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Your search keyword '"Rivera-Peña, Bianca"' showing total 7 results
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7 results on '"Rivera-Peña, Bianca"'

1. Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survival

Author

Rivera‑Peña, Bianca, primary, Folawiyo, Oluwasina, additional, Turaga, Nitesh, additional, Rodríguez‑Benítez, Rosa, additional, Felici, Marcos, additional, Aponte‑Ortiz, Jaime, additional, Pirini, Francesca, additional, Rodríguez‑Torres, Sebastián, additional, Vázquez, Roger, additional, López, Ricardo, additional, Sidransky, David, additional, Guerrero‑Preston, Rafael, additional, and Báez, Adriana, additional

Published
2024
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2. MDS-156 Pyrimethamine Shows Synergy and Efficacy in Combination With Venetoclax in Preclinical Models of Therapy Resistant MDS/AML

Author

Rivera-Peña, Bianca, primary, Chakraborty, Samarpana, additional, Shi, Yang, additional, Zhang, Hui, additional, Zhao, Rongbao, additional, Choudhary, Gaurav, additional, Gordon-Mitchell, Shanisha, additional, Pradhan, Kith, additional, Fu, Bowen, additional, Tosic, Isidora, additional, Schinke, Carolina, additional, Varshavsky, Asya, additional, Feld, Jonathan, additional, Goldfinger, Mendel, additional, Carbajal, Milagros, additional, Ramachandra, Nandini, additional, Konopleva, Marina, additional, Frank, David, additional, Saunthararajah, Yogen, additional, Verma, Amit, additional, and Shastri, Aditi, additional

Published
2023
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3. POSTER: MDS-156 Pyrimethamine Shows Synergy and Efficacy in Combination With Venetoclax in Preclinical Models of Therapy Resistant MDS/AML

Author

Rivera-Peña, Bianca, primary, Chakraborty, Samarpana, additional, Shi, Yang, additional, Zhang, Hui, additional, Zhao, Rongbao, additional, Choudhary, Gaurav, additional, Gordon-Mitchell, Shanisha, additional, Pradhan, Kith, additional, Fu, Bowen, additional, Tosic, Isidora, additional, Schinke, Carolina, additional, Varshavsky, Asya, additional, Feld, Jonathan, additional, Goldfinger, Mendel, additional, Carbajal, Milagros, additional, Ramachandra, Nandini, additional, Konopleva, Marina, additional, Frank, David, additional, Saunthararajah, Yogen, additional, Verma, Amit, additional, and Shastri, Aditi, additional

Published
2023
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4. Abstract 5765: Promoter DNA methylation patterns in oral, laryngeal, and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement, and survival in Latinos

Author

Rivera-Peña, BIanca, primary, Folawiyo, Oluwasina, additional, Turaga, Nitesh, additional, Rodríguez-Benítez, Rosa J., additional, Felici, Marco E., additional, Aponte-Ortiz, Jaime A., additional, Pirini, Francesca, additional, Rodríguez-Torres, Sebastián, additional, Vázquez, Roger, additional, López, Ricardo, additional, Sidransky, David, additional, Guerrero-Preston, Rafael E., additional, and Báez, Adriana, additional

Published
2023
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7. Transforming growth factor beta receptor type I (TGF-βRI) kinase inhibitors IOA-359 and IOA-360 stimulate erythropoiesis in MDS.

Author

Ramachandra, Nandini, Vegivinti, Charan Thej Reddy, Sahu, Srabani, Sanawar, Rahul, Rivera-Peña, Bianca, Aminov, Sarah, Fromowitz, Ariel, Zhang, Jinghang, Aodengtuya, Fnu, Pradhan, Kith, Zhao, Rongbao, Schwartz, Leya, Alluri, Srinivas, Thiruvananthapuram, Victor, Rabinovich, Emma, Ajibade, Opeyemi, Gordon-Mitchell, Shanisha, Shastri, Aditi, Deken, Marcel, and Yingling, Jonathan M.

Subjects
*TRANSFORMING growth factors-beta, *HEMATOPOIETIC stem cells, *MYELODYSPLASTIC syndromes, *ACUTE myeloid leukemia, *SMALL molecules
Abstract

AbstractOveractivation of the Transforming Growth Factor Beta (TGF-β) pathway is implicated in the pathogenesis of cytopenias in Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML). IOA-359 and IOA-360 are potent small molecule inhibitors of the TGF-beta Receptor type I kinase (TGF-βRI, also referred to as ALK5, activin receptor-like kinase 5) that abrogate SMAD phosphorylation in hematopoietic cell lines. Both inhibitors were able to inhibit TGF-β mediated gene transcription at specific doses. ALK5 inhibitors abrogated the growth inhibitory effects of TGF-β on healthy hematopoietic stem cells and stimulated hematopoietic differentiation in cell lines and MDS/AML specimens. These data demonstrate preclinical efficacy of two novel ALK5 inhibitors, IOA-359 and IOA-360, in stimulating erythroid differentiation in MDS and AML. [ABSTRACT FROM AUTHOR]

Published
2024
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