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1. Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage

Author

El Tal, Tala, Morin, Marie-Paule, Morris, Shaun K., Farrar, Daniel S., Berard, Roberta A., Kakkar, Fatima, Moore Hepburn, Charlotte, Baerg, Krista, Beaufils, Camille, Bennett, Terri-Lyn, Benseler, Susanne M., Beaudoin-Bussières, Guillaume, Chan, Kevin, Cyr, Claude, Dahdah, Nagib, Donner, Elizabeth J., Drouin, Olivier, Edjoc, Rojiemiahd, Eljaouhari, Maryem, Embree, Joanne E., Farrell, Catherine, Finzi, Andrés, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin Thibodeau, Melanie, Lang, Bianca, Laxer, Ronald M., Luu, Thuy Mai, McCrindle, Brian W., Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Proulx-Gauthier, Jean-Philippe, Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Thibeault, Roseline, Top, Karina A., Viel-Thériault, Isabelle, Haddad, Elie, Scuccimarri, Rosie, and Yeung, Rae S. M.

Published
2023
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2. Bloodstream Infections in Children Hospitalized for Influenza, the Canadian Immunization Monitoring Program Active

Author

Modler, Jacqueline, Morris, Shaun K., Bettinger, Julie A., Bancej, Christina, Burton, Catherine, Foo, Cheryl, Halperin, Scott A., Jadavji, Taj, Kazmi, Kescha, Sadarangani, Manish, Schober, Tilmann, Papenburg, Jesse, Bridger, Natalie, Top, Karina, Thibeault, Roseline, Moore, Dorothy L., Lebel, Marc, Saux, Nicole Le, Purewal, Rupeena, Sauvé, Laura, and Bullard, Jared

Published
2024
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5. SARS-CoV-2 infection in technology-dependent children: a multicenter case series

Author

Robinson, Joan, Dewan, Tammie, Morris, Shaun K., Bitnun, Ari, Gill, Peter, Tal, Tala El, Laxer, Ronald M., Yeh, E. Ann, Yea, Carmen, Ulloa-Gutierrez, Rolando, Brenes-Chacon, Helena, Yock-Corrales, Adriana, Ivankovich-Escoto, Gabriela, Soriano-Fallas, Alejandra, Mezerville, Marcela Hernandez-de, Papenburg, Jesse, Lefebvre, Marie-Astrid, Nateghian, Alireza, Aski, Behzad Haghighi, Manafi, Ali, Dwilow, Rachel, Bullard, Jared, Cooke, Suzette, Restivo, Lea, Lopez, Alison, Sadarangani, Manish, Roberts, Ashley, Le Saux, Nicole, Bowes, Jennifer, Purewal, Rupeena, Lautermilch, Janell, Wong, Jacqueline K., Piche, Dominique, Top, Karina A., Foo, Cheryl, Panetta, Luc, Merckx, Joanna, and Barton, Michelle

Published
2023
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6. Bloodstream Infections in Children Hospitalized for Influenza, the Canadian Immunization Monitoring Program Active (IMPACT)

Author

Modler, Jacqueline, Morris, Shaun K., Bettinger, Julie A., Bancej, Christina, Burton, Catherine, Foo, Cheryl, Halperin, Scott A., Jadavji, Taj, Kazmi, Kescha, Sadarangani, Manish, Schober, Tilmann, Papenburg, Jesse, Bridger, Natalie, Top, Karina, Thibeault, Roseline, Moore, Dorothy L., Lebel, Marc, Saux, Nicole Le, Purewal, Rupeena, Sauvé, Laura, and Bullard, Jared

Published
2023
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7. Outcomes of immunocompromised children hospitalized for Influenza, 2010-2021, the Canadian Immunization Monitoring Program Active (IMPACT)

Author

Foo, Cheryl, Bridger, Natalie, Halperin, Scott A., Top, Karina, Thibeault, Roseline, Papenburg, Jesse, Lebel, Marc, Le Saux, Nicole, Morris, Shaun K., Kazmi, Kescha, Bullard, Jared, Purewal, Rupeena, Jadavji, Taj, Burton, Catherine, Bettinger, Julie A., Sauvé, Laura, Sadarangani, Manish, Schober, Tilmann, Bancej, Christina, and Modler, Jacqueline

Published
2023
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8. Infants hospitalized for acute COVID-19: disease severity in a multicenter cohort study

Author

Merckx, Joanna, Morris, Shaun K., Bitnun, Ari, Gill, Peter, El Tal, Tala, Laxer, Ronald M., Yeh, Ann, Yea, Carmen, Ulloa-Gutierrez, Rolando, Brenes-Chacon, Helena, Yock-Corrales, Adriana, Ivankovich-Escoto, Gabriela, Soriano-Fallas, Alejandra, Hernandez-de Mezerville, Marcela, Papenburg, Jesse, Lefebvre, Marie-Astrid, Nateghian, Alireza, Haghighi Aski, Behzad, Manafi, Ali, Dwilow, Rachel, Bullard, Jared, Cooke, Suzette, Dewan, Tammie, Restivo, Lea, Lopez, Alison, Sadarangani, Manish, Roberts, Ashley, Barton, Michelle, Petel, Dara, Le Saux, Nicole, Bowes, Jennifer, Purewal, Rupeena, Lautermilch, Janell, Tehseen, Sarah, Bayliss, Ann, Wong, Jacqueline K., Viel-Thériault, Isabelle, Piche, Dominique, Top, Karina A., Leifso, Kirk, Foo, Cheryl, Panetta, Luc, and Robinson, Joan

Published
2022
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9. Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author

Farrar, Daniel S., Drouin, Olivier, Moore Hepburn, Charlotte, Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin Thibodeau, Melanie, Orkin, Julia, Ouldali, Naïm, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Proulx-Gauthier, Jean-Philippe, Purewal, Rupeena, Ricci, Christina, Sadarangani, Manish, Salvadori, Marina I., Thibeault, Roseline, Top, Karina A., Viel-Thériault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Published
2022
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10. The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: A population-based study

Author

Bancej, Christina, Burton, Catherine, Embree, Joanne, Foo, Cheryl, Bridger, Natalie, Morris, Robert, Jadavji, Taj, Lebel, Marc, Le Saux, Nicole, Top, Karina A., Tan, Ben, McConnell, Athena, Purewal, Rupeena, Déry, Pierre, Thibeault, Roseline, Vaudry, Wendy, Tran, Dat, Sauvé, Laura, Moore, Dorothy L., Lefebvre, Marie-Astrid, Groves, Helen E., Papenburg, Jesse, Mehta, Kayur, Bettinger, Julie A., Sadarangani, Manish, Halperin, Scott A., and Morris, Shaun K.

Published
2022
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11. Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study

Author

Merckx, Joanna, Cooke, Suzette, Tal, Tala El, Bitnun, Ari, Morris, Shaun K., Yeh, E. Ann, Yea, Carmen, Gill, Peter, Papenburg, Jesse, Lefebvre, Marie-Astrid, Scuccimarri, Rosie, Ulloa-Gutierrez, Rolando, Brenes-Chacon, Helena, Yock-Corrales, Adriana, Ivankovich-Escoto, Gabriela, Soriano-Fallas, Alejandra, Mezerville, Marcela Hernandez-de, Dewan, Tammie, Restivo, Lea, Nateghian, Alireza, Aski, Behzad Haghighi, Manafi, Ali, Dwilow, Rachel, Bullard, Jared, Lopez, Alison, Sadarangani, Manish, Roberts, Ashley, Barton, Michelle, Petel, Dara, Le Saux, Nicole, Bowes, Jennifer, Purewal, Rupeena, Lautermilch, Janell, Tehseen, Sarah, Bayliss, Ann, Wong, Jacqueline K., Leifso, Kirk, Foo, Cheryl, and Robinson, Joan

Subjects
Hospital care -- Statistics, Pediatric research, Health
Abstract

Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit (ICU) and explored changes in disease severity over time. Methods: We obtained data from chart reviews of children younger than 18 years with confirmed or probable MIS-C who were admitted to 15 hospitals in Canada, Iran and Costa Rica between Mar. 1, 2020, and Mar. 7, 2021. Using multivariable analyses, we evaluated whether admission date and other characteristics were associated with ICU admission or cardiac involvement. Results: Of 232 children with MIS-C (median age 5.8 yr), 130 (56.0%) were male and 50 (21.6%) had comorbidities. Seventy-three (31.5%) patients were admitted to the ICU but none died. We observed an increased risk of ICU admission among children aged 13-17 years (adjusted risk difference 27.7%, 95% confidence interval [CI] 8.3% to 47.2%), those aged 6-12 years (adjusted risk difference 25.2%, 95% CI 13.6% to 36.9%) or those with initial ferritin levels greater than 500 [micro]g/L (adjusted risk difference 18.4%, 95% CI 5.6% to 31.3%). Children admitted to hospital after Oct. 31, 2020, had numerically higher rates of ICU admission (adjusted risk difference 12.3%, 95% CI -0.3% to 25.0%) and significantly higher rates of cardiac involvement (adjusted risk difference 30.9%, 95% CI 17.3% to 44.4%). At Canadian sites, the risk of ICU admission was significantly higher for children admitted to hospital between December 2020 and March 2021 than those admitted between March and May 2020 (adjusted risk difference 25.3%, 95% CI 6.5% to 44.0%). Interpretation: We observed that age and higher ferritin levels were associated with more severe MIS-C. We observed greater severity of MIS-C later in the study period. Whether emerging SARS-CoV-2 variants pose different risks of severe MIS-C needs to be determined., Multisystem inflammatory syndrome in children (MIS-C) (1) manifests as immune dysregulation after SARS-CoV-2 infection. (2) The syndrome has no pathognomonic features. Thus, the diagnostic criteria of the Royal College of [...]

Published
2022
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12. Caracteristiques des hospitalisations au Canada d'enfants ayant contracte une infection aigue par le SRAS-CoV-2 en 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Infection, Health
Abstract

Contexte : Les facteurs de risque de complications graves de l'infection par le SRAS-CoV-2 n'ont pas ete bien etablis chez les enfants. Nous avons voulu decrire les hospitalisations pediatriques associees au SRAS-CoV-2 au Canada et identifier les facteurs de risque de maladie grave. Methodes : Nous avons procede a une etude prospective nationale en utilisant l'infrastructure du Programme canadien de surveillance pediatrique (PCSP). Les hospitalisations d'enfants ayant contracte une infection par le SRAS-CoV-2 confirmee en laboratoire de microbiologie ont ete rapportees du 8 avril au 31 decembre 2020 au moyen de questionnaires hebdomadaires en ligne distribues au reseau du PCSP, qui compte plus de 2800 pediatres. Nous avons categorise les hospitalisations comme suit : liees a la COVID-19, infections decouvertes fortuitement, ou hospitalisations pour des raisons sociales ou de controle des infections, et degage les facteurs de risque associes a la gravite de la maladie chez les patients hospitalises. Resultats : Sur les 264 hospitalisations d'enfants ayant contracte le SRAS-CoV-2 au cours de la periode de l'etude de 9 mois, 150 (56,8 %) ont ete associees a la COVID-19 et 100 (37,9 %o) etaient des cas decouverts fortuitement (admission pour d'autres raisons et decouverte fortuite du SRAS-CoV-2 par depistage positif). Les nourrissons (37,3 %) et les adolescents (29,6 %) representaient la majorite des cas. Parmi les hospitalisations liees a la COVID-19, 52 patients (34,7 %) etaient atteints d'une forme grave de la mala die, dont 42 (28,0 % des cas lies a la COVID-19) ont eu besoin d'une forme d'assistance respiratoire ou hemodynamique, et 59 (39,3 %o) presentaient au moins 1 comorbidite sous-jacente. Les enfants atteints d'obesite, de maladies neurologiques chroniques ou de maladies pulmonaires chroniques, a l'exclusion de l'asthme, etaient plus susceptibles de presenter une forme grave ou critique de la COVID-19. Interpretation : Parmi les enfants hospitalises au Canada chez lesquels on a diagnostique une infection par le SRAS-CoV-2 au debut de la pandemie de COVID-19, la decouverte fortuite du SRAS-CoV-2 a ete frequente. Chez les enfants hospitalises pour une COVID-19 aigue, l'obesite et les comorbidites neurologiques et respiratoires ont ete associees a une gravite accrue., En date du 31 decembre 2020, le Canada comptait 581 427 cas confirmes d'infection par le SRAS-CoV-2 (1). Comme dans d'autres pays, la plupart des infections confirmees ont ete diagnostiquees [...]

Published
2021
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13. Antibiotic use in children hospitalised for influenza, 2010–2021: the Canadian Immunization Monitoring Program Active (IMPACT).

Author

Schober, Tilmann, Morris, Shaun K., Bettinger, Julie A., Burton, Catherine, Halperin, Scott A., Jadavji, Taj, Kazmi, Kescha, Modler, Jacqueline, Sadarangani, Manish, Papenburg, Jesse, Foo, Cheryl, Bridger, Natalie, Top, Karina, Thibeault, Roseline, Lebel, Marc, Le Saux, Nicole, Bullard, Jared, Purewal, Rupeena, and Sauvé, Laura

Subjects
ANTIBIOTICS, INAPPROPRIATE prescribing (Medicine), DATA analysis, RESEARCH funding, LOGISTIC regression analysis, ANTIMICROBIAL stewardship, INFLUENZA, DESCRIPTIVE statistics, CHI-squared test, MANN Whitney U Test, ODDS ratio, STATISTICS, DATA analysis software, CONFIDENCE intervals, HOSPITAL care of children, CHILDREN
Abstract

Purpose: To determine characteristics associated with inappropriate antibiotic use amongst children hospitalised for influenza. Methods: We performed active surveillance for laboratory-confirmed influenza hospitalizations amongst children ≤ 16 years old at the 12 Canadian Immunization Monitoring Program Active hospitals, from September 2010 to August 2021. Antibiotic use was presumed appropriate if any of the following indications were met: age < 1 month, immunocompromised, hemoglobinopathy, laboratory-confirmed bacterial infection, radiographically confirmed pneumonia, admission to an intensive care unit and mechanical ventilation. Regression analyses were used to identify baseline and clinical characteristics associated with antibiotic use amongst patients without an appropriate indication. Results: Amongst 8971 children, 6424 (71.6%) received any antibiotics during their hospitalisation. Amongst the 4429 children without an appropriate indication, 2366 (53.2%) received antibiotics. Antibiotic use amongst children without appropriate indication differed between study centres, ranging from 33.2% to 66.1% (interquartile range [IQR] 50.6–56.3%); it did not change significantly over time (p-value for trend = 0.28). In multivariable analyses, older age (adjusted odds ratio [aOR] 0.97, 95% confidence interval [CI] 0.96–0.99), presence of any high-risk condition (aOR 0.80, 95% CI 0.70–0.92), influenza virus type B (aOR 0.8, 95% CI 0.70–0.91) and croup (aOR 0.64, 95% CI 0.49–0.83) were associated with less, whilst fever ≥ 38.5 °C (aOR 1.82, 95% CI 1.42–2.35) and hospitalisation duration (aOR 1.12, 95% CI 1.09–1.15) were associated with more inappropriate antibiotic use. Conclusions: Over two-third of children hospitalised for influenza received antibiotics, including over half of those without an appropriate indication for antibiotic treatment. Differences amongst study centres suggest the importance of contextual determinants of antibiotic use. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Children -- Diseases, Pediatric research -- 2020 AD, Hospital patients -- Statistics -- Demographic aspects -- 2020 AD, Health
Abstract

Background: Risk factors for severe outcomes of SARS-CoV-2 infection are not well established in children. We sought to describe pediatric hospital admissions associated with SARS-CoV-2 infection in Canada and identify risk factors for more severe disease. Methods: We conducted a national prospective study using the infrastructure of the Canadian Paediatric Surveillance Program (CPSP). Cases involving children who were admitted to hospital with microbiologically confirmed SARS-CoV-2 infection were reported from Apr. 8 to Dec. 31 2020, through weekly online questionnaires distributed to the CPSP network of more than 2800 pediatricians. We categorized hospital admissions as related to COVID-19, incidental, or for social or infection control reasons and determined risk factors for disease severity in hospital. Results: Among 264 hospital admissions involving children with SARS-CoV-2 infection during the 9-month study period, 150 (56.8%) admissions were related to COVID-19 and 100 (37.9%) were incidental infections (admissions for other reasons and found to be positive for SARS-CoV-2 on screening). Infants (37.3%) and adolescents (29.6%) represented most cases. Among hospital admissions related to COVID-19, 52 (34.7%) had critical disease, 42 (28.0%) of whom required any form of respiratory or hemodynamic support, and 59 (39.3%) had at least 1 underlying comorbidity. Children with obesity, chronic neurologic conditions or chronic lung disease other than asthma were more likely to have severe or critical COVID-19. Interpretation: Among children who were admitted to hospital with SARS-CoV-2 infection in Canada during the early COVID-19 pandemic period, incidental SARS-CoV-2 infection was common. In children admitted with acute COVID-19, obesity and neurologic and respiratory comorbidities were associated with more severe disease., As of Dec. 31, 2020, Canada had 581427 confirmed cases of SARS-CoV-2 infection. (1) Similar to other countries, most confirmed infections were in adults, in part because of initial testing [...]

Published
2021
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15. Association of cerebrospinal fluid parameters with treatment and complications among children with cerebrospinal fluid shunt infections: a multicenter study

Author

Hawkes, Michael T., primary, McAlpine, Alastair, additional, Barton, Michelle, additional, Ranger, Adrianna, additional, Balamohan, Archana, additional, Davies, H. Dele, additional, Skar, Gwenn, additional, Lefebvre, Marie-Astrid, additional, Almadani, Ahmed, additional, Freire, Dolores, additional, Saux, Nicole Le, additional, Bowes, Jennifer, additional, Srigley, Jocelyn A., additional, Passarelli, Patrick, additional, Bradley, John, additional, Khan, Sarah, additional, Purewal, Rupeena, additional, Viel-Thériault, Isabelle, additional, Robinson, Joan L., additional, and _, _, additional

Published
2023
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16. Association of cerebrospinal fluid parameters with treatment and complications among children with cerebrospinal fluid shunt infections: a multicenter study.

Author

Hawkes, Michael T., McAlpine, Alastair, Barton, Michelle, Ranger, Adrianna, Balamohan, Archana, Dele Davies, H., Skar, Gwenn, Lefebvre, Marie-Astrid, Almadani, Ahmed, Freire, Dolores, Le Saux, Nicole, Bowes, Jennifer, Srigley, Jocelyn A., Passarelli, Patrick, Bradley, John, Khan, Sarah, Purewal, Rupeena, Viel-Thériault, Isabelle, and Robinson, Joan L.

Published
2024
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17. Outcomes of immunocompromised children hospitalized for Influenza, 2010-2021, the Canadian Immunization Monitoring Program Active (IMPACT)

Author

Schober, Tilmann, primary, Morris, Shaun K., additional, Bettinger, Julie A., additional, Bancej, Christina, additional, Burton, Catherine, additional, Foo, Cheryl, additional, Halperin, Scott A., additional, Jadavji, Taj, additional, Kazmi, Kescha, additional, Modler, Jacqueline, additional, Sadarangani, Manish, additional, Papenburg, Jesse, additional, Bridger, Natalie, additional, Top, Karina, additional, Thibeault, Roseline, additional, Lebel, Marc, additional, Le Saux, Nicole, additional, Bullard, Jared, additional, Purewal, Rupeena, additional, and Sauvé, Laura, additional

Published
2023
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18. Comparison of pediatric ventriculo-peritoneal shunt infections arising in antibiotic-impregnated and standard catheters: a multicenter observational study

Author

Robinson, Joan, primary, Balamohan, Archana, additional, Barton, Michelle, additional, Lefebvre, Marie-Astrid, additional, Almadani, Ahmed, additional, Freire, Dolores, additional, McAlpine, Alastair, additional, Srigley, Jocelyn, additional, Passarelli, Patrick, additional, Bradley, John, additional, Davies, Dele, additional, Skar, Gwenn, additional, Viel-Theriault, Isabelle, additional, Khan, Sarah, additional, Purewal, Rupeena, additional, LeSaux, Nicole, additional, Bowes, Jennifer, additional, and Hawkes, Michael, additional

Published
2023
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19. Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study

Author

Yea, Carmen, Barton, Michelle, Bitnun, Ari, Morris, Shaun K., El Tal, Tala, Ulloa-Gutierrez, Rolando, Brenes-Chacon, Helena, Yock-Corrales, Adriana, Ivankovich-Escoto, Gabriela, Soriano-Fallas, Alejandra, Hernandez-de Mezerville, Marcela, Gill, Peter, Nateghian, Alireza, Aski, Behzad Haghighi, Manafi, Ali Anari, Dwilow, Rachel, Bullard, Jared, Papenburg, Jesse, Scuccimarri, Rosie, Lefebvre, Marie-Astrid, Cooke, Suzette, Dewan, Tammie, Restivo, Lea, Lopez, Alison, Sadarangani, Manish, Roberts, Ashley, Wong, Jacqueline, Saux, Nicole Le, Bowes, Jennifer, Purewal, Rupeena, Lautermilch, Janell, Foo, Cheryl, Merckx, Joanna, Robinson, Joan, and Yeh, E. Ann

Abstract

ABSTRACT:Background and Objectives:Neurological involvement associated with SARS-CoV-2 infection is increasingly recognized. However, the specific characteristics and prevalence in pediatric patients remain unclear. The objective of this study was to describe the neurological involvement in a multinational cohort of hospitalized pediatric patients with SARS-CoV-2.Methods:This was a multicenter observational study of children <18 years of age with confirmed SARS-CoV-2 infection or multisystemic inflammatory syndrome (MIS-C) and laboratory evidence of SARS-CoV-2 infection in children, admitted to 15 tertiary hospitals/healthcare centers in Canada, Costa Rica, and Iran February 2020–May 2021. Descriptive statistical analyses were performed and logistic regression was used to identify factors associated with neurological involvement.Results:One-hundred forty-seven (21%) of 697 hospitalized children with SARS-CoV-2 infection had neurological signs/symptoms. Headache (n= 103), encephalopathy (n= 28), and seizures (n= 30) were the most reported. Neurological signs/symptoms were significantly associated with ICU admission (OR: 1.71, 95% CI: 1.15–2.55; p= 0.008), satisfaction of MIS-C criteria (OR: 3.71, 95% CI: 2.46–5.59; p< 0.001), fever during hospitalization (OR: 2.15, 95% CI: 1.46–3.15; p< 0.001), and gastrointestinal involvement (OR: 2.31, 95% CI: 1.58–3.40; p< 0.001). Non-headache neurological manifestations were significantly associated with ICU admission (OR: 1.92, 95% CI: 1.08–3.42; p= 0.026), underlying neurological disorders (OR: 2.98, 95% CI: 1.49–5.97, p= 0.002), and a history of fever prior to hospital admission (OR: 2.76, 95% CI: 1.58–4.82; p< 0.001).Discussion:In this study, approximately 21% of hospitalized children with SARS-CoV-2 infection had neurological signs/symptoms. Future studies should focus on pathogenesis and long-term outcomes in these children.

Published
2024
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20. Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study

Author

Yea, Carmen, primary, Barton, Michelle, additional, Bitnun, Ari, additional, Morris, Shaun K, additional, El Tal, Tala, additional, Ulloa-Gutierrez, Rolando, additional, Brenes-Chacon, Helena, additional, Yock-Corrales, Adriana, additional, Ivankovich-Escoto, Gabriela, additional, Soriano-Fallas, Alejandra, additional, Hernandez-de Mezerville, Marcela, additional, Gill, Peter, additional, Nateghian, Alireza, additional, Haghighi Aski, Behzad, additional, Anari Manafi, Ali, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Papenburg, Jesse, additional, Scuccimarri, Rosie, additional, Lefebvre, Marie-Astrid, additional, Cooke, Suzette, additional, Dewan, Tammie, additional, Restivo, Lea, additional, Lopez, Alison, additional, Sadarangani, Manish, additional, Roberts, Ashley, additional, Wong, Jacqueline, additional, Le Saux, Nicole, additional, Bowes, Jennifer, additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Foo, Cheryl, additional, Merckx, Joanna, additional, Robinson, Joan, additional, and Yeh, E. Ann, additional

Published
2023
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21. 50 Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author

Farrar, Daniel, primary, Drouin, Olivier, additional, Hepburn, Charlotte Moore, additional, Baerg, Krista, additional, Chan, Kevin, additional, Cyr, Claude, additional, Donner, Elizabeth, additional, Embree, Joanne, additional, Farrell, Catherine, additional, Forgie, Sarah, additional, Giroux, Ryan, additional, Kang, Kristopher, additional, King, Melanie, additional, Laffin-Thibodeau, Melanie, additional, Luu, Thuy-Mai, additional, Orkin, Julia, additional, Ouldali, Naïm, additional, Papenburg, Jesse, additional, Pound, Catherine, additional, Price, Victoria E, additional, Proulx-Gauthier, Jean-Phillippe, additional, Purewal, Rupeena, additional, Sadarangani, Manish, additional, Salvadori, Marina, additional, Thibeault, Roseline, additional, Top, Karina, additional, Viel-Thériault, Isabelle, additional, Kakkar, Fatima, additional, and Morris, Shaun, additional

Published
2022
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22. SARS-CoV-2 infection in technology-dependent children: a multicenter case series

Author

Robinson, Joan, primary, Dewan, Tammie, additional, Morris, Shaun K., additional, Bitnun, Ari, additional, Gill, Peter, additional, Tal, Tala El, additional, Laxer, Ronald M., additional, Yeh, E. Ann, additional, Yea, Carmen, additional, Ulloa-Gutierrez, Rolando, additional, Brenes-Chacon, Helena, additional, Yock-Corrales, Adriana, additional, Ivankovich-Escoto, Gabriela, additional, Soriano-Fallas, Alejandra, additional, Mezerville, Marcela Hernandez-de, additional, Papenburg, Jesse, additional, Lefebvre, Marie-Astrid, additional, Nateghian, Alireza, additional, Aski, Behzad Haghighi, additional, Manafi, Ali, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Cooke, Suzette, additional, Restivo, Lea, additional, Lopez, Alison, additional, Sadarangani, Manish, additional, Roberts, Ashley, additional, Le Saux, Nicole, additional, Bowes, Jennifer, additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Wong, Jacqueline K., additional, Piche, Dominique, additional, Top, Karina A., additional, Foo, Cheryl, additional, Panetta, Luc, additional, Merckx, Joanna, additional, and Barton, Michelle, additional

Published
2022
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23. Risk factors for severe PCR-positive SARS-CoV-2 infection in hospitalised children

Author

Schober, Tilmann, primary, Caya, Chelsea, additional, Barton, Michelle, additional, Bayliss, Ann, additional, Bitnun, Ari, additional, Bowes, Jennifer, additional, Brenes-Chacon, Helena, additional, Bullard, Jared, additional, Cooke, Suzette, additional, Dewan, Tammie, additional, Dwilow, Rachel, additional, El Tal, Tala, additional, Foo, Cheryl, additional, Gill, Peter, additional, Haghighi Aski, Behzad, additional, Kakkar, Fatima, additional, Lautermilch, Janell, additional, Lefebvre, Marie-Astrid, additional, Leifso, Kirk, additional, Le Saux, Nicole, additional, Lopez, Alison, additional, Manafi, Ali, additional, Merckx, Joanna, additional, Morris, Shaun K, additional, Nateghian, Alireza, additional, Panetta, Luc, additional, Petel, Dara, additional, Piché, Dominique, additional, Purewal, Rupeena, additional, Restivo, Lea, additional, Roberts, Ashley, additional, Sadarangani, Manish, additional, Scuccimarri, Rosie, additional, Soriano-Fallas, Alejandra, additional, Tehseen, Sarah, additional, Top, Karina A, additional, Ulloa-Gutierrez, Rolando, additional, Viel-Theriault, Isabelle, additional, Wong, Jacqueline, additional, Yea, Carmen, additional, Yeh, Ann, additional, Yock-Corrales, Adriana, additional, Robinson, Joan L, additional, and Papenburg, Jesse, additional

Published
2022
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24. Thrombosis and hemorrhage experienced by hospitalized children with SARS‐CoV‐2 infection or MIS‐C: Results of the PICNIC registry

Author

Tehseen, Sarah, primary, Williams, Suzan, additional, Robinson, Joan, additional, Morris, Shaun K., additional, Bitnun, Ari, additional, Gill, Peter, additional, Tal, Tala El, additional, Yeh, Ann, additional, Yea, Carmen, additional, Ulloa‐Gutierrez, Rolando, additional, Brenes‐Chacon, Helena, additional, Yock‐Corrales, Adriana, additional, Ivankovich‐Escoto, Gabriela, additional, Soriano‐Fallas, Alejandra, additional, Papenburg, Jesse, additional, Lefebvre, Marie‐Astrid, additional, Scuccimarri, Rosie, additional, Nateghian, Alireza, additional, Aski, Behzad Haghighi, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Cooke, Suzette, additional, Restivo, Lea, additional, Lopez, Alison, additional, Sadarangani, Manish, additional, Roberts, Ashley, additional, Forbes, Michelle, additional, Saux, Nicole Le, additional, Bowes, Jennifer, additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Bayliss, Ann, additional, Wong, Jacqueline K., additional, Leifso, Kirk, additional, Foo, Cheryl, additional, Panetta, Luc, additional, Kakkar, Fatima, additional, Piche, Dominique, additional, Viel‐Theriault, Isabelle, additional, Merckx, Joanna, additional, and Lieberman, Lani, additional

Published
2022
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25. Duration of Antibiotic Therapy and Timing of Shunt Reimplantation in Pediatric CSF Shunt Infections: A Retrospective Multicenter Case Series

Author

Robinson, Joan L, primary, McAlpine, Alastair, additional, Barton, Michelle, additional, Balamohan, Archana, additional, Davies, H Dele, additional, Skar, Gwenn, additional, Lefebvre, Marie-Astrid, additional, Almadani, Ahmed, additional, Freire, Dolores, additional, Le Saux, Nicole, additional, Bowes, Jennifer, additional, Srigley, Jocelyn A, additional, Passarelli, Patrick, additional, Bradley, John, additional, Khan, Sarah, additional, Purewal, Rupeena, additional, Viel-Thériault, Isabelle, additional, and Hawkes, Michael T, additional

Published
2022
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26. Epidemiology and role of SARS-CoV-2 Linkage in Paediatric Inflammatory Multisystem Syndrome (PIMS): A Canadian Paediatric Surveillance Program National Prospective Study

Author

El Tal, Tala, primary, Morin, Marie-Paule, additional, Morris, Shaun, additional, Farrar, Daniel K, additional, Berard, Roberta A, additional, Kakkar, Fatima, additional, Moore Hepburn, Charlotte, additional, Baerg, Krista, additional, Beaufils, Camille, additional, Bennett, Terri-Lyn, additional, Benseler, Susuanne M, additional, Beaudoin-Bussieres, Guillaume, additional, Chan, Kevin, additional, Cyr, Claude, additional, Dahdah, Nagib, additional, Donner, Elizabeth J, additional, Drouin, Olivier, additional, Edjoc, Rojiemiahd, additional, Eljaouhari, Maryem, additional, Embree, Joanne E, additional, Farrell, Catherine, additional, Finzi, Andres, additional, Forgie, Sarah, additional, Giroux, Ryan, additional, Kang, Kristopher T, additional, King, Melanie, additional, Laffin Thibodeau, Melanie, additional, Lang, Bianca, additional, Laxer, Ronald M, additional, Luu, Thuy Mai, additional, McCrindle, Brian W, additional, Orkin, Julia, additional, Papenburg, Jesse, additional, Pound, Catherine M, additional, Price, Victoria E, additional, Proulx-Gauthier, Jean-Philippe, additional, Purewal, Rupeena, additional, Sadarangani, Manish, additional, Salvadori, Marina I, additional, Thibeault, Roseline, additional, Top, Karina A, additional, Viel-Theriault, Isabelle, additional, Haddad, Elie, additional, Scuccimarri, Rosie, additional, and Yeung, Rae SM, additional

Published
2022
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27. Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020—May 2021

Author

Farrar, Daniel S., primary, Drouin, Olivier, additional, Moore Hepburn, Charlotte, additional, Baerg, Krista, additional, Chan, Kevin, additional, Cyr, Claude, additional, Donner, Elizabeth J., additional, Embree, Joanne E., additional, Farrell, Catherine, additional, Forgie, Sarah, additional, Giroux, Ryan, additional, Kang, Kristopher T., additional, King, Melanie, additional, Laffin Thibodeau, Melanie, additional, Orkin, Julia, additional, Ouldali, Naïm, additional, Papenburg, Jesse, additional, Pound, Catherine M., additional, Price, Victoria E., additional, Proulx-Gauthier, Jean-Philippe, additional, Purewal, Rupeena, additional, Ricci, Christina, additional, Sadarangani, Manish, additional, Salvadori, Marina I., additional, Thibeault, Roseline, additional, Top, Karina A., additional, Viel Thériault, Isabelle, additional, Kakkar, Fatima, additional, and Morris, Shaun K., additional

Published
2022
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28. The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: A population-based study

Author

Groves, Helen E., primary, Papenburg, Jesse, additional, Mehta, Kayur, additional, Bettinger, Julie A., additional, Sadarangani, Manish, additional, Halperin, Scott A., additional, Morris, Shaun K., additional, Bancej, Christina, additional, Burton, Catherine, additional, Embree, Joanne, additional, Foo, Cheryl, additional, Bridger, Natalie, additional, Morris, Robert, additional, Jadavji, Taj, additional, Lebel, Marc, additional, Le Saux, Nicole, additional, Top, Karina A., additional, Tan, Ben, additional, McConnell, Athena, additional, Purewal, Rupeena, additional, Déry, Pierre, additional, Thibeault, Roseline, additional, Vaudry, Wendy, additional, Tran, Dat, additional, Sauvé, Laura, additional, Moore, Dorothy L., additional, and Lefebvre, Marie-Astrid, additional

Published
2022
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29. Hematologic manifestations of SARS-CoV-2 infection and MIS-C in hospitalized children. Results of the PICNIC registry.

Author

Tehseen, Sarah, primary, Williams, Suzan, additional, Robinson, Joan, additional, Morris, Shaun, additional, Tal, Tala, additional, Bitnun, Ari, additional, Gill, Peter, additional, Yeh, Ann, additional, Yea, Carmen, additional, Brenes, Helena, additional, Yock-Corrales, Adrianna, additional, Nuevo, Rolando, additional, Ivankovich-Esctoto, Gabriela, additional, Fallas, Alejandra, additional, Papenburg, Jesse, additional, Lefebvre, Marie-Astrid, additional, Scuccimarri, Rosie, additional, Nateghian, Alireza, additional, Aski, Behzad, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Restivo, Leo, additional, Cooke, Suzette, additional, Lopez, Alison, additional, Roberts, Ashley, additional, Sadarangani, Manish, additional, Forbes, Michelle Barton, additional, Saux, Nicole, additional, Bowes, Jennifer, additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Bayliss, Ann, additional, Wong, Jacqueline, additional, Leifso, Kirk, additional, Foo, Cheryl, additional, Panetta, Luc, additional, Kakkar, Fatima, additional, Piche, Dominique, additional, Viel-Theriault, Isabelle, additional, Merckx, Joanna, additional, and Lieberman, Lani, additional

Published
2022
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30. Infants Hospitalized for Acute COVID-19: Disease Severity in a Multicenter Cohort Study

Author

Merckx, Joanna, primary, Morris, Shaun K., additional, Bitnun, Ari, additional, Gill, Peter, additional, Tal, Tala El, additional, Laxer, Ronald M., additional, Yeh, Ann, additional, Yea, Carmen, additional, Ulloa-Gutierrez, Rolando, additional, Brenes-Chacon, Helena, additional, Yock-Corrales, Adriana, additional, Ivankovich-Escoto, Gabriela, additional, Soriano-Fallas, Alejandra, additional, de Mezerville, Marcela Hernandez, additional, Papenburg, Jesse, additional, Lefebvre, Marie-Astrid, additional, Nateghian, Alireza, additional, Aski, Behzad Haghighi, additional, Manafi, Ali, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Cooke, Suzette, additional, Dewan, Tammie, additional, Restivo, Lea, additional, Lopez, Alison, additional, Sadarangani, Manish, additional, Roberts, Ashley, additional, Barton, Michelle, additional, Petel, Dara, additional, Saux, Nicole Le, additional, Bowes, Jennifer, additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Tehseen, Sarah, additional, Bayliss, Ann, additional, Wong, Jacqueline K., additional, Viel-Thériault, Isabelle, additional, Piche, Dominique, additional, Top, Karina A., additional, Leifso, Kirk, additional, Foo, Cheryl, additional, Panetta, Luc, additional, and Robinson, Joan, additional

Published
2021
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31. Risk factors for severe PCR-positive SARS-CoV-2 infection in hospitalized children: a multicenter cohort study

Author

Schober, Tilmann, primary, Caya, Chelsea, additional, Barton, Michelle, additional, Bayliss, Ann, additional, Bitnun, Ari, additional, Bowes, Jennifer, additional, Brenes-Chacon, Helena, additional, Bullard, Jared, additional, Cooke, Suzette, additional, Dewan, Tammie, additional, Dwilow, Rachel, additional, El Tal, Tala, additional, Foo, Cheryl, additional, Gill, Peter, additional, Haghighi Aski, Behzad, additional, Kakkar, Fatima, additional, Lautermilch, Janell, additional, Laxer, Ronald M., additional, Lefebvre, Marie-Astrid, additional, Leifso, Kirk, additional, Le Saux, Nicole, additional, Lopez, Alison, additional, Manafi, Ali, additional, Morris, Shaun K., additional, Nateghian, Alireza, additional, Panetta, Luc, additional, Petel, Dara, additional, Piche, Dominique, additional, Purewal, Rupeena, additional, Restivo, Lea, additional, Roberts, Ashley, additional, Sadarangani, Manish, additional, Scuccimarri, Rosie, additional, Soriano-Fallas, Alejandra, additional, Tehseen, Sarah, additional, Top, Karina A., additional, Ulloa-Gutierrez, Rolando, additional, Viel-Theriaul, Isabelle, additional, Wong, Jacqueline K., additional, Yea, Carmen, additional, Yeh, Ann, additional, Yock-Corrales, Adriana, additional, Robinson, Joan, additional, and Papenburg, Jesse, additional

Published
2021
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32. Multicenter cohort study of multisystem inflammatory syndrome in children (MIS-C)

Author

Merckx, Joanna, primary, Cooke, Suzette, additional, Tal, Tala El, additional, Laxer, Ronald M., additional, Bitnun, Ari, additional, Morris, Shaun K., additional, Yeh, E. Ann, additional, Yea, Carmen, additional, Gill, Peter, additional, Papenburg, Jesse, additional, Lefebvre, Marie-Astrid, additional, Ulloa-Gutierrez, Rolando, additional, Brenes-Chacon, Helena, additional, Yock-Corrales, Adriana, additional, Ivankovich-Escoto, Gabriela, additional, Soriano-Fallas, Alejandra, additional, Mezerville, Marcela Hernandez-de, additional, Dewan, Tammie, additional, Restivo, Lea, additional, Nateghian, Alireza, additional, Aski, Behzad Haghighi, additional, Manafi, Ali, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Lopez, Alison, additional, Sadarangani, Manish, additional, Roberts, Ashley, additional, Barton, Michelle, additional, Petel, Dara, additional, Saux, Nicole Le, additional, Bowes, Jennifer, additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Tehseen, Sarah, additional, Bayliss, Ann, additional, Wong, Jacqueline K., additional, Leifso, Kirk, additional, Foo, Cheryl, additional, and Robinson, Joan, additional

Published
2021
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33. Cerebrospinal Fluid Shunt Infections: A Multicenter Pediatric Study.

Author

McAlpine, Alastair, Robinson, Joan L., Barton, Michelle, Balamohan, Archana, Davies, H. Dele, Skar, Gwenn, Lefebvre, Marie-Astrid, Almadani, Ahmed, Freire, Dolores, Le Saux, Nicole, Bowes, Jennifer, Srigley, Jocelyn A., Passarelli, Patrick, Bradley, John, Khan, Sarah, Purewal, Rupeena, Viel-Thériault, Isabelle, Ranger, Adrianna, and Hawkes, Michael T.

Published
2022
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34. Multicenter cohort study of children hospitalized with SARS-CoV-2 infection

Author

Barton, Michelle, primary, Papenburg, Jesse, additional, Ulloa-Gutierrez, Rolando, additional, Brenes-Chacon, Helena, additional, Yock-Corrales, Adriana, additional, Ivankovich-Escoto, Gabriela, additional, Soriano-Fallas, Alejandra, additional, Mezerville, Marcela Hernandez-de, additional, Bitnun, Ari, additional, Morris, Shaun K., additional, Tal, Tala El, additional, Yeh, E. Ann, additional, Gill, Peter, additional, Laxer, Ronald M., additional, Nateghian, Alireza, additional, Aski, Behzad Haghighi, additional, Manafif, Ali, additional, Lefebvre, Marie-Astrid, additional, Caya, Chelsea, additional, Cooke, Suzette, additional, Dewan, Tammie, additional, Restivo, Lea, additional, Viel-Thériault, Isabelle, additional, Trajtman, Adriana, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Sadarangani, Manish, additional, Roberts, Ashley, additional, Saux, Nicole Le, additional, Bowes, Jennifer, additional, Wong, Jacqueline K., additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Leifso, Kirk, additional, Foo, Cheryl, additional, Newhook, Leigh Anne, additional, Bayliss, Ann, additional, Petel, Dara, additional, and Robinson, Joan, additional

Published
2021
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35. Neurological Manifestations of SARS-CoV-2 in Hospitalized Children: A Multi-National Cohort Study

Author

Yea, Carmen, primary, Barton, Michelle, additional, Bitnun, Ari, additional, Morris, Shaun K., additional, El Tal, Tala, additional, Ulloa-Gutierrez, Rolando, additional, Brenes-Chacon, Helena, additional, Yock-Corrales, Adriana, additional, Ivankovich-Escoto, Gabriela, additional, Soriano-Fallas, Alejandra, additional, de Mezerville, Marcela Hernandez, additional, Laxer, Ronald M., additional, Gill, Peter, additional, Nateghian, Alireza, additional, Aski, Behzad Haghighi, additional, Manafi, Ali Anari, additional, Dwilow, Rachel, additional, Bullard, Jared, additional, Papenburg, Jesse, additional, Lefebvre, Marie-Astrid, additional, Cooke, Suzette, additional, Dewan, Tammie, additional, Restivo, Lea, additional, Lopez, Alison, additional, Sadarangani, Manish, additional, Roberts, Ashley, additional, Wong, Jacqueline, additional, Le Saux, Nicole, additional, Bowes, Jennifer, additional, Purewal, Rupeena, additional, Lautermilch, Janell, additional, Foo, Cheryl, additional, Robinson, Joan, additional, and Yeh, E. Ann, additional

Published
2021
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38. 24 Characteristics and Outcomes of Hospitalized Children by SARS-Cov-2 Lineage: An IMPACT Surveillance Network Analysis

Author

Farrar, Daniel, Bettinger, Julie, Audet, Annick, Campigotto, Aaron, Deeks, Shelley, Drouin, Olivier, Embree, Joanne, Haddad, Elie, Halperin, Scott, Jadavji, Tajdin, Kazmi, Kescha, Thibodeau, Melanie Laffin, Hepburn, Charlotte Moore, Papenburg, Jesse, Purewal, Rupeena, Sadarangani, Manish, Sauvé, Laura, Wilson, Sarah, Yeung, Rae, Top, Karina, Kakkar, Fatima, and Morris, Shaun

Published
2023
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39. Oxidative stress induces transient O-Glc NAc elevation and tau dephosphorylation in SH- SY5Y cells.

Author

Kátai, Emese, Pál, József, Poór, Viktor Soma, Purewal, Rupeena, Miseta, Attila, and Nagy, Tamás

Subjects
OXIDATIVE stress, TAU proteins, DEPHOSPHORYLATION, GLUCOSAMINE, PHOSPHORYLATION
Abstract

O-linked β- N-acetlyglucosamine or O-Glc NAc modification is a dynamic post-translational modification occurring on the Ser/Thr residues of many intracellular proteins. The chronic imbalance between phosphorylation and O-Glc NAc on tau protein is considered as one of the main hallmarks of Alzheimer's disease. In recent years, many studies also showed that O-Glc NAc levels can elevate upon acute stress and suggested that this might facilitate cell survival. However, many consider chronic stress, including oxidative damage as a major risk factor in the development of the disease. In this study, using the neuronal cell line SH- SY5Y we investigated the dynamic nature of O-Glc NAc after treatment with 0.5 mM H2O2 for 30 min. to induce oxidative stress. We found that overall O-Glc NAc quickly increased and reached peak level at around 2 hrs post-stress, then returned to baseline levels after about 24 hrs. Interestingly, we also found that tau protein phosphorylation at site S262 showed parallel, whereas at S199 and PHF1 sites showed inverse dynamic to O-Glycosylation. In conclusion, our results show that temporary elevation in O-Glc NAc modification after H2O2-induced oxidative stress is detectable in cells of neuronal origin. Furthermore, oxidative stress changes the dynamic balance between O-Glc NAc and phosphorylation on tau proteins. [ABSTRACT FROM AUTHOR]

Published
2016
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40. Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada.

Author

Farrar D, Hepburn CM, Drouin O, El Tal T, Morin MP, Berard R, King M, Thibodeau ML, Baerg K, Beaudoin-Bussières G, Beaufils C, Bennett TL, Benseler S, Chan K, Cyr C, Dahdah N, Donner E, Embree J, Farrell C, Finzi A, Forgie S, Giroux R, Kang K, Lang B, Laxer R, McCrindle B, Orkin J, Papenburg J, Pound C, Price V, Proulx-Gauthier JP, Purewal R, Sadarangani M, Salvadori M, Thibeault R, Top K, Viel-Thériault I, Haddad E, Scuccimarri R, Yeung R, Kakkar F, and Morris S

Abstract

Background: Direct comparisons of paediatric hospitalizations for acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) can inform health system planning. We describe the absolute and relative hospital burden of acute paediatric COVID-19 and MIS-C in Canada., Methods: This national prospective study was conducted via the Canadian Paediatric Surveillance Program from March 2020-May 2021. Children younger than 18 years old and hospitalized for acute COVID-19 or MIS-C were included in the analysis. Outcomes included supplemental oxygen (low-flow oxygen or high-flow nasal cannula), ventilation (non-invasive or conventional mechanical), vasopressors, paediatric intensive care unit (PICU) admission, or death. Adjusted risk differences (aRD) and 95% confidence intervals (CI) were calculated to identify factors associated with each diagnosis., Results: Overall, we identified 330 children hospitalized for acute COVID-19 (including five deaths) and 208 hospitalized for MIS-C (including zero deaths); PICU admission was required for 49.5% of MIS-C hospitalizations versus 18.2% of acute COVID-19 hospitalizations (aRD 20.3; 95% CI, 9.9-30.8). Resource use differed by age, with children younger than one year hospitalized more often for acute COVID-19 (aRD 43.4% versus MIS-C; 95% CI, 37.7-49.1) and more children 5-11 years hospitalized for MIS-C (aRD 38.9% vs. acute COVID-19; 95% CI, 31.0-46.9)., Conclusion: While there were more hospitalizations and deaths from acute paediatric COVID-19, MIS-C cases were more severe, requiring more intensive care and vasopressor support. Our findings suggest that both acute COVID-19 and MIS-C should be considered when assessing the overall burden of severe acute respiratory syndrome coronavirus 2 in hospitalized children., Competing Interests: Competing interests CMH is the Director of Children’s Mental Health of Ontario, and the Director of Medical Affairs for the Canadian Paediatric Society and Canadian Paediatric Surveillance Program. MPM has received consulting fees from Sobin and Abbvie and payment for expert testimony from the Canadian Medical Protective Association. RAB has received honoraria and participated in advisory boards with SOBI, Roche, Amgen, and AbbVie. KB served as Past President of the Community Paediatrics Section of the Canadian Paediatric Society and has received royalties from Brush Education. TLB is an employee of the Public Health Agency of Canada (PHAC). KC is Chair of the Acute Care Committee of the Canadian Paediatric Society and is past-president of the Emergency Medicine Section of the Canadian Paediatric Society. EJD is Chair of the Scientific Research Committee and a director of Epilepsy Canada. She is also a member of Partners Against Mortality in Epilepsy and the advisory boards of Cardiol, Pendopharm and Stoke Therapeutics. CF is Chair of the Scientific Steering Committee for the Canadian Paediatric Surveillance Program, former Chair of the Specialty Committee in Paediatrics of the Royal College of Physicians and Surgeons of Canada, former president of the Canadian Paediatric Society, and member of the Executive as Secretary of the Canadian Critical Care Society. She has received reimbursement for travel expenses from Canadian Paediatric Society and the Royal College of Physicians and Surgeons of Canada. She has also received an honorarium for a presentation at a continuing education conference from the Université de Sherbrooke. SF is the President of the Association of Medical Microbiology and Infectious Disease Canada and has received consulting fees from Toronto Metropolitan University. RML has received honoraria for serving as a consultant to Sobi, Novartis, Sanofi, and Eli Lilly, as chair for data monitoring committees for Eli Lilly and Novartis, and from the Canadian Rheumatology Association. JP has received consultant fees from AbbVie, honoraria from AbbVie, AstraZeneca and Seegene, and he received respiratory virus testing materials from Seegene for his institution. He has participated in ad hoc advisory board meetings for AbbVie and Merck and is a voting member of the National Advisory Committee on Immunization. RP is a consultant for Verity Pharmaceuticals. MS is supported via salary awards from the BC Children’s Hospital Foundation and the Michael Smith Foundation for Health Research and has been an investigator on projects funded by GlaxoSmithKline, Merck, Moderna, Pfizer, Sanofi-Pasteur, Seqirus, Symvivo and VBI Vaccines. All funds have been paid to his institute, and he has not received any personal payments. MIS is an employee of the Public Health Agency of Canada. EH has participated in advisory board meetings of CSL-Behring and Takeda, data safety monitoring boards of Rocket Pharmaceutical and Jasper Therapeutics, and has patent applications with Immugenia and Immune Biosolutions. RS has received honoraria and served on an advisory board and as a consultant with Novartis, honoraria from Canadian Rheumatology Association, is a board member for Rheumatology for All, and her institution receives funding from Bristol Myers Squibb for a patient registry for which she is Principal Investigator. RSMY has received grant funding from CFI, CIHR, Genome Canada, PHAC and the COVID-19 Immunity Task Force, and The Arthritis Society; is a member of the Science and Industry Advisory Committee at Genome Canada and Medical Advisory Board at Kawasaki Disease Canada; and a member of a data safety monitoring board for a study on IL-1 inhibitors for Kawasaki Disease. FK has received honoraria for presentations given to the Association des Pédiatres du Québec and receives CMV testing kits from Altona Diagnostics. SKM has received honoraria for lectures from GlaxoSmithKline, was a member of ad hoc advisory boards for Pfizer Canada and Sanofi Pasteur, and is an investigator on an investigator led grant from Pfizer. DSF, OD, TET, MK, and MLT have no conflicts of interest to report.

Published
2023
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41. Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells.

Author

Kátai E, Pál J, Poór VS, Purewal R, Miseta A, and Nagy T

Subjects
Cell Line, Tumor, Cell Survival drug effects, Fluorescent Antibody Technique, Glycosylation drug effects, Humans, Hydrogen Peroxide toxicity, N-Acetylglucosaminyltransferases genetics, N-Acetylglucosaminyltransferases metabolism, Nitrogenous Group Transferases genetics, Nitrogenous Group Transferases metabolism, Phosphorylation drug effects, RNA, Messenger genetics, RNA, Messenger metabolism, Real-Time Polymerase Chain Reaction, Time Factors, Acetylglucosamine metabolism, Oxidative Stress drug effects, tau Proteins metabolism
Abstract

O-linked β-N-acetlyglucosamine or O-GlcNAc modification is a dynamic post-translational modification occurring on the Ser/Thr residues of many intracellular proteins. The chronic imbalance between phosphorylation and O-GlcNAc on tau protein is considered as one of the main hallmarks of Alzheimer's disease. In recent years, many studies also showed that O-GlcNAc levels can elevate upon acute stress and suggested that this might facilitate cell survival. However, many consider chronic stress, including oxidative damage as a major risk factor in the development of the disease. In this study, using the neuronal cell line SH-SY5Y we investigated the dynamic nature of O-GlcNAc after treatment with 0.5 mM H 2 O 2 for 30 min. to induce oxidative stress. We found that overall O-GlcNAc quickly increased and reached peak level at around 2 hrs post-stress, then returned to baseline levels after about 24 hrs. Interestingly, we also found that tau protein phosphorylation at site S262 showed parallel, whereas at S199 and PHF1 sites showed inverse dynamic to O-Glycosylation. In conclusion, our results show that temporary elevation in O-GlcNAc modification after H 2 O 2 -induced oxidative stress is detectable in cells of neuronal origin. Furthermore, oxidative stress changes the dynamic balance between O-GlcNAc and phosphorylation on tau proteins., (© 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.)

Published
2016
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