6 results on '"Robin van den Berg"'
Search Results
2. The PRIME-NL study: evaluating a complex healthcare intervention for people with Parkinson’s disease in a dynamic environment
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Bart R. Maas, Robin van den Bergh, Sanne W. van den Berg, Eveline Hulstein, Niek Stadhouders, Patrick P.T. Jeurissen, Nienke M. de Vries, Bastiaan R. Bloem, Marten Munneke, Yoav Ben-Shlomo, and Sirwan K.L. Darweesh more...
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Complex intervention ,Integrated Care Model ,Parkinson’s disease ,Parkinsonism ,Design ,Statistical analysis plan ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background An innovative, integrative care model for people with Parkinson (PRIME Parkinson) has gradually been implemented in a selected region of the Netherlands since 2021. A prospective evaluation of this model (PRIME-NL study) was initiated in parallel, spanning the year prior to implementation (baseline) and the implementation period. Following publication of the original study protocol, the COVID-19 crisis delayed implementation of the full PRIME Parkinson care model by two years and hampered the recruitment of study participants. Objective To describe which methodological adjustments were made to the study protocol because of these developments. Methods We compare various outcomes between a region where PRIME Parkinson care was implemented (innovation region) versus the rest of the Netherlands (usual care region). We use healthcare claims data of virtually all people with Parkinson in the Netherlands and annual questionnaires in a representative subsample of 984 people with Parkinson, 566 caregivers and 192 healthcare professionals. Four major methodological adjustments had to be made since publication of the original protocol. First, we extended the evaluation period by two years. Second, we incorporated annual process measures of the stage of implementation of the new care model. Third, we introduced a real-time iterative feedback loop of interim results to relevant stakeholders. Fourth, we updated the statistical analysis plan. Discussion This manuscript provides transparency in how the design and analyses of the evaluation study had to be adapted to control for external influences in a dynamic environment, including eruption of the COVID-19 crisis. Our solutions could serve as a template for evaluating other complex healthcare interventions in a dynamic environment. more...
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- 2024
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3. Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art
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Jules M. Janssen Daalen, Robin van den Bergh, Eva M. Prins, Mahshid Sadat Chenarani Moghadam, Rudie van den Heuvel, Jeroen Veen, Soania Mathur, Hannie Meijerink, Anat Mirelman, Sirwan K. L. Darweesh, Luc J. W. Evers, and Bastiaan R. Bloem more...
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Digital biomarkers that remotely monitor symptoms have the potential to revolutionize outcome assessments in future disease-modifying trials in Parkinson’s disease (PD), by allowing objective and recurrent measurement of symptoms and signs collected in the participant’s own living environment. This biomarker field is developing rapidly for assessing the motor features of PD, but the non-motor domain lags behind. Here, we systematically review and assess digital biomarkers under development for measuring non-motor symptoms of PD. We also consider relevant developments outside the PD field. We focus on technological readiness level and evaluate whether the identified digital non-motor biomarkers have potential for measuring disease progression, covering the spectrum from prodromal to advanced disease stages. Furthermore, we provide perspectives for future deployment of these biomarkers in trials. We found that various wearables show high promise for measuring autonomic function, constipation and sleep characteristics, including REM sleep behavior disorder. Biomarkers for neuropsychiatric symptoms are less well-developed, but show increasing accuracy in non-PD populations. Most biomarkers have not been validated for specific use in PD, and their sensitivity to capture disease progression remains untested for prodromal PD where the need for digital progression biomarkers is greatest. External validation in real-world environments and large longitudinal cohorts remains necessary for integrating non-motor biomarkers into research, and ultimately also into daily clinical practice. more...
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- 2024
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4. Direct analysis of aldehydes and carboxylic acids in the gas phase by negative ionization selected ion flow tube mass spectrometry: Quantification and modelling of ion–molecule reactions
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Sylvie Lacombe, Jean-Marc Sotiropoulos, N. Costarramone, Mylène Ghislain, Mickael Le Bechec, Thierry Pigot, and Robin Van Den Berg
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Chemistry ,010401 analytical chemistry ,Organic Chemistry ,Inorganic chemistry ,Formaldehyde ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,Ion ,chemistry.chemical_compound ,Reaction rate constant ,Deprotonation ,13. Climate action ,Ionization ,Hydroxide ,Molecule ,Selected-ion flow-tube mass spectrometry ,Spectroscopy - Abstract
Rationale The concentrations of aldehydes and volatile fatty acids have to be controlled because of their potential harmfulness in indoor air or relationship with the organoleptic properties of agri-food products. Although several specific analytical methods are currently used, the simultaneous analysis of these compounds in a complex matrix remains a challenge. The combination of positive and negative ionization selected ion flow tube mass spectrometry (SIFT-MS) allows the accurate, sensitive and high-frequency analysis of complex gas mixtures of these compounds. Methods The ion-molecule reactions of negative precursor ions (OH- , O•- , O2 •- , NO2 - and NO3 - ) with five aldehydes and four carboxylic acids were investigated in order to provide product ions and rate constants for the quantification of these compounds by negative ion SIFT-MS. The results were compared with those obtained by conventional analysis methods and/or with already implemented SIFT-MS positive ionization methods. The modelling of hydroxide ion (OH- )/molecule reaction paths by ab-initio calculation allowed a better understanding of these gas-phase reactions. Results Deprotonation systematically occurs by reaction between negative ions and aldehydes or acids, leading to the formation of [M - H]- primary ions. Ab-initio calculations demonstrated the α-CH deprotonation of aldehydes and the acidic proton abstraction for fatty acids. For aldehydes, the presence of water in the flow tube leads to the formation of hydrated ions, [M - H]- .H2 O. With the NO2 - precursor ion, a second reaction channel results in ion-molecule association with the formation of M.NO2 - ions. Conclusions Except for formaldehyde, all the studied compounds can be quantified by negative ion SIFT-MS with significant rate constants. In addition to positive ion SIFT-MS with H3 O+ , O2 + and NO+ precursor ions, negative ionization with O•- , O2 •- , OH- , NO2 - and NO3 - extends the range of analysis of aldehydes and carboxylic acids in air without a preparation or separation step. This methodology was illustrated by the simultaneous quantification in single-scan experiments of seven aldehydes and six carboxylic acids released by building materials. more...
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- 2019
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5. Sodium pyrophosphate enhances iron bioavailability from bouillon cubes fortified with ferric pyrophosphate
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Diego Moretti, Wieneke P. Koppenol, Peter Murray, Christophe Zeder, Rajwinder K. Harika, Michael B. Zimmermann, Colin I. Cercamondi, Robin van den Berg, and Guus S M J E Duchateau
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Adult ,0301 basic medicine ,Absorption (pharmacology) ,Erythrocytes ,Adolescent ,Iron ,Sodium ,Inorganic chemistry ,Biological Availability ,Medicine (miscellaneous) ,chemistry.chemical_element ,Pyrophosphate ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,Humans ,Ferrous Compounds ,Fortified Food ,Iron deficiency (plant disorder) ,030109 nutrition & dietetics ,Nutrition and Dietetics ,biology ,Bioavailability ,Diphosphates ,Ferritin ,Intestinal Absorption ,Solubility ,chemistry ,Ferritins ,Food, Fortified ,biology.protein ,Digestion ,Female ,Caco-2 Cells ,Nuclear chemistry - Abstract
Fe fortification of centrally manufactured and frequently consumed condiments such as bouillon cubes could help prevent Fe deficiency in developing countries. However, Fe compounds that do not cause sensory changes in the fortified product, such as ferric pyrophosphate (FePP), exhibit low absorption in humans. Tetra sodium pyrophosphate (NaPP) can form soluble complexes with Fe, which could increase Fe bioavailability. Therefore, the aim of this study was to investigate Fe bioavailability from bouillon cubes fortified with either FePP only, FePP+NaPP, ferrous sulphate (FeSO4) only, or FeSO4+NaPP. We first conducted in vitro studies using a protocol of simulated digestion to assess the dialysable and ionic Fe, and the cellular ferritin response in a Caco-2 cell model. Second, Fe absorption from bouillon prepared from intrinsically labelled cubes (2·5 mg stable Fe isotopes/cube) was assessed in twenty-four Fe-deficient women, by measuring Fe incorporation into erythrocytes 2 weeks after consumption. Fe bioavailability in humans increased by 46 % (P4 only and with FeSO4+NaPP was 33·8 and 27·8 %, respectively (NS). The outcome from the human study is in agreement with the dialysable Fe from the in vitro experiments. Our findings suggest that the addition of NaPP could be a promising strategy to increase Fe absorption from FePP-fortified bouillon cubes, and if confirmed by further research, for other fortified foods with complex food matrices as well. more...
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- 2016
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6. Usability and utility of a remote monitoring system to support physiotherapy for people with Parkinson's disease
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Robin van den Bergh, Luc J. W. Evers, Nienke M. de Vries, Ana L. Silva de Lima, Bastiaan R. Bloem, Giulio Valenti, and Marjan J. Meinders
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Parkinson's disease ,physiotherapy ,remote monitoring ,physical activity ,falls ,telemedicine ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundPhysiotherapy for persons with Parkinson's disease (PwPD) could benefit from objective and continuous tracking of physical activity and falls in daily life.ObjectivesWe designed a remote monitoring system for this purpose and describe the experiences of PwPD and physiotherapists who used the system in daily clinical practice.MethodsTwenty-one PwPD (15 men) wore a sensor necklace to passively record physical activity and falls for 6 weeks. They also used a smartphone app to self-report daily activities, (near-)falls and medication intake. They discussed those data with their PD-specialized physiotherapist (n = 9) during three regular treatment sessions. User experiences and aspects to be improved were gathered through interviews with PwPD and physiotherapists, resulting in system updates. The system was evaluated in a second pilot with 25 new PwPD (17 men) and eight physiotherapists.ResultsWe applied thematic analysis to the interview data resulting in two main themes: usability and utility. First, the usability of the system was rated positively, with the necklace being easy to use. However, some PwPD with limited digital literacy or cognitive impairments found the app unclear. Second, the perceived utility of the system varied among PwPD. While many PwPD were motivated to increase their activity level, others were not additionally motivated because they perceived their activity level as high. Physiotherapists appreciated the objective recording of physical activity at home and used the monitoring of falls to enlarge awareness of the importance of falls for PwPD. Based on the interview data of all participants, we drafted three user profiles for PwPD regarding the benefits of remote monitoring for physiotherapy: for profile 1, a monitoring system could act as a flagging dashboard to signal the need for renewed treatment; for profile 2, a monitoring system could be a motivational tool to maintain physical activity; for profile 3, a monitoring system could passively track physical activity and falls at home. Finally, for a subgroup of PwPD the burdens of monitoring will outweigh the benefits.ConclusionsOverall, both PwPD and physiotherapists underline the potential of a remote monitoring system to support physiotherapy by targeting physical activity and (near-)falls. Our findings emphasize the importance of personalization in remote monitoring technology, as illustrated by our user profiles. more...
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- 2023
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