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Your search keyword '"Rong-Jiao Yang"' showing total 3 results
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3 results on '"Rong-Jiao Yang"'

1. Association between hypokalemia and small bowel capsule endoscopy completion rates in patients in South China: A prospective single-center study

Author

Huo-Ye Gan, Tie-Li Peng, Kai-Hua Su, Lin-Li Zhao, Li-Qin Jian, Rong-Jiao Yang, Han-Xian Zhang, and Ru-Yin Pan

Subjects
Completion rate, hypokalemia, small bowel capsule endoscopy, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background/Aims: Approximately 20–30% of small bowel capsule endoscopies (SBCEs) do not reach the cecum at the completion of the examination. We aimed to determine whether hypokalemia influences the completion rate and small bowel transit time (SBTT) of SBCE. Patients and Methods: From January to December 2017, 112 patients (18–75 years old) who underwent SBCE were assessed consecutively for enrolment in our study. On the day of the procedure, a blood test was performed prior to capsule ingestion. The completion rate, gastric transit time (GTT), SBTT, and diagnostic yield were recorded for each SBCE. Results: The SBCE completion rate was lower in the hypokalemia group than that in the normal potassium group (55.6% (15/27) vs. 76.5% (65/85), P = 0.036). The median GTT was 55.5 ± 47.1 min in the hypokalemia group and 46.7 ± 44.5 min in the normal potassium group (P > 0.05). The median SBTT was 412.8 ± 123.3 min in the hypokalemia group and 367.3 ± 172.5 min in the normal potassium group (P > 0.05). The diagnostic yields of the hypokalemia and normal potassium groups were 74.1% and 78.8%, respectively (P = 1.00). Conclusion: Hypokalemia may decrease the SBCE completion rate. Physicians should consider the possibility of hypokalemia after bowel preparation because this condition is not rare. Potassium deficiencies should be rectified prior to performing SBCE procedures to increase the SBCE completion rate.

Published
2019
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2. Macrophage migration inhibitory factor siRNA inhibits hepatic metastases of colorectal cancer cells

Author

Li-Jing Wang, Hao-Jie Zhong, Hui-Xian Xu, Lan Li, Harry Hua-Xiang Xia, Wei-Qing Ma, Yu Chen, Xing-Xiang He, Ya-Min Wang, Rong-Jiao Yang, and Li-Hao Wu

Subjects
Male, Colorectal cancer, animal diseases, Down-Regulation, Apoptosis, chemical and pharmacologic phenomena, Mice, 03 medical and health sciences, Liver Neoplasms, Experimental, 0302 clinical medicine, Downregulation and upregulation, Antigen, In vivo, Cell Line, Tumor, otorhinolaryngologic diseases, medicine, Animals, Neoplasm Invasiveness, T-Lymphoma Invasion and Metastasis-inducing Protein 1, RNA, Small Interfering, Macrophage Migration-Inhibitory Factors, Caspase 8, Mice, Inbred BALB C, Caspase 3, Chemistry, Histocompatibility Antigens Class II, respiratory system, medicine.disease, biological factors, In vitro, Antigens, Differentiation, B-Lymphocyte, Intramolecular Oxidoreductases, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Macrophage migration inhibitory factor, Colorectal Neoplasms, 030215 immunology
Abstract

The purpose of this study was to assess the anti-tumor effects of macrophage migration inhibitory factor (MIF) siRNA on colorectal cancer in a mouse xenograft model. MIF specific siRNA (MIF siRNA) or a nonspecific control siRNA was introduced to murine colorectal cancer CT-26 cells. Mouse xenograft models of colorectal cancer were established. MIF siRNA, control siRNA or water was injected twice a week intravenously for 4 weeks. MIF siRNA inhibited the proliferation and migration, while induced apoptosis of CT-26 cells in vitro. Injection of MIF siRNA resulted in a significant decrease of serum MIF and VEGF levels, and the weight and volume of cecum-grafted tumors in vivo. In contrast, the number of apoptotic cells and caspase-3 expression were increased by MIF siRNA in cecum graft tumor tissues. Moreover, the water and fodder consumption were significantly improved by MIF siRNA treatment. Importantly, MIF siRNA reduced the hepatic metastases from colorectal cancer. Our results suggest that siRNA targeting MIF is a promising agent for the treatment of hepatic metastasis of colorectal cancer cells.

Published
2017

3. Efficacy of two different dosages of levofloxacin in curing Helicobacter pylori infection: A Prospective, Single-Center, randomized clinical trial

Author

Lin-Li Zhao, Li-Ya Yao, Rong-Jiao Yang, Tie-Li Peng, Kai-Hua Su, You-Ming Huang, and Huo-Ye Gan

Subjects
Adult, Diarrhea, Male, medicine.medical_specialty, lcsh:Medicine, macromolecular substances, Levofloxacin, Group B, Drug Administration Schedule, Esomeprazole, law.invention, Helicobacter Infections, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Randomized controlled trial, law, Internal medicine, Medicine, Humans, Prospective Studies, lcsh:Science, Adverse effect, Prospective cohort study, Multidisciplinary, Dose-Response Relationship, Drug, Helicobacter pylori, business.industry, lcsh:R, Amoxicillin, Exanthema, Middle Aged, bacterial infections and mycoses, Anti-Ulcer Agents, Anti-Bacterial Agents, Treatment Outcome, 030220 oncology & carcinogenesis, lcsh:Q, 030211 gastroenterology & hepatology, Drug Therapy, Combination, Female, business, Bismuth, medicine.drug
Abstract

Bismuth + proton pump inhibitor (PPI) + amoxicillin + levofloxacin is one of the bismuth quadruple therapy regimens widely used for the eradication of H. pylori infection. The recommended dosage of levofloxacin is 500 mg once daily or 200 mg twice daily to eradicate H. pylori infection. The aim of the present open-label, randomized control trial was to compare the effectiveness, safety, and compliance of different dosages of levofloxacin used to cure Helicobacter pylori infection. Eligible patients were randomly assigned to receive esomeprazole, amoxicillin, colloidal bismuth pectin and levofloxacin 500 mg once/day (group A) or levofloxacin 200 mg twice/day (group B) for 14 days. The primary outcome was the eradication rates in the intention-to-treat (ITT) and per protocol (PP) analyses. Overall, 400 patients were enrolled. The eradication rates in group A and group B were 77.5% and 79.5% respectively, in the ITT analysis, and 82.9% and 86.4%, respectively, in the PP analysis. No significant differences were found between two groups in terms of eradication rate, adverse effects or compliance. Oral levofloxacin 200 mg twice daily was similar in efficacy for eradicating H. pylori infection to oral levofloxacin 500 mg once daily but with lower mean total costs.

Published
2018

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