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The article suggests art and ESP integration in a foreign language classroom at technical university. The authors describe five parts of the art and ESP integrated project "Water treatment" developed for teaching chemical engineers ESP at tertiary level. Each part of the project combines art such as poster drawing, writing a poem, creating a brand and making videos with ESP purposes. The results of the pedagogical experiment conducted at the National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute" (Igor Sikorsky KPI) proved the improvement of professional language, engineering creativity, intellectual engagement and collaboration skills of the students of the experimental group. The answers of the questionnaires conducted among the ESP teachers and students of Igor Sikorsky KPI showed their positive feedback about art and ESP integration. The issues of engineering creativity, active engagement, collaboration and authentic material usage were studied as components of multidisciplinary and multipurpose art and ESP integrated approach. The concluding part of the article outlines the main problems which can occur while integrating art and ESP in Ukraine such as lack of time and materials for exploring art, possible s?epticism towards art elements in ESP.

Antarctica's ice shelves modulate the grounded ice flow, and weakening of ice shelves due to climate forcing will decrease their 'buttressing' effect, causing a response in the grounded ice. While the processes governing ice-shelf weakening are complex, uncertainties in the response of the grounded ice sheet are also difficult to assess. The Antarctic BUttressing Model Intercomparison Project (ABUMIP) compares ice-sheet model responses to decrease in buttressing by investigating the 'end-member' scenario of total and sustained loss of ice shelves. Although unrealistic, this scenario enables gauging the sensitivity of an ensemble of 15 ice-sheet models to a total loss of buttressing, hence exhibiting the full potential of marine ice-sheet instability. All models predict that this scenario leads to multi-metre (1-12 m) sea-level rise over 500 years from present day. West Antarctic ice sheet collapse alone leads to a 1.91-5.08 m sea-level rise due to the marine ice-sheet instability. Mass loss rates are a strong function of the sliding/friction law, with plastic laws cause a further destabilization of the Aurora and Wilkes Subglacial Basins, East Antarctica. Improvements to marine ice-sheet models have greatly reduced variability between modelled ice-sheet responses to extreme ice-shelf loss, e.g. compared to the SeaRISE assessments.

The sea level contribution of the Antarctic ice sheet constitutes a large uncertainty in future sea level projections. Here we apply a linear response theory approach to 16 state-of-the-art ice sheet models to estimate the Antarctic ice sheet contribution from basal ice shelf melting within the 21st century. The purpose of this computation is to estimate the uncertainty of Antarctica's future contribution to global sea level rise that arises from large uncertainty in the oceanic forcing and the associated ice shelf melting. Ice shelf melting is considered to be a major if not the largest perturbation of the ice sheet's flow into the ocean. However, by computing only the sea level contribution in response to ice shelf melting, our study is neglecting a number of processes such as surface-mass-balance-related contributions. In assuming linear response theory, we are able to capture complex temporal responses of the ice sheets, but we neglect any self-dampening or self-amplifying processes. This is particularly relevant in situations in which an instability is dominating the ice loss. The results obtained here are thus relevant, in particular wherever the ice loss is dominated by the forcing as opposed to an internal instability, for example in strong ocean warming scenarios. In order to allow for comparison the methodology was chosen to be exactly the same as in an earlier study (Levermann et al., 2014) but with 16 instead of 5 ice sheet models. We include uncertainty in the atmospheric warming response to carbon emissions (full range of CMIP5 climate model sensitivities), uncertainty in the oceanic transport to the Southern Ocean (obtained from the time-delayed and scaled oceanic subsurface warming in CMIP5 models in relation to the global mean surface warming), and the observed range of responses of basal ice shelf melting to oceanic warming outside the ice shelf cavity. This uncertainty in basal ice shelf melting is then convoluted with the linear response functions of each of the 16 ice sheet models to obtain the ice flow response to the individual global warming path. The model median for the observational period from 1992 to 2017 of the ice loss due to basal ice shelf melting is 10.2 mm, with a likely range between 5.2 and 21.3 mm. For the same period the Antarctic ice sheet lost mass equivalent to 7.4mm of global sea level rise, with a standard deviation of 3.7mm (Shepherd et al., 2018) including all processes, especially surface-mass-balance changes. For the unabated warming path, Representative Concentration Pathway 8.5 (RCP8.5), we obtain a median contribution of the Antarctic ice sheet to global mean sea level rise from basal ice shelf melting within the 21st century of 17 cm, with a likely range (66th percentile around the mean) between 9 and 36 cm and a very likely range (90th percentile around the mean) between 6 and 58 cm. For the RCP2.6 warming path, which will keep the global mean temperature below 2 °C of global warming and is thus consistent with the Paris Climate Agreement, the procedure yields a median of 13 cm of global mean sea level contribution. The likely range for the RCP2.6 scenario is between 7 and 24 cm, and the very likely range is between 4 and 37 cm. The structural uncertainties in the method do not allow for an interpretation of any higher uncertainty percentiles.We provide projections for the five Antarctic regions and for each model and each scenario separately. The rate of sea level contribution is highest under the RCP8.5 scenario. The maximum within the 21st century of the median value is 4 cm per decade, with a likely range between 2 and 9 cm per decade and a very likely range between 1 and 14 cm per decade.

Pliocene global temperatures periodically exceeded modern levels, offering insights into ice sheet sensitivity to warm climates. Ice-proximal geologic records from this period provide crucial but limited glimpses of Antarctic Ice Sheet behavior. We use an ice sheet model driven by climate model snapshots to simulate transient glacial cyclicity from 4.5 to 2.6 Ma, providing spatial and temporal context for geologic records. By evaluating model simulations against a comprehensive synthesis of geologic data, we translate the intermittent geologic record into a continuous reconstruction of Antarctic sea level contributions, revealing a dynamic ice sheet that contributed up to 25 m of glacial-interglacial sea level change. Model grounding line behavior across all major Antarctic catchments exhibits an extended period of receded ice during the mid-Pliocene, coincident with proximal geologic data around Antarctica but earlier than peak warmth in the Northern Hemisphere. Marine ice sheet collapse is triggered with 1.5 °C model subsurface ocean warming. Geologically validated ice-sheet model reconstructions show large-scale fluctuations between glacial and interglacial periods, suggesting that the Antarctic Ice Sheet is highly sensitive to past and future warm conditions. [ABSTRACT FROM AUTHOR]

Aims Intermittent catheters (ICs) are commonly used in bladder management, but catheter-associated urinary tract infections (CAUTIs) remain challenging. Insertion tips may reduce the risk of CAUTIs by minimizing bacterial transfer along the urinary tract. However, there are few laboratory tests to evaluate such technologies. We describe the use of an adapted in vitro urethra agar model to assess bacterial displacement by ICs. Methods and results Simulated urethra agar channels (UACs) were prepared with catheter-specific sized channels in selective media specific to the challenge organisms. UACs were inoculated with Escherichia coli and Enterococcus faecalis before insertion of ICs, and enumeration of UAC sections was performed following insertion. Four ICs were evaluated: Cure Catheter® Closed System (CCS), VaPro Plus Pocket™, Bard® Touchless® Plus, and SpeediCath® Flex Set. CCS demonstrated significantly reduced bacterial displacement along the UACs compared to the other ICs and was also the only IC with undetectable levels of bacteria toward the end of the UAC (representing the proximal urethra). Conclusion The bacterial displacement test demonstrated significant differences in bacterial transfer between the test ICs with insertion tips, which may reflect their different designs. This method is useful for evaluating CAUTI prevention technology and may help guide future technology innovations. [ABSTRACT FROM AUTHOR]

The intensification of industrial biopharmaceutical production and the integration of process steps pave the way for patients to access affordable treatments. The predominantly batchwise biomanufacturing of established cell clarification technologies, stainless steel disc stack centrifugation (DSC) and single‐use (SU) depth filtration (DF), pose technological and economical bottlenecks, that include low biomass loading capacities and low product recoveries. Therefore, a novel SU‐based clarification platform was developed combining fluidized bed centrifugation (FBC) with integrated filtration. The feasibility of this approach was investigated for high cell concentration with more than 100E6 cells/mL. Furthermore, scalability to 200 L bioreactor scale was tested for moderate cell concentrations. In both trials, low harvest turbidities (4 NTU) and superior antibody recoveries (95%) were achieved. The impact on the overall economics of industrial SU biomanufacturing using an up‐scaled FBC approach was compared with DSC and DF technologies for different process parameters. As a result, the FBC showed to be the most cost‐effective alternative for annual mAb production below 500 kg. In addition, the FBC clarification of increasing cell concentrations was found to have minimal impact on overall process costs, in contrast to established technologies, demonstrating that the FBC approach is particularly suitable for intensified processes. [ABSTRACT FROM AUTHOR]

Freshwater discharge from ice sheets induces surface atmospheric cooling and subsurface ocean warming, which are associated with negative and positive feedbacks respectively. However, uncertainties persist regarding these feedbacks' relative strength and combined effect. Here we assess associated feedbacks in a coupled ice sheet-climate model, and show that for the Antarctic Ice Sheet the positive feedback dominates in moderate future warming scenarios and in the early stage of ice sheet retreat, but is overwhelmed by the negative feedback in intensive warming scenarios when the West Antarctic Ice Sheet undergoes catastrophic collapse. The Atlantic Meridional Overturning Circulation is affected by freshwater discharge from both the Greenland and the Antarctic ice sheets and, as an interhemispheric teleconnection bridge, exacerbates the opposing ice sheet's retreat via the Bipolar Seesaw. These results highlight the crucial role of ice sheet-climate interactions via freshwater flux in future ice sheet retreat and associated sea-level rise. Ice sheet freshwater discharge interacts with the climate and affects the ice sheet's sensitivity to climate change. This study shows that the overall feedback shifts from positive to negative as the pace of future warming intensifies [ABSTRACT FROM AUTHOR]

About 34 million years ago, Earth's climate cooled and an ice sheet formed on Antarctica as atmospheric carbon dioxide (CO2) fell below ~750 parts per million (ppm). Sedimentary cycles from a drill core in the western Ross Sea provide direct evidence of orbitally controlled glacial cycles between 34 million and 31 million years ago. Initially, under atmospheric CO2 levels of ≥600 ppm, a smaller Antarctic Ice Sheet (AIS), restricted to the terrestrial continent, was highly responsive to local insolation forcing. A more stable, continental-scale ice sheet calving at the coastline did not form until ~32.8 million years ago, coincident with the earliest time that atmospheric CO2 levels fell below ~600 ppm. Our results provide insight into the potential of the AIS for threshold behavior and have implications for its sensitivity to atmospheric CO2 concentrations above present-day levels.

Geological records from the Antarctic margin offer direct evidence of environmental variability at high southern latitudes and provide insight regarding ice sheet sensitivity to past climate change. The early to mid-Miocene (23-14 Mya) is a compelling interval to study as global temperatures and atmospheric CO2 concentrations were similar to those projected for coming centuries. Importantly, this time interval includes the Miocene Climatic Optimum, a period of global warmth during which average surface temperatures were 3-4 °C higher than today. Miocene sediments in the ANDRILL-2A drill core from the Western Ross Sea, Antarctica, indicate that the Antarctic ice sheet (AIS) was highly variable through this key time interval. A multiproxy dataset derived from the core identifies four distinct environmental motifs based on changes in sedimentary facies, fossil assemblages, geochemistry, and paleotemperature. Four major disconformities in the drill core coincide with regional seismic discontinuities and reflect transient expansion of grounded ice across the Ross Sea. They correlate with major positive shifts in benthic oxygen isotope records and generally coincide with intervals when atmospheric CO2 concentrations were at or below preindustrial levels (∼280 ppm). Five intervals reflect ice sheet minima and air temperatures warm enough for substantial ice mass loss during episodes of high (∼500 ppm) atmospheric CO2 These new drill core data and associated ice sheet modeling experiments indicate that polar climate and the AIS were highly sensitive to relatively small changes in atmospheric CO2 during the early to mid-Miocene.

The semi and fully continuous production of monoclonal antibodies (mAbs) has been gaining traction as a lower cost, and efficient production of mAbs to broaden patient access. To be truly flexible and adaptive to process demands, the industry has lacked sufficient advanced control strategies. The variation of the upstream product concentration typically cannot be handled by the downstream capture step, which is configured for a constant feed concentration and fixed binding capacity. This inflexibility leads to losses of efficiency and product yield. This study shows that these challenges can be overcome by a novel advanced control strategy concept that includes dynamic control throughout a perfusion bioreactor, with cell retention by alternating tangential flow, integrated with simulated moving bed (SMB) multi‐column chromatography. The automation workflow and advanced control strategy were implemented through the use of a visual programming development environment. This enabled dynamic flow control across the upstream and downstream process integrated with a dynamic column loading of the SMB. A sensor prototype, based on continuous biolayer interferometry measurements was applied to detect mAb breakthrough within the last column flow‐through to manage column switching. This novel approach provided higher specificity and lower background signal compared to commonly used spectroscopy methods, resulting in an optimized resin utilization while simultaneously avoiding product loss. The dynamic loading was found to provide a twofold increase of the mAb concentration in the eluate compared to a conservative approach with a predefined recipe with similar impurity removal. This concept shows that advanced control strategies can lead to significant process efficiency and yield improvement. [ABSTRACT FROM AUTHOR]