Search

Your search keyword '"Pelargonio, Gemma"' showing total 316 results
Start Over Author "Pelargonio, Gemma" Publication Year Range Last 10 years
316 results on '"Pelargonio, Gemma"'

1. Contact-force local impedance algorithm to guide effective pulmonary vein isolation in AF patients: 1-year outcome from an international multicenter clinical setting

Author

Solimene, Franscesco, Maggio, Ruggero, De Sanctis, Valerio, Escande, William, Malacrida, Maurizio, Stabile, Giuseppe, Zakine, Cyril, Champ-Rigot, Laure, Anselmino, Matteo, Ferraro, Anna, Mantica, Massimo, Zucchelli, Giulio, Dell’Era, Gabriele, Mascia, Giuseppe, Ricci Maga, Renata, Pandozi, Claudio, Rossi, Pietro, Scaglione, Marco, Zingarini, Gianluca, Garnier, Fabien, Loricchio, Maria Luisa, Pelargonio, Gemma, and Lepillier, Antoine

Published
2024
Full Text
View/download PDF

5. Novel cryoballoon technology for atrial fibrillation ablation: Impact of pulmonary vein variant anatomy, cooling characteristics, and 1-year outcome from the CHARISMA registry

Author

Schiavone, Marco, Bianchi, Stefano, Malacrida, Maurizio, Fassini, Gaetano, Ricciolino, Riccardo, Pecora, Domenico, Pelargonio, Gemma, Iacopino, Saverio, Ducceschi, Valentino, Maggio, Ruggero, Bianchini, Lorenzo, La Greca, Carmelo, Rossi, Pietro, Bencardino, Gianluigi, Moltrasio, Massimo, Di Belardino, Natale, Pepi, Patrizia, Rossi, Luca, Santagostino, Matteo, Tondo, Claudio, and De Simone, Antonio

Published
2024
Full Text
View/download PDF

9. Anatomical Annulus Predictors of New Permanent Pacemaker Implantation Risk after Balloon-expandable Trans-catheter Aortic Valve Implantation

Author

Bianchini, Francesco, primary, Bianchini, Emiliano, additional, Romagnoli, Enrico, additional, Aurigemma, Cristina, additional, Zito, Andrea, additional, Busco, Marco, additional, Nesta, Marialisa, additional, Bruno, Piergiorgio, additional, Laezza, Domenico, additional, Giambusso, Nicole, additional, Natale, Luigi, additional, Pelargonio, Gemma, additional, Burzotta, Francesco, additional, and Trani, Carlo, additional

Published
2024
Full Text
View/download PDF

10. Characteristics and Outcome of Patients with or without Previous Implantable Cardioverter Defibrillator Interventions Undergoing Ablation for Ventricular Tachycardia.

Author

Bencardino, Gianluigi, Narducci, Maria Lucia, Scacciavillani, Roberto, Gabrielli, Francesca Augusta, Pelargonio, Gemma, Massetti, Massimo, Crea, Filippo, and Lanza, Gaetano Antonio

Subjects
THUNDERSTORMS, VENTRICULAR tachycardia, VENTRICULAR arrhythmia, VENTRICULAR fibrillation, CATHETER ablation, BODY surface mapping, IMPLANTABLE cardioverter-defibrillators
Abstract

Background: Catheter ablation (CA) is a well-established treatment in patients with ventricular tachycardia and appropriate implantable cardioverter defibrillator (ICD) therapies. Methods: We enrolled 57 consecutive carriers of ICD undergoing CA for electrical storm (ES). Our aim was to investigate differences in clinical, device-related, and electroanatomic features among patients who had history of appropriate ICD interventions before the ES compared to those who had not. The primary endpoint was a composite of death from any cause and recurrences of sustained VT, ventricular fibrillation, appropriate ICD therapy, or ES. Results: During a median follow up of 39 months, 28 patients (49%) met the primary endpoint. Those with previous ICD interventions had a higher prevalence of late potentials and a greater unipolar low-voltage area at electroanatomic mapping. Patients who met the primary endpoint had a higher prevalence of ATP/shock episodes preceding the ES event. At Cox regression analysis, non-ischemic dilated cardiomyopathy (NIDCM), QRS duration, and previous ATP and/or shock before the ES were associated with arrhythmic recurrences and/or death. At multivariate analysis, NIDCM and previous shock were associated with arrhythmic recurrences and/or death. Conclusions: A history of recurrent ICD therapies predicts worse outcomes when CA is needed because of ES. Although more studies are needed to definitively address this question, our data speak in support of an early referral for CA of ES. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Atrial High-Rate Episodes and Subclinical Atrial Fibrillation: State of the Art and Clinical Questions with Complex Solutions.

Author

Brookles, Carola Griffith, De Ponti, Roberto, Russo, Vincenzo, Ziacchi, Matteo, Pelargonio, Gemma, Casella, Michela, Lauretti, Maurelio, Vilotta, Manola, Themistoclakis, Sakis, D’Onofrio, Antonio, Boriani, Giuseppe, and Anselmino, Matteo

Abstract

Atrial high-rate episodes (AHREs) and subclinical atrial fibrillation (AF) are frequently registered in asymptomatic patients with cardiac implantable electronic devices (CIEDs) and insertable cardiac monitors (ICMs). While an increased risk of thromboembolic events (e.g., stroke) and benefits from anticoagulation have been widely assessed in the setting of clinical AF, concerns persist about optimal clinical management of subclinical AF/AHREs. As a matter of fact, an optimal threshold of subclinical episodes’ duration to predict stroke risk is still lacking and recently published randomized clinical trials assessing the impact of anticoagulation on thromboembolic events in this specific setting have shown contrasting results. The aim of this review is to summarize current evidence regarding classification and clinical impact of subclinical AF/AHREs and to discuss the latest evidence regarding the potential benefit of anticoagulation in this setting, highlighting which clinical questions are still unanswered. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Abstract 15458: Incidence of Ventricular Arrhythmias Related to Covid Infection and Vaccination in Patients With Brugada Syndrome: Insights From a Large Italian Multicenter Study

Author

Conti, Sergio, Dello Russo, Antonio, Compagnucci, Paolo, Massara, Francesca, Tondo, Claudio, Ribatti, Valentina, Marcon, Lorenzo, Pelargonio, Gemma, Narducci, Maria Lucia, De Francesco, Luca, Calo, Leonardo, Martino, Annamaria, Balla, Cristina, Iacopino, Saverio, Sgarito, Giuseppe, Patti, Giuseppe, Ghiglieno, Chiara, DellʼEra, Gabriele, Forleo, Giovanni B, Schiavone, Marco, and Casella, Michela

Published
2022
Full Text
View/download PDF

18. Prior myocarditis and ventricular arrhythmias: The importance of scar pattern

Author

Casella, Michela, Bergonti, Marco, Narducci, Maria Lucia, Persampieri, Simone, Gasperetti, Alessio, Conte, Edoardo, Catto, Valentina, Carbucicchio, Corrado, Guerra, Federico, Pontone, Gianluca, Andreini, Daniele, Basso, Cristina, Di Biase, Luigi, Santangeli, Pasquale, Natale, Andrea, Pelargonio, Gemma, Russo, Antonio Dello, and Tondo, Claudio

Published
2021
Full Text
View/download PDF

19. Anatomical Annulus Predictors of New Permanent Pacemaker Implantation Risk after Balloon-expandable Trans-catheter Aortic Valve Implantation

Author

Bianchini, Francesco, Bianchini, Emiliano, Romagnoli, Enrico, Aurigemma, Cristina, Zito, Andrea, Busco, Marco, Nesta, Marialisa, Bruno, Piergiorgio, Laezza, Domenico, Giambusso, Nicole, Natale, Luigi, Pelargonio, Gemma, Burzotta, Francesco, Trani, Carlo, Bruno, Piergiorgio (ORCID:0000-0002-1075-5808), Natale, Luigi (ORCID:0000-0002-7949-5119), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Bianchini, Francesco, Bianchini, Emiliano, Romagnoli, Enrico, Aurigemma, Cristina, Zito, Andrea, Busco, Marco, Nesta, Marialisa, Bruno, Piergiorgio, Laezza, Domenico, Giambusso, Nicole, Natale, Luigi, Pelargonio, Gemma, Burzotta, Francesco, Trani, Carlo, Bruno, Piergiorgio (ORCID:0000-0002-1075-5808), Natale, Luigi (ORCID:0000-0002-7949-5119), Burzotta, Francesco (ORCID:0000-0002-6569-9401), and Trani, Carlo (ORCID:0000-0001-9777-013X)

Abstract

New-generation transcatheter-heart-valves (THV) have significantly improved technical success and procedural safety of transcatheter-aortic-valve-implantation (TAVI) procedures, but incidence of permanent pacemaker implantation (PPI) remains a concern.The study aimed to assess the role of anatomical annulus features in determining peri-procedural conduction disturbances leading to new-PPI following TAVI with the last generation Edwards Sapien balloon-expandable valves (BEV). In the context of a prospective single-center registry, we integrated clinical and procedural predictors of PPI with anatomical data derived from multi-slice-computed-tomography (MSCT). A total of 210 consecutive patients treated with balloon expandable Edwards THV were included in the study from 2015 to 2023. Technical success was achieved in 197 (93.8%) procedures, and 26 patients (12.4%) required new-PPI at 30-day follow-up (median time-to-implantation 3 days). At the univariable logistic-regression analysis, pre-procedural right bundle branch block (RBBB; OR:2.24 [95%CI:1.01-4.97], p=0.047), annulus eccentricity ≥0.25 (OR:5.43 [95%CI:2.21-13.36], p<0.001), calcium volume at annulus of the right coronary cusp (RCC) >48 mm3 (OR:2.60 [95%CI:1.13-5.96], p=0.024) and prosthesis implantation depth greater than membranous septum length (OR:2.17 [95%CI: 1.10-4.28], p=0.026) were associated with new-PPI risk. At multivariable analysis pre-procedural RBBB (OR:2.81 [95%CI:1.01-7.85], p=0.049), annulus eccentricity ≥0.25 (OR:4.14 [95%CI:1.85-9.27], p<0.001), and annulusRCC calcium >48 mm3 (OR:2.89 [95%CI:1.07-7.82], p=0.037) were confirmed as independent predictors of new-PPI. In conclusion, specific anatomical features of the aortic valve annulus might have an additive role in determining the occurrence of conduction disturbances in patients undergoing TAVI with BEV. This suggests the possibility to use the MSCT to improve the prediction of post-TAVI new-PPI risk.

Published
2024

22. Closed loop stimulation reduces the incidence of atrial high-rate episodes compared with conventional rate-adaptive pacing in patients with sinus node dysfunctions.

Author

Pisanò, Ennio C L, Calvi, Valeria, Viscusi, Miguel, Rapacciuolo, Antonio, Lazzari, Ludovico, Bontempi, Luca, Pelargonio, Gemma, Arena, Giuseppe, Caccavo, Vincenzo, Wang, Chun-Chieh, Merkely, Béla, Lin, Lian-Yu, Oh, Il-young, Bertaglia, Emanuele, Saporito, Davide, Menichelli, Maurizio, Nicosia, Antonino, Carretta, Domenico M, Coppolino, Aldo, and Ching, Chi Keong

Abstract

Aims Subclinical atrial fibrillation (AF) is associated with increased risk of progression to clinical AF, stroke, and cardiovascular death. We hypothesized that in pacemaker patients requiring dual-chamber rate-adaptive (DDDR) pacing, closed loop stimulation (CLS) integrated into the circulatory control system through intra-cardiac impedance monitoring would reduce the occurrence of atrial high-rate episodes (AHREs) compared with conventional DDDR pacing. Methods and results Patients with sinus node dysfunctions (SNDs) and an implanted pacemaker or defibrillator were randomly allocated to dual-chamber CLS (n = 612) or accelerometer-based DDDR pacing (n = 598) and followed for 3 years. The primary endpoint was time to the composite endpoint of the first AHRE lasting ≥6 min, stroke, or transient ischaemic attack (TIA). All AHREs were independently adjudicated using intra-cardiac electrograms. The incidence of the primary endpoint was lower in the CLS arm (50.6%) than in the DDDR arm (55.7%), primarily due to the reduction in AHREs lasting between 6 h and 7 days. Unadjusted site-stratified hazard ratio (HR) for CLS vs. DDDR was 0.84 [95% confidence interval (CI), 0.72–0.99; P = 0.035]. After adjusting for CHA2DS2-VASc score, the HR remained 0.84 (95% CI, 0.71–0.99; P = 0.033). In subgroup analyses of AHRE incidence, the incremental benefit of CLS was greatest in patients without atrioventricular block (HR, 0.77; P = 0.008) and in patients without AF history (HR, 0.73; P = 0.009). The contribution of stroke/TIA to the primary endpoint (1.3%) was low and not statistically different between study arms. Conclusion Dual-chamber CLS in patients with SND is associated with a significantly lower AHRE incidence than conventional DDDR pacing. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. High‐density mapping of Koch's triangle during sinus rhythm and typical atrioventricular nodal re‐entrant tachycardia, integrated with direct recording of atrio‐ventricular node structure potential

Author

Pandozi, Claudio, primary, Botto, Giovanni Luca, additional, Loricchio, Maria Luisa, additional, D'Ammando, Matteo, additional, Lavalle, Carlo, additional, Del Giorno, Giuseppe, additional, Matteucci, Andrea, additional, Mariani, Marco Valerio, additional, Nicolis, Daniele, additional, Segreti, Luca, additional, Papa, Andrea Antonio, additional, Casale, Maria Carla, additional, Galeazzi, Marco, additional, Russo, Maurizio, additional, Di Belardino, Natale, additional, Pelargonio, Gemma, additional, Centurion Aznaran, Carlos, additional, Malacrida, Maurizio, additional, Maddaluno, Francesco, additional, Treglia, Simona, additional, Piccolo, Francesco, additional, and Colivicchi, Furio, additional

Published
2024
Full Text
View/download PDF

26. Prognostic value of the Tpeak-Tend interval for in-hospital subacute ventricular arrhythmias in tako-tsubo syndrome

Author

Rosa, Giulio La, Pelargonio, Gemma, Narducci, Maria Lucia, Pinnacchio, Gaetano, Bencardino, Gianluigi, Perna, Francesco, Follesa, Federico, Galiuto, Leonarda, and Crea, Filippo

Subjects
síndrome de tako-tsubo, medicina personalizada, arritmias ventriculares, electrocardiografía, electrocardiography, personalized medicine, tako-tsubo syndrome, tpeak-t end, tpeak-tend, ventricular arrhythmias, General Medicine
Abstract

The clinical value of electrocardiogram (ECG) repolarization parameters associated with ventricular arrhythmias (VAs) in tako-tsubo syndrome is still under debate. We aimed to evaluate ECG predictors of subacute VAs, defined as those occurring after the first 48 hours from admission.This single-center observational study enrolled patients admitted to the cardiology department between 2012 and 2018 with a confirmed diagnosis of tako-tsubo syndrome. Data collection included a 12-lead ECG on admission and at 48 hours, continuous telemetry monitoring, blood testing, transthoracic echocardiography, and coronary angiography during hospitalization. VA events were defined as: premature ventricular contractions ≥ 2000 within a 24-hour window of telemetry monitoring, ventricular fibrillation, sustained ventricular tachycardia (VT), polymorphic VT, and nonsustained VT.A total of 87 patients (age 72 ± 12 years) were enrolled. During a median of 8 days of hospitalization, subacute VAs were documented in 22 patients (25%) after a median of 91 hours from admission. Subacute VAs were associated with an increase in mortality during hospitalization (P = .030). The corrected global (mean of the 12-lead ECG values) Tpeak-Tend interval at 48 hours from admission was an independent predictor of subacute VAs and was statistically superior to the standard corrected QT interval (Z test, P = .040). A cutoff of 108 msec for the corrected global Tpeak-Tend yielded a 71% sensitivity and 72% specificity for subacute VAs.In patients with tako-tsubo syndrome, subacute VAs are associated with repolarization alterations that can be identified on conventional ECG using the Tpeak-Tend interval.

Published
2023

27. Pulmonary vein isolation by means of a novel cryoballoon technology in paroxysmal atrial fibrillation patients: 1‐year outcome from a large Italian multicenter clinical registry

Author

Bianchi, Stefano, primary, De Simone, Antonio, additional, Iacopino, Saverio, additional, Fassini, Gaetano, additional, Malacrida, Maurizio, additional, Rossi, Pietro, additional, Stabile, Giuseppe, additional, Petretta, Andrea, additional, Tundo, Fabrizio, additional, Cauti, Filippo Maria, additional, Iuliano, Sara, additional, Filannino, Pasquale, additional, Moltrasio, Massimo, additional, Morlacchi Bonfanti, Michela, additional, Pelargonio, Gemma, additional, Pecora, Domenico, additional, Ferraro, Anna, additional, and Tondo, Claudio, additional

Published
2023
Full Text
View/download PDF

29. Reply by Casella et al to Letter Regarding Article, “Incidence of ventricular arrhythmias related to Covid infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring”

Author

Casella, Michela, primary, Conti, Sergio, additional, Compagnucci, Paolo, additional, Ribatti, Valentina, additional, Narducci, Maria Lucia, additional, Marcon, Lorenzo, additional, Massara, Francesca, additional, Valeri, Yari, additional, Francesco, Luca De, additional, Martino, Annamaria, additional, Ghiglieno, Chiara, additional, Schiavone, Marco, additional, Balla, Cristina, additional, Dell'Era, Gabriele, additional, Pelargonio, Gemma, additional, Forleo, Giovanni Battista, additional, Iacopino, Saverio, additional, Sgarito, Giuseppe, additional, Calò, Leonardo, additional, Tondo, Claudio, additional, Russo, Antonio Dello, additional, and Patti, Giuseppe, additional

Published
2023
Full Text
View/download PDF

32. Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring

Author

Casella, Michela, primary, Conti, Sergio, additional, Compagnucci, Paolo, additional, Ribatti, Valentina, additional, Narducci, Maria Lucia, additional, Marcon, Lorenzo, additional, Massara, Francesca, additional, Valeri, Yari, additional, De Francesco, Luca, additional, Martino, Anna Maria, additional, Ghiglieno, Chiara, additional, Schiavone, Marco, additional, Balla, Cristina, additional, Dell'Era, Gabriele, additional, Pelargonio, Gemma, additional, Forleo, Giovanni Battista, additional, Iacopino, Saverio, additional, Sgarito, Giuseppe, additional, Calò, Leonardo, additional, Tondo, Claudio, additional, Russo, Antonio Dello, additional, and Patti, Giuseppe, additional

Published
2023
Full Text
View/download PDF

34. PO-04-222 OUTFLOW TRACT VERSUS NON-OUTFLOW TRACT VENTRICULAR ARRHYTHMIAS IN ATHLETES: MYOCARDIAL SUBSTRATE AND LONG-TERM CLINICAL OUTCOMES

Author

Compagnucci, Paolo, primary, Casella, Michela, additional, Narducci, Maria Lucia, additional, Cammarano, Michela, additional, VOLPATO, GIOVANNI, additional, Pelargonio, Gemma, additional, Andreini, Daniele, additional, Conte, Edoardo, additional, Palmieri, Vincenzo, additional, Coretti, Francesca, additional, Lo Russo, Gerardo, additional, Crea, Filippo, additional, Tondo, Claudio, additional, and Russo, Antonio Dello, additional

Published
2023
Full Text
View/download PDF

35. Human cardiac progenitor cells with regenerative potential can be isolated and characterized from 3D-electro-anatomic guided endomyocardial biopsies

Author

D'Amario, Domenico, Leone, Antonio Maria, Narducci, Maria Lucia, Smaldone, Costantino, Lecis, Dalgisio, Inzani, Frediano, Luciani, Marco, Siracusano, Andrea, La Neve, Federica, Manchi, Melissa, Pelargonio, Gemma, Perna, Francesco, Bruno, Piergiorgio, Massetti, Massimo, Pitocco, Dario, Cappetta, Donato, Esposito, Grazia, Urbanek, Konrad, De Angelis, Antonella, Rossi, Francesco, Piacentini, Roberto, Angelini, Giulia, Li Puma, Domenica Donatella, Grassi, Claudio, De Paolis, Elisa, Capoluongo, Ettore, Silvestri, Valentina, Merlino, Biagio, Marano, Riccardo, and Crea, Filippo

Published
2017
Full Text
View/download PDF

37. Mechanisms, prevalence and management of cardiac arrhythmias in cancer patients: a comprehensive review.

Author

Flore, Francesco, Scacciavillani, Roberto, Iannaccone, Giulia, Narducci, Maria Lucia, Pinnacchio, Gaetano, Bencardino, Gianluigi, Perna, Francesco, Spera, Francesco Raffaele, Comerci, Gianluca, Camilli, Massimiliano, Lombardo, Antonella, Lanza, Gaetano Antonio, Crea, Filippo, and Pelargonio, Gemma

Abstract

Recently, prognosis and survival of cancer patients has improved due to progression and refinement of cancer therapies; however, cardiovascular sequelae in this population augmented and now represent the second cause of death in oncological patients. Initially, the main issue was represented by heart failure and coronary artery disease, but a growing body of evidence has now shed light on the increased arrhythmic risk of this population, atrial fibrillation being the most frequently encountered. Awareness of arrhythmic complications of cancer and its treatments may help oncologists and cardiologists to develop targeted approaches for the management of arrhythmias in this population. In this review, we provide an updated overview of the mechanisms triggering cardiac arrhythmias in cancer patients, their prevalence and management. In oncological patients the second cause of death is represented by cardiovascular diseases, due to heart failure, coronary artery disease and arrhythmias. In this review, we provide an overview of mechanisms, prevalence and management of cardiac arrhythmias in this population. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

38. Clinical Impact of Cardiac Fibrosis on Arrhythmia Recurrence after Ablation in Adults with Congenital Heart Disease

Author

Perna, Francesco, primary, Telesca, Alessandro, additional, Scacciavillani, Roberto, additional, Narducci, Maria Lucia, additional, Bencardino, Gianluigi, additional, Pinnacchio, Gaetano, additional, Spera, Francesco Raffaele, additional, Sabarese, Rocco, additional, Comerci, Gianluca, additional, and Pelargonio, Gemma, additional

Published
2023
Full Text
View/download PDF

40. PROGNOSIS OF PATIENTS UNDERGOING CATHETER ABLATION OF ARRHYTHMIC STORM IN PATIENTS WITH AND WITHOUT HISTORY OF PREVIOUS ICD INTERVENTIONS

Author

Bencardino, Gianluigi, primary, Scacciavillani, Roberto, additional, narducci, maria lucia, additional, perna, francesco, additional, Comerci, Gianluca, additional, Gabrielli, Francesca Augusta, additional, Pinnacchio, Gaetano, additional, Spera, Francesco Raffaele, additional, and Pelargonio, Gemma, additional

Published
2023
Full Text
View/download PDF

41. Different Phases of Disease in Lymphocytic Myocarditis

Author

Casella, Michela, primary, Gasperetti, Alessio, additional, Compagnucci, Paolo, additional, Narducci, Maria Lucia, additional, Pelargonio, Gemma, additional, Catto, Valentina, additional, Carbucicchio, Corrado, additional, Bencardino, Gianluigi, additional, Conte, Edoardo, additional, Schicchi, Nicolò, additional, Andreini, Daniele, additional, Pontone, Gianluca, additional, Giovagnoni, Andrea, additional, Rizzo, Stefania, additional, Inzani, Frediano, additional, Basso, Cristina, additional, Natale, Andrea, additional, Tondo, Claudio, additional, Russo, Antonio Dello, additional, and Crea, Filippo, additional

Published
2023
Full Text
View/download PDF

42. Ventricular tachycardia ablation through radiation therapy (VT-ART) consortium: Concept description of an observational multicentric trial via matched pair analysis

Author

Cellini, Francesco, primary, Narducci, Maria Lucia, additional, Pavone, Chiara, additional, Bencardino, Gianluigi, additional, Perna, Francesco, additional, Pinnacchio, Gaetano, additional, Chiesa, Silvia, additional, Massaccesi, Mariangela, additional, Gambacorta, Maria Antonietta, additional, Manfrida, Stefania, additional, Longo, Silvia, additional, Mannocci, Alice, additional, Di Gregorio, Giuseppe, additional, Boldrini, Luca, additional, Tagliaferri, Luca, additional, Indovina, Luca, additional, Placidi, Lorenzo, additional, Stimato, Gerardina, additional, Spera, Francesco Raffaele, additional, Scacciavillani, Roberto, additional, Crea, Filippo, additional, Valentini, Vincenzo, additional, and Pelargonio, Gemma, additional

Published
2023
Full Text
View/download PDF

43. Mortality after transvenous lead extraction: A risk prediction model for sustainable care delivery

Author

Narducci, Maria Lucia, primary, Ruscio, Eleonora, additional, Nurchis, Mario Cesare, additional, Domenico, Pascucci, additional, Scacciavillani, Roberto, additional, Bencardino, Gianluigi, additional, Perna, Francesco, additional, Pelargonio, Gemma, additional, Massetti, Massimo, additional, Damiani, Gianfranco, additional, and Crea, Filippo, additional

Published
2023
Full Text
View/download PDF

44. Ventricular tachycardia ablation through radiation therapy (VT-ART) consortium: Concept description of an observational multicentric trial via matched pair analysis

Author

Cellini, Francesco, Narducci, Maria Lucia, Pavone, Chiara, Bencardino, Gianluigi, Perna, Francesco, Pinnacchio, Gaetano, Chiesa, Silvia, Massaccesi, Mariangela, Gambacorta, Maria Antonietta, Manfrida, Stefania, Longo, Silvia, Mannocci, Alice, Di Gregorio, Giuseppe, Boldrini, Luca, Tagliaferri, Luca, Indovina, Luca, Placidi, Lorenzo, Stimato, Gerardina, Spera, Francesco Raffaele, Scacciavillani, Roberto, Crea, Filippo, Valentini, Vincenzo, Pelargonio, Gemma, Cellini, Francesco (ORCID:0000-0002-2145-2300), Chiesa, Silvia (ORCID:0000-0003-0168-3459), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Tagliaferri, Luca (ORCID:0000-0003-2308-0982), Crea, Filippo (ORCID:0000-0001-9404-8846), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Cellini, Francesco, Narducci, Maria Lucia, Pavone, Chiara, Bencardino, Gianluigi, Perna, Francesco, Pinnacchio, Gaetano, Chiesa, Silvia, Massaccesi, Mariangela, Gambacorta, Maria Antonietta, Manfrida, Stefania, Longo, Silvia, Mannocci, Alice, Di Gregorio, Giuseppe, Boldrini, Luca, Tagliaferri, Luca, Indovina, Luca, Placidi, Lorenzo, Stimato, Gerardina, Spera, Francesco Raffaele, Scacciavillani, Roberto, Crea, Filippo, Valentini, Vincenzo, Pelargonio, Gemma, Cellini, Francesco (ORCID:0000-0002-2145-2300), Chiesa, Silvia (ORCID:0000-0003-0168-3459), Gambacorta, Maria Antonietta (ORCID:0000-0001-5455-8737), Tagliaferri, Luca (ORCID:0000-0003-2308-0982), Crea, Filippo (ORCID:0000-0001-9404-8846), and Valentini, Vincenzo (ORCID:0000-0003-4637-6487)

Abstract

Introduction: Monomorphic ventricular tachycardia (VT) is a life-threatening condition often observed in patients with structural heart disease. Ventricular tachycardia ablation through radiation therapy (VT-ART) for sustained monomorphic ventricular tachycardia seems promising, effective, and safe. VT-ART delivers focused, high-dose radiation, usually in a single fraction of 25 Gy, allowing ablation of VT by inducing myocardial scars. The procedure is fully non-invasive; therefore, it can be easily performed in patients with contraindications to invasive ablation procedures. Definitive data are lacking, and no direct comparison with standard procedures is available.Discussion: The aim of this multicenter observational study is to evaluate the efficacy and safety of VT-ART, comparing the clinical outcome of patients undergone to VT-ART to patients not having received such a procedure. The two groups will not be collected by direct, prospective accrual to avoid randomization among the innovative and traditional arm: A retrospective selection through matched pair analysis will collect patients presenting features similar to the ones undergone VT-ART within the consortium (in each center independently). Our trial will enroll patients with optimized medical therapy in whom endocardial and/or epicardial radiofrequency ablation (RFA), the gold standard for VT ablation, is either unfeasible or fails to control VT recurrence. Our primary outcome is investigating the difference in overall cardiovascular survival among the group undergoing VT-ART and the one not exposed to the innovative procedure. The secondary outcome is evaluating the difference in ventricular event-free survival after the last procedure (i.e., last RFA vs. VT-ART) between the two groups. An additional secondary aim is to evaluate the reduction in the number of VT episodes comparing the 3 months before the procedure to the ones recorded at 6 months (from the 4th to 6th month) following VT-ART and RFA, resp

Published
2023

45. Mortality after transvenous lead extraction: A risk prediction model for sustainable care delivery

Author

Narducci, Maria Lucia, Ruscio, Eleonora, Nurchis, Mario Cesare, Pascucci, Domenico, Scacciavillani, Roberto, Bencardino, Gianluigi, Perna, Francesco, Pelargonio, Gemma, Massetti, Massimo, Damiani, Gianfranco, Crea, Filippo, Nurchis, Mario Cesare (ORCID:0000-0002-9345-4292), Domenico, Pascucci (ORCID:0000-0002-5804-2284), Massetti, Massimo (ORCID:0000-0002-7100-8478), Damiani, Gianfranco (ORCID:0000-0003-3028-6188), Crea, Filippo (ORCID:0000-0001-9404-8846), Narducci, Maria Lucia, Ruscio, Eleonora, Nurchis, Mario Cesare, Pascucci, Domenico, Scacciavillani, Roberto, Bencardino, Gianluigi, Perna, Francesco, Pelargonio, Gemma, Massetti, Massimo, Damiani, Gianfranco, Crea, Filippo, Nurchis, Mario Cesare (ORCID:0000-0002-9345-4292), Domenico, Pascucci (ORCID:0000-0002-5804-2284), Massetti, Massimo (ORCID:0000-0002-7100-8478), Damiani, Gianfranco (ORCID:0000-0003-3028-6188), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

Background and aims: Transvenous lead extraction (TLE) has become a pivotal part of a comprehensive lead management strategy, dealing with a continuously increasing demand. Nonetheless, the literature about the long-term impact of TLE on survivals is still lacking. Given these knowledge gaps, the aim of our study was to analyse very long-term mortality in patients undergoing TLE in public health perspective. Methods: This prospective, single-centre, observational study enrolled consecutive patients with cardiac implantable electronic device (CIED) who underwent TLE, from January 2005 to January 2021. The main goal was to establish the independent predictors of very long-term mortality after TLE. We also aimed at assessing procedural and hospitalization-related costs. Results: We enrolled 435 patients (mean age 70 ± 12 years, with mean lead dwelling time 6.8 ± 16.7 years), with prevalent infective indication to TLE (92%). Initial success of TLE was achieved in 98% of population. After a median follow-up of 4.5 years (range: 1 month-15.5 years), 150 of the 435 enrolled patients (34%) died. At multivariate analysis, death was predicted by: age (≥77 years, OR: 2.55, CI: 1.8-3.6, p < 0.001), chronic kidney disease (CKD) defined as severe reduction of estimated glomerular filtration rate (eGFR <30 mL/min/1.73 m2 , OR: 1.75, CI: 1.24-2.4, p = 0.001) and systolic dysfunction assessed before TLE defined as left ventricular ejection fraction (LVEF) <40%, OR: 1.78, CI 1.26-2.5, p = 0.001. Mean extraction cost was €5011 per patient without reimplantation and €6336 per patient with reimplantation respectively. Conclusions: Our study identified three predictors of long-term mortality in a high-risk cohort of patients with a cardiac device infection, undergoing successful TLE. The future development of a mortality risk score before might impact on public health strategy.

Published
2023

46. 610 EMERGING TRIGGERS OF ARRHYTHMIC EVENTS IN REMOTE MONITORED PATIENTS

Author

Giordano, Federica, primary, Telesca, Alessandro, additional, Ballacci, Federico, additional, Flore, Francesco, additional, Scacciavillani, Roberto, additional, Bencardino, Gianluigi, additional, Perna, Francesco, additional, Pinnacchio, Gaetano, additional, Spera, Francesco Raffaele, additional, Pelargonio, Gemma, additional, Antonio Montone, Rocco, additional, Niccoli, Giampaolo, additional, Crea, Filippo, additional, and Lucia Narducci, Maria, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results