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49 results on '"Pelayo, M."'

13. Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells

Author

Bull, N, Stylianou, E, Kaveh, D, Pinpathomrat, N, Pasricha, J, Harrington-Kandt, R, Garcia-Pelayo, M, Hogarth, P, and McShane, H

Abstract

BCG, the only vaccine licensed against tuberculosis, demonstrates variable efficacy in humans. Recent preclinical studies highlight the potential for mucosal BCG vaccination to improve protection. Lung tissue-resident memory T cells reside within the parenchyma, potentially playing an important role in protective immunity to tuberculosis. We hypothesised that mucosal BCG vaccination may enhance generation of lung tissue-resident T cells, affording improved protection against Mycobacterium tuberculosis. In a mouse model, mucosal intranasal (IN) BCG vaccination conferred superior protection in the lungs compared to the systemic intradermal (ID) route. Intravascular staining allowed discrimination of lung tissue-resident CD4+ T cells from those in the lung vasculature, revealing that mucosal vaccination resulted in an increased frequency of antigen-specific tissue-resident CD4+ T cells compared to systemic vaccination. Tissue-resident CD4+ T cells induced by mucosal BCG displayed enhanced proliferative capacity compared to lung vascular and splenic CD4+ T cells. Only mucosal BCG induced antigen-specific tissue-resident T cells expressing a PD-1+ KLRG1− cell-surface phenotype. These cells constitute a BCG-induced population which may be responsible for the enhanced protection observed with IN vaccination. We demonstrate that mucosal BCG vaccination significantly improves protection over systemic BCG and this correlates with a novel population of BCG-induced lung tissue-resident CD4+ T cells.

Published
2018
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14. Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Author

Maidana, P., primary, Fritzler, A., additional, Mocarbel, Y., additional, Perez Lana, M. B., additional, González, D., additional, Rosales, M., additional, González de Chazal, F., additional, Sternberg, K., additional, Lamas Majek, E., additional, Mallea-Gil, S., additional, Genovesi, E., additional, Pelayo, M., additional, Fabre, B., additional, and Mesch, V., additional

Published
2019
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18. Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF

Author

Pokorney, Sean D, Piccini, Jonathan P., Stevens, Susanna R., Patel, Manesh R., Pieper, Karen S., Halperin, Jonathan L., Breithardt, Günter, Singer, Daniel E., Hankey, Graeme J., Hacke, Werner, Becker, Richard C., Berkowitz, Scott D., Nessel, Christopher C., Mahaffey, Kenneth W., Fox, Keith A. A., Califf, Robert M., Anderson, J., Bedwell, N., Bilsker, M., Bruce, G., Agah, R., Desantis, M., Eisenberg, S., Flores, A., Herzog, W., Klein, S., Snyder, H., Krueger, S., Almaguer, E., Lavie, E., Lee, C., Mallis, G., Modi, M., Woodworth, G., Niazi, I., Peart, B., Sundaram, S., Snoddy, B., Sotolongo, R., Moloney, J., Vijayaraghavan, K., Whittier, F., Yellen, L., Banerjee, S., Lustgarten, D., Suresh, D., Gelernt, M., Levinson, L., Ghanekar, R., Kneller, G., Hall, C., Fadl, Y., Pirwitz, M., French, W., Mayer, N., Pugeda, J., Steel, K., Mody, F., Malik, A., Chandna, H., Go, A., Emlein, G., Bowden, W., Moscoso, R., Hodson, R., Berk, M., Pan, D., Pappas, J., Orchard, R., Lynchard, G., Vijay, N., Khan, W., El Khadra, M., Antonishen, M., Cucher, F., Staab, M., Zebrack, J., Borromeo, S., Heilman, J., Chaturvedi, S., Makam, S., Turk, S., Hyers, T., Williams, G., Labroo, A., Gill, S., Myears, D., Weinstein, J., Shanes, J., Chandrashekhar, Y., Shah, S., Reiter, W., Logemann, T., Almquist, A., Bhagwat, R., Tak, T., Shen Ling, J., Patel, P., Artis, A., Arouni, A., Lauer, M., Kinney, K., Elsen, J., Roan, P., Villafria, R., Sumpter, M., Ip, J., Welka, S., Schifferdecker, B., Sandoval, R., Speirs, S., Jones, A., Haldis, T., Kazmierski, J., Sutherland, J., Dietrich, D., Telfer, E., Berry, J., Mcelveen, A., Russell, J., Sackett, M., Antonios, N., Smith, D., Vora, K., Kirby, A., Lui, H., Mego, D., Ziada, K., Navas, J., Taussig, A., Koren, M., Vogel, C., Saba, F., Parrott, C., Schneider, R., Shirwany, A., Rubin, M., Treasure, C., Bertolet, B., Chang, M., Langberg, J., Becker, R., Cohen, Y., Mcgrew, F., White, J., Arzola, F., Zelenka, J., Tannenbaum, A., Fernandes, V., Jamnadas, P., Agamasu, J., Collins, B., Jauch, W., Sasseen, B., Hotchkiss, D., Abadier, R., Osunkoya, A., Schlau, A., Chappel, C., Foster, M., Braun, E., Mostel, E., Capo, J., Ashchi, M., Howard, V., Albirini, A., Burger, A., Rolston, D., Staniloae, C., Bacon, J., Wiseman, A., Mcgarvey, J., Sonel, A., Hamroff, G., Chang, D., Daboul, N., Broderick, G., Meholick, A., Corbelli, J., Silverman, R., Raffetto, J., Fishberg, R., Georgeson, S., Held, J., Seidner, M., Saint Jacques, H., Heitner, J., Kutalek, S., Friedlander, I., Hutchinson, B., Walia, J., Kondo, N., Smiley, N., Blitz, L., Dale, H., Sulman, S., Szulawski, I., Modares, F., Martin, R., Nahhas, A., Renzi, M., Akyea Djamson, A., Alfieri, A., Sandhu, J., Voyce, S., Amaram, S., Meyerrose, G., Shoukfeh, M., Lee, F., Villegas, B., Idowu, O., Khera, A., Sam, C., Vo, A., Lieber, I., Smith, T., Awan, N., Tsai, C., Ganim, R., Alzaghrini, G., Pitt, W., Shepherd, A., Tang, S., Stoltz, S., Nelson, W., Cox, S., Meymandi, S., Melucci, M., Thomas, G., Gogia, H., Machell, C., Chandrasekaran, S., Brown, C., Jetty, P., Miller, G., Dykstra, G., Jaffrani, N., Zakhary, B., Caruso, A., Zolty, R., Fox, D., Jacobs, G., Lebenthal, M., Mukherjee, S., Zimetbaum, P., Kingsley, J., Jones, R., Robinson, V., Kenton, D., Usedom, J., Williams, S., Snipes, C., Wilson, V., Hasty, R., Shoemaker, J., Donahue, M., Al Saghir, Y., Thomsen, E., Yarows, S., Chastain, S., Mclaughlin, P., Wakham, M., Shrestha, D., Simmons, J., Fisher, D., Seymour, Z., Frandsen, B., First, B., Sharpe, C., Popeil, L., Guthrie, R., Hunter, J., Alvarado, O., Sandberg, J., Gutman, N., Belber, A., Arkhipov, M., Ballyzek, M., Baranov, A., Barbarash, O., Barbarich, V., Belenky, D., Berkovich, O., Bokarev, I., Boyarkin, M., Vaniev, S., Volkova, E., Gratsiansky, N., Demin, A., Zadionchenko, V., Zateyshchikov, D., Zrazhevsky, K., Mazaev, V., Martynov, A., Mikhailov, S., Mkrtchian, V., Novozhenov, V., Raskina, T., Rebrov, A., Sanina, N., Simanekov, V., Sitnikova, M., Smolenskaya, O., Stryuk, R., Storozhakov, G., Tankhilevich, B., Tereschenko, S., Khokhlov, A., Khrustalev, O., Chernov, S., Shvarts, Y., Shubik, Y., Shulman, V., Yakushin, S., Bugrova, O., Ivleva, A., Libis, R., Khozyainova, N., Maslov, S., Baranova, E., Sherenkov, A., Libov, I., Lusov, V., Chumakova, G., Kuznetsov, V., Ryamzina, I., Reshetko, O., Boldueva, S., Alekseeva, N., Novikova, T., Dvornikov, V., Idrisova, E., Shostak, N., Yarokhno, N., Tebloev, K., Treshkur, T., Mazurov, V., Loktin, E., Sedavnyh, I., Alexeeva, O., Yakhontova, P., Repin, A., Izmozherova, N., Kostenko, V., Fokin, A., Ketova, G., Kouz, S., Leader, R., Ayala Paredes, F., Luton, R., Ma, P., Pandey, S., Pesant, Y., Senior, R., Vertes, G., Bell, A., Crowley, D., Vizel, S., Lasko, B., Landry, D., Berger, L., Heath, J., Bessoudo, R., Ling, M., Tellier, G., Berlingieri, J., Kafka, H., Hill, L., Mazza, G., O'Mahony, W., Chilvers, M., O'Mahony, M., Newman, D., Silagy, S., Heffernan, M., Bennett, M., Bhesania, T., Rockman, G., Ng, K., Kalra, B., Meneses, G., Liang, W., Cheung, M., Kozak, J., Pugen, G., Vavougios, J., Kates, M., Nunes Vaz, C., Jaffer, S., Orfi, J., Faiers, A., Chung, C., Felsen, S., Bergman, S., Bernstein, I., Brownscombe, L., Stockdill, J., Silver, E., Ezekiel, D., Jagan, N., Khurana, M., Reisler, H., Goldman, H., Maung, T., Wong, F., Gillis, G., Vexler, R., Goldberg, B., Luterman, M., Gould, D., Coutu, B., Ouellet, A., Macdonald, P., Jones, M., Collette, R., Chong, P., Fargher, T., St Maurice, F., Fortin, C., Chehayeb, R., Proulx, G., Roy, R., Liutkus, J., Syan, G., Rupka, D., Lichtenstein, T., Kooy, J., Papastergiou, D., Lubelsky, B., Doyle, W., Rajakumar, A., Cha, J., Choudhry, A., Bhamjee, H., Mawji, A., Durfresne, M., Constance, C., Mutrie, J., Najarali, A., Warren, R., Mucha, M., Borts, D., Nord, P., Carrier, S., Dawood, M., Sabe Affaki, G., Archibald, J., Abram, N., Teitelbaum, E., Ebrahim, I., Siebert, R., van Zyl, L., Theron, H., Lloyd, E., Sommers, R., Podgorski, G., Steingo, L., Dalby, A., Bayat, J., Herbst, L., Bester, F., Corbett, C., Bennett, J., Roodt, A., Roux, J., Abelson, M., Mohamed, Z., Nortje, H., Da Silva, A., Nikolaides, K., Liagkas, K., Papasteriadis, E., Achimastos, A., Koliopoulos, N., Trikas, A., Manolis, A., Ruiter, J., Basart, D., Crijns, H., Withagen, A., Janssen, M., Van Langeveld, R., van Gelder, I., Hamer, B., Van Der Heijden, R., Hertzeberger, D., Van Hessen, M., Pieterse, M., Groutars, R., Kuijper, A., De Ruiter, G., van Boven, A., Hoogslag, P., Kragten, H., Thijssen, H., Veldkamp, R., Scavee, C., Heidbuchel, H., Debruyne, P., Deruyter, B., El Ali, H., Goethals, M., Cytryn, R., Striekwold, H., De Wolf, L., Goethals, P., Provenier, F., Hellemans, S., Galinier, M., Coisne, D., Koenig, A., Galley, D., Destrac, S., Leduc, J., Rifai, A., Citron, B., Ellie, E., Fournier, P., Steg, G., Landel, R., Robinson, A., Ziegler, F., Boulliat, J., Zuber, M., Vida, M., Galve Basilio, E., Lopez, M., Íñiguez, C., Iglesias Alonso, L., Cavero Gibanel, M., Olivan Martinez, J., Calvo Iglesias, F., Marco Vera, P., Bruguera Cortada, J., Jaber Houbani, A., Merino, J., Olaz Preciado, F., Balaguer, J., de la Hera Galarza, J., Martinez Rubio, A., Fontcuberta, J., Sotillo Marti, J., Gonzalez Juanatey, J., Del Campo, R., Vivanco, G., Alvarez Garcia, P., Pelayo, M., Lippai, J., Zamolyi, K., Károly, T., Vertes, A., Nagy, A., Kosa, I., Janosi, A., Lupkovics, G., Kalo, E., Forster, T., Kis, E., Tenczer, J., Bereczki, D., Komoly, S., Csanyi, A., Kiss, R., Valikovics, A., Dioszeghy, P., Masini, F., Terrosu, P., Cirrincione, V., Marabotti, C., Cosmi, F., Salvioni, A., Binetti, G., Piovaccari, G., Nassiacos, D., Boriani, Giuseppe, Calvi, V., De Caterina, R., Pengo, V., Parati, G., Carolei, A., D'Angelo, A., Di Biase, M., Fattore, L., Agnelli, G., Merlini, P., Furlan, M., Rasura, M., Gandolfo, C., Ageno, W., Piovella, F., Micieli, G., Cinteza, M., Fierbinteanu, C., Natase Melicovici, D., Ionescu, D., Macarie, C., Nanea, I., Radoi, M., Tatu Chitoiu, G., Dragulescu, S., Tudose, A., Militaru, C., Bengus, C., Ungureanu, G., Tau, A., Popa, V., Pirvu, O., Bojinca, M., Sipciu, D., Popescu, M., Chiru, M., Vinereanu, D., Tudoran, M., Cojocaru, T., Vintila, M., Aron, G., Petrascu, O., Bolohan, F., Baumgartner, R., Sekoranja, L., Vojacek, J., Lacnak, B., Kellnerova, I., Dunaj, M., Cihalik, C., Janota, T., Janousek, J., Bouchal, P., Spacek, R., Choi Siruckova, J., Heinc, P., Vojtisek, P., Pirchala, M., Malecha, J., Padour, F., Linhart, A., Mandysova, E., Jandik, J., Zidkova, E., Sipula, D., Ostadal, P., Polasek, R., Stransky, V., Marcinek, G., Rysava, D., Osmancik, P., Huber, K., Drexel, H., Brainin, M., Eichinger Hasenauer, S., Lang, W., Pilger, E., Moriarty, A., Hudson, I., Tang, K., Cleland, J., Macwalter, R., Cooke, J., Mcinnes, G., Durairaj, R., Macleod, M., Murdoch, D., Kadr, H., Lip, G., Andrews, R., Hunt, B., Jackson, P., Roffe, C., Syed, H., Bath, P., Coyle, J., Kelly, D., Stender, S., Torppedersen, C., Tuxen, C., Jensen, G., Melchior, T., Klarlund, K., Dahlstrom, C., Nielsen, T., Nielsen, E., Bronnum Schou, J., Sykulski, R., Blomstrom, P., Lindholm, C., Wallen, T., Nilsson, C., Bertholds, E., Carlsater, J., Sirnes, P., Elle, S., Risberg, K., Furuseth, K., Skag, A., Hoivik, H., Landmark, N., Kjaernli, T., Berg Johansen, J., Gradek, G., Drzewiecki, A., Pluta, W., Szwed, H., Trusz Gluza, M., Ogorek, M., Loboz Grudzien, K., Ruszkowski, P., Sciborski, R., Kopaczewski, J., Jaworska, K., Kubica, J., Opolski, G., Hoffman, A., Krzciuk, M., Sinkiewicz, W., Piotrowski, W., Kolodziej, P., Goszczynska, M., Rynkiewicz, A., Chojnowska, L., Lewczuk, J., Biedrzycka, M., Piepiorka, M., Kowal, J., Karczmarczyk, A., Pruszczyk, P., Tendera, M., Gaciong, Z., Krzeminska Pakula, M., Kornacewicz Jach, Z., Kania, G., Brachmann, J., Lawall, H., Guelker, H., Spitzer, S., Moebiuswinkler, S., Dempfle, C., Bode, C., Darius, H., Genth Zotz, S., Sommer, S., Roehnisch, J., Strasser, R., Daenschel, W., Schwencke, C., vom Dahl, J., Meuser, M., Behrens Spandau, S., Behrens Humbold, S., Muegge, A., Schoen, N., Grooterhorst, P., Ebert, H., Kraemer, A., Kohler, B., Taggeselle, J., Claus, G., Sarnighausen, H., Al Zoebi, A., Schroeder, T., Weissbrodt, M., Lange, R., Gabelmann, M., Kaeaeb, S., Doerr, M., Boscher, D., Bosch, R., Sonntag, F., Bauknecht, C., Omran, H., Leicht, M., Veltkamp, R., Hohensee, H., Dieckmann, H., Winkelmann, B., Bernhardt, P., Schnabel, A., Kadel, C., Proskynitopoulos, N., Seidl, K., Schellong, S., Rios, C., Guevara, C., Coloma, R., Torrejon, H., Parra Galvan, J., Drago Silva, J., Gallegos, J., Mendoza, A., Negron, S., Watanabe, L., Medina, F., Virgen Carrilo, L., Alvarez Lopez, H., Rodriguez, I., Leiva Pons, J., Baños Velasco, A., Villarreal Careaga, J., De los Rios, M., Alcocer Gamba, M., Llamas Esperon, G., Villeda, E., Ahuad Guerrero, A., Alvariqueta, A., Amuchastegui, M., Bluguermann, J., Caime, G., Cuneo, C., Gabito, A., Garcia Brasca, D., Hominal, M., Jure, H., Luquez, H., Montana, O., Piskorz, D., Listorti, S., Serra, J., Sessa, H., Varini, S., Vita, N., Aiub, J., Mackinnon, I., Chekherdemian, S., Castagnino, J., Cimbaro Canella, J., Sgammini, H., Escudero, A., Albina, G., Rapallo, C., Balparda, C., Chahin, M., Fuentealba, V., Riccitelli, M., Casabe, J., Lobo Marquez, L., Kevorkian, R., Cuadrado, J., Dran, R., Muntaner, J., Gonzalez, M., Cartasegna, L., Hasbani, E., Hrabar, A., Sanchez, A., Vogel, D., Hershson, A., Avezum, A., Jaber, J., Ernesto Leaes, P., Bozza, A., Lorga Filho, A., Pimentel Filho, P., Moura Jorge, J., Maia, L., Manenti, E., D'Aurea Mora, R., de Souza Neto, J., Precoma, D., Rabelo, A., Rocha, J., Rossi, P., Kerr Saraiva, J., Zimerman, L., Bodanese, L., Figueiredo, E., de Souza, W. Sebba Barroso, Braga, J., Alessi, S., Gomes, M., Silva, R., Teixeira, M., Costa, F., Motta, M., Sobral Filho, D., Reis, G., Garbelini, B., Zimmermann, S., Pereira Barretto, A., Dohmann, H., Barreto Filho, J., Ghorayeb, N., Borelli, F., Rossi dos Santos, F., Lopes Prudente, M., Vejar, M., Lanas, F., Del Pino, R., Potthoff, S., Charme, G., Aguirre, A., Saldana, A., Garces, E., Bunster, L., Figueroa, H., Olivares, C., Raffo, C., Vergara, E., Sepulveda, P., Jano, G., Morales Alvarado, J., Suarez, R., Urina, M., Perez, G., Quintero, A., Pava, L., Botero Lopez, R., Luengas, C., Hernandez, E., Sanchez, D., Poveda, C., Coronel, J., Beltran, R., Jaramillo, C., Pardo, J., Ponte Negretti, C., Isea, J., Vergara, G., Morr, I., Sim, K., Wan Ahmad, W., Yusof, Z., Rosman, A., Basri, H., Thompson, P., Jeffery, P., Purnell, I., Roberts Thomson, P., Heddle, W., Waites, J., Walters, D., Amerena, J., Challa, P., Karrasch, J., Lowy, A., Fitzpatrick, D., Parsons, M., Phan, T., Bladin, C., Donnan, G., Aroney, G., Gerraty, R., Anderson, C., Blombery, P., Martin, P., Tissa Wijeratne, K., Cross, D., Crimmins, D., Packham, D., Jackson, D., Chua, W., Merino, R., Magno, M., Tirador, L., Batalla, E., Manalo, C., Uy, N., Ebo, G., Reyes, E., Bernan, A., Richards, M., Hart, H., Mann, S., Fisher, R., Stewart, R., Wilkins, G., Barber, A., Tan, R., Ong, H., Singh, R., Sukonthasarn, A., Tanomsup, S., Krittayaphong, R., Piamsomboon, C., Piyayotai, D., Sunsaneewitayakul, B., Baek, S., Seo, H., Rim, S., Kim, C., Kim, K., Ryu, K., Jo, S., Tahk, S., Lee, H., Kim, Y., Shin, D., Choi, Y., Chung, N., Namgung, J., Hong, T., Shin, W., Jin, S., Yan, X., Fu, G., Lu, G., Yang, K., Xu, D., Chen, J., Liu, J., Wu, S., Song, J., Liao, Y., Xu, B., Li, Z., Ma, S., Yin, Y., Zhao, Y., Hu, D., Ma, C., Ma, J., Sun, J., Li, H., Hong, X., Yu, B., Lu, Q., Yang, J., Wu, Z., Li, Y., Huang, Y., Wang, Y., Liu, M., Cheng, Y., Yang, T., Chen, K., Wang, H., Yuan, Z., Wang, J., Zeng, Z., Chen, Y., Yavuzgil, O., Kozan, O., Etemoglu, M., Diker, E., Belgi, A., Ceyhan, C., Cin, V., Yilmaz, O., Ata, N., Altunkeser, B., Agacdiken Agir, A., Karadede, A., Topsakal, R., Gulati, R., Madhavan, A., Jain, S., Oomman, A., Janorkar, S., Kumar, P., Madhukar Naik, A., Thacker, H., Rajasekhar, V., Reddy, R., Keshavamurthy, C., Jain, P., Gowdappa, B., Gadkari, M., Abhyankar, A., Ramesh Babu, B., Vydianathan, P., Sinha, S., Garg, N., Rao, S., Gautam, P., Chockalingam, K., Kumbla, M., Panwar, R., Banker, D., Kaste, M., Jäkälä, P., Roine, R., Mihov, A., Raev, D., Yordanova, V., Dimitrova, S., Benov, H., Tsanova, V., Kyolean, M., Marchev, S., Stoikov, A., Zdravkov, N., Ramshev, K., Krastev, A., Stamenova, P., Angelova, I., Pencheva, G., Grigorova, V., Petrauskiene, B., Skripkauskiene, I., Raugaliene, R., Norkiene, S., Mazutavicius, R., Kavoliuniene, A., Aidietiene, S., Aganauskiene, J., Dailydkiene, A., Marcinkeviciene, J., Grigoniene, L., Anusauskiene, J., Kavaliauskiene, R., Lizogub, V., Rudenko, L., Tseluyko, V., Voronkov, L., Sychov, O., Svyshchenko, Y., Sirenko, Y., Serkova, V., Seredyuk, N., Pertseva, T., Netyazhenko, V., Lishnevska, V., Kupchynska, O., Koval, O., Koshukova, G., Karpenko, O., Grishyna, O., Faynyk, A., Dzyak, G., Dyadyk, O., Yena, L., Volkov, V., Rudyk, I., Kopytsya, M., Kononenko, L., Amosova, K., Zhurba, S., Kazimirko, V., Iuzkiv, I., Shershnyova, O., Khomazyuk, T., Batushkin, V., Vykhovanyuk, I., Popik, G., Skrebkov, V., Skurtov, A., Mishchenko, T., Lytvynenko, N., Sokolova, L., Vatutin, M., Shved, M., Rebrov, B., Kadina, L., Vajda, M., Ursol, G., Zheleznyy, V., Vysochanska, T., Gozhenko, A., Fan, K., Ho, D., Tse, H., Yu, C., Wong, L., Yeh, H., Pai, P., Hsieh, I., Huang, C., Hsieh, Y., Yin, W., Tsai, L., Huang, T., Chen, C., Chiang, F., Ueng, K., Charng, M., Marmor, A., Katz, A., Butnaru, A., Lewis, B., Eldar, M., Rosenhack, S., Elias, N., Koifman, B., Shochat, M., Swissa, M., Zimlichman, R., Bental, T., Weiss, A., Ganam, R., Elias, M., Nseir, W., Oliven, A., Brenner, B., Dayan, M., Pokorney, S, Piccini, J, Stevens, S, Patel, M, Pieper, K, Halperin, J, Breithardt, G, Singer, D, Hankey, G, Hacke, W, Becker, R, Berkowitz, S, Nessel, C, Mahaffey, K, Fox, K, Califf, R, Parati, G, Neurologian yksikkö, and Clinicum

Subjects
Male, Time Factors, medicine.medical_treatment, Administration, Oral, Comorbidity, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, THERAPY, Sudden Cardiac Death, 3124 Neurology and psychiatry, Sudden cardiac death, 0302 clinical medicine, Rivaroxaban, Risk Factors, Cause of Death, Atrial Fibrillation, 80 and over, Medicine, Arrhythmia and Electrophysiology, atrial fibrillation, 030212 general & internal medicine, Stroke, Cause of death, Original Research, CATHETER ABLATION, Aged, 80 and over, DABIGATRAN, Age Factors, Atrial fibrillation, 3. Good health, Intention to Treat Analysis, Treatment Outcome, Mortality, Warfarin, Aged, Anticoagulants, Double-Blind Method, Drug Administration Schedule, Factor Xa Inhibitors, Female, Humans, Multivariate Analysis, Proportional Hazards Models, Risk Assessment, Sex Factors, Cardiology and Cardiovascular Medicine, Administration, medicine.drug, Oral, medicine.medical_specialty, Catheter ablation, Dabigatran, 03 medical and health sciences, RISK-FACTOR, Intensive care medicine, METAANALYSIS, Ischemic Stroke, Intracranial Hemorrhage, Heart Failure, CONGESTIVE-HEART-FAILURE, business.industry, EFFICACY, medicine.disease, warfarin, Emergency medicine, FOLLOW-UP, business
Abstract

Background Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all‐cause mortality may guide interventions. Methods and Results In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose‐adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all‐cause mortality in the 14 171 participants in the intention‐to‐treat population. The median age was 73 years, and the mean CHADS 2 score was 3.5. Over 1.9 years of median follow‐up, 1214 (8.6%) patients died. Kaplan–Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all‐cause mortality was observed between the rivaroxaban and warfarin arms ( P =0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33–1.70, P CI 1.51–1.90, P Conclusions In a large population of patients anticoagulated for nonvalvular atrial fibrillation, ≈7 in 10 deaths were cardiovascular, whereas Clinical Trial Registration URL : https://www.clinicaltrials.gov/ . Unique identifier: NCT 00403767.

Published
2016
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19. Clasificación microscópica de las lesiones cutáneas producidas por Hypoderma lineatum

Author

Cabanelas, E., Panadero, R., Fuertes, M., Fernández Fernández, M., Benavides, Julio, López, C., Pérez Creo, A., Díaz, P., Morrondo-Pelayo, M. Patrocinio, Díez-Baños, Pablo, and Pérez Pérez, Valentín

Abstract

Trabajo presentado a la: XXVII Reunión de la Sociedad Española de Anatomía Patológica Veterinaria. (Barcelona, España, 17 al 19 Junio, 2015).

Published
2015

20. Preliminary results of an inter-laboratory study on quantitative phase analysis

Author

Suárez, M., Aparicio, P., Barrenechea, J. F., Cuevas, J., Delgado, R., Fernández, A. M., Huertas, F. J., García-González, M. T., García-Romero, Emilia, González, I., Fernández, R., León-Reina, Laura, López-Galindo, A., Párraga, J., Pelayo, M., Pozo, E., Pozo, M., Martín-García, J. M., Nieto, F., Sánchez-Bellón, A., Santarén, J., Ruiz, A. I., Terroso, E., and Terroso, D.

Abstract

Trabajo presentado en el Euroclay, celebrado en Edimburgo (Escocia), del 5 al 10 de julio de 2015, Quantitative phase analysis (QPA) of clayey materials using X-Ray diffraction data has always been a challenge. While quantitative methods based on Rietveld analysis offer excellent results for non-clay minerals, they become problematic when high crystallochemical and order degree variations are present in the phases, as is the case of most clay minerals. In the summer of 2014, the Spanish Clay Society (Sociedad Española de Arcillas, SEA) proposed a collective QPA experiment to its members. The aim was to compare the results obtained in different clay laboratories studying the same samples by X-Ray diffraction. This comparative study is a starting point for a long-term work focused on the development of an optimized QPA guide for clay minerals adapted to modern equipment and software. The results presented in this talk are those from the 2014 preliminary study in which the 22 participant laboratories analyzed three samples following their own laboratory routines. The only condition was not to use other complementary techniques for the quantification (e.g. IR spectroscopy, thermal or chemical analysis). The samples were mixtures of nearly pure quartz, feldspar, calcite, alunite, and different clays. Clay minerals included two different smectites (with low and high crystallinity), sepiolite, kaolinite and palygorskite. The set of procedures, technical characteristics of the equipment, and software used in each laboratory was very different and, as a consequence, comparison of the results is not straightforward. The results were classified into "Reflecting Powers Method" (RPM) and “Relative Intensity Ratio (RIR) – Rietveld methods” groups. As it is well known RPM is based on the peaks areas while RIR is based on the peak intensities. As expected, a high dispersion of the results was found both globally and per group. At first glance, RPM returned, on average, better approximations to the true composition of the samples. Interestingly that trend was clearer in samples with clay minerals having higher variability in crystallochemistry and crystalline range order.

Published
2015

22. Evidence of montmorillonite/Fe-rich smectite transformation in the Morrón de Mateo bentonite deposit (Spain): Implications for the clayey barrier behaviour

Author

Pelayo, M., García Romero, Emilia, Labajo, M.A., Pérez del Villar Guillén, L., Pelayo, M., García Romero, Emilia, Labajo, M.A., and Pérez del Villar Guillén, L.

Abstract

The Morrón de Mateo bentonite deposit (Cabo de Gata region, Spain) has been studied as a natural analogue of the thermal and geochemical effects on the clayey barrier in a deep geological repository of high level radioactive wastes. This deposit was intruded by a volcanic dome inducing an increase of temperature and supplying Fe–Mg-rich solutions, which were responsible for the alteration of the previously bentonitised pyroclastic materials (white tuff formation). The textural, mineralogical and crystallochemical features of the smectites located within the vicinity and away from the dome have been studied in order to elucidate the intrusion effects on these smectites. The results obtained show that distal smectites are Al-montmorillonites, similar to those from other bentonite deposits in the Cabo de Gata region; whereas proximal smectites are a mixture of Al-montmorillonites, Fe-rich montmorillonites and beidellites, and intermediate smectites between beidellite and Fe-rich-saponite. The textural relationships between these smectites indicate that smectites with intermediate composition come from the transformation of Al-montmorillonite, through gradual steps, consisting of increasingly Mg and Fe-rich smectites. This transformation process is confirmed when the structural formulae of proximal smectites are plotted on the MgVIvs (Al + Fe3 +)VI diagram. Thus, a gradual transition from dioctahedral smectites to smectites with an intermediate chemical composition is observed, which tend toward trioctahedral smectites. These observations suggest that the transformation of dioctahedral smectites into an intermediate term between di- and trioctahedral Fe-rich smectites could be originated under natural conditions. This transformation can be considered as an analogue process to that expected in the bentonite barrier from a deep geological repository of radioactive wastes whether the two following conditions would occur: i) an increase of temperature due to the radioactive, ENRESA/CIEMAT, Depto. de Mineralogía y Petrología, Fac. de Ciencias Geológicas, FALSE, pub

Published
2016

23. Characterization of soil erosion indicators using hyperspectral data from a Mediterranean rainfed cultivated region

Author

Schmid, T., Rodriguez-Rastrero, M., Escribano, P., Palacios-Orueta, Alicia, Ben-Dor, E., Plaza, A., Milewski, R., Huesca, M., Bracken, A., Cicuendez, V., Pelayo, M., Chabrillat, S., Schmid, T., Rodriguez-Rastrero, M., Escribano, P., Palacios-Orueta, Alicia, Ben-Dor, E., Plaza, A., Milewski, R., Huesca, M., Bracken, A., Cicuendez, V., Pelayo, M., and Chabrillat, S.

Abstract

The determination of surface soil properties is an important application of remotely sensed hyperspectral imagery. Moreover, different soil properties can be associated with erosion processes, with significant implications for land management and agricultural uses. This study integrates hyperspectral data supported by morphological and physico-chemical ground data to identify and map soil properties that can be used to assess soil erosion and accumulation. These properties characterize different soil horizons that emerge at the surface as a consequence of the intensity of the erosion processes, or the result of accumulation conditions. This study includes: 1) field and laboratory characterization of the main soil types in the study area; 2) identification and definition of indicators of soil erosion and accumulation stages (SEAS); 3) compilation of the site-specific MEDiterranean Soil Erosion Stages (MEDSES) spectral library of soil surface characteristics using field spectroscopy; 4) using hyperspectral airborne data to determine a set of endmembers for different SEAS and introducing these into the support vector machine (SVM) classifier to obtain their spatial distribution; and 5) evaluation of the accuracy of the classification applying a field validation protocol. The study region is located within an agricultural region in Central Spain, representative of Mediterranean agricultural uses dominated by a gently sloping relief, and characterized by soils with contrasting horizons. Results show that the proposed method is successful in mapping different SEAS that indicate preservation, partial loss, or complete loss of fertile soils, as well as down-slope accumulation of different soil materials.

Published
2016

24. Evidence of montmorillonite/Fe-rich smectite transformation in the Morrón de Mateo bentonite deposit (Spain): Implications for the clayey barrier behaviour

Author

Empresa Nacional de Residuos Radiactivos (España), Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (España), Pelayo, M., García-Romero, Emilia, Labajo, M. A., Pérez Del Villar, L., Empresa Nacional de Residuos Radiactivos (España), Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (España), Pelayo, M., García-Romero, Emilia, Labajo, M. A., and Pérez Del Villar, L.

Abstract

The Morrón de Mateo bentonite deposit (Cabo de Gata region, Spain) has been studied as a natural analogue of the thermal and geochemical effects on the clayey barrier in a deep geological repository of high level radioactive wastes. This deposit was intruded by a volcanic dome inducing an increase of temperature and supplying Fe–Mg-rich solutions, which were responsible for the alteration of the previously bentonitised pyroclastic materials (white tuff formation). The textural, mineralogical and crystallochemical features of the smectites located within the vicinity and away from the dome have been studied in order to elucidate the intrusion effects on these smectites. The results obtained show that distal smectites are Al-montmorillonites, similar to those from other bentonite deposits in the Cabo de Gata region; whereas proximal smectites are a mixture of Al-montmorillonites, Fe-rich montmorillonites and beidellites, and intermediate smectites between beidellite and Fe-rich-saponite. The textural relationships between these smectites indicate that smectites with intermediate composition come from the transformation of Al-montmorillonite, through gradual steps, consisting of increasingly Mg and Fe-rich smectites. This transformation process is confirmed when the structural formulae of proximal smectites are plotted on the MgVIvs (Al + Fe3 +)VI diagram. Thus, a gradual transition from dioctahedral smectites to smectites with an intermediate chemical composition is observed, which tend toward trioctahedral smectites. These observations suggest that the transformation of dioctahedral smectites into an intermediate term between di- and trioctahedral Fe-rich smectites could be originated under natural conditions. This transformation can be considered as an analogue process to that expected in the bentonite barrier from a deep geological repository of radioactive wastes whether the two following conditions would occur: i) an increase of temperature due to the radioactive

Published
2016

27. Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF

Author

Pokorney, Sean D., primary, Piccini, Jonathan P., additional, Stevens, Susanna R., additional, Patel, Manesh R., additional, Pieper, Karen S., additional, Halperin, Jonathan L., additional, Breithardt, Günter, additional, Singer, Daniel E., additional, Hankey, Graeme J., additional, Hacke, Werner, additional, Becker, Richard C., additional, Berkowitz, Scott D., additional, Nessel, Christopher C., additional, Mahaffey, Kenneth W., additional, Fox, Keith A. A., additional, Califf, Robert M., additional, Anderson, J., additional, Bedwell, N., additional, Bilsker, M., additional, Bruce, G., additional, Agah, R., additional, DeSantis, M., additional, Eisenberg, S., additional, Flores, A., additional, Herzog, W., additional, Klein, S., additional, Snyder, H., additional, Krueger, S., additional, Almaguer, E., additional, Lavie, E., additional, Lee, C., additional, Mallis, G., additional, Modi, M., additional, Woodworth, G., additional, Niazi, I., additional, Peart, B., additional, Sundaram, S., additional, Snoddy, B., additional, Sotolongo, R., additional, Moloney, J., additional, Vijayaraghavan, K., additional, Whittier, F., additional, Yellen, L., additional, Banerjee, S., additional, Lustgarten, D., additional, Suresh, D., additional, Gelernt, M., additional, Levinson, L., additional, Ghanekar, R., additional, Kneller, G., additional, Hall, C., additional, Fadl, Y., additional, Pirwitz, M., additional, French, W., additional, Mayer, N., additional, Pugeda, J., additional, Steel, K., additional, Mody, F., additional, Malik, A., additional, Chandna, H., additional, Go, A., additional, Emlein, G., additional, Bowden, W., additional, Moscoso, R., additional, Hodson, R., additional, Berk, M., additional, Pan, D., additional, Pappas, J., additional, Orchard, R., additional, Lynchard, G., additional, Vijay, N., additional, Khan, W., additional, El Khadra, M, additional, Antonishen, M., additional, Cucher, F., additional, Staab, M., additional, Zebrack, J., additional, Borromeo, S, additional, Heilman, J., additional, Chaturvedi, S., additional, Makam, S., additional, Turk, S., additional, Hyers, T., additional, Williams, G., additional, Labroo, A., additional, Gill, S., additional, Myears, D., additional, Weinstein, J., additional, Shanes, J., additional, Chandrashekhar, Y., additional, Shah, S., additional, Reiter, W., additional, Logemann, T., additional, Almquist, A., additional, Bhagwat, R., additional, Tak, T., additional, Shen‐Ling, J., additional, Patel, P., additional, Artis, A., additional, Arouni, A., additional, Lauer, M., additional, Kinney, K., additional, Elsen, J., additional, Roan, P., additional, Villafria, R., additional, Sumpter, M., additional, Ip, J., additional, Welka, S., additional, Schifferdecker, B., additional, Sandoval, R., additional, Speirs, S., additional, Jones, A., additional, Haldis, T., additional, Kazmierski, J., additional, Sutherland, J., additional, Dietrich, D., additional, Telfer, E., additional, Berry, J., additional, McElveen, A., additional, Russell, J., additional, Sackett, M., additional, Antonios, N., additional, Smith, D., additional, Vora, K., additional, Kirby, A., additional, Lui, H., additional, Mego, D., additional, Ziada, K., additional, Navas, J., additional, Taussig, A., additional, Koren, M., additional, Vogel, C., additional, Saba, F., additional, Parrott, C., additional, Schneider, R., additional, Shirwany, A., additional, Rubin, M., additional, Treasure, C, additional, Bertolet, B., additional, Chang, M., additional, Langberg, J., additional, Becker, R., additional, Cohen, Y., additional, McGrew, F., additional, White, J., additional, Arzola, F., additional, Zelenka, J., additional, Tannenbaum, A., additional, Fernandes, V., additional, Jamnadas, P., additional, Agamasu, J., additional, Collins, B., additional, Jauch, W., additional, Sasseen, B., additional, Hotchkiss, D., additional, Abadier, R., additional, Osunkoya, A., additional, Schlau, A., additional, Chappel, C., additional, Foster, M., additional, Braun, E., additional, Mostel, E., additional, Capo, J., additional, Ashchi, M., additional, Howard, V., additional, Albirini, A., additional, Burger, A., additional, Rolston, D., additional, Staniloae, C., additional, Bacon, J., additional, Wiseman, A., additional, McGarvey, J, additional, Sonel, A., additional, Hamroff, G., additional, Chang, D., additional, Daboul, N., additional, Broderick, G., additional, Meholick, A., additional, Corbelli, J., additional, Silverman, R., additional, Raffetto, J., additional, Fishberg, R., additional, Georgeson, S., additional, Held, J., additional, Seidner, M., additional, Saint‐Jacques, H., additional, Heitner, J., additional, Kutalek, S., additional, Friedlander, I., additional, Hutchinson, B., additional, Walia, J., additional, Kondo, N., additional, Smiley, N., additional, Blitz, L., additional, Dale, H., additional, Sulman, S., additional, Szulawski, I., additional, Modares, F., additional, Martin, R., additional, Nahhas, A., additional, Renzi, M., additional, Akyea‐Djamson, A., additional, Alfieri, A., additional, Sandhu, J., additional, Voyce, S., additional, Amaram, S., additional, Meyerrose, G., additional, Shoukfeh, M., additional, Lee, F., additional, Villegas, B., additional, Idowu, O., additional, Khera, A., additional, Sam, C., additional, Vo, A., additional, Lieber, I., additional, Smith, T., additional, Awan, N., additional, Tsai, C., additional, Ganim, R., additional, Alzaghrini, G., additional, Pitt, W., additional, Shepherd, A., additional, Tang, S., additional, Stoltz, S., additional, Nelson, W., additional, Cox, S., additional, Meymandi, S., additional, Melucci, M., additional, Thomas, G., additional, Gogia, H., additional, Machell, C., additional, Chandrasekaran, S., additional, Brown, C., additional, Jetty, P., additional, Miller, G., additional, Dykstra, G., additional, Jaffrani, N., additional, Zakhary, B., additional, Caruso, A., additional, Zolty, R., additional, Fox, D., additional, Jacobs, G., additional, Lebenthal, M., additional, Mukherjee, S., additional, Zimetbaum, P., additional, Kingsley, J., additional, Jones, R., additional, Robinson, V., additional, Kenton, D., additional, Usedom, J., additional, Williams, S., additional, Snipes, C., additional, Wilson, V., additional, Hasty, R., additional, Shoemaker, J., additional, Donahue, M., additional, Al‐Saghir, Y., additional, Thomsen, E., additional, Yarows, S., additional, Chastain, S., additional, McLaughlin, P., additional, Wakham, M., additional, Shrestha, D., additional, Simmons, J., additional, Fisher, D., additional, Seymour, Z., additional, Frandsen, B., additional, First, B., additional, Sharpe, C., additional, Popeil, L., additional, Guthrie, R., additional, Hunter, J., additional, Alvarado, O., additional, Sandberg, J., additional, Gutman, N., additional, Belber, A., additional, Arkhipov, M., additional, Ballyzek, M., additional, Baranov, A., additional, Barbarash, O., additional, Barbarich, V., additional, Belenky, D., additional, Berkovich, O., additional, Bokarev, I., additional, Boyarkin, M., additional, Vaniev, S., additional, Volkova, E., additional, Gratsiansky, N., additional, Demin, A., additional, Zadionchenko, V., additional, Zateyshchikov, D., additional, Zrazhevsky, K., additional, Mazaev, V., additional, Martynov, A., additional, Mikhailov, S., additional, Mkrtchian, V., additional, Novozhenov, V., additional, Raskina, T., additional, Rebrov, A., additional, Sanina, N., additional, Simanekov, V., additional, Sitnikova, M., additional, Smolenskaya, O., additional, Stryuk, R., additional, Storozhakov, G., additional, Tankhilevich, B., additional, Tereschenko, S., additional, Khokhlov, A., additional, Khrustalev, O., additional, Chernov, S., additional, Shvarts, Y., additional, Shubik, Y., additional, Shulman, V., additional, Yakushin, S., additional, Bugrova, O., additional, Ivleva, A., additional, Libis, R., additional, Khozyainova, N., additional, Maslov, S., additional, Baranova, E., additional, Sherenkov, A., additional, Libov, I., additional, Lusov, V., additional, Chumakova, G., additional, Kuznetsov, V., additional, Ryamzina, I., additional, Reshetko, O., additional, Boldueva, S., additional, Alekseeva, N., additional, Novikova, T., additional, Dvornikov, V., additional, Idrisova, E., additional, Shostak, N., additional, Yarokhno, N., additional, Tebloev, K., additional, Treshkur, T., additional, Mazurov, V., additional, Loktin, E., additional, Sedavnyh, I., additional, Alexeeva, O., additional, Yakhontova, P., additional, Repin, A., additional, Izmozherova, N., additional, Kostenko, V., additional, Fokin, A., additional, Ketova, G., additional, Kouz, S., additional, Leader, R., additional, Ayala‐Paredes, F., additional, Luton, R., additional, Ma, P., additional, Pandey, S., additional, Pesant, Y., additional, Senior, R., additional, Vertes, G., additional, Bell, A., additional, Crowley, D., additional, Vizel, S., additional, Lasko, B., additional, Landry, D., additional, Berger, L., additional, Heath, J., additional, Bessoudo, R., additional, Ling, M., additional, Tellier, G., additional, Berlingieri, J., additional, Kafka, H., additional, Hill, L., additional, Mazza, G., additional, O'Mahony, W., additional, Chilvers, M., additional, O'Mahony, M., additional, Newman, D., additional, Silagy, S., additional, Heffernan, M., additional, Bennett, M., additional, Bhesania, T., additional, Rockman, G., additional, Ng, K., additional, Kalra, B., additional, Meneses, G., additional, Liang, W., additional, Cheung, M., additional, Kozak, J., additional, Pugen, G., additional, Vavougios, J., additional, Kates, M., additional, Nunes‐Vaz, C., additional, Jaffer, S., additional, Orfi, J., additional, Faiers, A., additional, Chung, C., additional, Felsen, S., additional, Bergman, S., additional, Bernstein, I., additional, Brownscombe, L., additional, Stockdill, J., additional, Silver, E., additional, Ezekiel, D., additional, Jagan, N., additional, Khurana, M., additional, Reisler, H., additional, Goldman, H., additional, Maung, T., additional, Wong, F., additional, Gillis, G., additional, Vexler, R., additional, Goldberg, B., additional, Luterman, M., additional, Gould, D., additional, Coutu, B., additional, Ouellet, A., additional, MacDonald, P., additional, Jones, M., additional, Collette, R., additional, Chong, P., additional, Fargher, T., additional, St‐Maurice, F., additional, Fortin, C., additional, Chehayeb, R., additional, Proulx, G., additional, Roy, R., additional, Liutkus, J., additional, Syan, G., additional, Rupka, D., additional, Lichtenstein, T., additional, Kooy, J., additional, Papastergiou, D., additional, Lubelsky, B., additional, Doyle, W., additional, Rajakumar, A., additional, Cha, J., additional, Choudhry, A., additional, Bhamjee, H., additional, Mawji, A., additional, Durfresne, M., additional, Constance, C., additional, Mutrie, J., additional, Najarali, A., additional, Warren, R., additional, Mucha, M., additional, Borts, D., additional, Nord, P., additional, Carrier, S., additional, Dawood, M., additional, Sabe‐Affaki, G., additional, Archibald, J., additional, Abram, N., additional, Teitelbaum, E., additional, Ebrahim, I., additional, Siebert, R., additional, van Zyl, L., additional, Theron, H., additional, Lloyd, E., additional, Sommers, R., additional, Podgorski, G., additional, Steingo, L., additional, Dalby, A., additional, Bayat, J., additional, Herbst, L., additional, Bester, F., additional, Corbett, C., additional, Bennett, J., additional, Roodt, A., additional, Roux, J., additional, Abelson, M., additional, Mohamed, Z., additional, Nortje, H., additional, Da Silva, A., additional, Nikolaides, K., additional, Liagkas, K., additional, Papasteriadis, E., additional, Achimastos, A., additional, Koliopoulos, N., additional, Trikas, A., additional, Manolis, A., additional, Ruiter, J., additional, Basart, D., additional, Crijns, H., additional, Withagen, A., additional, Janssen, M., additional, Van Langeveld, R, additional, van Gelder, I., additional, Hamer, B., additional, Van Der Heijden, R, additional, Hertzeberger, D., additional, Van Hessen, M, additional, Pieterse, M., additional, Groutars, R., additional, Kuijper, A., additional, De Ruiter, G, additional, van Boven, A., additional, Hoogslag, P., additional, Kragten, H., additional, Thijssen, H., additional, Veldkamp, R., additional, Scavee, C., additional, Heidbuchel, H., additional, Debruyne, P., additional, Deruyter, B., additional, El Ali, H, additional, Goethals, M., additional, Cytryn, R., additional, Striekwold, H., additional, De Wolf, L, additional, Goethals, P., additional, Provenier, F., additional, Hellemans, S., additional, Galinier, M., additional, Coisne, D., additional, Koenig, A., additional, Galley, D., additional, Destrac, S., additional, Leduc, J., additional, Rifai, A., additional, Citron, B., additional, Ellie, E., additional, Fournier, P., additional, Steg, G., additional, Landel, R., additional, Robinson, A., additional, Ziegler, F., additional, Boulliat, J., additional, Zuber, M., additional, Vida, M., additional, Galve Basilio, E., additional, Lopez, M., additional, Íñiguez, C., additional, Iglesias Alonso, L., additional, Cavero Gibanel, M., additional, Olivan Martinez, J., additional, Calvo Iglesias, F., additional, Marco Vera, P., additional, Bruguera Cortada, J., additional, Jaber Houbani, A., additional, Merino, J., additional, Olaz Preciado, F., additional, Balaguer, J., additional, de la Hera Galarza, J, additional, Martinez Rubio, A., additional, Fontcuberta, J., additional, Sotillo Marti, J., additional, Gonzalez Juanatey, J., additional, Del Campo, R., additional, Vivanco, G., additional, Alvarez Garcia, P., additional, Pelayo, M., additional, Lippai, J., additional, Zamolyi, K., additional, Károly, T., additional, Vertes, A., additional, Nagy, A., additional, Kosa, I., additional, Janosi, A., additional, Lupkovics, G., additional, Kalo, E., additional, Forster, T., additional, Kis, E., additional, Tenczer, J., additional, Bereczki, D., additional, Komoly, S., additional, Csanyi, A., additional, Kiss, R., additional, Valikovics, A., additional, Dioszeghy, P., additional, Masini, F., additional, Terrosu, P., additional, Cirrincione, V., additional, Marabotti, C., additional, Cosmi, F., additional, Salvioni, A., additional, Binetti, G., additional, Piovaccari, G., additional, Nassiacos, D., additional, Boriani, G., additional, Calvi, V., additional, De Caterina, R, additional, Pengo, V., additional, Parati, G., additional, Carolei, A., additional, D'Angelo, A., additional, Di Biase, M., additional, Fattore, L., additional, Agnelli, G., additional, Merlini, P., additional, Furlan, M., additional, Rasura, M., additional, Gandolfo, C., additional, Ageno, W., additional, Piovella, F., additional, Micieli, G., additional, Cinteza, M., additional, Fierbinteanu, C., additional, Natase‐Melicovici, D., additional, Ionescu, D., additional, Macarie, C., additional, Nanea, I., additional, Radoi, M., additional, Tatu‐Chitoiu, G., additional, Dragulescu, S., additional, Tudose, A., additional, Militaru, C., additional, Bengus, C., additional, Ungureanu, G., additional, Tau, A., additional, Popa, V., additional, Pirvu, O., additional, Bojinca, M., additional, Sipciu, D., additional, Popescu, M., additional, Chiru, M., additional, Vinereanu, D., additional, Tudoran, M., additional, Cojocaru, T., additional, Vintila, M., additional, Aron, G., additional, Petrascu, O., additional, Bolohan, F., additional, Baumgartner, R., additional, Sekoranja, L., additional, Vojacek, J., additional, Lacnak, B., additional, Kellnerova, I., additional, Dunaj, M., additional, Cihalik, C., additional, Janota, T., additional, Janousek, J., additional, Bouchal, P., additional, Spacek, R., additional, Choi Siruckova, J., additional, Heinc, P., additional, Vojtisek, P., additional, Pirchala, M., additional, Malecha, J., additional, Padour, F., additional, Linhart, A., additional, Mandysova, E., additional, Jandik, J., additional, Zidkova, E., additional, Sipula, D., additional, Ostadal, P., additional, Polasek, R., additional, Stransky, V., additional, Marcinek, G., additional, Rysava, D., additional, Osmancik, P., additional, Huber, K., additional, Drexel, H., additional, Brainin, M., additional, Eichinger‐Hasenauer, S., additional, Lang, W., additional, Pilger, E., additional, Moriarty, A., additional, Hudson, I., additional, Tang, K., additional, Cleland, J., additional, MacWalter, R., additional, Cooke, J., additional, McInnes, G., additional, Durairaj, R., additional, MacLeod, M., additional, Murdoch, D., additional, Kadr, H., additional, Lip, G., additional, Andrews, R., additional, Hunt, B., additional, Jackson, P., additional, Roffe, C., additional, Syed, H., additional, Bath, P., additional, Coyle, J., additional, Kelly, D., additional, Stender, S., additional, TorpPedersen, C., additional, Tuxen, C., additional, Jensen, G., additional, Melchior, T., additional, Klarlund, K., additional, Dahlstrom, C., additional, Nielsen, T., additional, Nielsen, E., additional, Bronnum‐Schou, J., additional, Sykulski, R., additional, Blomstrom, P., additional, Lindholm, C., additional, Wallen, T., additional, Nilsson, C., additional, Bertholds, E., additional, Carlsater, J., additional, Sirnes, P., additional, Elle, S., 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Amuchastegui, M., additional, Bluguermann, J., additional, Caime, G., additional, Cuneo, C., additional, Gabito, A., additional, Garcia Brasca, D., additional, Hominal, M., additional, Jure, H., additional, Luquez, H., additional, Montana, O., additional, Piskorz, D., additional, Listorti, S., additional, Serra, J., additional, Sessa, H., additional, Varini, S., additional, Vita, N., additional, Aiub, J., additional, MacKinnon, I., additional, Chekherdemian, S., additional, Castagnino, J., additional, Cimbaro Canella, J., additional, Sgammini, H., additional, Escudero, A., additional, Albina, G., additional, Rapallo, C., additional, Balparda, C., additional, Chahin, M., additional, Fuentealba, V., additional, Riccitelli, M., additional, Casabe, J., additional, Lobo Marquez, L., additional, Kevorkian, R., additional, Cuadrado, J., additional, Dran, R., additional, Muntaner, J., additional, Gonzalez, M., additional, Cartasegna, L., additional, Hasbani, E., additional, Hrabar, A., additional, Sanchez, A., additional, Vogel, D., additional, Hershson, A., additional, Avezum, A., additional, Jaber, J., additional, Ernesto Leaes, P., additional, Bozza, A., additional, Lorga Filho, A., additional, Pimentel Filho, P., additional, Moura Jorge, J., additional, Maia, L., additional, Manenti, E., additional, D'Aurea Mora, R, additional, de Souza Neto, J, additional, Precoma, D., additional, Rabelo, A., additional, Rocha, J., additional, Rossi, P., additional, Kerr Saraiva, J., additional, Zimerman, L., additional, Bodanese, L., additional, Figueiredo, E., additional, de Souza, W. Sebba Barroso, additional, Braga, J., additional, Alessi, S., additional, Gomes, M., additional, Silva, R., additional, Teixeira, M., additional, Costa, F., additional, Motta, M., additional, Sobral Filho, D., additional, Reis, G., additional, Garbelini, B, additional, Zimmermann, S., additional, Pereira Barretto, A., additional, Dohmann, H., additional, Barreto Filho, J., additional, Ghorayeb, N., additional, Borelli, F., additional, Rossi dos Santos, F., additional, Lopes Prudente, M., additional, Vejar, M., additional, Lanas, F., additional, Del Pino, R., additional, Potthoff, S., additional, Charme, G., additional, Aguirre, A., additional, Saldana, A., additional, Garces, E., additional, Bunster, L., additional, Figueroa, H., additional, Olivares, C., additional, Raffo, C., additional, Vergara, E., additional, Sepulveda, P., additional, Jano, G., additional, Morales Alvarado, J., additional, Suarez, R., additional, Urina, M., additional, Perez, G., additional, Quintero, A., additional, Pava, L., additional, Botero Lopez, R., additional, Luengas, C., additional, Hernandez, E., additional, Sanchez, D., additional, Poveda, C., additional, Coronel, J., additional, Beltran, R., additional, Jaramillo, C., additional, Pardo, J., additional, Ponte Negretti, C., additional, Isea, J., additional, Vergara, G., additional, Morr, I., additional, Sim, K., additional, Wan Ahmad, W., additional, Yusof, Z., additional, Rosman, A., additional, Basri, H, additional, Thompson, P., additional, Jeffery, I., additional, Purnell, P., additional, Roberts‐Thomson, P., additional, Heddle, W., additional, Waites, J., additional, Walters, D., additional, Amerena, J., additional, Challa, P., additional, Karrasch, J., additional, Lowy, A., additional, Fitzpatrick, D., additional, Parsons, M., additional, Phan, T., additional, Bladin, C., additional, Donnan, G., additional, Aroney, G., additional, Gerraty, R., additional, Anderson, C., additional, Blombery, P., additional, Martin, P., additional, Tissa Wijeratne, K., additional, Cross, D., additional, Crimmins, D., additional, Packham, D., additional, Jackson, D., additional, Chua, W., additional, Merino, R., additional, Magno, M., additional, Tirador, L., additional, Batalla, E., additional, Manalo, C., additional, Uy, N., additional, Ebo, G., additional, Reyes, E., additional, Bernan, A., additional, Richards, M., additional, Hart, H., additional, Mann, S., additional, Fisher, R., additional, Stewart, R., additional, Wilkins, G., additional, Barber, A., additional, Tan, R., additional, Ong, H., additional, Singh, R., additional, Sukonthasarn, A., additional, Tanomsup, S., additional, Krittayaphong, R., additional, Piamsomboon, C., additional, Piyayotai, D., additional, Sunsaneewitayakul, B., additional, Baek, S., additional, Seo, H., additional, Rim, S., additional, Kim, C., additional, Kim, K., additional, Ryu, K., additional, Jo, S., additional, Tahk, S., additional, Lee, H., additional, Kim, Y., additional, Shin, D., additional, Choi, Y., additional, Chung, N., additional, Namgung, J., additional, Hong, T., additional, Shin, W., additional, Jin, S., additional, Yan, X., additional, Fu, G., additional, Lu, G., additional, Yang, K., additional, Xu, D., additional, Chen, J., additional, Liu, J., additional, Wu, S., additional, Song, J., additional, Liao, Y., additional, Xu, B., additional, Li, Z., additional, Ma, S., additional, Yin, Y., additional, Zhao, Y., additional, Hu, D., additional, Ma, C., additional, Ma, J., additional, Sun, J., additional, Li, H., additional, Hong, X., additional, Yu, B., additional, Lu, Q., additional, Yang, J., additional, Wu, Z., additional, Li, Y., additional, Huang, Y., additional, Wang, Y., additional, Liu, M., additional, Cheng, Y., additional, Yang, T., additional, Chen, K., additional, Wang, H., additional, Yuan, Z., additional, Wang, J., additional, Zeng, Z., additional, Chen, Y., additional, Yavuzgil, O., additional, Kozan, O., additional, Etemoglu, M., additional, Diker, E., additional, Belgi, A., additional, Ceyhan, C., additional, Cin, V., additional, Yilmaz, O., additional, Ata, N., additional, Altunkeser, B., additional, Agacdiken Agir, A., additional, Karadede, A., additional, Topsakal, R., additional, Gulati, R., additional, Madhavan, A., additional, Jain, S., additional, Oomman, A., additional, Janorkar, S., additional, Kumar, P., additional, Madhukar Naik, A., additional, Thacker, H., additional, Rajasekhar, V., additional, Reddy, R., additional, Keshavamurthy, C., additional, Jain, P., additional, Gowdappa, B., additional, Gadkari, M., additional, Abhyankar, A., additional, Ramesh Babu, B., additional, Vydianathan, P., additional, Sinha, S., additional, Garg, N., additional, Rao, S., additional, Gautam, P., additional, Chockalingam, K., additional, Kumbla, M., additional, Panwar, R., additional, Banker, D., additional, Kaste, M., additional, Jäkälä, P., additional, Roine, R., additional, Mihov, A., additional, Raev, D., additional, Yordanova, V., additional, Dimitrova, S., additional, Benov, H., additional, Tsanova, V., additional, Kyolean, M., additional, Marchev, S., additional, Stoikov, A., additional, Zdravkov, N., additional, Ramshev, K., additional, Krastev, A., additional, Stamenova, P., additional, Angelova, I., additional, Pencheva, G., additional, Grigorova, V., additional, Petrauskiene, B., additional, Skripkauskiene, I., additional, Raugaliene, R., additional, Norkiene, S., additional, Mazutavicius, R., additional, Kavoliuniene, A., additional, Aidietiene, S., additional, Aganauskiene, J., additional, Dailydkiene, A., additional, Marcinkeviciene, J., additional, Grigoniene, L., additional, Anusauskiene, J., additional, Kavaliauskiene, R., additional, Lizogub, V., additional, Rudenko, L., additional, Tseluyko, V., additional, Voronkov, L., additional, Sychov, O., additional, Svyshchenko, Y., additional, Sirenko, Y., additional, Serkova, V., additional, Seredyuk, N., additional, Pertseva, T., additional, Netyazhenko, V., additional, Lishnevska, V., additional, Kupchynska, O., additional, Koval, O., additional, Koshukova, G., additional, Karpenko, O., additional, Grishyna, O., additional, Faynyk, A., additional, Dzyak, G., additional, Dyadyk, O., additional, Yena, L., additional, Volkov, V., additional, Rudyk, I., additional, Kopytsya, M., additional, Kononenko, L., additional, Amosova, K., additional, Zhurba, S., additional, Kazimirko, V., additional, Iuzkiv, I., additional, Shershnyova, O., additional, Khomazyuk, T., additional, Batushkin, V., additional, Vykhovanyuk, I., additional, Popik, G., additional, Skrebkov, V., additional, Skurtov, A., additional, Mishchenko, T., additional, Lytvynenko, N., additional, Sokolova, L., additional, Vatutin, M., additional, Shved, M., additional, Rebrov, B., additional, Kadina, L., additional, Vajda, M., additional, Ursol, G., additional, Zheleznyy, V., additional, Vysochanska, T., additional, Gozhenko, A., additional, Fan, K., additional, Ho, D., additional, Tse, H., additional, Yu, C., additional, Wong, L., additional, Yeh, H., additional, Pai, P., additional, Hsieh, I., additional, Huang, C., additional, Hsieh, Y., additional, Yin, W., additional, Tsai, L., additional, Huang, T., additional, Chen, C., additional, Chiang, F., additional, Ueng, K., additional, Charng, M., additional, Marmor, A., additional, Katz, A., additional, Butnaru, A., additional, Lewis, B., additional, Eldar, M., additional, Rosenhack, S., additional, Elias, N., additional, Koifman, B., additional, Shochat, M., additional, Swissa, M., additional, Zimlichman, R., additional, Bental, T., additional, Weiss, A., additional, Ganam, R., additional, Elias, M., additional, Nseir, W., additional, Oliven, A., additional, Brenner, B., additional, and Dayan, M., additional

Published
2016
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28. Histological and immunohistochemical characterization of Hypoderma lineatum (Diptera: Oestridae) warbles

Author

Xunta de Galicia, Ministerio de Economía y Competitividad (España), Cabanelas, E., Panadero, R., Fuertes Franco, Miguel, Fernández Fernández, Miguel, Benavides, Julio, López, C., Pérez-Creo, A., Díaz, P., Morrondo-Pelayo, M. Patrocinio, Díez-Baños, Pablo, Pérez Pérez, Valentín, Xunta de Galicia, Ministerio de Economía y Competitividad (España), Cabanelas, E., Panadero, R., Fuertes Franco, Miguel, Fernández Fernández, Miguel, Benavides, Julio, López, C., Pérez-Creo, A., Díaz, P., Morrondo-Pelayo, M. Patrocinio, Díez-Baños, Pablo, and Pérez Pérez, Valentín

Abstract

© 2015 Elsevier B.V. Hypoderma larvae are tissue invading parasites which spend several months migrating within the host tissues before completing their development in the sub-dermal tissues of the back. Subcutaneous stages of the parasite produce an inflammatory reaction in the skin called >warbles>, as well as holes through which larvae breathe. In order to elucidate the microscopical structure of the warbles, three hides from warbled cows were collected in a slaughterhouse in Lugo (NW, Spain) between March and May 2012. A total of 60 skin samples, including warbles at different phases of development, were chosen for histopathological and immunohistochemical examination. Microscopic lesions were classified into three groups, according to the predominance and distribution of different cell populations. In warbles containing living or recently dead larvae with apparently well preserved cuticle (type 1), plasma cells were observed in high number. However, macrophages and lymphocytes were the predominant cells in granulomas (type 2) formed in relation to remnants of the dead parasite, containing or not remains of the altered cuticle. Scars (type 3) were characterized by granulation tissue. Immunohistochemistry showed that B lymphocytes and IgG+ cells were predominant in the lesions, as long as the cuticle of the larvae is intact. On the other side, CD3+ lymphocytes increased once cuticle is destroyed and a granuloma is formed. Macrophages, revealed by CD68+, MAC387+ and lysozyme immunolabelling, were detected in all types of lesions, but they were more abundant in type 2 and scarce in scars. These cells appeared isolated around the intact larvae or forming aggregates around its remains in the granuloma. Moreover, a strong immunolabelling against MAC387 antibody was registered in the squamous epithelium covering the breathing pore. This finding may be associated with the expression of calprotectin, a molecule involved on the healing process of the skin after larvae out

Published
2015

29. Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+KLRG1−CD4+T cells

Author

Bull, N. C., Stylianou, E., Kaveh, D. A., Pinpathomrat, N., Pasricha, J., Harrington-Kandt, R., Garcia-Pelayo, M. C., Hogarth, P. J., and McShane, H.

Abstract

BCG, the only vaccine licensed against tuberculosis, demonstrates variable efficacy in humans. Recent preclinical studies highlight the potential for mucosal BCG vaccination to improve protection. Lung tissue-resident memory T cells reside within the parenchyma, potentially playing an important role in protective immunity to tuberculosis. We hypothesised that mucosal BCG vaccination may enhance generation of lung tissue-resident T cells, affording improved protection against Mycobacterium tuberculosis. In a mouse model, mucosal intranasal (IN) BCG vaccination conferred superior protection in the lungs compared to the systemic intradermal (ID) route. Intravascular staining allowed discrimination of lung tissue-resident CD4+T cells from those in the lung vasculature, revealing that mucosal vaccination resulted in an increased frequency of antigen-specific tissue-resident CD4+T cells compared to systemic vaccination. Tissue-resident CD4+T cells induced by mucosal BCG displayed enhanced proliferative capacity compared to lung vascular and splenic CD4+T cells. Only mucosal BCG induced antigen-specific tissue-resident T cells expressing a PD-1+KLRG1−cell-surface phenotype. These cells constitute a BCG-induced population which may be responsible for the enhanced protection observed with IN vaccination. We demonstrate that mucosal BCG vaccination significantly improves protection over systemic BCG and this correlates with a novel population of BCG-induced lung tissue-resident CD4+T cells.

Published
2019
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32. Ultrasound features and ultrasound scores in the differentiation between benign and malignant adnexal masses

Author

Pelayo, M. (Mar)

Subjects
Área de Medicina Clínica y Epidemiología, CA125, Transvaginal ultrasound, Adnexal masses, IOTA simple rules risk assessment, O-RADS, ADNEX model, Subjective assessment
Abstract

Background: Several ultrasound (US) features help ultrasound experts in the classification of benign vs. malignant adnexal masses. US scores serve in this differentiation, but they all have misdiagnoses. The main objective of this study is to evaluate what ultrasound characteristics are associated with malignancy influencing ultrasound scores. Methods: This is a retrospective analysis of ultrasound features of adnexal lesions of women managed surgically. Ultrasound characteristics were analyzed, and masses were classified by subjective assessment of the ultrasonographer (SA) and other ultrasound scores (IOTA Simple Rules Risk Assessment SRRA, ADNEX model, and O-RADS). Results: Of a total of 187 adnexal masses studied, 134 were benign (71.7%) and 53 were malignant (28.3%). SA, IOTA SRRA, ADNEX model with or without CA125 and O-RADS had high levels of sensitivity (93.9%, 81.1%, 94.3%, 88.7%, 98.1%) but lower specificity (80.2%, 82.1%, 82.8%, 77.6%, 73.1%) with similar AUC (0.87, 0.87, 0.92, 0.90, 0.86). Ultrasound features significantly related with malignancy were the presence of irregular contour, absence of acoustic shadowing, vascularized solid areas, & GE;1 papillae, vascularized septum, and moderate-severe ascites. Conclusion: IOTA SRRA, ADNEX model, and O-RADS can help in the classification of benign and malignant masses. Certain ultrasound characteristics studied in ultrasound scores are associated with malignancy.

Published
2023

33. Application of ultrasound scores (subjective assessment, simple rules risk assessment, ADNEX model, O-RADS) to adnexal masses of difficult classification

Author

Pelayo, M. (Mar)

Subjects
Área de Medicina Clínica y Epidemiología, Transvaginal ultrasound, Adnexal masses, IOTA simple rules risk assessment, O-RADS, ADNEX model, CA125, Subjective assessment, Mature cystic teratoma, Serous cystadenoma, Mucinous cystadenoma, Brenner tumour, Cystadenofibroma, Fibroma, Borderline carcinoma, Serous ovarian carcinoma, Clear cell carcinoma, Endometriod carcinoma
Abstract

Featured Application Ultrasound scores should consider that some frequent masses such as fibromas, cystoadenofibromas, some mucinous cystadenomas and Brenner tumors may present some characteristics that induce confusion with malignant lesions. Some malignant lesions are not always identified as malignant.Abstract Background: Ultrasound features help to differentiate benign from malignant masses, and some of them are included in the ultrasound (US) scores. The main aim of this work is to describe the ultrasound features of certain adnexal masses of difficult classification and to analyse them according to the most frequently used US scores. Methods: Retrospective studies of adnexal lesions are difficult to classify by US scores in women undergoing surgery. Ultrasound characteristics were analysed, and masses were classified according to the Subjective Assessment of the ultrasonographer (SA) and other US scores (IOTA Simple Rules Risk Assessment-SRRA, ADNEX model with and without CA125 and O-RADS). Results: A total of 133 adnexal masses were studied (benign: 66.2%, n:88; malignant: 33.8%, n:45) in a sample of women with mean age 56.5 & PLUSMN; 7.8 years. Malignant lesions were identified by SA in all cases. Borderline ovarian tumors (n:13) were not always detected by some US scores (SRRA: 76.9%, ADNEX model without and with CA125: 76.9% and 84.6%) nor were serous carcinoma (n:19) (SRRA: 89.5%), clear cell carcinoma (n:9) (SRRA: 66.7%) or endometrioid carcinoma (n:4) (ADNEX model without CA125: 75.0%). While most teratomas and serous cystadenomas have been correctly differentiated, other benign lesions were misclassified because of the presence of solid areas or papillae. Fibromas (n:13) were better identified by SA (23.1% malignancy), but worse with the other US scores (SRRA: 69.2%, ADNEX model without and with CA125: 84.6% and 69.2%, O-RADS: 53.8%). Cystoadenofibromas (n:10) were difficult to distinguish from malignant masses via all scores except SRRA (SA: 70.0%, SRRA: 20.0%, ADNEX model without and with CA125: 60.0% and 50.0%, O-RADS: 90.0%). Mucinous cystadenomas (n:12) were misdiagnosed as malignant in more than 15% of the cases in all US scores (SA: 33.3%, SRRA: 16.7%, ADNEX model without and with CA125: 16.7% and 16.7%, O-RADS:41.7%). Brenner tumors are also difficult to classify using all scores. Conclusion: Some malignant masses (borderline ovarian tumors, serous carcinoma, clear cell carcinoma, endometrioid carcinomas) are not always detected by US scores. Fibromas, cystoadenofibromas, some mucinous cystadenomas and Brenner tumors may present solid components/papillae that may induce confusion with malignant lesions. Most teratomas and serous cystadenomas are usually correctly classified.

Published
2023

34. Persistent BCG bacilli perpetuate CD4 T effector memory and optimal protection against tuberculosis.

Author

Kaveh, Daryan A., Carmen Garcia-Pelayo, M., and Hogarth, Philip J.

Subjects
*TUBERCULOSIS vaccines, *BCG vaccines, *CD4 antigen, *IMMUNE response, *LABORATORY mice, *COMPARATIVE studies
Abstract

Tuberculosis (TB) remains one of the most important infectious diseases of man and animals, and the only available vaccine (BCG) requires urgent replacement or improvement. To facilitate this, the protective mechanisms induced by BCG require further understanding. As a live attenuated vaccine, persistence of BCG bacilli in the host may be a crucial mechanism. We have investigated the long term persistence of BCG following vaccination and the influence on the induced immune response and protection, using an established murine model. We sought to establish whether previously identified BCG-specific CD4 T EM cells represent genuine long-lived memory cells of a relatively high frequency, or are a consequence of continual priming by chronically persistent BCG vaccine bacilli. By clearing persistent bacilli, we have compared immune responses (spleen and lung CD4: cytokine producing T effector/T EM ; TCR-specific) and BCG-induced protection, in the presence and absence of these persisting vaccine bacilli. Viable BCG bacilli persisted for at least 16 months post-vaccination, associated with specific CD4 T effector/T EM and tetramer-specific responses. Clearing these bacilli abrogated all BCG-specific CD4 T cells whilst only reducing protection by 1 log 10 . BCG may induce two additive mechanisms of immunity: (i) dependant on the presence of viable bacilli and T EM ; and (ii) independent of these factors. These data have crucial implications on the rational generation of replacement TB vaccines, and the interpretation of BCG induced immunity in animal models. [ABSTRACT FROM AUTHOR]

Published
2014
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35. Experiencia con cuatro casos clínicos, ¿puede la encefalopatía traumática crónica estar asociada a un traumatismo craneoencefálico único?

Author

del Pilar Sáinz Pelayo, M., Pelayo, R., Albu, S., and Figueira, C.

Abstract

La encefalopatía traumática crónica (ETC) es una enfermedad neurodegenerativa que afecta a personas que han padecido traumatismos craneales repetitivos. No obstante, también durante el seguimiento de los pacientes con traumatismo craneoencefálico (TCE) único se pueden observar cambios respecto de su situación previa. Presentamos cuatro casos clínicos de pacientes visitados en la consulta externa del Instituto Guttmann entre 2017 y 2019, afectos de secuelas leves de TCE grave y único que han desarrollado posteriormente una enfermedad neurodegenerativa sin un diagnóstico concreto y que pudiesen cumplir criterios clínicos de síndrome de encefalopatía traumática crónica. Los médicos rehabilitadores son los profesionales con mayor posibilidad de identificar estos pacientes, indicando las exploraciones complementarias necesarias y estableciendo nuevos objetivos de rehabilitación.

Published
2021
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36. Foreign body in a Zenker's diverticulum.

Author

Vidal Pelayo M, Honrubia López R, González Redondo G, García García L, and Comas Redondo C

Abstract

Zenker's diverticulum (ZD) is an uncommon disorder that can cause dysphagia with risk of aspiration. While surgical treatment has been the mainstay for many years, endoscopic diverticulotomy has emerged as a first-line option with favorable outcomes. We present the case of a 93-year-old woman with no significant past medical history who was diagnosed with a 6 cm ZD. Due to dysphagia, she experienced significant weight loss and was at risk of malnutrition. She developed aspiration pneumonia and required admission to our center. Given her condition and inability to swallow, a nasogastric tube was placed under radiological guidance for nutritional support pending definitive treatment. On radiographic localization of the ZD, a radiopaque metallic density image was observed that had not been identified in previous imaging. Suspecting a possible retained foreign body in the large diverticulum, a gastroscopy was performed. During the procedure, the ZD was accessed and a 10 mm metallic object was identified. The object was extracted using a Roth net, confirming the suspicion of a foreign body lodged in the ZD. The metallic piece was later identified as a patient's dental prosthesis. After resolution of the aspiration pneumonia, endoscopic-assisted diverticulotomy was performed. The procedure was carried out under deep sedation with cricopharyngeal myotomy without immediate complications. After 48 hours of hospitalization, the patient was discharged without requiring a nasogastric tube for feeding.

Published
2024
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37. Application of Ultrasound Scores (Subjective Assessment, Simple Rules Risk Assessment, ADNEX Model, O-RADS) to Adnexal Masses of Difficult Classification.

Author

Pelayo M, Sancho-Sauco J, Sánchez-Zurdo J, Perez-Mies B, Abarca-Martínez L, Cancelo-Hidalgo MJ, Sainz-Bueno JA, Alcázar JL, and Pelayo-Delgado I

Abstract

Background: Ultrasound features help to differentiate benign from malignant masses, and some of them are included in the ultrasound (US) scores. The main aim of this work is to describe the ultrasound features of certain adnexal masses of difficult classification and to analyse them according to the most frequently used US scores., Methods: Retrospective studies of adnexal lesions are difficult to classify by US scores in women undergoing surgery. Ultrasound characteristics were analysed, and masses were classified according to the Subjective Assessment of the ultrasonographer (SA) and other US scores (IOTA Simple Rules Risk Assessment-SRRA, ADNEX model with and without CA125 and O-RADS)., Results: A total of 133 adnexal masses were studied (benign: 66.2%, n:88; malignant: 33.8%, n:45) in a sample of women with mean age 56.5 ± 7.8 years. Malignant lesions were identified by SA in all cases. Borderline ovarian tumors (n:13) were not always detected by some US scores (SRRA: 76.9%, ADNEX model without and with CA125: 76.9% and 84.6%) nor were serous carcinoma (n:19) (SRRA: 89.5%), clear cell carcinoma (n:9) (SRRA: 66.7%) or endometrioid carcinoma (n:4) (ADNEX model without CA125: 75.0%). While most teratomas and serous cystadenomas have been correctly differentiated, other benign lesions were misclassified because of the presence of solid areas or papillae. Fibromas (n:13) were better identified by SA (23.1% malignancy), but worse with the other US scores (SRRA: 69.2%, ADNEX model without and with CA125: 84.6% and 69.2%, O-RADS: 53.8%). Cystoadenofibromas (n:10) were difficult to distinguish from malignant masses via all scores except SRRA (SA: 70.0%, SRRA: 20.0%, ADNEX model without and with CA125: 60.0% and 50.0%, O-RADS: 90.0%). Mucinous cystadenomas (n:12) were misdiagnosed as malignant in more than 15% of the cases in all US scores (SA: 33.3%, SRRA: 16.7%, ADNEX model without and with CA125: 16.7% and 16.7%, O-RADS:41.7%). Brenner tumors are also difficult to classify using all scores., Conclusion: Some malignant masses (borderline ovarian tumors, serous carcinoma, clear cell carcinoma, endometrioid carcinomas) are not always detected by US scores. Fibromas, cystoadenofibromas, some mucinous cystadenomas and Brenner tumors may present solid components/papillae that may induce confusion with malignant lesions. Most teratomas and serous cystadenomas are usually correctly classified.

Published
2023
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38. Impact of routine preoperative 18 FDG PET/CT on the surgical management of primary colorectal cancer.

Author

Mogollón-González M, Conde-Muiño R, Rodríguez-Fernández A, Navarro-Pelayo M, Domínguez-Bastante M, and Palma P

Subjects
Humans, Fluorodeoxyglucose F18, Radiopharmaceuticals, Retrospective Studies, Positron-Emission Tomography methods, Neoplasm Staging, Positron Emission Tomography Computed Tomography, Colorectal Neoplasms diagnostic imaging, Colorectal Neoplasms surgery, Colorectal Neoplasms pathology
Abstract

Objectives: Determine the usefulness of [18F]-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 FDG-PET/CT) in the preoperative setting of colorectal cancer (CRC), assessing its impact on changes in management strategy., Methods: Retrospective study of CRC patients who underwent preoperative 18 FDG-PET/CT and CT staging scans in a single referral center. The agreement between 18 FDG-PET/CT, contrast-enhanced CT, and colonoscopy for the surgical location was compared using the κ coefficient. Maximum standardized uptake (SUV max ) value was obtained. Univariate and multivariate analyses were conducted., Results: One hundred ninety-five patients were included. 18 FDG-PET/CT improved tumor localization in 84.6% (165/195) of cases (κ value 0.798, p < 0.001), thus correcting endoscopic errors 69.7% (30/43) of the time. In patients with incomplete colonoscopies, 18 FDG-PET/CT detected synchronous tumors in 2.5% (5/195) patients, overlooked by CT staging scans. Based on extracolonic 18 FDG-uptake, the second primary malignancy was diagnosed in 7(3.6%,7/195) patients and total accuracy for lymph node and distant metastasis was 66.1% and 98.4%, respectively. The treatment plan was altered in 30 (15.4%, 30/196) patients. There was a significant association between the SUV max and tumor size (odds ratio [OR] 4.254, p = 0.003) and the depth of tumor invasion (OR 1.696, p = 0.026)., Conclusions: Based on its ability to aid in preoperative evaluation and definitively alter surgical treatment planning, 18 FDG-PET/CT should be further evaluated in primary CRC., (© 2023 Wiley Periodicals LLC.)

Published
2023
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39. Ultrasound Features and Ultrasound Scores in the Differentiation between Benign and Malignant Adnexal Masses.

Author

Pelayo M, Sancho-Sauco J, Sanchez-Zurdo J, Abarca-Martinez L, Borrero-Gonzalez C, Sainz-Bueno JA, Alcazar JL, and Pelayo-Delgado I

Abstract

Background: Several ultrasound (US) features help ultrasound experts in the classification of benign vs. malignant adnexal masses. US scores serve in this differentiation, but they all have misdiagnoses. The main objective of this study is to evaluate what ultrasound characteristics are associated with malignancy influencing ultrasound scores., Methods: This is a retrospective analysis of ultrasound features of adnexal lesions of women managed surgically. Ultrasound characteristics were analyzed, and masses were classified by subjective assessment of the ultrasonographer (SA) and other ultrasound scores (IOTA Simple Rules Risk Assessment SRRA, ADNEX model, and O-RADS)., Results: Of a total of 187 adnexal masses studied, 134 were benign (71.7%) and 53 were malignant (28.3%). SA, IOTA SRRA, ADNEX model with or without CA125 and O-RADS had high levels of sensitivity (93.9%, 81.1%, 94.3%, 88.7%, 98.1%) but lower specificity (80.2%, 82.1%, 82.8%, 77.6%, 73.1%) with similar AUC (0.87, 0.87, 0.92, 0.90, 0.86). Ultrasound features significantly related with malignancy were the presence of irregular contour, absence of acoustic shadowing, vascularized solid areas, ≥1 papillae, vascularized septum, and moderate-severe ascites., Conclusion: IOTA SRRA, ADNEX model, and O-RADS can help in the classification of benign and malignant masses. Certain ultrasound characteristics studied in ultrasound scores are associated with malignancy.

Published
2023
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41. Comparison of Ultrasound Scores in Differentiating between Benign and Malignant Adnexal Masses.

Author

Pelayo M, Pelayo-Delgado I, Sancho-Sauco J, Sanchez-Zurdo J, Abarca-Martinez L, Corraliza-Galán V, Martin-Gromaz C, Pablos-Antona MJ, Zurita-Calvo J, and Alcázar JL

Abstract

Subjective ultrasound assessment by an expert examiner is meant to be the best option for the differentiation between benign and malignant adnexal masses. Different ultrasound scores can help in the classification, but whether one of them is significantly better than others is still a matter of debate. The main aim of this work is to compare the diagnostic performance of some of these scores in the evaluation of adnexal masses in the same set of patients. This is a retrospective study of a consecutive series of women diagnosed as having a persistent adnexal mass and managed surgically. Ultrasound characteristics were analyzed according to IOTA criteria. Masses were classified according to the subjective impression of the sonographer and other ultrasound scores (IOTA simple rules -SR-, IOTA simple rules risk assessment -SRRA-, O-RADS classification, and ADNEX model -with and without CA125 value-). A total of 122 women were included. Sixty-two women were postmenopausal (50.8%). Eighty-one women had a benign mass (66.4%), and 41 (33.6%) had a malignant tumor. The sensitivity of subjective assessment, IOTA SR, IOTA SRRA, and ADNEX model with or without CA125 and O-RADS was 87.8%, 66.7%, 78.1%, 95.1%, 87.8%, and 90.2%, respectively. The specificity for these approaches was 69.1%, 89.2%, 72.8%, 74.1%, 67.9%, and 60.5%, respectively. All methods with similar AUC (0.81, 0.78, 0.80, 0.88, 0.84, and 0.75, respectively). We concluded that IOTA SR, IOTA SRRA, and ADNEX models with or without CA125 and O-RADS can help in the differentiation of benign and malignant masses, and their performance is similar to the subjective assessment of an experienced sonographer.

Published
2023
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42. Contribution of Outpatient Ultrasound Transvaginal Biopsy and Puncture in the Diagnosis and Treatment of Pelvic Lesions: A Bicenter Study.

Author

Pelayo-Delgado I, Sancho J, Pelayo M, Corraliza V, Perez-Mies B, Del Valle C, Abarca L, Pablos MJ, Martin-Gromaz C, Pérez-Vidal JR, Penades I, Garcia E, Llanos MC, and Alcazar JL

Abstract

Background: The use of transvaginal ultrasound guided biopsy and puncture of pelvic lesions is a minimally invasive technique that allows for accurate diagnosis. It has many advantages compared to other more invasive (lower complication rate) or non-invasive techniques (accurate diagnosis). Furthermore, it offers greater availability, it does not radiate, enables the study of pelvic masses accessible vaginally with ultrasound control in real time, and it is possible to use the colour Doppler avoiding puncturing large vessels among others. The main aim of the work is to describe a standardized ambulatory technique and to determine its usefulness., Methods: This is a retrospective study of ultrasound transvaginal punctures (core needle biopsies and cytologies) and drainages of pelvic lesions performed on an outpatient basis during the last two years. The punctures were made with local anesthesia, under transvaginal ultrasound guidance with an automatic or semi-automatic 18G biopsy needle with a length of 20-25 cm and a penetration depth of 12 or 22 mm. The material obtained was sent for anatomopathological, cytological and/or microbiological study if necessary., Results: A total of 42 women were recruited in two centers. Fifty procedures (nine punctures, seven drains, and 34 biopsies) were performed. In five cases the punction and drain provided clinical relief in benign pelvic masses. Regarding material of the biopsies performed, 15 were vaginal in women previously histerectomized, finding 10 carcinomas, eight were ovarian tumours in advanced stages or peritoneal carcinomatosis obtaining the appropriate histology in each case, seven were suspicious cervical biopsies finding carcinomas in five of them, three were myometrial biopsies including one breast carcinoma metastasis in the miometrium and a benign placental nodule, and a periurethral biopsy was performed on a woman with a history of endometrial cancer confirming recurrence. The pathological diagnosis was satisfactory in all cases, confirming the nature of the lesion (25 malignant-ten vaginal recurrences of previous gynaecological cancers, eight cases of primary ovarian/peritoneal carcinoma, four new diagnosis of cervical malignant masses, one cervical metastasis of lymphoma, one periurethral recurrence of endometrial carcinoma and one recurrence of breast cancer in the myometrium-and 23 benign). The tolerance was excellent and no complications were detected., Conclusion: The ambulatory ultrasound transvaginal puncture and drainage technique is useful for obtaining a sample for pathological and microbiological diagnosis with excellent tolerance that can be used to rule out the recurrence of malignant lesions or progression of the disease, diagnose masses not accessible to gynecological exploration (vaginal vault, myometrium or cervix) and for early histologic diagnosis in cases of advanced peritoneal carcinomatosis or ovarian carcinoma as well as drainage and cytological study of cystic pelvic masses.

Published
2023
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43. [Experience with 4 clinical cases. Traumatic encephalopathy may be associated with a single traumatic brain injury?]

Author

Sáinz Pelayo MDP, Pelayo Vergara R, Albu S, and Figueira C

Subjects
Humans, Brain Injuries, Traumatic complications, Brain Injuries, Traumatic diagnosis, Chronic Traumatic Encephalopathy complications, Chronic Traumatic Encephalopathy etiology, Neurodegenerative Diseases complications
Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that affects people who had repetitive head trauma. Also, in single traumatic brain injury (TBI), changes may be found during the follow-up visits. We present four clinical cases of patients visited at the Institut Guttmann clinic between 2017 and 2019. They were affected by mild sequelae of severe and unique TBI who have subsequently developed a neurodegenerative disease without a specific diagnosis, and who could meet clinical criteria for chronic traumatic encephalopathy syndrome. Rehabilitation doctors are the professionals with the greatest possibility of identifying a suggestive clinic of this pathology, they can order the appropriate studies and indicate the new rehabilitation goals according to the new neurological situation., (Copyright © 2021. Publicado por Elsevier España, S.L.U.)

Published
2022
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44. Genetics and epidemiology of aniridia: Updated guidelines for genetic study.

Author

Blanco-Kelly F, Tarilonte M, Villamar M, Damián A, Tamayo A, Moreno-Pelayo MA, Ayuso C, and Cortón M

Subjects
Humans, Mutation, PAX6 Transcription Factor genetics, Aniridia diagnosis, Cerebellar Ataxia, WAGR Syndrome
Abstract

Aniridia is a panocular disease characterized by iris hypoplasia, accompanied by other ocular manifestations, with a high clinical variability and overlapping with different abnormalities of the anterior and posterior segment. This review focuses on the genetic features of this autosomal dominant pathology, which is caused by the haploinsufficiency of the PAX6 gene. Mutations causing premature stop codons are the most frequent among the wider mutational spectrum of PAX6, with more than 600 different mutations identified so far. Recent advances in next-generation sequencing (NGS) have increased the diagnostic yield in aniridia and contributed to elucidate new etiopathogenic mechanisms leading to PAX6 haploinsufficiency. Here, we also update good practices and recommendations to improve genetic testing and clinical management of aniridia using more cost-effective NGS analysis. Those new approaches also allow studying simultaneously both structural variants and point-mutations in PAX6 as well as other genes for differential diagnosis, simultaneously. Some patients with atypical phenotypes might present mutations in FOXC1 and PITX2, both genes causing a wide spectrum of anterior segment dysgenesis, or in ITPR1, which is responsible for a distinctive form of circumpupillary iris aplasia present in Gillespie syndrome, or other mutations in minor genes. Since aniridia can also associate extraocular anomalies, as it occurs in carriers of PAX6 and WT1 microdeletions leading to WAGR syndrome, genetic studies are crucial to assure a correct diagnosis and clinical management, besides allowing prenatal and preimplantational genetic testing in families., (Copyright © 2021 The Author(s). Published by Elsevier España, S.L.U. All rights reserved.)

Published
2021
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45. An Unusual Case of Prolymphocytic Leukemia Transformation in a Patient With Chronic Lymphocytic Leukemia.

Author

Bell S, Lattanzio N, Braham J, Campdesuner V, Abdelal Q, Vartanov A, and Pelayo M

Subjects
Aged, Humans, Immunotherapy, In Situ Hybridization, Fluorescence, Male, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Leukemia, Prolymphocytic genetics
Abstract

B-cell prolymphocytic leukemia (B-PLL) is a rare leukemia characterized by rapidly increasing leukocytosis with splenomegaly and lymphadenopathy. Treatment strategies are largely based on studies of chronic lymphocytic leukemia (CLL). Antibodies against the cell surface protein CD20 are considered to be first-line therapy. A 76-year-old male with known CLL presented 2 weeks after starting chemoimmunotherapy for newly refractory CLL after failing ibrutinib therapy. White blood cell count was elevated at 226.7 × 10 3 /µL. Fluorescent in situ hybridization analysis of a bone marrow specimen showed new development of complex cytogenetics. Flow cytometry revealed B cells appearing slightly dimmer on CD45 and brighter on CD20 compared with typical B-CLL suggestive of less mature lymphocyte forms. The patient was diagnosed with B-PLL and started on obinutuzumab and venetoclax with rapid normalization of white blood cells. This case recapitulates the challenges in diagnosing and treating B-PLL. Ibrutinib resistance is a growing area of study with several proposed mechanisms of acquired resistance. The pathogenesis of B-PLL is not completely understood, although mutations in MYC are presumed to play a role.

Published
2021
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46. [Spasticity in neurological pathologies. An update on the pathophysiological mechanisms, advances in diagnosis and treatment].

Author

Sáinz-Pelayo MP, Albu S, Murillo N, and Benito-Penalva J

Subjects
Algorithms, Humans, Muscle Spasticity diagnosis, Muscle Spasticity etiology, Muscle Spasticity physiopathology, Muscle Spasticity therapy, Nervous System Diseases complications
Abstract

Introduction: Spasticity is a frequent clinical sign in people with neurological diseases that affects mobility and causes serious complications: pain, joint limitation, muscular contractions and bed sores, which have a significant effect on the individual's functionality and quality of life., Aim: To review the integration, description and critical interpretation of the most recent scientific evidence on the clinical variability of spasticity and associated symptoms, the different pathophysiological mechanisms and their relevance in the diagnostic and therapeutic approach., Development: A search was conducted in the scientific publications on the different aspects of spasticity grouped into two main categories: cerebral and spinal cord pathologies. The epidemiological, clinical and pathophysiological aspects, clinical and instrumental diagnoses, and the physiotherapeutic, pharmacological and surgical approach to spasticity in each group of pathologies were all reviewed., Conclusion: Spasticity is related to structural lesions and maladaptive neuroplastic changes that determine an important variability in its clinical expression. Although its diagnosis presents important limitations, the use of clinical and neurophysiological diagnostic tools aimed at achieving different approaches in cases of neurological pathologies originating in the brain and in the spinal cord could optimise the effectiveness of spasticity therapies.

Published
2020
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47. Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin.

Author

Barragán-Cárdenas A, Urrea-Pelayo M, Niño-Ramírez VA, Umaña-Pérez A, Vernot JP, Parra-Giraldo CM, Fierro-Medina R, Rivera-Monroy Z, and García-Castañeda J

Abstract

The cytotoxic effect against the breast cancer cell line MDA-MB-468 of the palindromic peptide LfcinB (21-25) Pal : 1 RWQWRWQWR 9 and its analogous peptides, obtained via alanine scanning, was evaluated. The results indicate that the palindromic peptide exhibited a concentration-dependent cytotoxic effect against this cell line. The cytotoxic effect of the palindromic peptide was fast and selective and was sustained for up to 48 h of treatment. MDA-MB-468 cells treated with the palindromic peptide exhibited severe cellular damage, acquiring rounded forms and shrinkage, a behavior typical of apoptotic events. The analogous peptides exhibited fewer cytotoxic effects than the original palindromic peptide, suggesting that the substitution of any amino acid with alanine diminishes the cytotoxic effect. The Arg and Trp residues proved to be the most relevant for the cytotoxic effect; the analogous peptides with substitutions of Trp with Ala did not induce a change in cellular morphology, while analogous peptides with substitutions of Arg or Gln with Ala induced cellular damage. Also, neither the palindromic peptide nor its analogues exerted a significant cytotoxic effect on normal fibroblasts, indicating that the peptides had a selective cytotoxic effect on cancerous cells. The peptide LfcinB (21-25) Pal , and its analogues exhibited antibacterial activity against E. coli and S. aureus strains and a selective cytotoxic effect against the breast cancer cell line MDA-MB-468., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Published
2020
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48. Induction and maintenance of a phenotypically heterogeneous lung tissue-resident CD4 + T cell population following BCG immunisation.

Author

Bull NC, Kaveh DA, Garcia-Pelayo MC, Stylianou E, McShane H, and Hogarth PJ

Subjects
Adjuvants, Immunologic administration & dosage, Animals, Female, Immunogenicity, Vaccine, Immunologic Memory, Interferon-gamma, Lung cytology, Mice, Mice, Inbred BALB C, Parenchymal Tissue cytology, BCG Vaccine administration & dosage, CD4-Positive T-Lymphocytes immunology, Lung immunology, Parenchymal Tissue immunology, Tuberculosis, Pulmonary prevention & control
Abstract

Tuberculosis (TB) is the biggest cause of human mortality from an infectious disease. The only vaccine currently available, bacille Calmette-Guérin (BCG), demonstrates some protection against disseminated disease in childhood but very variable efficacy against pulmonary disease in adults. A greater understanding of protective host immune responses is required in order to aid the development of improved vaccines. Tissue-resident memory T cells (T RM ) are a recently-identified subset of T cells which may represent an important component of protective immunity to TB. Here, we demonstrate that intradermal BCG vaccination induces a population of antigen-specific CD4 + T cells within the lung parenchyma which persist for >12 months post-vaccination. Comprehensive flow cytometric analysis reveals this population is phenotypically and functionally heterogeneous, and shares characteristics with lung vascular and splenic CD4 + T cells. This underlines the importance of utilising the intravascular staining technique for definitive identification of tissue-resident T cells, and also suggests that these anatomically distinct cellular subsets are not necessarily permanently resident within a particular tissue compartment but can migrate between compartments. This lung parenchymal population merits further investigation as a critical component of a protective immune response against Mycobacterium tuberculosis (M. tb)., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2018
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49. Hibernoma as an incidental finding on (18)F-FDG-PET/CT in lymphoma patient follow-up.

Author

Navarro-Pelayo MM, Rodríguez-Fernández A, Ramírez-Navarro Á, Martín-Castro A, Gómez-Río M, and Llamas-Elvira JM

Subjects
Adipose Tissue, Brown metabolism, Adipose Tissue, Brown pathology, Fluorine Radioisotopes analysis, Fluorine Radioisotopes pharmacokinetics, Fluorodeoxyglucose F18 analysis, Fluorodeoxyglucose F18 pharmacokinetics, Humans, Incidental Findings, Lipoma metabolism, Lipoma pathology, Magnetic Resonance Imaging, Male, Middle Aged, Muscle Neoplasms metabolism, Muscle Neoplasms pathology, Radiopharmaceuticals analysis, Radiopharmaceuticals pharmacokinetics, Ultrasonography, Lipoma diagnostic imaging, Lymphoma, Follicular diagnostic imaging, Muscle Neoplasms diagnostic imaging, Neoplasms, Second Primary diagnostic imaging, Positron Emission Tomography Computed Tomography
Published
2016
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