Search

Your search keyword '"Pancholi, Harshida"' showing total 10 results
Start Over Author "Pancholi, Harshida" Publication Year Range Last 10 years
10 results on '"Pancholi, Harshida"'

1. Somatostatin regulates central clock function and circadian responses to light

Author

Joye, Deborah A. M., primary, Rohr, Kayla E., additional, Suenkens, Kimberlee, additional, Wuorinen, Alissa, additional, Inda, Thomas, additional, Arzbecker, Madeline, additional, Mueller, Emma, additional, Huber, Alec, additional, Pancholi, Harshida, additional, Blackmore, Murray G., additional, Carmona-Alcocer, Vania, additional, and Evans, Jennifer A., additional

Published
2023
Full Text
View/download PDF

10. Seasonal plasticity in GABA A signaling is necessary for restoring phase synchrony in the master circadian clock network.

Author

Rohr KE, Pancholi H, Haider S, Karow C, Modert D, Raddatz NJ, and Evans J

Subjects
Animals, Biological Transport, Chlorides metabolism, Mice, Neuronal Plasticity, Photoperiod, Seasons, Circadian Clocks, Signal Transduction, Suprachiasmatic Nucleus physiology, gamma-Aminobutyric Acid metabolism
Abstract

Annual changes in the environment threaten survival, and numerous biological processes in mammals adjust to this challenge via seasonal encoding by the suprachiasmatic nucleus (SCN). To tune behavior according to day length, SCN neurons display unified rhythms with synchronous phasing when days are short, but will divide into two sub-clusters when days are long. The transition between SCN states is critical for maintaining behavioral responses to seasonal change, but the mechanisms regulating this form of neuroplasticity remain unclear. Here we identify that a switch in chloride transport and GABA A signaling is critical for maintaining state plasticity in the SCN network. Further, we reveal that blocking excitatory GABA A signaling locks the SCN into its long day state. Collectively, these data demonstrate that plasticity in GABA A signaling dictates how clock neurons interact to maintain environmental encoding. Further, this work highlights factors that may influence susceptibility to seasonal disorders in humans., Competing Interests: KR, HP, SH, CK, DM, NR, JE No competing interests declared, (© 2019, Rohr et al.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results