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210 results on '"Reuter, Sebastian"'

1. Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity

Author

Herrmann, Alexandra, Gege, Christian, Wangen, Christina, Wagner, Sabrina, Kögler, Melanie, Cordsmeier, Arne, Irrgang, Pascal, Ip, Wing-Hang, Weil, Tatjana, Hunszinger, Victoria, Groß, Rüdiger, Heinen, Natalie, Pfaender, Stephanie, Reuter, Sebastian, Klopfleisch, Robert, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Grunwald, Thomas, Hietel, Benjamin, Cynis, Holger, Münch, Jan, Sparrer, Konstantin M.J., Ensser, Armin, Tenbusch, Matthias, Dobner, Thomas, Vitt, Daniel, Kohlhof, Hella, and Hahn, Friedrich

Published
2024
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11. SARS-CoV-2 particles promote airway epithelial differentiation and ciliation

Author

Gonzalez-Rubio, Julian, primary, Le-Trilling, Vu Thuy Khanh, additional, Baumann, Lea, additional, Cheremkhina, Maria, additional, Kubiza, Hannah, additional, Luengen, Anja E., additional, Reuter, Sebastian, additional, Taube, Christian, additional, Ruetten, Stephan, additional, Duarte Campos, Daniela, additional, Cornelissen, Christian G., additional, Trilling, Mirko, additional, and Thiebes, Anja Lena, additional

Published
2023
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12. Europäisches Arbeitsrecht: Grundlagen - Richtlinien - Folgen für das deutsche Recht

Author

Ulrich Preis, Adam Sagan, Wiebke Brose, Matteo Fornasier, Timon Grau, Michael Grünberger, Felix Hartmann, Johannes Heuschmid, Tim Husemann, Christian Mehrens, Thomas Müller-Bonanni, Sebastian Naber, Stephan Pötters, Ulrich Preis, Marc Reuter, Sebastian Roloff, Adam Sagan, Piero Sansone, Florian Schi, Ulrich Preis, Adam Sagan, Wiebke Brose, Matteo Fornasier, Timon Grau, Michael Grünberger, Felix Hartmann, Johannes Heuschmid, Tim Husemann, Christian Mehrens, Thomas Müller-Bonanni, Sebastian Naber, Stephan Pötters, Ulrich Preis, Marc Reuter, Sebastian Roloff, Adam Sagan, Piero Sansone, Florian Schi

Published
2018

14. International Harting Open Source Award 2016: Fawkes for the RoboCup Logistics League

Author

Niemueller, Tim, Neumann, Tobias, Henke, Christoph, Schönitz, Sebastian, Reuter, Sebastian, Ferrein, Alexander, Jeschke, Sabina, Lakemeyer, Gerhard, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Behnke, Sven, editor, Sheh, Raymond, editor, Sarıel, Sanem, editor, and Lee, Daniel D., editor

Published
2017
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15. Improvements for a Robust Production in the RoboCup Logistics League 2016

Author

Niemueller, Tim, Neumann, Tobias, Henke, Christoph, Schönitz, Sebastian, Reuter, Sebastian, Ferrein, Alexander, Jeschke, Sabina, Lakemeyer, Gerhard, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Behnke, Sven, editor, Sheh, Raymond, editor, Sarıel, Sanem, editor, and Lee, Daniel D., editor

Published
2017
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21. Microbes little helpers and suppliers for therapeutic asthma approaches.

Author

Reuter, Sebastian, Raspe, Jonas, and Taube, Christian

Subjects
*THERAPEUTICS, *AUTOIMMUNE diseases, *REGULATORY T cells, *ASTHMA, *LUNG diseases, *MAST cells
Abstract

Bronchial asthma is a prevalent and increasingly chronic inflammatory lung disease affecting over 300 million people globally. Initially considered an allergic disorder driven by mast cells and eosinophils, asthma is now recognized as a complex syndrome with various clinical phenotypes and immunological endotypes. These encompass type 2 inflammatory endotypes characterized by interleukin (IL)-4, IL-5, and IL-13 dominance, alongside others featuring mixed or non-eosinophilic inflammation. Therapeutic success varies significantly based on asthma phenotypes, with inhaled corticosteroids and beta-2 agonists effective for milder forms, but limited in severe cases. Novel antibody-based therapies have shown promise, primarily for severe allergic and type 2-high asthma. To address this gap, novel treatment strategies are essential for better control of asthma pathology, prevention, and exacerbation reduction. One promising approach involves stimulating endogenous anti-inflammatory responses through regulatory T cells (Tregs). Tregs play a vital role in maintaining immune homeostasis, preventing autoimmunity, and mitigating excessive inflammation after pathogenic encounters. Tregs have demonstrated their ability to control both type 2-high and type 2-low inflammation in murine models and dampen human cell-dependent allergic airway inflammation. Furthermore, microbes, typically associated with disease development, have shown immune-dampening properties that could be harnessed for therapeutic benefits. Both commensal microbiota and pathogenic microbes have demonstrated potential in bacterial-host interactions for therapeutic purposes. This review explores microbe-associated approaches as potential treatments for inflammatory diseases, shedding light on current and future therapeutics. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease

Author

Reuter, Sebastian, Raspe, Jonas, Uebner, Hendrik, Contoyannis, Alexandros, Pastille, Eva, Westendorf, Astrid M, Caso, Georgia C, Cover, Timothy L, Müller, Anne, Taube, Christian, University of Zurich, and Reuter, Sebastian

Subjects
2403 Immunology, Immunology, 10061 Institute of Molecular Cancer Research, 2723 Immunology and Allergy, Medizin, Immunology and Allergy, 570 Life sciences, biology, 610 Medicine & health
Abstract

BackgroundAsthma is an incurable heterogeneous disease with variations in clinical and underlying immunological phenotype. New approaches could help to support existing therapy concepts. Neonatal infection of mice with Helicobacter pylori or administration of H. pylori-derived extracts or molecules after birth have been shown to prevent the development of allergic airway disease later in life. This study evaluated the potential therapeutic efficacy of H. pylori vacuolating cytotoxin A (VacA) in allergic airway inflammation and investigated the underlying immunological mechanisms for its actions.MethodsMurine models of allergic airway diseases, and murine and human in vitro models were used.ResultsIn both an acute model and a therapeutic house dust mite model of allergic airway disease, treatment with H. pylori-derived VacA reduced several asthma hallmarks, including airway hyperresponsiveness, inflammation and goblet cell metaplasia. Flow cytometry and ELISA analyses revealed induction of tolerogenic dendritic cells (DC) and FoxP3 positive regulatory T cells (Tregs), and a shift in the composition of allergen-specific immunoglobulins. Depletion of Tregs during treatment with VacA reversed treatment-mediated suppression of allergic airway disease. Human monocyte derived DCs (moDC) that were exposed to VacA induced Tregs in co-cultured naïve autologous T cells, replicating key observations made in vivo.ConclusionH. pylori-derived VacA suppressed allergic airway inflammation via induction of Tregs in both allergic airway disease models. These data suggest that the immunomodulatory activity of VacA could potentially be exploited for the prevention and treatment of allergic airway disease.

Published
2023

23. Fawkes for the RoboCup Logistics League

Author

Niemueller, Tim, Reuter, Sebastian, Ferrein, Alexander, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Almeida, Luis, editor, Ji, Jianmin, editor, Steinbauer, Gerald, editor, and Luke, Sean, editor

Published
2015
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24. The Carologistics Approach to Cope with the Increased Complexity and New Challenges of the RoboCup Logistics League 2015

Author

Niemueller, Tim, Reuter, Sebastian, Ewert, Daniel, Ferrein, Alexander, Jeschke, Sabina, Lakemeyer, Gerhard, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Almeida, Luis, editor, Ji, Jianmin, editor, Steinbauer, Gerald, editor, and Luke, Sean, editor

Published
2015
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25. Evaluation of the RoboCup Logistics League and Derived Criteria for Future Competitions

Author

Niemueller, Tim, Reuter, Sebastian, Ferrein, Alexander, Jeschke, Sabina, Lakemeyer, Gerhard, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Almeida, Luis, editor, Ji, Jianmin, editor, Steinbauer, Gerald, editor, and Luke, Sean, editor

Published
2015
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27. Loss of the cyclin kinase inhibitor p27kip1 opens a therapeutic window by deregulating pathway choice after DNA double strand breaks

Author

Malek, Nisar, primary, Bozko, Przemyslaw, additional, Bui, Khac Cuong, additional, Rahbari, Mohammad, additional, Mattern, Sven, additional, Missios, Pavlos, additional, Sulyok, Mihály, additional, Garcia-Beccaria, Maria, additional, Fernandez, Mirian, additional, Roessler, Stephanie, additional, Goeppert, Benjamin, additional, Götze, Julian, additional, Scholta, Tim, additional, Reuter, Sebastian, additional, Nguyen, Thi Mai Ly, additional, Toulany, Mahmoud, additional, Shi, Ying, additional, Riebold, Mathias, additional, Rudalska, Ramona, additional, Dauch, Daniel, additional, Zender, Lars, additional, Schirmacher, Peter, additional, Zips, Daniel, additional, Singer, Stephan, additional, and Heikenwaelder, Mattias, additional

Published
2023
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29. A Test Bench for a Self-Driving Model Car: Embedded Software Testing in a Teaching Environment

Author

Hochschule für Technik, Wirtschaft und Kultur Leipzig, Reuter, Sebastian, Czekansky, Jakob, Bienhaus, Diethelm, Hochschule für Technik, Wirtschaft und Kultur Leipzig, Reuter, Sebastian, Czekansky, Jakob, and Bienhaus, Diethelm

Abstract

While teaching projects offer great opportunities for students to develop their skill set, they can suffer from accessibility problems. A problem specific to embedded software projects concerns the limited access to hardware components. The impact of this limitation is especially noticeable when it comes to testing, where the availability of only a few or even one complete system under test creates a tight bottleneck, which leads to less testing being done and consequently to lower-quality software. The test system presented here aims to alleviate these problems for a specific example project – a self-driving model car called the “cITIcar” – by providing a modular test bench controlled by a remote access test software. This increases accessibility to development of embedded system of the example project and thereby the potential for student participation while simplifying review and maintenance by more experienced team members. The chosen approach also opens up the possibility for reuse with similar teaching projects or even embedded systems courses.

Published
2023

30. Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease

Author

Reuter, Sebastian; https://orcid.org/0000-0002-1784-0124, Raspe, Jonas, Uebner, Hendrik, Contoyannis, Alexandros, Pastille, Eva, Westendorf, Astrid M, Caso, Georgia C, Cover, Timothy L, Müller, Anne; https://orcid.org/0000-0002-1368-8276, Taube, Christian, Reuter, Sebastian; https://orcid.org/0000-0002-1784-0124, Raspe, Jonas, Uebner, Hendrik, Contoyannis, Alexandros, Pastille, Eva, Westendorf, Astrid M, Caso, Georgia C, Cover, Timothy L, Müller, Anne; https://orcid.org/0000-0002-1368-8276, and Taube, Christian

Abstract

BACKGROUND: Asthma is an incurable heterogeneous disease with variations in clinical and underlying immunological phenotype. New approaches could help to support existing therapy concepts. Neonatal infection of mice with Helicobacter pylori or administration of H. pylori-derived extracts or molecules after birth have been shown to prevent the development of allergic airway disease later in life. This study evaluated the potential therapeutic efficacy of H. pylori vacuolating cytotoxin A (VacA) in allergic airway inflammation and investigated the underlying immunological mechanisms for its actions. METHODS: Murine models of allergic airway diseases, and murine and human in vitro models were used. RESULTS: In both an acute model and a therapeutic house dust mite model of allergic airway disease, treatment with H. pylori-derived VacA reduced several asthma hallmarks, including airway hyperresponsiveness, inflammation and goblet cell metaplasia. Flow cytometry and ELISA analyses revealed induction of tolerogenic dendritic cells (DC) and FoxP3 positive regulatory T cells (Tregs), and a shift in the composition of allergen-specific immunoglobulins. Depletion of Tregs during treatment with VacA reversed treatment-mediated suppression of allergic airway disease. Human monocyte derived DCs (moDC) that were exposed to VacA induced Tregs in co-cultured naïve autologous T cells, replicating key observations made in vivo. CONCLUSION: H. pylori-derived VacA suppressed allergic airway inflammation via induction of Tregs in both allergic airway disease models. These data suggest that the immunomodulatory activity of VacA could potentially be exploited for the prevention and treatment of allergic airway disease.

Published
2023

36. A Test Bench for a Self-Driving Model Car: Embedded Software Testing in a Teaching Environment

Author

Reuter, Sebastian, Czekansky, Jakob, Bienhaus, Diethelm, and Hochschule für Technik, Wirtschaft und Kultur Leipzig

Subjects
Embedded Testing, Teaching Project, Accessibility, Reusability
Abstract

While teaching projects offer great opportunities for students to develop their skill set, they can suffer from accessibility problems. A problem specific to embedded software projects concerns the limited access to hardware components. The impact of this limitation is especially noticeable when it comes to testing, where the availability of only a few or even one complete system under test creates a tight bottleneck, which leads to less testing being done and consequently to lower-quality software. The test system presented here aims to alleviate these problems for a specific example project – a self-driving model car called the “cITIcar” – by providing a modular test bench controlled by a remote access test software. This increases accessibility to development of embedded system of the example project and thereby the potential for student participation while simplifying review and maintenance by more experienced team members. The chosen approach also opens up the possibility for reuse with similar teaching projects or even embedded systems courses.

Published
2023

42. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo

Author

Ulges, Alexander, Klein, Matthias, Reuter, Sebastian, Gerlitzki, Bastian, Hoffmann, Markus, Grebe, Nadine, Staudt, Valérie, Stergiou, Natascha, Bohn, Toszka, Brühl, Till-Julius, Muth, Sabine, Yurugi, Hajime, Rajalingam, Krishnaraj, Bellinghausen, Iris, Tuettenberg, Andrea, Hahn, Susanne, Reißig, Sonja, Haben, Irma, Zipp, Frauke, Waisman, Ari, Probst, Hans-Christian, Beilhack, Andreas, Buchou, Thierry, Filhol-Cochet, Odile, Boldyreff, Brigitte, Breloer, Minka, Jonuleit, Helmut, Schild, Hansjörg, Schmitt, Edgar, and Bopp, Tobias

Published
2015
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43. Cyber-Physical System Intelligence

Author

Niemueller, Tim, primary, Zwilling, Frederik, additional, Lakemeyer, Gerhard, additional, Löbach, Matthias, additional, Reuter, Sebastian, additional, Jeschke, Sabina, additional, and Ferrein, Alexander, additional

Published
2016
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45. Influence of the early-life gut microbiota on the immune responses to an inhaled allergen

Author

Borbet, Timothy C, Pawline, Miranda B, Zhang, Xiaozhou, Wipperman, Matthew F, Reuter, Sebastian, Maher, Timothy, Li, Jackie, Iizumi, Tadasu, Gao, Zhan, Daniele, Megan, Taube, Christian, Koralov, Sergei B, Müller, Anne, Blaser, Martin J, and University of Zurich

Subjects
Immunology, Pyroglyphidae, 10061 Institute of Molecular Cancer Research, Immunity, Medizin, Amoxicillin, 610 Medicine & health, Allergens, Azithromycin, Immunoglobulin E, Anti-Bacterial Agents, Gastrointestinal Microbiome, Mice, Th2 Cells, Immunology and Allergy, Animals, Cytokines, 570 Life sciences, biology
Abstract

Antibiotics, among the most used medications in children, affect gut microbiome communities and metabolic functions. These changes in microbiota structure can impact host immunity. We hypothesized that early-life microbiome alterations would lead to increased susceptibility to allergy and asthma. To test this, mouse pups between postnatal days 5-9 were orally exposed to water (control) or to therapeutic doses of azithromycin or amoxicillin. Later in life, these mice were sensitized and challenged with a model allergen, house dust mite (HDM), or saline. Mice with early-life azithromycin exposure that were challenged with HDM had increased IgE and IL-13 production by CD4

Published
2022
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