results: We launched the CPDR in China based on the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network (PD‐MDCNC). A total of 3148 PD patients were enrolled comprising 1623 men (51.6%) and 1525 women (48.4%). The proportions of early‐onset PD (EOPD, age at onset ≤50 years) and late‐onset PD (LOPD) were 897 (28.5%) and 2251 (71.5%), respectively. Stratification by age at onset showed that EOPD manifested milder motor and nonmotor phenotypes and was related to increased probability of dyskinesia. Comparison across genders suggested a slightly older average age at PD onset, milder motor symptoms, and a higher rate of developing levodopa‐induced dyskinesias in women. Conclusions: The CPDR is one of the largest multicenter, observational, longitudinal, and natural history studies of PD in China. It offers an opportunity to expand the understanding of clinical features, genetic, imaging, and biological markers of PD progression. © 2022 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Gene4PD: A Comprehensive Genetic Database of Parkinson’s Disease

Author

Li, Bin, primary, Zhao, Guihu, additional, Zhou, Qiao, additional, Xie, Yali, additional, Wang, Zheng, additional, Fang, Zhenghuan, additional, Lu, Bin, additional, Qin, Lixia, additional, Zhao, Yuwen, additional, Zhang, Rui, additional, Jiang, Li, additional, Pan, Hongxu, additional, He, Yan, additional, Wang, Xiaomeng, additional, Luo, Tengfei, additional, Zhang, Yi, additional, Wang, Yijing, additional, Chen, Qian, additional, Liu, Zhenhua, additional, Guo, Jifeng, additional, Tang, Beisha, additional, and Li, Jinchen, additional

Published
2021
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