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Your search keyword '"Posa, Francesca"' showing total 23 results
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23 results on '"Posa, Francesca"'

11. BMP‐2 Signaling and Mechanotransduction Synergize to Drive Osteogenic Differentiation via YAP/TAZ

Author

Wei, Qiang, primary, Holle, Andrew, additional, Li, Jie, additional, Posa, Francesca, additional, Biagioni, Francesca, additional, Croci, Ottavio, additional, Benk, Amelie S., additional, Young, Jennifer, additional, Noureddine, Fatima, additional, Deng, Jie, additional, Zhang, Man, additional, Inman, Gareth J., additional, Spatz, Joachim P., additional, Campaner, Stefano, additional, and Cavalcanti‐Adam, Elisabetta A., additional

Published
2020
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17. High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability

Author

Brunetti, Giacomina, primary, Di Benedetto, Adriana, additional, Posa, Francesca, additional, Colaianni, Graziana, additional, Faienza, Maria Felicia, additional, Ballini, Andrea, additional, Colucci, Silvia, additional, Passeri, Giovanni, additional, Lo Muzio, Lorenzo, additional, Grano, Maria, additional, and Mori, Giorgio, additional

Published
2018
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20. NURR1 Downregulation Favors Osteoblastic Differentiation of MSCs

Author

Di Benedetto, Adriana, primary, Posa, Francesca, additional, Carbone, Claudia, additional, Cantore, Stefania, additional, Brunetti, Giacomina, additional, Centonze, Matteo, additional, Grano, Maria, additional, Lo Muzio, Lorenzo, additional, Cavalcanti-Adam, Elisabetta A., additional, and Mori, Giorgio, additional

Published
2017
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23. Vitamin D Promotes MSC Osteogenic Differentiation Stimulating Cell Adhesion and α V β 3 Expression.

Author

Posa F, Di Benedetto A, Cavalcanti-Adam EA, Colaianni G, Porro C, Trotta T, Brunetti G, Lo Muzio L, Grano M, and Mori G

Abstract

Vitamin D (Vit D) by means of its biological active form, 1 α ,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In this work, we present for the first time the effect of 1,25(OH) 2 D 3 on MSC adhesion. Considering that cell adhesion to the substrate is fundamental for cell commitment and differentiation, we focused on the expression of α V β 3 integrin, which has a key role in the commitment of MSCs to the osteoblastic lineage. Our data indicate that Vit D increases α V β 3 integrin expression inducing the formation of focal adhesions (FAs). Moreover, we assayed MSC commitment in the presence of the extracellular matrix (ECM) glycoprotein fibronectin (FN), which is able to favor cell adhesion on surfaces and also to induce osteopontin (OPN) expression: this suggests that Vit D and FN synergize in supporting cell adhesion. Taken together, our findings provide evidence that Vit D can promote osteogenic differentiation of MSCs through the modulation of α V β 3 integrin expression and its subcellular organization, thus favoring binding with the matrix protein (FN).

Published
2018
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