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Your search keyword '"Rodion Lebedev"' showing total 2 results
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2 results on '"Rodion Lebedev"'

1. One-Pot Sequence of Staudinger/aza-Wittig/Castagnoli–Cushman Reactions Provides Facile Access to Novel Natural-like Polycyclic Ring Systems

Author

Rodion Lebedev, Dmitry Dar’in, Grigory Kantin, Olga Bakulina, and Mikhail Krasavin

Subjects
Staudinger/aza-Wittig, Castagnoli–Cushman, imine, homophthalic anhydride, lactam, azide, Organic chemistry, QD241-441
Abstract

Realization of the one-pot Staudinger/aza-Wittig/Castagnoli–Cushman reaction sequence for a series of azido aldehydes and homophthalic anhydrides is described. The reaction proceeded at room temperature and delivered novel polyheterocycles related to the natural product realm in high yields and high diastereoselectivity. The methodology has been extended to three other cyclic anhydrides. These further unravel the potential of the Castagnoli–Cushman reaction in generating polyheterocyclic molecular scaffolds.

Published
2022
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2. In situ generation of imines by the Staudinger/aza-Wittig tandem reaction combined with thermally induced Wolff rearrangement for one-pot three-component β-lactam synthesis

Author

Polina Paramonova, Rodion Lebedev, Olga Bakulina, Dmitry Dar'in, and Mikhail Krasavin

Subjects
Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry
Abstract

A diastereoselective three-component one-pot lactam synthesis involving the in situ generation of imines via the Staudinger/aza-Wittig tandem reaction combined with the Wolff rearrangement and ketene–imine cycloaddition was developed.

Published
2022

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