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Ultrasonic gauging and defect detection of metallic pipes is a multi-disciplinary task, as it has to be performed in situ and involves several difficulties due to their curvature, limited access and corroded/eroded surface roughness due to harsh operating conditions. This research paper focuses on the investigation of employing a focused piezoelectric transducer in an immersion pulse-echo (PE) mode to measure the wall thickness (WT) from the inner side of the metallic pipes and to detect defects in the pipes. This paper also provides advances for understanding ultrasonic wave propagation in metallic pipes by simulation study using modern finite element technology and validating the results experimentally using battery-operated, water-immersible, IP67-grade stand-alone two-channel ultrasonic instrumentation that can move inside the pipe under test in flowing liquids such as water or oil. A simulation model has been established for time-of-flight (TOF) measurements for metallic pipes with various wall thicknesses, detection of standard defects and wall-thinning by inspecting the inner diameter (ID) surface of pipes and the pipe filled with water. The simulated results for the metallic pipes are in good agreement with the experimental data, providing an accurate and quantitative assessment of WT in the presence or absence of defects. [ABSTRACT FROM AUTHOR]

Ultrasonic non-destructive evaluation of concrete submerged in water is a complex phenomenon that has important implications for the durability and safety of marine structures such as bridges, piers and offshore platforms. The scattering of ultrasonic waves inside concrete materials with aggregate size comparable to the ultrasound wavelength often limits the interpretation of inspection results. To enhance the understanding of ultrasonic wave propagation inside the underwater concrete, numerical simulations using the finite element method (FEM) with the Transient Acoustics-Piezoelectric Interaction application mode of Multiphysics software package have been developed. This study focuses on developing a 2D numerical model to reproduce and illustrate the propagation of ultrasound in seven types of underwater concrete test blocks with various types of inclusions and voids embedded inside it. The B-Scan 2D images of the concrete test blocks were acquired using the simulated data and compared with experimental results acquired using an in-house developed four-channel ultrasonic imaging system. Both simulation and experimental results showed a good resemblance, indicating that B-Scan imaging can be applied to identify and characterise various types of defects and inclusions in underwater concrete structures, providing better assessment of the material than conventional ultrasonic pulse velocity (UPV) method. [ABSTRACT FROM AUTHOR]

In a typical catalytic trickle bed type of process reactor, capturing representations of steady-state flow features as well as situations like channelling or bypassing is a challenging task. Transmission-type industrial process tomography (PT) based on gamma radiation can be employed in many chemical and process industries as a tool for localizing the problem area for quick and economical troubleshooting. Industrial PT technology often makes use of either penetrating radiation like radioisotope based gamma rays, X-rays, microwaves or ultrasonic waves. We have developed a new gamma-ray transmission tomography system in collaboration with the Indian Oil Corporation Ltd. (IOCL R&D Unit, Faridabad, India). The system makes use of thirty two scintillator based gamma-ray detectors in addition to a host of other sub-systems. This paper evaluates the performance of the system considering systematic and automated data acquisition, capabilities of the reconstruction software as well as experimental verification using actual flow dynamics in the process column to map the steady state three phase liquid gas flow distribution across a plane in the presence of catalyst. [ABSTRACT FROM AUTHOR]

With an objective to improve the profiles of the 1st generation non-basic MCHR1 antagonists, a lean design approach of replacing the bicyclic thienopyrimidine core with a monocyclic pyrrol-2-one chemotype was examined in the context of reducing aromatic ring count, while also contemplating enhanced flexibility as a means of decreasing flat character. The new compounds exhibited potent antagonism up to the sub-nanomolar range, thereby implying that the monocyclic ring could effectively serve as an effective bioisostere of the bicyclic system. The prototype compound 2m offered benefits like improved potency, reduced half-life, and enhanced solubility, while also demonstrating >5% reduction in weight gain in rats, thereby providing proof-of-concept for this new class of compounds as anti-obesity agents., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Murugaiah A M Subbaiah reports a relationship with Syngene International Ltd that includes: employment. Murugaiah A M Subbaiah has patent #US9499482 issued to Bristol Myers Squibb. There is no conflict of interest to disclose. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Masson SAS. All rights reserved.)

Chronic Human Immunodeficiency Virus (HIV) infection remains a significant challenge to global public health. Despite advances in antiretroviral therapy (ART), which has transformed HIV infection from a fatal disease into a manageable chronic condition, a definitive cure remains elusive. One of the key features of HIV infection is chronic immune activation and inflammation, which are strongly associated with, and predictive of, HIV disease progression, even in patients successfully treated with suppressive ART. Chronic inflammation is characterized by persistent inflammation, immune cell metabolic dysregulation, and cellular exhaustion and dysfunction. This review aims to summarize current knowledge of the interplay between chronic inflammation, immune metabolism, and T cell dysfunction in HIV infection, and also discusses the use of humanized mice models to study HIV immune pathogenesis and develop novel therapeutic strategies.

Adaptor protein 2-associated kinase 1 (AAK1) is a serine/threonine kinase that was identified as a therapeutic target for the potential treatment of neuropathic pain. Inhibition of AAK1 in the central nervous system, particularly within the spinal cord, was found to be the relevant site for achieving an antinociceptive effect. We previously reported that compound 7 is a brain-penetrant, AAK1 inhibitor that showed efficacy in animal models for neuropathic pain. One approach we took to improve upon the potency of 7 involved tying the amide back into the neighboring phenyl ring to form a bicyclic heterocycle. Investigation of the structure-activity relationships (SARs) of substituents on the resultant quinazoline and quinoline ring systems led to the identification of ( S )-31 , a brain-penetrant, AAK1-selective inhibitor with improved enzyme and cellular potency compared to 7 . The synthesis, SAR, and in vivo evaluation of a series of quinazoline and quinoline-based AAK1 inhibitors are described herein.

Industrial Computed Tomography (ICT) is a radiation based cross sectional imaging technique that requires a sample to be manipulated precisely in a specific geometry to acquire analytically useful data. Unlike medical CT, industrial CT may require use of gamma radiation from radio-isotopes like Co 60 , Cs 137 etc. having higher energy radiations for penetrating through higher density and thickness of material under inspection. Data acquisition in ICT involves use of a mechanical manipulator to rotate either the specimen or the source and detectors assembly in circular and linear geometry. Misalignment in mechanical set-up leads to significant artifacts in CT image. The effects may be even more pronounced in data acquired with discrete detector as against Linear Detector Array (LDA) because of certain built-in mechanical integrity associated with LDA. This paper discusses cross correlation based software correction method for combination of gamma ray source and NaI (Tl) scintillation detector based transmission ICT system in parallel beam CT geometry. The proposed correction does not require calibration of the set-up and any prior knowledge of the sample geometry or composition. This data driven correction yields improved CT reconstruction with limited data. The method is demonstrated with a mathematical simulation and applied to experimental data for validation., (Copyright © 2020. Published by Elsevier Ltd.)

Detailed information on shark and ray fisheries in the Andaman and Nicobar Islands, India are limited, including information on the diversity and biological characteristics of these species. We carried out fish landing surveys in South Andamans from January 2017 to May 2018, a comprehensive and cost-effective way to fill this data gap. We sampled 5,742 individuals representing 57 shark and ray species landed from six types of fishing gears. Of the 36 species of sharks and 21 species of rays landed, six species of sharks (Loxodon macrorhinus, Carcharhinus amblyrhynchos, Sphyrna lewini, C. albimarginatus, C. brevipinna, and Paragaleus randalli) comprised 83.35% of shark landings, while three species of rays (Pateobatis jenkinsii, Himantura leoparda and H. tutul) comprised 48.82% of ray landings, suggesting a species dominance in the catch or fishing region. We provide insights into the biology of species with extensions in maximum size for seven shark species. Additionally, we document an increase in the known ray diversity for the islands and for India with three previously unreported ray species. We found that amongst sharks, mature individuals of small-bodied species (63.48% males of total landings of species less than 1.5 m total length when mature) and immature individuals of larger species (84.79% males of total landings of species larger than 1.5 m total length when mature) were mostly landed; whereas for rays, mature individuals were predominantly landed (80.71% males of total landings) likely reflecting differences in habitat preferences along life-history stages across species and fishing gear. The largest size range in sharks was recorded in landings from pelagic longlines and gillnets. Further, the study emphasizes the overlap between critical habitats and fishing grounds, where immature sharks and gravid females were landed in large quantities which might be unsustainable in the long-term. Landings were female-biased in C. amblyrhynchos, S. lewini and P. jenkinsii, and male-biased in L. macrorhinus and H. leoparda, indicating either spatio-temporal or gear-specific sexual segregation in these species. Understanding seasonal and biological variability in the shark and ray landings over a longer study period across different fisheries will inform future conservation and fishery management measures for these species in the Andaman and Nicobar Islands., Competing Interests: The authors have declared that no competing interests exist.

The paper proposed a novel hardware (FPGA) implementation of the coherent averaging architecture for the reconfigurable ultrasonic NDT system. The proposed hardware architecture uses the addressing based shifting technique for the addition operation and Radix-2 non-restoring algorithm for the division operation. Since the amount of hardware required by the proposed averaging scheme is independent of the number of averages, it supports on-the-fly control on the number of averages. Compared to conventional architecture, it provides 96% reduction in memory storage, 98% reduction in the number of adders, and 32% reduction in the processing time for the case of 64 coherent averages. For the experimentation, the ultrasonic imaging system designed and developed by the authors has been utilized. The developed system further supports dynamic on-line reconfiguration of the analog front-end hardware, real-time data acquisition, real-time hardware based data processing, and data transfer operations. The performance of implemented coherent averaging has been presented by various applications such as removal of RF random false-echoes, smoothing of A-scan waveforms and speckle removal of B-scan images., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Without drastic efforts to reduce carbon emissions and mitigate globalized stressors, tropical coral reefs are in jeopardy. Strategic conservation and management requires identification of the environmental and socioeconomic factors driving the persistence of scleractinian coral assemblages-the foundation species of coral reef ecosystems. Here, we compiled coral abundance data from 2,584 Indo-Pacific reefs to evaluate the influence of 21 climate, social and environmental drivers on the ecology of reef coral assemblages. Higher abundances of framework-building corals were typically associated with: weaker thermal disturbances and longer intervals for potential recovery; slower human population growth; reduced access by human settlements and markets; and less nearby agriculture. We therefore propose a framework of three management strategies (protect, recover or transform) by considering: (1) if reefs were above or below a proposed threshold of >10% cover of the coral taxa important for structural complexity and carbonate production; and (2) reef exposure to severe thermal stress during the 2014-2017 global coral bleaching event. Our findings can guide urgent management efforts for coral reefs, by identifying key threats across multiple scales and strategic policy priorities that might sustain a network of functioning reefs in the Indo-Pacific to avoid ecosystem collapse.

Ring artifacts have been studied for X-ray based Computed Tomography (CT) systems but not on γ-ray based in-situ applications. This paper discusses application of recently proposed automatic ring artifact reduction method (Yoon et al., 2016) on previously obtained experimental projection data from a γ-ray based Industrial Process Tomography (IPT) system for a prototype catalytic column. Studies include qualitative and quantitative evaluation of the method. It is observed that ring artifacts are suppressed without loss of significant information in γ-ray PT images., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Herds of dugong, a largely tropical marine megaherbivore, are known to undertake long-distance movements, sequentially overgrazing seagrass meadows in their path. Given their drastic declines in many regions, it is unclear whether at lower densities, their grazing is less intense, reducing their need to travel between meadows. We studied the effect of the feeding behaviour of a small dugong population in the Andaman and Nicobar archipelago, India to understand how small isolated populations graze seagrasses. In the seven years of our observation, all recorded dugongs travelled either solitarily or in pairs, and their use of seagrasses was limited to 8 meadows, some of which were persistently grazed. These meadows were relatively large, contiguous and dominated by short-lived seagrasses species. Dugongs consumed approximately 15% of meadow primary production, but there was a large variation (3-40% of total meadow production) in consumption patterns between meadows. The impact of herbivory was relatively high, with shoot densities c. 50% higher inside herbivore exclosures than in areas exposed to repeated grazing. Our results indicate that dugongs in the study area repeatedly graze the same meadows probably because the proportion of primary production consumed reduces shoot density to levels that are still above values that can trigger meadow abandonment. This ability of seagrasses to cope perhaps explains the long-term site fidelity shown by individual dugongs in these meadows. The fact that seagrass meadows in the archipelago are able to support dugong foraging requirements allows us to clearly identify locations where this remnant population persists, and where urgent management efforts can be directed.