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27 results on '"Rosas, Elaine Cruz"'

5. Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions

Author

Correa, Luana Barbosa, primary, Gomes-da-Silva, Natália Cristina, additional, dos Santos, Clenilton Costa, additional, Rebelo Alencar, Luciana Magalhães, additional, Graças Muller de Oliveira Henriques, Maria das, additional, Bhattarai, Prapanna, additional, Zhu, Lin, additional, Noronha Souza, Pedro Filho, additional, Rosas, Elaine Cruz, additional, and Santos-Oliveira, Ralph, additional

Published
2024
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7. Contributors

Author

Abdel-Azeem, Ahmed M., primary, Abdel-Azeem, Mohamed A., additional, Aizat, Wan Mohd, additional, Akanda, Khokon Miah, additional, Alsenosy, Abdelwahab A., additional, Correa, Luana Barbosa, additional, Bauerova, Katarina, additional, Benjamin, Rodney L., additional, Bisen, Prakash S., additional, Bloomer, Richard J., additional, Butawan, Matthew, additional, Cheesman, Matthew, additional, Chera, Hymie, additional, Cicuttini, Flavia M., additional, Cock, Ian Edwin, additional, Dai, Zhaoli, additional, Daich, Jonathan, additional, Dhanoa, Harman, additional, Dinesh, Palani, additional, Dixit, Meenal, additional, Felson, David T., additional, Shishavan, Neda Ghamarzad, additional, Ghiasvand, Reza, additional, Govil, Sumit, additional, Goyal, Ramesh K., additional, das Graças Henriques, Maria, additional, Hussain, Sultana Monira, additional, Jadhav, Indrani, additional, Karunakaran, Rohini, additional, Karunaratne, Diyathi Tharindhi, additional, Khalil, Waleed F., additional, Kuncirova, Viera, additional, Lim, Yuan Z., additional, Lodhi, Santram, additional, Machado, Michel Mansur, additional, Mariño, Eliana, additional, Marzaimi, Ili Natasya, additional, Mbizo, Justice, additional, McLeod, Keiran H., additional, Miraghajani, Maryam, additional, Nagar, Menachem, additional, Nandave, Mukesh, additional, Ojha, Shreesh, additional, Okafor, Anthony, additional, Ongchai, Siriwan, additional, Pandey, Vikas, additional, Pannu, Arzoo, additional, Pareek, Shalini, additional, Patel, Kanika, additional, Patel, Dinesh Kumar, additional, Masud Parvez, G.M., additional, Pedersen, Brian A., additional, Perera, Pathirage Kamal, additional, Ponist, Silvester, additional, Gargari, Bahram Pourghassem, additional, Przyborowski, Jerzy A., additional, Pundarikakshudu, Kilambi, additional, Rasool, Mahaboobkhan, additional, Richards, James L., additional, Rosas, Elaine Cruz, additional, Rosen, Yitzhak, additional, Sadanandan, Srikumar Padmalayam, additional, Shaheen, Hazem M., additional, Shrivastava, Divya, additional, Shukla, Rajesh, additional, Slovak, Lukas, additional, de Oliveira, Luís Flávio Souza, additional, Stone, Leauna M., additional, Subramaniyan, Vetriselvan, additional, Sulima, Paweł, additional, Sutton, Melanie A., additional, Taylor, Jared F., additional, Vieira, Angélica Thomaz, additional, Vadnere, Gautam P., additional, Vahedi, Maryam, additional, van der Merwe, Marie, additional, Vinolo, Marco Aurélio Ramirez, additional, Wang, Yuanyuan, additional, Yap, Yu Anne, additional, Yazdi, Puya G., additional, Yeap, Swan Sim, additional, and Zuravski, Luísa, additional

Published
2019
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9. Chitosan-graphene quantum dot based active film as smart wound dressing

Author

Ribeiro, Elisabete Regina Fernandes Ramos, primary, Correa, Luana Barbosa, additional, Ricci-Junior, Eduardo, additional, Souza, Pedro Filho Noronha, additional, dos Santos, Clenilton Costa, additional, de Menezes, Alan Silva, additional, Rosas, Elaine Cruz, additional, Bhattarai, Prapanna, additional, Attia, Mohamed F., additional, Zhu, Lin, additional, Alencar, Luciana Magalhães Rebelo, additional, and Santos-Oliveira, Ralph, additional

Published
2023
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10. Using pure Fucoidan and radiolabeled Fucoidan (99mTc-Fucoidan) as a new agent for inflammation diagnosis and therapy

Author

Costa, Bianca, primary, Corrêa, Luana Barbosa, additional, Silva, Patrícia MachadoRodrigues e, additional, Jannini de Sá, Yago Amigo Pinho, additional, Guimarães, Fernanda Verdini, additional, Alencar, Luciana Magalhães Rebelo, additional, Simões, Rafael Loureiro, additional, Helal-Neto, Edward, additional, Ricci-Junior, Eduardo, additional, Muller de Oliveira Henriques, Maria das Graças, additional, Rosas, Elaine Cruz, additional, and Santos-Oliveira, Ralph, additional

Published
2022
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13. Anti-Inflammatory Activity and Chemical Analysis of Different Fractions from Solidago chilensis Inflorescence

Author

de Brito, Thais Morais, primary, Amendoeira, Fabio Coelho, additional, de Oliveira, Temistocles Barroso, additional, Doro, Laís Higino, additional, Garcia, Esdras Barbosa, additional, da Silva, Naína Monsores Felix, additional, da Silva Chaves, Amanda, additional, Muylaert, Flavia Fontenelle, additional, Pádua, Tatiana Almeida, additional, Rosas, Elaine Cruz, additional, Henriques, Maria das Graças M. O., additional, da Silva Frutuoso, Valber, additional, Valverde, Simone Sacramento, additional, and Ferraris, Fausto Klabund, additional

Published
2021
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15. Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results

Author

Magne, Tais Monteiro, primary, Helal-Neto, Edward, additional, Correa, Luana Barbosa, additional, Rebelo Alencar, Luciana Magalhães, additional, Gemini Piperni, Sara, additional, Iram, Surtaj H., additional, Bhattarai, Prapanna, additional, Zhu, Lin, additional, Ricci-Junior, Eduardo, additional, de Oliveira Henriques, Maria das Graças Muller, additional, Rosas, Elaine Cruz, additional, and Santos-Oliveira, Ralph, additional

Published
2021
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18. Intra-articular use of radium dichloride ([223Ra] RaCl2) showed relevant anti-inflammatory response on experimental arthritis model.

Author

Corrêa, Luana Barbosa, de Oliveira Henriques, Maria das Graças Muller, Rosas, Elaine Cruz, and Santos-Oliveira, Ralph

Subjects
RHEUMATOID arthritis, AUTOIMMUNE diseases, INFLAMMATION, RADIOISOTOPES, ZYMOSAN
Abstract

Rheumatoid arthritis (RA) is an inflammatory chronic autoimmune disease. The treatment of RA is difficult and, in many cases, ineffective, and the arsenal of drugs is limited. Due the longevity of the disease, RA may cause extreme musculoskeletal disorders with a high impact on quality of life. Also, RA is related with severe comorbidities decreasing the life expectancy. Finally, RA has been reported to impact in economy and healthy public. In this direction, the necessity to discover new strategies to efficiently treat RA is immediate. In this direction, we have reported the use of low doses of [223Ra] RaCl2 (radium dichloride) as intra-articular injection to treat RA. Mice were post-treated with [223Ra] RaCl2 (1.48 µCi; i.a.) 24 h after zymosan stimulus. Zymosan-induced arthrithis is responsible for leucocyte recruitment (total leukocytes, neutrophils, and mononuclear cells), which were inhibited by intra-articular injection of [223Ra] RaCl2 (69%, 77%, and 66%, respectively). [ABSTRACT FROM AUTHOR]

Published
2021
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19. Cannabinoid Receptors as Regulators of Neutrophil Activity in Inflammatory Diseases

Author

Rosas, Elaine Cruz and Souza, Mariana C.

Subjects
Medical
Abstract

Cannabinoids are compounds present in Cannabis sativa (phytocannabinoids), endogenously produced (endocannabinoids) or synthesized, that bind to G protein-coupled receptors named cannabinoid receptors B1 and B2. They were first described as psychotropic compounds; however, cannabinoids are also potent immunoregulatory agents. Cannabinoids can modulate neutrophil activity in sterile and infectious inflammatory diseases. Concerning sterile inflammatory diseases as arthritis, ischemic diseases, and colitis, the use of CB2 agonist impairs the intracellular signaling pathways involved in the production of inflammatory mediators and expression of adhesion molecules. As a consequence, neutrophils did not release metalloproteinases either to adhere to endothelial cells, resulting in reduced tissue damage. A similar anti-inflammatory CB2 agonist mechanism of action in sepsis and mycobacterial infection models is observed. However, it is not clear if inflammation resolution promoted by cannabinoid treatment during infection is also related to microbial viability. Despite the growing literature showing the effects of cannabinoids on neutrophils, there are still some gaps that should be filled before proposing cannabinoid-based drugs to treat neutrophil-dependent diseases.

Published
2019

20. Cannabinoid Receptors as Regulators of Neutrophil Activity in Inflammatory Diseases

Author

Souza, Mariana Conceição, Rosas, Elaine Cruz, Souza, Mariana Conceição, and Rosas, Elaine Cruz

Abstract

Cannabinoids are compounds present in Cannabis sativa (phytocannabinoids), endogenously produced (endocannabinoids) or synthesized, that bind to G protein-coupled receptors named cannabinoid receptors B1 and B2. They were first described as psychotropic compounds; however, cannabinoids are also potent immunoregulatory agents. Cannabinoids can modulate neutrophil activity in sterile and infectious inflammatory diseases. Concerning sterile inflammatory diseases as arthritis, ischemic diseases, and colitis, the use of CB2 agonist impairs the intracellular signaling pathways involved in the production of inflammatory mediators and expression of adhesion molecules. As a consequence, neutrophils did not release metalloproteinases either to adhere to endothelial cells, resulting in reduced tissue damage. A similar anti-inflammatory CB2 agonist mechanism of action in sepsis and mycobacterial infection models is observed. However, it is not clear if inflammation resolution promoted by cannabinoid treatment during infection is also related to microbial viability. Despite the growing literature showing the effects of cannabinoids on neutrophils, there are still some gaps that should be filled before proposing cannabinoid-based drugs to treat neutrophil-dependent diseases.

Published
2018
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21. Neutrophils in Rheumatoid Arthritis : a Target For Discovering New Therapies Based On Natural Products

Author

Rosas, Elaine Cruz

Subjects
Medical / Hematology
Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disorder with an important inflammatory component in joints. Neutrophils are the most abundant leukocytes in inflamed joints, and play an essential role in the initiation and progression of RA. Neutrophil effector mechanisms include the release of proinflammatory cytokines, reactive oxygen and nitrogen species (ROS and RNS), and granules containing degradative enzymes, which can cause further damage to the tissue and amplify the neutrophil response. Therefore, the modulation of neutrophil migration and functions is a potential target for pharmacological intervention in arthritis. The pharmacologic treatment options for RA are diverse. The current treatments are mostly symptomatic and have side effects, high costs, and an increased risk of malignancies. Because of these limitations, there is a growing interest in the use of natural products as therapies or adjunct therapies. Herbal products have attracted considerable interest over the past decade because of their multiple beneficial effects such as their antioxidant, anti-inflammatory, antiproliferative, and immunomodulatory properties. This chapter focuses on the role of neutrophils in the pathogenesis of arthritis and the action of substances from natural products as putative antirheumatic therapies.

Published
2017

23. In Vitro and In Vivo Evaluation of DMSO and Azone as Penetration Enhancers for Cutaneous Application of Celecoxib

Author

Senna, Thassia D´Arc, primary, Mata dos Santos, Hilton Antonio, additional, Kibwila, Daniel Mabundu, additional, Leitao, Alvaro Costa, additional, Santos Pyrrho, Alexandre dos, additional, de Padula, Marcelo, additional, Rosas, Elaine Cruz, additional, Padua, Tatiana Almeida, additional, Lara, Marilisa Guimaraes, additional, and Riemma Pierre, Maria Bernadete, additional

Published
2017
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24. Anti-inflammatory Effect of Methyl Gallate on Experimental Arthritis: Inhibition of Neutrophil Recruitment, Production of Inflammatory Mediators, and Activation of Macrophages

Author

Correa, Luana Barbosa, primary, Pádua, Tatiana Almeida, additional, Seito, Leonardo Noboru, additional, Costa, Thadeu Estevam Moreira Maramaldo, additional, Silva, Magaiver Andrade, additional, Candéa, André Luis Peixoto, additional, Rosas, Elaine Cruz, additional, and Henriques, Maria G., additional

Published
2016
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25. Anti-inflammatory effect of Schinus terebinthifolius Raddi hydroalcoholic extract on neutrophil migration in zymosan-induced arthritis

Author

Rosas, Elaine Cruz, primary, Correa, Luana Barbosa, additional, Pádua, Tatiana de Almeida, additional, Costa, Thadeu Estevam Moreira Maramaldo, additional, Luiz Mazzei, José, additional, Heringer, Alan Patrick, additional, Bizarro, Carlos Alberto, additional, Kaplan, Maria Auxiliadora Coelho, additional, Figueiredo, Maria Raquel, additional, and Henriques, Maria G, additional

Published
2015
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26. Chitosan-graphene quantum dot based active film as smart wound dressing

Author

Ribeiro, Elisabete Regina Fernandes Ramos, Correa, Luana Barbosa, Ricci-Junior, Eduardo, Souza, Pedro Filho Noronha, dos Santos, Clenilton Costa, de Menezes, Alan Silva, Rosas, Elaine Cruz, Bhattarai, Prapanna, Attia, Mohamed F., Zhu, Lin, Alencar, Luciana Magalhães Rebelo, and Santos-Oliveira, Ralph

Abstract

Graphene quantum dots (GQDs), are biocompatible materials, with mechanical strength and stability. Chitosan, has antibacterial and anti-inflammatory properties, and biocompatibility. Wound healing is a challenging process especially in chronic diseases and infection. In this study, films consisting of chitosan and graphene quantum dots were developed for application in infected wounds. The chitosan-graphene films were prepared in the acidic solution followed by slow solvent evaporation and drying. The chitosan-graphene films were characterized by the scanning electron microscopy, x-ray diffraction, atomic force microscopy, Raman spectroscopy and thermogravimetric analysis. The films’ was evaluated by the wound healing assays, hemolytic potential, and nitrite production, cytokine production and swelling potential. The obtained films were flexible and well-structured, promoting cell migration, greater antibacterial activity, lower hemolytic activity, and maintaining wound moisture. Our data suggested that the use of graphene quantum dot-containing chitosan films would be an efficient and promising way in combating wounds.

Published
2022
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27. Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action.

Author

Gomes-da-Silva NC, Corrêa LB, González MM, Silva França ÁR, Rebelo Alencar LM, Rosas EC, Ricci-Junior E, Borges Aguiar TK, Noronha Souza PF, and Santos-Oliveira R

Abstract

Introduction: Nanoceria is a well-known nanomaterial with various properties, including antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects that require further exploration, particularly its anti-inflammatory and antimicrobial activities., Method: The global demand for novel anti-inflammatory and antimicrobial drugs underscores the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally, we investigated the mechanism of action of nanoceria against Cryptococcus neoformans (ATCC 32045), Candida parapsilosis (ATCC 22019), Candida krusei (ATCC 6258), and Candida albicans., Result: The results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory profile, revealing the cellular mechanisms involved in the anti-inflammatory response. Concerning the antimicrobial effect, it was observed that nanoceria have a more pronounced impact on Candida parapsilosis, leading to the formation of pronounced pores on the surface of this species., Conclusion: Finally, biochemical analysis revealed transitory alterations, mainly in liver enzymes. The data support the use of nanoceria as a potential anti-inflammatory and antimicrobial drug and elucidate some of the mechanisms involved, shedding light on the properties of this nanodrug., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2024
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