Search

Your search keyword '"Rehman, Rakhshinda"' showing total 18 results
Start Over Author "Rehman, Rakhshinda" Publication Year Range Last 10 years
18 results on '"Rehman, Rakhshinda"'

2. Contributors

Author

Aikawa, Elena, primary, Anderson, S.G., additional, Araújo Passos, Livia Silva, additional, Arefin, Samsul, additional, Arvidsson, Per M., additional, Avolio, Alberto, additional, Bachler, Martin, additional, Bäck, Magnus, additional, Bashline, Michael J., additional, Becker-Greene, Dakota, additional, Bellinge, Jamie, additional, Bennasroune, Amar, additional, Blaise, Sébastien, additional, Borlaug, Barry A., additional, Boutouyrie, Pierre, additional, Breet, Y., additional, Breslin, Jerome W., additional, Budoff, Matthew J., additional, Butlin, Mark, additional, Cecelja, Marina, additional, Chen, Chen-Huan, additional, Cheng, Hao-Min, additional, Cheng, Yi-Bang, additional, Chirinos, Julio A., additional, Chowienczyk, Phil, additional, Chuang, Shao-Yuan, additional, Clavel, Marie-Annick, additional, Cohen, Jordana B., additional, Corcoran, Alexis M., additional, Cornwell, William K., additional, Corrales–Medina, Vicente F., additional, Côté, Nancy, additional, Coutinho, Thais, additional, Cox, James, additional, Cruickshank, J.K., additional, Dai, Lu, additional, Daskalopoulou, Stella S., additional, Davy, Kevin P., additional, De Buyzere, Marc L., additional, Dieffenbach, Paul B., additional, Duca, Laurent, additional, Dwivedi, Girish, additional, Edwards, David G., additional, Farquhar, William B., additional, Fernhall, Bo, additional, Floras, John S., additional, Fredenburgh, Laura E., additional, Fukumitsu, Masafumi, additional, Gafane-Matemane, L., additional, Gahungu, Nestor, additional, Ghanem, Ahmed K., additional, Gillebert, Thierry C., additional, Gillery, Philippe, additional, Gomez, Delphine, additional, Guzzetti, Ezequiel, additional, Hametner, Bernhard, additional, Hashimoto, Junichiro, additional, Heffernan, Kevin S., additional, Hibner, Brooks A., additional, Hobson, Sam, additional, Hu, Nien-Wen, additional, Hughes, T.M., additional, Humphrey, Jay D., additional, Jaisson, Stéphane, additional, Kachenoura, Nadjia, additional, Kario, Kazuomi, additional, Katakam, Prasad V.G., additional, Katsuumi, Goro, additional, Kondiboyina, Avinash, additional, Kovács, Sándor J., additional, Kruger, R., additional, Kublickiene, Karolina, additional, Lacolley, Patrick, additional, Laffargue, Muriel, additional, Lampejo, Arinola O., additional, Laucyte-Cibulskiene, Agne, additional, Laurent, Stéphane, additional, Lee, Hae-Young, additional, Lefferts, Wesley K., additional, Lefferts, Elizabeth C., additional, Leite-Moreira, Adelino F., additional, Liew, Chee H., additional, Lima, Joao A.C., additional, Lourenço, André P., additional, Maki-Petaja, Kaisa, additional, Maracle, Marcy, additional, Martiny, Laurent, additional, Maurice, Pascal, additional, Mayer, Christopher C., additional, McDonnell, Barry J., additional, McEvoy, John W., additional, Meyer, M.L., additional, Michel, Jean-Baptiste, additional, Millar, Philip J., additional, Minamino, Tohru, additional, Mitchell, Gary F., additional, Murfee, Walter L., additional, Mynard, Jonathan P., additional, Nardone, Massimo, additional, Nilsson, Peter M., additional, O'Gallagher, Kevin, additional, Ohyama, Yoshiaki, additional, Omote, Kazunori, additional, Park, Jeong Bae, additional, Peirce, Shayn M., additional, Pibarot, Philippe, additional, Pierce, Gary L., additional, Prenner, Stuart B., additional, Protogerou, Athanase, additional, Pyeritz, Reed E., additional, Quail, Michael A., additional, Reddy, Yogesh N.V., additional, Redheuil, Alban, additional, Regnault, Véronique, additional, Rehman, Rakhshinda, additional, Rietzschel, Ernst R., additional, Romier-Crouzet, Béatrice, additional, Rooprai, Jasjit, additional, Salvi, Lucia, additional, Salvi, Paolo, additional, Sartelet, Hervé, additional, Schmelzer, Christian E.H., additional, Schutte, A.E., additional, Schwarz, Angelina, additional, Segers, Patrick, additional, Sharman, James E., additional, Shimizu, Ippei, additional, Simon, Marc A., additional, Sosa, Piera, additional, Spronck, Bart, additional, Stenvinkel, Peter, additional, Stöhr, Eric J., additional, Strauss-Kruger, M., additional, Suarez-Martinez, Ariana, additional, Suda, Masayoshi, additional, Sung, Shih-Hsien, additional, Tan, Isabella, additional, Terentes-Printzios, Dimitrios, additional, Townsend, Raymond R., additional, Tran, Andrew H., additional, Urbina, Elaine M., additional, Venkatesh, Bharath Ambale, additional, Vlachopoulos, Charalambos, additional, Vonk Noordegraaf, Anton, additional, Wahart, Amandine, additional, Wang, Ji-Guang, additional, Wassertheurer, Siegfried, additional, Webb, Andrew James, additional, Weber, Thomas, additional, Westerhof, Berend E., additional, Wilkinson, Ian B., additional, and Yoshida, Yohko, additional

Published
2022
Full Text
View/download PDF

4. Cellular Distribution of Secreted Phospholipase A2 in Lungs of IPF Patients and Its Inhibition in Bleomycin-Induced Pulmonary Fibrosis in Mice

Author

Jaiswal, Ashish, primary, Rehman, Rakhshinda, additional, Dutta, Joytri, additional, Singh, Sabita, additional, Ray, Archita, additional, Shridhar, Malathy, additional, Jaisankar, Jaswant, additional, Bhatt, Manas, additional, Khandelwal, Dikshit, additional, Sahoo, Bandya, additional, Ram, Arjun, additional, and Mabalirajan, Ulaganathan, additional

Published
2023
Full Text
View/download PDF

7. A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature

Author

Dieffenbach, Paul B., primary, Mallarino Haeger, Christina, additional, Rehman, Rakhshinda, additional, Corcoran, Alexis M., additional, Coronata, Anna Maria F., additional, Vellarikkal, Shamsudheen K., additional, Chrobak, Izabela, additional, Waxman, Aaron B., additional, Vitali, Sally H., additional, Sholl, Lynette M., additional, Padera, Robert F., additional, Lagares, David, additional, Polverino, Francesca, additional, Owen, Caroline A., additional, and Fredenburgh, Laura E., additional

Published
2021
Full Text
View/download PDF

9. Abstract 13348: Single Nuclear RNA-seq of Human Thoracic Aortic Dissection Identifies Expansion of Vascular Smooth Muscle Cells With a Distinct Transcriptional Phenotype

Author

Vellarikkal, Shamsudheen, primary, Atri, Deepak, additional, Lee-Kim, Vivian, additional, Reddy, Ankith, additional, Kaneko, Tsuyoshi, additional, MALLIDI, Hari R, additional, Rehman, Rakhshinda, additional, Shekar, Prem S, additional, Fredenburgh, Laura E, additional, Sias-Garcia, Oscar, additional, Muehlschlegel, J Daniel D, additional, and Gupta, Rajat, additional

Published
2021
Full Text
View/download PDF

11. Noncanonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis

Author

Rehman, Rakhshinda, primary, Vijayakumar, Vijay Elakkya, additional, Jaiswal, Ashish, additional, Jain, Vaibhav, additional, Mukherjee, Shravani, additional, Vellarikkal, Shamsudheen Karuthedath, additional, Dieffenbach, Paul B., additional, Fredenburgh, Laura E., additional, Prakash, Y. S., additional, Ghosh, Balaram, additional, Agrawal, Anurag, additional, and Mabalirajan, Ulaganathan, additional

Published
2020
Full Text
View/download PDF

12. Docosahexaenoic acid (DHA), a nutritional supplement, modulates steroid insensitivity in asthma

Author

Panda, Lipsa, primary, Gheware, Atish P, additional, Jaiswal, Ashish, additional, Saha, Dhurjhoti, additional, Desiraju, Bapu Koundinya, additional, Rehman, Rakhshinda, additional, Ray, Archita, additional, Dutta, Joytri, additional, Singh, Sabita, additional, Yadav, Manish Kumar, additional, Sowpati, Divya Tej, additional, Chattopadhyay, Samit, additional, SubbaRao, Madhunapantula V., additional, Mahesh, Padukudru Anand, additional, Prakash, Y. S., additional, Chowdhury, Shantanu, additional, Agrawal, Anurag, additional, Ghosh, Balaram, additional, and Mabalirajan, Ulaganathan, additional

Published
2020
Full Text
View/download PDF

14. Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress

Author

Sharma, Anchal, primary, Ansari, Asgar Hussain, additional, Kumari, Renu, additional, Pandey, Rajesh, additional, Rehman, Rakhshinda, additional, Mehani, Bharati, additional, Varma, Binuja, additional, Desiraju, Bapu K., additional, Mabalirajan, Ulaganathan, additional, Agrawal, Anurag, additional, and Mukhopadhyay, Arijit, additional

Published
2017
Full Text
View/download PDF

15. Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress

Author

Sharma, Anchal, primary, Ansari, Asgar Hussain, additional, Kumari, Renu, additional, Pandey, Rajesh, additional, Rehman, Rakhshinda, additional, Mehani, Bharati, additional, Varma, Binuja, additional, Desiraju, Bapu K., additional, Mabalirajan, Ulaganathan, additional, Agrawal, Anurag, additional, and Mukhopadhyay, Arijit, additional

Published
2016
Full Text
View/download PDF

17. Parabromophenacyl Bromide Inhibits Subepithelial Fibrosis by Reducing TGF-β1 in a Chronic Mouse Model of Allergic Asthma.

Author

Ram, Arjun, Mabalirajan, Ulaganathan, Jaiswal, Ashish, Rehman, Rakhshinda, Singh, Vijay Pal, and Ghosh, Balaram

Subjects
PULMONARY fibrosis treatment, ASTHMA treatment, TRANSFORMING growth factors-beta, BROMIDES, EPITHELIAL cells, PHENYL compound derivatives, ANIMAL models of asthma, HYPERPLASIA, THERAPEUTICS
Abstract

Background: Our previous study showed that parabromophenacyl bromide (PBPB) inhibits the features of allergic airway inflammation and airway hyperresponsiveness (AHR). However, its effect on airway remodeling, e.g. subepithelial fibrosis in a chronic allergic asthma model, was not investigated. We examined this issue in this study. Methods: PBPB was administered to mice with an induced chronic asthmatic condition. AHR was estimated at the end of the experiment, followed by euthanasia. Lung sections were stained with hematoxylin and eosin, periodic acid-Schiff and Masson's trichrome to determine airway inflammation, goblet cell metaplasia and subepithelial fibrosis, respectively. Transforming growth factor-β1 (TGF-β1) was estimated in lung homogenates. To determine the effect of PBPB on smooth-muscle hyperplasia, immunohistochemistry against α-smooth-muscle actin was performed on the lung sections. Results: Chronic ovalbumin challenges in a mouse model of allergic asthma caused significant subepithelial fibrosis and elevated TGF-β1, along with significant AHR. PBPB attenuated subepithelial fibrosis with a reduction of lung TGF-β1, airway inflammation and AHR without affecting goblet cell metaplasia. It also attenuated smooth-muscle hyperplasia with a reduction in the expression of α-smooth-muscle actin in the lungs. Conclusion: Our findings indicate that PBPB attenuates some crucial features of airway remodeling such as subepithelial fibrosis and smooth-muscle hyperplasia. These data suggest that PBPB could therefore be a therapeutic drug for chronic asthma. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

18. Noncanonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis.

Author

Rehman R, Vijayakumar VE, Jaiswal A, Jain V, Mukherjee S, Vellarikkal SK, Dieffenbach PB, Fredenburgh LE, Prakash YS, Ghosh B, Agrawal A, and Mabalirajan U

Subjects
Animals, Asthma pathology, Asthma prevention & control, Endoplasmic Reticulum Stress physiology, Epithelial Cells pathology, Humans, Inflammation metabolism, Lung metabolism, Lung pathology, Mice, Oxidative Stress physiology, Respiratory Hypersensitivity pathology, Epithelial Cells metabolism, Homeostasis physiology, Inflammation prevention & control, Ku Autoantigen metabolism
Abstract

Airway epithelial homeostasis is under constant threat due to continuous exposure to the external environment, and abnormally robust sensitivity to external stimuli is critical to the development of airway diseases, including asthma. Ku is a key nonhomologous end-joining DNA repair protein with diverse cellular functions such as VDJ recombination and telomere length maintenance. Here, we show a novel function of Ku in alleviating features of allergic airway inflammation via the regulation of mitochondrial and endoplasmic reticulum (ER) stress. We first determined that airway epithelial cells derived from both asthmatic lungs and murine asthma models demonstrate increased expression of 8-hydroxy-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage. Ku protein expression was dramatically reduced in the bronchial epithelium of patients with asthma as well as in human bronchial epithelial cells exposed to oxidative stress. Knockdown of Ku70 or Ku80 in naïve mice elicited mitochondrial collapse or ER stress, leading to bronchial epithelial cell apoptosis and spontaneous development of asthma-like features, including airway hyperresponsiveness, airway inflammation, and subepithelial fibrosis. These findings demonstrate an essential noncanonical role for Ku proteins in asthma pathogenesis, likely via maintenance of organelle homeostasis. This novel function of Ku proteins may also be important in other disease processes associated with organelle stress.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results