12 results on '"Rodrigues, Lenize da Silva"'
Search Results
2. Eletrocardiograma na Avaliação Pré-Operatória do Paciente de Baixo Risco: Evidências Atuais
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Oliveira, Francisco José de, primary, Garcia, Leonardo Rufino, additional, Mellucci, Pedro Luciano, additional, Rodrigues, Lenize da Silva, additional, and Bertanha, Matheus, additional
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- 2024
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3. Association between deep vein thrombosis and stent patency in symptomatic iliac vein compression syndrome: Systematic review and meta-analysis
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Rodrigues, Lenize da Silva, Bertanha, Matheus, El Dib, Regina, and Moura, Regina
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- 2021
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4. Deciphering Key microRNA Regulated Pathways in Tissue-Engineered Blood Vessels: Implications for Vascular Scaffold Production.
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Rodrigues, Lenize da Silva, Felix, Tainara Francini, Minutentag, Iael Weissberg, Reis, Patricia Pintor, and Bertanha, Matheus
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TISSUE scaffolds , *GENE expression , *BLOOD vessels , *VASCULAR smooth muscle , *CARDIOVASCULAR system , *ENDOTHELIUM , *ENDOTHELIAL cells - Abstract
MicroRNAs (miRNAs) are non-coding RNAs involved in the regulation of gene expression associated with cell differentiation, proliferation, adhesion, and important biological functions such as inflammation. miRNAs play roles associated with the pathogenesis of chronic degenerative disorders including cardiovascular diseases. Understanding the influence of miRNAs and their target genes can effectively streamline the identification of key biologically active pathways that are important in the development of vascular grafts through the tissue engineering of blood vessels. To determine miRNA expression levels and identify miRNA target genes and pathways with biological roles in scaffolds that have been repopulated with adipose-derived stem cells (ASCs) generated through tissue engineering for the construction of blood vessels. miRNA quantification assays were performed in triplicate to determine miRNA expression in a total of 20 samples: five controls (natural inferior vena cava), five scaffolds recellularized with ASCs and differentiated into the endothelium (luminal layer), five samples of complete scaffolds seeded with ASCs differentiated into the endothelium (luminal layer) and smooth muscle (extraluminal layer), and five samples of ASC without cell differentiation. Several differentially expressed miRNAs were identified and predicted to modulate target genes with roles in key pathways associated with angiogenesis, vascular system control, and endothelial and smooth muscle regulation, including migration, proliferation, and growth. These findings underscore the involvement of these pathways in the regulatory mechanisms that are essential for vascular scaffold production through tissue engineering. Our research contributes to the knowledge of miRNA-regulated mechanisms, which may impact the design of vascular substitutes, and provide valuable insights for enhancing clinical practice. The molecular pathways regulated by miRNAs in tissue engineering of blood vessels (TEBV) allowed us to elucidate the main phenomena involved in cellular differentiation to constitute a blood vessel, with the main pathways being essential for angiogenesis, cellular differentiation, and differentiation into vascular smooth muscle. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Nebulized enriched heparin to treat no critical patients with Sars-Cov-2: Triple-blind clinical trial
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Bertanha, Matheus, Rodrigues, Lenize da Silva, Mellucci Filho, Pedro Luciano, Moroz, Andrei, Pardini, Maria Inês de Moura Campos, Sobreira, Marcone Lima, Durigon, Edison Luiz, Machado, Rafael Rahal Guaragna, Grotto, Rejane Maria Tommasini, Lima, Marcelo Andrade de, Nader, Helena Bonciani, Moraes, Marli Leite de, Barbosa, Alexandre Naime, Medolago, Natália Bronzatto, Cardoso, Fábio Florença, Magro, Angelo José, Carvalho, Cristiane Rodrigues Guzzo, Moraes, Leonardo Nazário de, Alvarado, Rita de Cássia, Nunes, Helga Caputo, Campos, Gustavo Constantino de, Grillo, Vinicius Tadeu Ramos da Silva, Sertorio, Nathalia Dias, and Fortaleza, Carlos Magno Castelo Branco
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- 2021
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6. Evaluation of Biointegration and Inflammatory Response to Blood Vessels Produced by Tissue Engineering—Experimental Model in Rabbits
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Secondo, Mariana Thaís Silva, primary, Rodrigues, Lenize da Silva, additional, Ramos, Leandro Pereira Miranda, additional, Bovolato, Ana Lívia Carvalho, additional, Rodriguez-Sanchez, Diego Noé, additional, Sobreira, Marcone Lima, additional, Moraes, Marcelo Padovani de Toledo, additional, and Bertanha, Matheus, additional
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- 2022
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7. Urinary Bladder Patch Made with Decellularized Vein Scaffold Seeded with Adipose-Derived Mesenchymal Stem Cells: Model in Rabbits
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Piovesana, Tadeu Ravazi, primary, Rodrigues, Lenize da Silva, additional, Bovolato, Ana Livia de Carvalho, additional, Rodríguez-Sánchez, Diego Noé, additional, Rinaldi, Jaqueline Carvalho, additional, Santos, Nilton José, additional, Mori, Julia Calvi, additional, Lourenção, Pedro Luiz Toledo de Arruda, additional, Birch, Lynn, additional, and Bertanha, Matheus, additional
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- 2022
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8. Quantification of adhesion of mesenchymal stem cells spread on decellularized vein scaffold
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Rodrigues, Lenize da Silva, primary, Bovolato, Ana Lívia de Carvalho, additional, Silva, Bárbara Esteves, additional, Chizzolini, Leticia Victória, additional, Cruz, Bianca Latance da, additional, Moraes, Marcelo Padovani de Toledo, additional, Lourenção, Pedro Luiz Toledo de Arruda, additional, and Bertanha, Matheus, additional
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- 2021
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9. Evaluation of biological integration and inflammatory response to blood vessels produced by tissue engineering
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Miranda, Leandro Pereira, primary, Rodrigues, Lenize Da Silva, primary, Deffune, Elenice, primary, Sobreira, Marcone Lima, primary, and Bertanha, Matheus, primary
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- 2019
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10. Systematic Review with meta-analysis of the indication of the endovascular treatment in the Cockett Syndrome in patients with and without thrombosis of the common left iliac vein
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Rodrigues, Lenize da Silva [UNESP], Universidade Estadual Paulista (Unesp), Moura, Regina [UNESP], and El Dib, Regina Paolucci [UNESP]
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Clinical procedures ,Angioplastia ,Procedimentos endovasculares ,Procedimentos clínicos ,Síndrome de Cockett ,Angioplasty ,Cockett syndrome ,Thrombosis ,May-Thurner syndrome ,Occlusion of the vascular graf ,Síndrome de May-Thurner ,Oclusão de enxerto vascular ,Endovascular procedures ,Trombose ,Medical examinations ,Indicação terapêutica ,Exames médicos ,Therapeutic indication - Abstract
Submitted by LENIZE DA SILVA RODRIGUES (nize_silva@hotmail.com) on 2017-09-27T19:16:54Z No. of bitstreams: 1 DISSERTACAO DE MESTRADO PESQUISA CLINICA - LENIZE DA SILVA RODRIGUES.pdf: 2672614 bytes, checksum: 59d7f6f68213dfaccdca11f5c0b0f7bf (MD5) Approved for entry into archive by Monique Sasaki (sayumi_sasaki@hotmail.com) on 2017-09-28T14:36:32Z (GMT) No. of bitstreams: 1 rodrigues_ls_me_bot.pdf: 2672614 bytes, checksum: 59d7f6f68213dfaccdca11f5c0b0f7bf (MD5) Made available in DSpace on 2017-09-28T14:36:32Z (GMT). No. of bitstreams: 1 rodrigues_ls_me_bot.pdf: 2672614 bytes, checksum: 59d7f6f68213dfaccdca11f5c0b0f7bf (MD5) Previous issue date: 2017-09-01 A Síndrome de Cockett (SC) se deve a uma compressão extrínseca da veia ilíaca comum esquerda (VICE) pela artéria ilíaca comum direita (AICD). Em consequência há o desenvolvimento de lesões intraluminais. Este cruzamento entre a artéria e a veia é considerada uma condição anatômica usual, porém em cerca de 29% da população ela pode torna-se sintomática. Os sintomas causados pela SC são: edema, dor, claudicação venosa, hiperemia, varizes e úlceras, podendo evoluir também com complicações como trombose venosa, embolia pulmonar, e mais raramente com Flegmasia Cerúlea Dolens. Até hoje não existe consenso sobre a melhor forma de tratar pacientes com SC na presença ou ausência de trombose da VICE, dividindo as opiniões se deve ser feito o tratamento clínico e/ou endovascular. Preferencialmente alguns autores optam pelas técnicas endovasculares em todos os casos e sugerem que a mesma seja realizada, na tentativa de melhorar a fluxo venoso evitando as complicações tardias. Á curto prazo, os resultados do tratamento endovascular com stents, tem mostrado excelente perviedade, embora estejam alguns deles associados ao uso de antiagregantes, anticoagulantes e ao tratamento clinico convencional com a meia elástica. Objetivo: O presente estudo teve a finalidade de comparar os resultados de perviedade e a taxa de complicações ocorridas em pacientes portadores da SC, tratados com angioplastia e stent, na presença e ausência de trombose da VICE, utilizando a Revisão Sistemática e Meta-análise de estudos observacionais. Método: Foram utilizadas as recomendações do manual Cochrane Handbook for Intervention Reviews produzido pela Cochrane que orienta a produção de revisões sistemáticas utilizando como referência para a escolha do método. A produção desta dissertação e manuscrito foi baseada no MOOSE statement para garantir que todas as etapas do estudo sejam reportadas claramente. As bases de dados utilizadas foram: Medline, EMBASE, LILACS, Scopus, Scielo, Pubmed e, Web of Science. A data da última busca foi 06 de abril de 2017. Esta pesquisa incluiu estudo de 2 grupos principais, tratados com angioplastia e stent: no G1: foram incluídos pacientes com a SC ausência trombose VICE e no G2 foram incluídos pacientes com SC presença de trombose da VICE. Resultados: De 250 artigos foram selecionados 3 estudos comparativos observacionais, sendo o número total de pacientes avaliados igual a 243. Nestes trabalhos selecionados foram associados ao tratamento endovascular o uso de antiagregantes plaquetários, anticoagulantes durante o período 3 a 12 meses e o uso da meia elástica. A patência primária, respectivamente, no G1 e G2 foi de e 93,4% e 89,2% (OR 0.55, 95% IC [0.15, 2.06], P= 0.37; I2=29%, P=0.24). E a patência secundária, respectivamente, de G1 e G2 foi de 93.5% e 82.06% (OR 0.50, 95% IC [0.05, 4.72], P= 0.54; I2=69%, P=0.04). Embora não estatisticamente significante, observa-se uma tendência em ocorrer maior patência nos pacientes do G1. Em relação ás complicações no total, houve tendência maior no G2 em relação ao G1. Conclusão: Os resultados obtidos neste estudo de revisão sistemática, mostraram que o tratamento endovascular é eficaz em ambos os grupos à curto prazo e longo prazo, mas, sugere que no grupo 1 a perviedade é discretamente melhor que no grupo 2, com menores complicações. The Cockett Syndrome (CS) is due to an extrinsic compression of the common left iliac vein (CLIV) by the common right iliac artery (CRIA). Consequently, there is a development of intraluminal lesions. This crossing between the artery and the vein is considered a usual anatomic condition; however, in about 29% of the population it may become symptomatic. The symptoms caused by the CS are: edema, pain, venous claudication, hyperemia, varicose veins e ulcers, being possible also to evolve with complications such as venous thrombosis, pulmonary emboli and more rarely with Flegmasia Cerúlea Dolens. Until today there´s no consensus about the best way to treat patients with CS in either the presence or the absence of CLIV thrombosis, it has been dividing opinions whether the clinical or the endovascular treatment should be done. Preferably, some authors choose the endovascular techniques in all cases and suggest that it be performed, in the attempt of improving the venous flow thus avoiding later complications. In short term the results of the endovascular treatment with stents, have shown excellent patency, although some of them are associated to the use of antiplatelet, anticoagulants and to the conventional clinical treatment with compression stocking. Objective: the present study had as goal to compare the results of the patency and the complication rate occurred in patients bearing the CS, treated with angioplasty and stent, in the presence and absence of the CLIV thrombosis, using the Systematic Review and Meta-Analysis in the observational studies. Method: It has been used the recommendations of the manual Cochrane Handbook for Intervention Reviews which orients the production of systematic reviews using as reference for the choice of the method. The production if this dissertation and manuscript has been based on the MOOSE statement to assure that all phases of the study be reported with clarity. The data bases used were: Medline, EMBASE, LILACS, Scopus, Scielo, Pubmed and, Web of Science. The date of the last search was April 6th 2017. This research includes the study of two main groups, both treated with angioplasty and stent: in the G1: it has been included patients with CS without CLIV thrombosis and in the G2: it has been included patients showing CS without CLIV thrombosis. Results: From 250 articles, it has been selected three comparative observational studies, being the total number of analyzed patients equal to 243. In these selected works it has been associated the use of antiplatelet, anticoagulants during the period from 3 to 12 months and the use of the compression stocking. The primary patency, respectively, in G1 and G2 has been of 93.4% and 89.2% (OR 0.55 (95% IC [0.15, 2.06], P= 0.374; I2=29%, P=0.24). And the secondary patency, respectively, in G1 and G2 has been of 93.5% and 82.06% (OR 0.50, 95% IC [0.05, 4.72], P= 0.54; I2=69%, P=0.04). Even though statistically not relevant in both patencies, it can be observed a tendency in the occurrence of a greater patency in patients from G1. In relation to the complications in the total, there has been difference being greater G2 in relation to the G1. Conclusion: The results obtained in the study of systematic review, have shown that the endovascular treatment is effective in short and long terms, but it suggests that in group 1 the patency is discreetly greater than in group 2, with less complications.
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- 2017
11. Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds.
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Moraes CMB, Bassanelli AM, Rodrigues LDS, Barud HDS, Fontes ML, Lourenção PLTA, Castro MCNE, and Bertanha M
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- Humans, Male, Female, Prospective Studies, Middle Aged, Aged, Treatment Outcome, Chronic Disease, Cellulose therapeutic use, Cellulose administration & dosage, Leg Ulcer therapy, Bandages, Aged, 80 and over, Pain Measurement, Hydrogels therapeutic use, Wound Healing, Quality of Life
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Purpose: To evaluate using a biocellulose-based hydrogel as an adjuvant in the healing process of arterial ulcers., Methods: A prospective single group quasi-experimental study was carried out with chronic lower limb arterial ulcer patients. These patients received biocellulose-based hydrogel dressings and outpatient guidance on dressing and periodic reassessments. The primary outcomes were the ulcer-healing rate and product safety, which were assessed by ulcer area measured in photographic records of pre-treatment and posttreatment after 7, 30, and 60 days. Secondary outcomes were related to clinical assessment by the quality-of-life scores (SF-36 and EQ-5D) and pain, evaluated by the visual analogue scale (VAS)., Results: Seventeen participants were included, and one of them was excluded. Six patients (37%) had complete wound healing, and all patients had a significant reduction in the ulcer area during follow-up (233.6mm2 versus 2.7mm2) and reduction on the score PUSH 3.0 (p < 0.0001). The analysis of the SF-36 and EQ-5D questionnaires showed a statistically significant improvement in almost all parameters analyzed and with a reduction of pain assessed by the VAS., Conclusions: The biocellulose-based hydrogel was safe and showed a good perspective to promoting the necessary conditions to facilitate partial or complete healing of chronic arterial ulcers within a 60-day follow-up. Quality of life and pain were positively affected by the treatment.
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- 2024
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12. Electrocardiography in the Pre-Operative Assessment of Low-Risk Patients: Current Evidence.
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Oliveira Filho FJ, Garcia LR, Mellucci Filho PL, Rodrigues LDS, and Bertanha M
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- Humans, Preoperative Care, Electrocardiography
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- 2024
- Full Text
- View/download PDF
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