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1,945 results on '"Park, Jin‐Young"'

14. Occlusive membranes for guided regeneration of inflamed tissue defects

Author

Choi, Woojin, Mangal, Utkarsh, Park, Jin-Young, Kim, Ji-Yeong, Jun, Taesuk, Jung, Ju Won, Choi, Moonhyun, Jung, Sungwon, Lee, Milae, Na, Ji-Yeong, Ryu, Du Yeol, Kim, Jin Man, Kwon, Jae-Sung, Koh, Won-Gun, Lee, Sangmin, Hwang, Patrick T. J., Lee, Kee-Joon, Jung, Ui-Won, Cha, Jae-Kook, Choi, Sung-Hwan, and Hong, Jinkee

Published
2023
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29. Long-term maturation of human cortical organoids matches key early postnatal transitions

Author

Gordon, Aaron, Yoon, Se-Jin, Tran, Stephen S, Makinson, Christopher D, Park, Jin Young, Andersen, Jimena, Valencia, Alfredo M, Horvath, Steve, Xiao, Xinshu, Huguenard, John R, Pașca, Sergiu P, and Geschwind, Daniel H

Subjects
Biomedical and Clinical Sciences, Neurosciences, Pediatric, Biotechnology, Stem Cell Research, Genetics, Human Genome, Neurological, Cell Differentiation, DNA Methylation, Gene Regulatory Networks, Humans, In Vitro Techniques, Induced Pluripotent Stem Cells, Neurodegenerative Diseases, Organoids, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Human stem-cell-derived models provide the promise of accelerating our understanding of brain disorders, but not knowing whether they possess the ability to mature beyond mid- to late-fetal stages potentially limits their utility. We leveraged a directed differentiation protocol to comprehensively assess maturation in vitro. Based on genome-wide analysis of the epigenetic clock and transcriptomics, as well as RNA editing, we observe that three-dimensional human cortical organoids reach postnatal stages between 250 and 300 days, a timeline paralleling in vivo development. We demonstrate the presence of several known developmental milestones, including switches in the histone deacetylase complex and NMDA receptor subunits, which we confirm at the protein and physiological levels. These results suggest that important components of an intrinsic in vivo developmental program persist in vitro. We further map neurodevelopmental and neurodegenerative disease risk genes onto in vitro gene expression trajectories to provide a resource and webtool (Gene Expression in Cortical Organoids, GECO) to guide disease modeling.

Published
2021

39. Metaverse-Driven Interactive Performing Arts Content Development

Author

Park, Jin Young, Lim, Yang Kyu, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Stephanidis, Constantine, editor, Antona, Margherita, editor, Ntoa, Stavroula, editor, and Salvendy, Gavriel, editor

Published
2022
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45. A 10-Gene Signature to Predict the Prognosis of Early-Stage Triple-Negative Breast Cancer

Author

Kim, Chang Min, primary, Park, Kyong Hwa, additional, Yu, Yun Suk, additional, Kim, Ju Won, additional, Park, Jin Young, additional, Park, Kyunghee, additional, Yu, Jong-Han, additional, Lee, Jeong Eon, additional, Sim, Sung Hoon, additional, Seo, Bo Kyoung, additional, Kim, Jin Kyeoung, additional, Lee, Eun Sook, additional, Park, Yeon Hee, additional, and Kong, Sun-Young, additional

Published
2024
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48. Human 3D cellular model of hypoxic brain injury of prematurity.

Author

Pașca, Anca M, Park, Jin-Young, Shin, Hyun-Woo, Qi, Qihao, Revah, Omer, Krasnoff, Rebecca, O'Hara, Ruth, Willsey, A Jeremy, Palmer, Theo D, and Pașca, Sergiu P

Subjects
Cerebral Cortex, Organoids, Humans, Brain Injuries, Hypoxia, Brain, T-Box Domain Proteins, Cell Hypoxia, Models, Neurological, Infant, Newborn, Neurogenesis, Unfolded Protein Response, Neural Stem Cells, Infant, Extremely Premature, Hypoxia, Brain, Models, Neurological, Infant, Newborn, Extremely Premature, Immunology, Medical and Health Sciences
Abstract

Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1,2. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called encephalopathy of prematurity3. Over 80% of infants born before post-conception week 25 have moderate-to-severe long-term neurodevelopmental impairments4. The susceptible cell types in the cerebral cortex and the molecular mechanisms underlying associated gray-matter defects in premature infants remain unknown. Here we used human three-dimensional brain-region-specific organoids to study the effect of oxygen deprivation on corticogenesis. We identified specific defects in intermediate progenitors, a cortical cell type associated with the expansion of the human cerebral cortex, and showed that these are related to the unfolded protein response and changes. Moreover, we verified these findings in human primary cortical tissue and demonstrated that a small-molecule modulator of the unfolded protein response pathway can prevent the reduction in intermediate progenitors following hypoxia. We anticipate that this human cellular platform will be valuable for studying the environmental and genetic factors underlying injury in the developing human brain.

Published
2019

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