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Along with the rapid development of electronic technology, the appeal of information technology to students and teachers in domestic and international information education has become universal. Education-related departments aim to positively cultivate the professional information knowledge and skills of teachers. The use of information technology in instruction allows students to enhance their creativity and learning motivation. A total of 232 college students from Fujian Province participated in the experimental research. The results show the following: (1) the application of information technology to e-book teaching could enhance a sense of achievement of students in self-directed learning, and students could answer test questions in a confidential and relaxed manner; (2) the application of information technology to e-book teaching activates teaching flexibility, and many teaching models, such as teaching by wandering around, interactive teaching, and blended teaching, are therefore derived to enhance the richness of teaching; (3) the application of information technology to e-book teaching bridges the distance between instructors and students and leads to a deeper understanding of learning conditions of students, expanding the possibilities for content planning and teaching models. The results give rise to suggestions enhancing enjoyment in learning and promoting higher motivation and more effective teaching., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Sun and Pan.)