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1. International severe asthma registry (ISAR): protocol for a global registry

Author

FitzGerald, J.M. (J Mark), Tran, T.N. (Trung N.), Alacqua, M. (Marianna), Altraja, A. (Alan), Backer, V. (Vibeke), Bjermer, L. (Leif), Bjornsdottir, U. (Unnur), Bourdin, A. (Arnaud), Brusselle, G.G. (Guy), Bulathsinhala, L. (Lakmini), Busby, J. (John), Canonica, G. (Gwalter), Carter, V. (Victoria), Chaudhry, I. (Isha), Cho, Y.S. (You Sook), Christoff, G. (George), Cosio, B.G. (Borja G.), Costello, A. (Anthony), Eleangovan, N. (Neva), Gibson, P.G., Heaney, L.G. (Liam G.), Heffler, E. (E.), Hew, M. (Mark), Hosseini, N. (Naeimeh), Iwanaga, T. (Takashi), Jackson, D.J. (David J.), Jones, R. (Rupert), Koh, M.S. (Mariko S.), Le, T. (Thao), Lehtimäki, L. (Lauri), Ludviksdottir, D. (Dora), Maitland-van der Zee, A-H. (Anke-Hilse), Menzies-Gow, A. (Andrew), Murray, R.B. (Ruth B.), Papadopoulos, N., Perez-de-Llano, L. (Luis), Peters, M. (Matthew), Pfeffer, P.E. (Paul E.), Popov, T.A., Porsbjerg, C. (Celeste), Price, C.A. (Chris A.), Rhee, C.K. (Chin K.), Sadatsafavi, M. (Mohsen), Tohda, Y. (Yuji), Wang, E. (Eileen), Wechsler, M.E. (Michael E.), Zangrilli, J. (James), Price, D. (David), FitzGerald, J.M. (J Mark), Tran, T.N. (Trung N.), Alacqua, M. (Marianna), Altraja, A. (Alan), Backer, V. (Vibeke), Bjermer, L. (Leif), Bjornsdottir, U. (Unnur), Bourdin, A. (Arnaud), Brusselle, G.G. (Guy), Bulathsinhala, L. (Lakmini), Busby, J. (John), Canonica, G. (Gwalter), Carter, V. (Victoria), Chaudhry, I. (Isha), Cho, Y.S. (You Sook), Christoff, G. (George), Cosio, B.G. (Borja G.), Costello, A. (Anthony), Eleangovan, N. (Neva), Gibson, P.G., Heaney, L.G. (Liam G.), Heffler, E. (E.), Hew, M. (Mark), Hosseini, N. (Naeimeh), Iwanaga, T. (Takashi), Jackson, D.J. (David J.), Jones, R. (Rupert), Koh, M.S. (Mariko S.), Le, T. (Thao), Lehtimäki, L. (Lauri), Ludviksdottir, D. (Dora), Maitland-van der Zee, A-H. (Anke-Hilse), Menzies-Gow, A. (Andrew), Murray, R.B. (Ruth B.), Papadopoulos, N., Perez-de-Llano, L. (Luis), Peters, M. (Matthew), Pfeffer, P.E. (Paul E.), Popov, T.A., Porsbjerg, C. (Celeste), Price, C.A. (Chris A.), Rhee, C.K. (Chin K.), Sadatsafavi, M. (Mohsen), Tohda, Y. (Yuji), Wang, E. (Eileen), Wechsler, M.E. (Michael E.), Zangrilli, J. (James), and Price, D. (David)

Abstract

BACKGROUND: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour. METHODS: ISAR is a multi-disciplinary initiative benefitting from the combined experience of the ISAR Steering Committee (ISC; comprising 47 clinicians and researchers across 29 countries, who have a special interest and/or experience in severe asthma management or establishment and maintenance of severe asthma registries) in collaboration with scientists and experts in database management and communication. Patients (≥18 years old) receiving treatment according to the 2018 definitions of the Global Initiative for Asthma (GINA) Step 5 or uncontrolled on GINA Step 4 treatment will be included. Data will be collected on a core set of 95 variables identified using the Delphi method. Participating registries will agree to provide acces

Published
2020
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2. International Severe Asthma Registry Mission Statement

Author

Canonica, G.W., Alacqua, M., Altraja, A., Backer, V., Bel, E., Bjermer, L. (Leif), Price, D. (David), Canonica, G.W., Alacqua, M., Altraja, A., Backer, V., Bel, E., Bjermer, L. (Leif), and Price, D. (David)

Abstract

Regional and/or national severe asthma registries provide valuable country-specific information. However, they are often limited in scope within the broader definitions of severe asthma, have insufficient statistical power to answer many research questions, lack intraoperability to share lessons learned, and have fundamental differences in data collected, making cross comparisons difficult. What is missing is a worldwide registry which brings all severe asthma data together in a cohesive way, under a single umbrella, based on standardized data collection protocols, permitting data to be shared seamlessly. The International Severe Asthma Registry (ISAR; http://isaregistries.org/) is the first global adult severe asthma registry. It is a joint initiative where national registries (both newly created and preexisting) retain ownership of their own data but open their borders and share data with ISAR for ethically approved research purposes. Its strength comes from collection of patient-level, anonymous, longitudinal, reallife, standardized, high-quality data (using a core set of variables) from countries across the

Published
2020
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3. Next-generation ARIA care pathways for rhinitis and asthma: A model for multimorbid chronic diseases

Author

Bousquet, J.J. (J. Jean), Schünemann, H.J. (Holger), Togias, A., Erhola, M. (Marina), Hellings, P.W. (Peter), Zuberbier, T. (Torsten), Agache, I. (Ioana), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Becker, S. (Sven), Bedolla-Barajas, M. (Martin), Bewick, M. (Michael), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Boulet, L.P., Bourrez, J.M. (Jean Marc), Brusselle, G.G. (Guy), Chavannes, N.H. (Nicolas), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Gaga, M. (Mina), Haahtela, T. (Tari), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Le, L.T., Larenas-Linnemann, D. (Désirée), Laune, D. (Daniel), Lourenço, O.M. (Olga M.), Menditto, E. (Enrica), Mullol, J. (Joaquin), Okamoto, Y. (Yashitaka), Papadopoulos, N., Pham-Thi, N. (Nhân), Picard, R. (Robert), Pinnock, H. (Hilary), Roche, N. (Nicolas), Roller-Wirnsberger, R.E. (Regina E.), Rolland, C. (Christine), Samolinski, B. (Boleslaw), Sheikh, A. (Aziz), Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Valiulis, A. (Arunas), Valovirta, E. (Erkka), Vasankari, T. (Tuula), Ventura, M.-T. (Maria-Teresa), Walker, S. (Samantha), Williams, S. (Sian), Akdis, C.A. (Cezmi A.), Annesi-Maesano, I. (Isabella), Arnavielhe, S. (Sylvie), Basagaña, X. (Xavier), Bateman, E.D. (Eric), Bedbrook, A. (Anna), Bennoor, K.S. (K.), Benveniste, S. (Samuel), Bergmann, K.-C. (Karl-Christian), Bialek, S. (Slawomir), Billo, N. (Nils), Bindslev-Jensen, C. (Carsten), Bjermer, L. (Leif), Blain, H. (Hubert), Bonini, M. (Matteo), Bonniaud, P. (Philippe), Bouchard, J. (Jacques), Briedis, V. (Vitalis), Brightling, C.E. (Christofer E.), Brozek, J., Buhl, R. (Roland), Buonaiuto, R. (Roland), Canonica, G.W. (Giorgo W.), Cardona, D. (Doris), Carriazo, A.M. (Ana M.), Carr, W.W. (Warner), Cartier, C. (Christine), Casale, T.B. (Thomas), Cecchi, L. (Lorenzo), Cepeda Sarabia, A.M. (Alfonso M.), Chkhartishvili, E. (Eka), Chu, D.K. (Derek K.), Cingi, C. (Cemal), Colgan, E. (Elaine), De Sousa, J.C. (Jaime Correia), Courbis, A.L. (Anne Lise), Custovic, A. (Adnan), Cvetkosvki, B. (Biljana), Damato, G. (Gennaro), Da Silva, J. (Jane), Dantas, C. (Carina), Dokic, D. (D.), Dauvilliers, Y. (Yves), Dedeu, A. (Antoni), De Feo, G. (Giulia), Devillier, P. (Philippe), Di Capua, S. (Stefania), Dykewickz, M. (Marc), Dubakiene, R. (R.), Ebisawa, M. (Motohiro), El-Gamal, Y. (Y.), Eller, E. (Esben), Emuzyte, R., Farrell, J. (John), Fink-Wagner, A. (Antjie), Fiocchi, A. (Alessandro), Fontaine, J.F. (Jean F.), Gemicioǧlu, B. (Bilun), Schmid-Grendelmeir, P. (Peter), Gamkrelidze, A. (Amiran), Garcia-Aymerich, J. (Judith), Gomez, M. (Maximiliano), Diaz, S.G. (Sandra González), Gotua, M. (M.), Guldemond, N. (Nick), Guzmán, M.A. (M.), Hajjam, J. (Jawad), O'Hourihane, J.B. (John B.), Humbert, M. (Marc), Iaccarino, G. (Guido), Ierodiakonou, D. (Despo), Ivancevich, J.C. (Juan), Joos, G.F. (Guy), Jung, K.-S. (Ki-Suck), Jutel, M. (M.), Kaidashev, I. (Igor), Kalayci, O. (Omer), Kardas, P. (Przemyslaw), Keil, M. (Mark), Khaitov, M. (Mussa), Khaltaev, N., Kleine-Tebbe, J. (Jörg), Kowalski, M.L., Kritikos, V. (Vicky), Kull, C.A. (Christian), Leonardini, L. (Lisa), Lieberman, A.P. (Andrew), Lipworth, B., Lødrup Carlsen, K.C. (K. C.), Loureiro, C.C. (Claudia C.), Louis, R. (Renaud), Mair, A. (Alpana), Marien, G. (Gert), Mahboub, B., Malva, J. (Joao), Manning, P. (Patrick), De Manuel Keenoy, E. (Esteban), Marshall, G.D., Masjedi, M.R. (Mohamed R.), Maspero, J.F. (Jorge F.), Mathieu-Dupas, E. (Eve), Matricardi, P.M. (Poalo M.), Melén, E. (Eric), Melo-Gomes, E. (Elisabete), Meltzer, E.O., Mercier, J. (Jacques), Miculinic, N. (Neven), Mihaltan, F. (Florin), Milenkovic, B. (Branislava), Moda, G. (Giuliana), Mogica-Martinez, M.-D. (Maria-Dolores), Mohammad, Y., Montefort, S. (Steve), Monti, R. (Ricardo), Morais-Almeida, M. (Mario), Mösges, R. (Ralph), Münter, L. (Lars), Muraro, A. (Antonella), Murray, R. (Ruth), Naclerio, R., Napoli, L. (Luigi), Namazova-Baranova, L. (Leila), Neffen, H. (Hugo), Nekam, K. (Kristoff), Neou, A. (A.), Novellino, E. (Enrico), Nyembue, D. (Dieudonné), O'Hehir, R. (Robin), Ohta, K., Okubo, K. (Kimi), Onorato, G. (Gabrielle), Ouedraogo, S., Pali-Schöll, I. (I.), Palkonen, S. (Susanna), Panzner, P. (P.), Park, H.-S. (Hae-Sim), Pépin, J.-L. (Jean-Louis), Pereira, A.-M. (Ana-Maria), Pfaar, O. (Oliver), Paulino, E. (Ema), Phillips, J. (Jim), Plavec, D. (Davor), Popov, T.A. (Ted A.), Portejoie, F. (Fabienne), Price, D. (David), Prokopakis, E.P. (Emmanuel P.), Pugin, B. (Benoit), Raciborski, F. (Filip), Rajabian-Söderlund, R. (Rojin), Reitsma, S. (Sietze), Rodo, X. (Xavier), Romano, A., Rosario, N. (Nelson), Rottem, M. (Menahenm), Ryan, D. (Dermot), Salimäki, J. (Johanna), Sanchez-Borges, M.M. (Mario M.), Sisul, J.C. (J.), Solé, D. (Dirceu), Somekh, D. (David), Sooronbaev, T. (Talant), Sova, M. (Milan), Spranger, O., Stellato, C. (Cristina), Stelmach, R. (Rafael), Ulrik, C.S., Thibaudon, M. (Michel), To, T. (Teresa), Todo Bom, A., Tomazic, P.V. (Peter V.), Valero, A.A. (Antonio A.), Valenta, R. (Rudolph), Valentin-Rostan, M. (Marylin), Van Der Kleij, R.M. (Rianne Mjj), Vandenplas, O. (Olivier), Vezzani, G. (Giorgio), Viart, F. (Frédéric), Viegi, G., Wallace, D. (D.), Wagenmann, M. (Martin), Wang, D.Y. (De Y.), Waserman, S. (Susan), Wickman, M. (Magnus), Williams, D., Wong, G. (G.), Wroczynski, P. (Piotr), Yiallouros, P.K. (P.), Yorgancioglu, A. (Arzu), Yusuf, O.M. (Osman), Zar, H.J. (Heahter J.), Zeng, S. (Stéphane), Zernotti, M., Zhang, L. (Luo), Zhong, N.S. (Nan S.), Zidarn, M. (Mihaela), Bousquet, J.J. (J. Jean), Schünemann, H.J. (Holger), Togias, A., Erhola, M. (Marina), Hellings, P.W. (Peter), Zuberbier, T. (Torsten), Agache, I. (Ioana), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Becker, S. (Sven), Bedolla-Barajas, M. (Martin), Bewick, M. (Michael), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Boulet, L.P., Bourrez, J.M. (Jean Marc), Brusselle, G.G. (Guy), Chavannes, N.H. (Nicolas), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Gaga, M. (Mina), Haahtela, T. (Tari), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Le, L.T., Larenas-Linnemann, D. (Désirée), Laune, D. (Daniel), Lourenço, O.M. (Olga M.), Menditto, E. (Enrica), Mullol, J. (Joaquin), Okamoto, Y. (Yashitaka), Papadopoulos, N., Pham-Thi, N. (Nhân), Picard, R. (Robert), Pinnock, H. (Hilary), Roche, N. (Nicolas), Roller-Wirnsberger, R.E. (Regina E.), Rolland, C. (Christine), Samolinski, B. (Boleslaw), Sheikh, A. (Aziz), Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Valiulis, A. (Arunas), Valovirta, E. (Erkka), Vasankari, T. (Tuula), Ventura, M.-T. (Maria-Teresa), Walker, S. (Samantha), Williams, S. (Sian), Akdis, C.A. (Cezmi A.), Annesi-Maesano, I. (Isabella), Arnavielhe, S. (Sylvie), Basagaña, X. (Xavier), Bateman, E.D. (Eric), Bedbrook, A. (Anna), Bennoor, K.S. (K.), Benveniste, S. (Samuel), Bergmann, K.-C. (Karl-Christian), Bialek, S. (Slawomir), Billo, N. (Nils), Bindslev-Jensen, C. (Carsten), Bjermer, L. (Leif), Blain, H. (Hubert), Bonini, M. (Matteo), Bonniaud, P. (Philippe), Bouchard, J. (Jacques), Briedis, V. (Vitalis), Brightling, C.E. (Christofer E.), Brozek, J., Buhl, R. (Roland), Buonaiuto, R. (Roland), Canonica, G.W. (Giorgo W.), Cardona, D. (Doris), Carriazo, A.M. (Ana M.), Carr, W.W. (Warner), Cartier, C. (Christine), Casale, T.B. (Thomas), Cecchi, L. (Lorenzo), Cepeda Sarabia, A.M. (Alfonso M.), Chkhartishvili, E. (Eka), Chu, D.K. (Derek K.), Cingi, C. (Cemal), Colgan, E. (Elaine), De Sousa, J.C. (Jaime Correia), Courbis, A.L. (Anne Lise), Custovic, A. (Adnan), Cvetkosvki, B. (Biljana), Damato, G. (Gennaro), Da Silva, J. (Jane), Dantas, C. (Carina), Dokic, D. (D.), Dauvilliers, Y. (Yves), Dedeu, A. (Antoni), De Feo, G. (Giulia), Devillier, P. (Philippe), Di Capua, S. (Stefania), Dykewickz, M. (Marc), Dubakiene, R. (R.), Ebisawa, M. (Motohiro), El-Gamal, Y. (Y.), Eller, E. (Esben), Emuzyte, R., Farrell, J. (John), Fink-Wagner, A. (Antjie), Fiocchi, A. (Alessandro), Fontaine, J.F. (Jean F.), Gemicioǧlu, B. (Bilun), Schmid-Grendelmeir, P. (Peter), Gamkrelidze, A. (Amiran), Garcia-Aymerich, J. (Judith), Gomez, M. (Maximiliano), Diaz, S.G. (Sandra González), Gotua, M. (M.), Guldemond, N. (Nick), Guzmán, M.A. (M.), Hajjam, J. (Jawad), O'Hourihane, J.B. (John B.), Humbert, M. (Marc), Iaccarino, G. (Guido), Ierodiakonou, D. (Despo), Ivancevich, J.C. (Juan), Joos, G.F. (Guy), Jung, K.-S. (Ki-Suck), Jutel, M. (M.), Kaidashev, I. (Igor), Kalayci, O. (Omer), Kardas, P. (Przemyslaw), Keil, M. (Mark), Khaitov, M. (Mussa), Khaltaev, N., Kleine-Tebbe, J. (Jörg), Kowalski, M.L., Kritikos, V. (Vicky), Kull, C.A. (Christian), Leonardini, L. (Lisa), Lieberman, A.P. (Andrew), Lipworth, B., Lødrup Carlsen, K.C. (K. C.), Loureiro, C.C. (Claudia C.), Louis, R. (Renaud), Mair, A. (Alpana), Marien, G. (Gert), Mahboub, B., Malva, J. (Joao), Manning, P. (Patrick), De Manuel Keenoy, E. (Esteban), Marshall, G.D., Masjedi, M.R. (Mohamed R.), Maspero, J.F. (Jorge F.), Mathieu-Dupas, E. (Eve), Matricardi, P.M. (Poalo M.), Melén, E. (Eric), Melo-Gomes, E. (Elisabete), Meltzer, E.O., Mercier, J. (Jacques), Miculinic, N. (Neven), Mihaltan, F. (Florin), Milenkovic, B. (Branislava), Moda, G. (Giuliana), Mogica-Martinez, M.-D. (Maria-Dolores), Mohammad, Y., Montefort, S. (Steve), Monti, R. (Ricardo), Morais-Almeida, M. (Mario), Mösges, R. (Ralph), Münter, L. (Lars), Muraro, A. (Antonella), Murray, R. (Ruth), Naclerio, R., Napoli, L. (Luigi), Namazova-Baranova, L. (Leila), Neffen, H. (Hugo), Nekam, K. (Kristoff), Neou, A. (A.), Novellino, E. (Enrico), Nyembue, D. (Dieudonné), O'Hehir, R. (Robin), Ohta, K., Okubo, K. (Kimi), Onorato, G. (Gabrielle), Ouedraogo, S., Pali-Schöll, I. (I.), Palkonen, S. (Susanna), Panzner, P. (P.), Park, H.-S. (Hae-Sim), Pépin, J.-L. (Jean-Louis), Pereira, A.-M. (Ana-Maria), Pfaar, O. (Oliver), Paulino, E. (Ema), Phillips, J. (Jim), Plavec, D. (Davor), Popov, T.A. (Ted A.), Portejoie, F. (Fabienne), Price, D. (David), Prokopakis, E.P. (Emmanuel P.), Pugin, B. (Benoit), Raciborski, F. (Filip), Rajabian-Söderlund, R. (Rojin), Reitsma, S. (Sietze), Rodo, X. (Xavier), Romano, A., Rosario, N. (Nelson), Rottem, M. (Menahenm), Ryan, D. (Dermot), Salimäki, J. (Johanna), Sanchez-Borges, M.M. (Mario M.), Sisul, J.C. (J.), Solé, D. (Dirceu), Somekh, D. (David), Sooronbaev, T. (Talant), Sova, M. (Milan), Spranger, O., Stellato, C. (Cristina), Stelmach, R. (Rafael), Ulrik, C.S., Thibaudon, M. (Michel), To, T. (Teresa), Todo Bom, A., Tomazic, P.V. (Peter V.), Valero, A.A. (Antonio A.), Valenta, R. (Rudolph), Valentin-Rostan, M. (Marylin), Van Der Kleij, R.M. (Rianne Mjj), Vandenplas, O. (Olivier), Vezzani, G. (Giorgio), Viart, F. (Frédéric), Viegi, G., Wallace, D. (D.), Wagenmann, M. (Martin), Wang, D.Y. (De Y.), Waserman, S. (Susan), Wickman, M. (Magnus), Williams, D., Wong, G. (G.), Wroczynski, P. (Piotr), Yiallouros, P.K. (P.), Yorgancioglu, A. (Arzu), Yusuf, O.M. (Osman), Zar, H.J. (Heahter J.), Zeng, S. (Stéphane), Zernotti, M., Zhang, L. (Luo), Zhong, N.S. (Nan S.), and Zidarn, M. (Mihaela)

Abstract

Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhi-nitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.

Published
2019
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4. Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study

Author

Braido, F. (Fulvio), Brusselle, G.G. (Guy), Guastalla, D. (Daniele), Ingrassia, E. (Eleonora), Nicolini, G. (Gabriele), Price, D. (David), Roche, N. (Nicolas), Soriano, J.B. (Joan B.), Worth, H. (Heinrich), Braido, F. (Fulvio), Brusselle, G.G. (Guy), Guastalla, D. (Daniele), Ingrassia, E. (Eleonora), Nicolini, G. (Gabriele), Price, D. (David), Roche, N. (Nicolas), Soriano, J.B. (Joan B.), and Worth, H. (Heinrich)

Abstract

Background: According to the Global Initiative of Asthma, the aim of asthma treatment is to gain and maintain control. In the INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study, we evaluated the level of asthma control and quality of life (Q

Published
2016
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5. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author

Bousquet, J. (Jean), Hellings, P.W. (Peter), Agache, I., Bedbrook, A. (Anna), Bachert, C. (Claus), Bergmann, K.-C. (Karl-Christian), Bewick, M., Bindslev-Jensen, C. (Carsten), Bosnic-Anticevitch, S., Bucca, C., Caimmi, D.P., Camargos, P., Canonica, G. (Gwalter), Casale, T.B. (Thomas), Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W.J. (Wytske), Guldemond, N.A., Haahtela, T. (Tari), Illario, M., Just, P.M., Keil, M. (Mark), Klimek, L. (Ludger), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Morais-Almeida, M. (Mario), Mullol, J., Murray, R., Naclerio, R., O'hehir, R.E., Papadopoulos, N., Pawankar, R. (Ruby), Potter, P., Ryan, D. (Dermot), Samolinski, B., Schünemann, H.J. (Holger), Sheikh, A. (Aziz), Simons, F.E.R., Stellato, C., Todo Bom, A., Tomazic, P.V., Valiulis, A. (Arunas), Valovirta, E. (Erkka), Ventura, M.T., Wickman, M. (Magnus), Young, I., Yorgancioglu, A., Zuberbier, T. (Torsten), Aberer, W. (W.), Akdis, C.A., Annesi-Maesano, I. (Isabella), Ankri, J., Ansotegui, I.J. (I.), Anto, J.M. (Josep), Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I. (Ilaria), Barbara, C., Barbagallo, M., Bateman, E.D. (Eric), Beghe, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M., Białoszewski, A.Z., Bieber, T. (Thomas), Bjermer, L. (Leif), Blain, H., Blasi, F. (Francesco), Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosse, I., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R., Braido, F. (Fulvio), Briggs, A. (Andrew), Brightling, C.E. (C.), Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F., Calderon, M. (Moises), Camuzat, T., Cardona, D. (Doris), Carreiro-Martins, P., Carriazo, A.M., Carlsen, K.H. (Karin), Carr, W.W. (Warner), Cepeda Sarabia, A.M., Cesari, M., Chatzi, L. (Leda), Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G. (G.), De Sousa, J.C. (J. Correia), Cox, L. (Linda), Crooks, G., Custovic, A. (Adnan), Dahlen, S.E., Darsow, U. (U.), Dedeu, T., Deleanu, D. (D.), Denburg, J., De Vries, G., Didier, A., Dinh-Xuan, A.T., Dokic, D. (D.), Douagui, H., Dray, G., Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G. (George), Dykewicz, M.S., Eklund, P., El-Gamal, Y. (Y.), Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fletcher, M. (M.), Forastiere, F., Gaga, M. (Mina), Gamkrelidze, A. (Amiran), Gemicioǧlu, B., Gereda, J.E. (J.), Van Wick, R.G. (R. Gerth), González Diaz, S. (S.), Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A. (M.), Hellquist-Dahl, B. (B.), Heinrich, J. (Joachim), Horak, F., Hourihane, J.O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E.J., Jeandel, C., Johnston, S.L., Joos, G.F. (Guy), Jonquet, O., Jung, K.S., Jutel, M. (M.), Kaidashev, I., Khaitov, M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Kardas, P., Keith, P.K., Kerkhof, M. (Marjan), Kerstjens, H.A.M. (Huib), Khaltaev, N., Kogevinas, M. (Manolis), Kolek, V., Koppelman, G.H. (Gerard), Kowalski, M.L., Kuitunen, M., Kull, C.A. (Christian), Kvedariene, V. (Violeta), Lambrecht, B.N.M. (Bart), Lau, S. (Susanne), Laune, D., Le, L.T., Lieberman, A.P. (Andrew), Lipworth, B., Li, J. (J.), Lødrup Carlsen, K.C. (K. C.), Louis, R. (Renaud), Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E. (Erik), Melo-Gomes, E., Meltzer, E.O., Mercier, J., Merk, J. (Jeroen), Miculinic, N., Mihaltan, F. (F.), Milenkovic, B. (Branislava), Millot-Keurinck, J., Mohammad, Y., Momas, I. (I.), Mösges, R. (Ralph), Muraro, A., Namazova-Baranova, L. (L.), Nadif, R. (Rachel), Neffen, H., Nekam, K., Nieto, A. (Antonio), Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T.D. (T.), Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. (Pierluigi), Pali-Schöll, I. (I.), Palkonen, S., Panzner, P. (P.), Papi, A., Park, H.S., Passalacqua, G. (Giovanni), Pedersen, S.E. (Soren E.), Pereira, A.M., Pfaar, O. (Oliver), Picard, R., Pigearias, B. (B.), Pin, I. (Isabelle), Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Postma, D.S. (Dirkje), Poulsen, L.K., Price, D. (David), Rabe, K.F. (Klaus F.), Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodríguez-Mañas, L. (Leocadio), Rolland, C., Roman Rodriguez, M. (M.), Romano, A., Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Scichilone, N., Schmid-Grendelmeier, P. (Peter), Serrano, E., Shields, M.D., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I., Smit, H.A. (Henriëtte), Solé, D. (D.), Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J. (Peter), Strandberg, T., Sunyer, J. (Jordi), Thijs, C. (Carel), Triggiani, M. (M.), Valenta, R., Valero, A.L. (A.), Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O. (Olivier), Varona, L.L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D.Y. (De Yun), Wahn, U. (Ulrich), Werfel, T., Whalley, B., Williams, D., Williams, S., Wilson, N., Wright, J. (Juliet), Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zaidi, A., Zar, H.J., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M. (M.), Bousquet, J. (Jean), Hellings, P.W. (Peter), Agache, I., Bedbrook, A. (Anna), Bachert, C. (Claus), Bergmann, K.-C. (Karl-Christian), Bewick, M., Bindslev-Jensen, C. (Carsten), Bosnic-Anticevitch, S., Bucca, C., Caimmi, D.P., Camargos, P., Canonica, G. (Gwalter), Casale, T.B. (Thomas), Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W.J. (Wytske), Guldemond, N.A., Haahtela, T. (Tari), Illario, M., Just, P.M., Keil, M. (Mark), Klimek, L. (Ludger), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Morais-Almeida, M. (Mario), Mullol, J., Murray, R., Naclerio, R., O'hehir, R.E., Papadopoulos, N., Pawankar, R. (Ruby), Potter, P., Ryan, D. (Dermot), Samolinski, B., Schünemann, H.J. (Holger), Sheikh, A. (Aziz), Simons, F.E.R., Stellato, C., Todo Bom, A., Tomazic, P.V., Valiulis, A. (Arunas), Valovirta, E. (Erkka), Ventura, M.T., Wickman, M. (Magnus), Young, I., Yorgancioglu, A., Zuberbier, T. (Torsten), Aberer, W. (W.), Akdis, C.A., Annesi-Maesano, I. (Isabella), Ankri, J., Ansotegui, I.J. (I.), Anto, J.M. (Josep), Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I. (Ilaria), Barbara, C., Barbagallo, M., Bateman, E.D. (Eric), Beghe, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M., Białoszewski, A.Z., Bieber, T. (Thomas), Bjermer, L. (Leif), Blain, H., Blasi, F. (Francesco), Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosse, I., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R., Braido, F. (Fulvio), Briggs, A. (Andrew), Brightling, C.E. (C.), Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F., Calderon, M. (Moises), Camuzat, T., Cardona, D. (Doris), Carreiro-Martins, P., Carriazo, A.M., Carlsen, K.H. (Karin), Carr, W.W. (Warner), Cepeda Sarabia, A.M., Cesari, M., Chatzi, L. (Leda), Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G. (G.), De Sousa, J.C. (J. Correia), Cox, L. (Linda), Crooks, G., Custovic, A. (Adnan), Dahlen, S.E., Darsow, U. (U.), Dedeu, T., Deleanu, D. (D.), Denburg, J., De Vries, G., Didier, A., Dinh-Xuan, A.T., Dokic, D. (D.), Douagui, H., Dray, G., Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G. (George), Dykewicz, M.S., Eklund, P., El-Gamal, Y. (Y.), Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fletcher, M. (M.), Forastiere, F., Gaga, M. (Mina), Gamkrelidze, A. (Amiran), Gemicioǧlu, B., Gereda, J.E. (J.), Van Wick, R.G. (R. Gerth), González Diaz, S. (S.), Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A. (M.), Hellquist-Dahl, B. (B.), Heinrich, J. (Joachim), Horak, F., Hourihane, J.O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E.J., Jeandel, C., Johnston, S.L., Joos, G.F. (Guy), Jonquet, O., Jung, K.S., Jutel, M. (M.), Kaidashev, I., Khaitov, M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Kardas, P., Keith, P.K., Kerkhof, M. (Marjan), Kerstjens, H.A.M. (Huib), Khaltaev, N., Kogevinas, M. (Manolis), Kolek, V., Koppelman, G.H. (Gerard), Kowalski, M.L., Kuitunen, M., Kull, C.A. (Christian), Kvedariene, V. (Violeta), Lambrecht, B.N.M. (Bart), Lau, S. (Susanne), Laune, D., Le, L.T., Lieberman, A.P. (Andrew), Lipworth, B., Li, J. (J.), Lødrup Carlsen, K.C. (K. C.), Louis, R. (Renaud), Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E. (Erik), Melo-Gomes, E., Meltzer, E.O., Mercier, J., Merk, J. (Jeroen), Miculinic, N., Mihaltan, F. (F.), Milenkovic, B. (Branislava), Millot-Keurinck, J., Mohammad, Y., Momas, I. (I.), Mösges, R. (Ralph), Muraro, A., Namazova-Baranova, L. (L.), Nadif, R. (Rachel), Neffen, H., Nekam, K., Nieto, A. (Antonio), Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T.D. (T.), Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. (Pierluigi), Pali-Schöll, I. (I.), Palkonen, S., Panzner, P. (P.), Papi, A., Park, H.S., Passalacqua, G. (Giovanni), Pedersen, S.E. (Soren E.), Pereira, A.M., Pfaar, O. (Oliver), Picard, R., Pigearias, B. (B.), Pin, I. (Isabelle), Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Postma, D.S. (Dirkje), Poulsen, L.K., Price, D. (David), Rabe, K.F. (Klaus F.), Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodríguez-Mañas, L. (Leocadio), Rolland, C., Roman Rodriguez, M. (M.), Romano, A., Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Scichilone, N., Schmid-Grendelmeier, P. (Peter), Serrano, E., Shields, M.D., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I., Smit, H.A. (Henriëtte), Solé, D. (D.), Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J. (Peter), Strandberg, T., Sunyer, J. (Jordi), Thijs, C. (Carel), Triggiani, M. (M.), Valenta, R., Valero, A.L. (A.), Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O. (Olivier), Varona, L.L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D.Y. (De Yun), Wahn, U. (Ulrich), Werfel, T., Whalley, B., Williams, D., Williams, S., Wilson, N., Wright, J. (Juliet), Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zaidi, A., Zar, H.J., Zernotti, M., Zhang, L., Zhong, N., and Zidarn, M. (M.)

Abstract

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA - disseminated and implemented in over 70 countries globally - is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social ine

Published
2016
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6. Allergy immunotherapy across the life cycle to promote active and healthy ageing: From research to policies

Author

Calderon, M. (Moises), Demoly, P., Casale, T.B. (Thomas), Akdis, C.A., Bachert, C. (Claus), Bewick, M., Bilò, B.M., Bohle, B. (B.), Bonini, S. (Sergio), Bush, A. (Andrew), Caimmi, D.P., Canonica, G. (Gwalter), Cardona, D. (Doris), Chiriac, A.M. (A.), Cox, L. (Linda), Custovic, A. (Adnan), Blay, F. de, Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G. (George), Durham, S.R. (Stephen), Eng, C. (Charis), Fiocchi, A. (Alessandro), Fox, A.T., Gerth van Wijk, R. (Roy), Gomez, R.M., Haathela, T., Halken, S. (Susanne), Hellings, P.W. (Peter), Jacobsen, L., Just, P.M., Tanno, L.K., Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Knol, E.F. (Edward Frank), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Linneberg, A. (Allan), Matricardi, M., Malling, H.-J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G. (Giovanni), Pastorello, E., Pfaar, O. (Oliver), Price, D. (David), Del Rio, P.R. (P. Rodriguez), Ruëff, R., Samolinski, B., Scadding, G.K., Senti, G., Shamji, M.H., Sheikh, A. (Aziz), Sisul, J.C. (J.), Solé, D. (D.), Sturm, G.J., Tabar, A., Van Ree, R., Ventura, M.T., Vidal, C. (Carmen), Varga, E.M., Worm, M. (M.), Zuberbier, T. (Torsten), Bousquet, J. (Jean), Calderon, M. (Moises), Demoly, P., Casale, T.B. (Thomas), Akdis, C.A., Bachert, C. (Claus), Bewick, M., Bilò, B.M., Bohle, B. (B.), Bonini, S. (Sergio), Bush, A. (Andrew), Caimmi, D.P., Canonica, G. (Gwalter), Cardona, D. (Doris), Chiriac, A.M. (A.), Cox, L. (Linda), Custovic, A. (Adnan), Blay, F. de, Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G. (George), Durham, S.R. (Stephen), Eng, C. (Charis), Fiocchi, A. (Alessandro), Fox, A.T., Gerth van Wijk, R. (Roy), Gomez, R.M., Haathela, T., Halken, S. (Susanne), Hellings, P.W. (Peter), Jacobsen, L., Just, P.M., Tanno, L.K., Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Knol, E.F. (Edward Frank), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Linneberg, A. (Allan), Matricardi, M., Malling, H.-J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G. (Giovanni), Pastorello, E., Pfaar, O. (Oliver), Price, D. (David), Del Rio, P.R. (P. Rodriguez), Ruëff, R., Samolinski, B., Scadding, G.K., Senti, G., Shamji, M.H., Sheikh, A. (Aziz), Sisul, J.C. (J.), Solé, D. (D.), Sturm, G.J., Tabar, A., Van Ree, R., Ventura, M.T., Vidal, C. (Carmen), Varga, E.M., Worm, M. (M.), Zuberbier, T. (Torsten), and Bousquet, J. (Jean)

Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

Published
2016
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7. Real-world research and its importance in respiratory medicine

Author

Price, D. (David), Brusselle, G.G. (Guy), Roche, N. (Nicolas), Freeman, D. (Daryl), Chisholm, A. (Alison), Price, D. (David), Brusselle, G.G. (Guy), Roche, N. (Nicolas), Freeman, D. (Daryl), and Chisholm, A. (Alison)

Abstract

Clinical practice requires a complex interplay between experience and training, research, guidelines and judgement, and must not only draw on data from traditional or classical randomised controlled trials (cRCTs), but also from pragmatically designed studies that better reflect real-life clinical practice. To minimise extraneous variables and to optimize their internal validity, cRCTs exclude patients, clinical characteristics and variations in care that could potentially confound outcomes. The result is that respiratory cRCTs often enrol a small, non-representative subset of patients and overlook the important interplay and interactions between patients and the real world, which can effect treatment outcomes. Evidence from real-life studies (e.g. naturalistic or pragmatic clinical trials and observational studies encompassing healthcare database studies and cohort studies) can be combined with cRCT evidence to provide a fuller picture of intervention effectiveness and realistic treatment outcomes, and can provide useful insights into alternative management approaches in more challenging asthma patients. The Respiratory Effectiveness Group (REG), in collaboration with the European Academy of Allergy and Clinical Immunology (EAACI) and the European Respiratory Society (ERS), is developing quality appraisal tools and methods for integrating different sources of evidence. A REG/EAACI taskforce aims to help support future guideline developers to avoid a one-size-fits-all approach to recommendations and to tailor the conclusions of their meta-analyses to the populations under consideration.

Published
2015
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