335 results on '"Poli, Giulio"'
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2. Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease
3. A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds
4. An update on antibacterial AlkylGuanidino Ureas: Design of new derivatives, synergism with colistin and data analysis of the whole library
5. Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors
6. miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4
7. Virtual screening and crystallographic studies reveal an unexpected γ-lactone derivative active against MptpB as a potential antitubercular agent
8. Carbonic Anhydrase Inhibitors: Identifying Therapeutic Cancer Agents Through Virtual Screening
9. Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA
10. Watermelon: setup and validation of an in silico fragment-based approach
11. An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent
12. Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold
13. Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
14. The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis
15. N-aryl-N′-ureido-O-sulfamates as potent and selective inhibitors of hCA VB over hCA VA: Deciphering the binding mode of new potential agents in mitochondrial dysfunctions
16. Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system
17. Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity
18. Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying in vivo cardioprotective activities
19. N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties
20. Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines
21. The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel
22. Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment
23. Identification of New GSK3β Inhibitors through a Consensus Machine Learning-Based Virtual Screening
24. A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
25. Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors
26. Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents
27. Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system
28. VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules
29. MolBook UNIPI─Create, Manage, Analyze, and Share Your Chemical Data for Free
30. A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
31. Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists
32. Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying in vivocardioprotective activitiesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00489a
33. An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65.
34. New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2
35. Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?
36. Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives
37. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
38. Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors
39. Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches
40. Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations
41. Novel Potent and Selective Agonists of the GPR55 Receptor Based on the 3-Benzylquinolin-2(1H)-One Scaffold
42. Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
43. Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
44. New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds
45. VenomPred: A Machine Learning Based Platform for Molecular Toxicity Predictions
46. From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives
47. Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin
48. New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy
49. New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy.
50. Mealworm (Tenebrio molitor): Potential and Challenges to Promote Circular Economy
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