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3. Contributors

Author

Abraham, Devaprabu, primary, Abraham, Nikita R., additional, Agarwal, Amit, additional, Ahadi, Mahsa S., additional, Alameer, Ehab, additional, Alobuia, Wilson, additional, Alon, Eran E., additional, Angkoon, Anuwong, additional, Al-Qurayshi, Zaid, additional, Angell, Trevor E., additional, Angelos, Peter, additional, Baek, Jung Hwan, additional, Baloch, Zubair W., additional, Barczyński, Marcin, additional, Bauer, Andrew J., additional, Bellantone, Rocco, additional, Berdelou, Amandine, additional, Bergenfeltz, Anders, additional, Bernet, Victor J., additional, Bible, Keith C., additional, Bilezikian, John Paul, additional, Bonilla-Velez, Juliana, additional, Boucai, Laura, additional, Brent, Gregory A., additional, Breuskin, Ingrid, additional, Brierley, James Duncan, additional, Brisebois, Simon, additional, Brooks, Jennifer, additional, Brumund, Kevin T., additional, Bura, Mijenko, additional, Alvarez, Jean Gabriel Bustamante, additional, Carneiro-Pla, Denise, additional, Cernea, Claudio R., additional, Chang, Rita Yuk-kwan, additional, Chen, Amy, additional, Chiang, Feng-Yu, additional, Chintakuntlawar, Ashish V., additional, Cho, Nancy L., additional, Chung, Woong Youn, additional, Cibas, Edmund S., additional, Dacey, Carolyn, additional, Davies, Louise, additional, De Crea, Carmela, additional, Delbridge, Leigh, additional, Diercks, Gillian, additional, Doherty, Gerard M., additional, Dralle, Henning, additional, Duh, Quan-Yang, additional, Dunlap, Quinn Alexander, additional, Durante, Cosmio, additional, Eltelety, Ahmad Mohamed, additional, Evans, Douglas B., additional, Fadda, Guido, additional, Faquin, William C., additional, Felger, Erin, additional, Ferris, Robert L., additional, Filetti, Sebastiano, additional, Freeman, Jeremy L., additional, Fundakowski, Christopher, additional, Ganly, Ian, additional, Gigliotti, Benjamin Joseph, additional, Gill, Anthony J., additional, Giordano, Thomas J., additional, Giuliani, Meredith E., additional, Gooi, Zhen, additional, Gopal, Raj K., additional, Guerlain, Joanne, additional, Hadoux, Julien, additional, Hales, Nathan, additional, Hartl, Dana, additional, Haugen, Bryan R., additional, Haymart, Megan R., additional, Inabnet, William B., additional, Irish, Jonathan, additional, Iwata, Ayaka, additional, Kamani, Dipti, additional, Kandil, Emad, additional, Kaplan, Edwin L., additional, Kazahaya, Ken, additional, Kebebew, Electron, additional, Kim, Matthew I., additional, Kovatch, Kevin J., additional, Lang, Brian H.H., additional, Leboulleux, Sophie, additional, Leung, Angela M., additional, Levine, Robert A., additional, Liddy, Whitney, additional, LiVolsi, Virginia A., additional, Lombardi, Celestino Pio, additional, Lubitz, Carrie C., additional, Machens, Andreas, additional, Maghami, Ellie, additional, Mandel, Susan J., additional, Maniakas, Anastasios, additional, Mathisen, Douglas J., additional, Mathur, Aarti, additional, Merati, Albert, additional, Milas, Mira, additional, Miyauchi, Akira, additional, Monteiro, Eric, additional, Netterville, James L., additional, Nikiforov, Yuri E., additional, Orloff, Lisa A., additional, Pandian, T.K., additional, Parangi, Sareh, additional, Parikh, Sanjay, additional, Park, Auh Whan, additional, Pearce, Elizabeth N., additional, Pellitteri, Phillip K., additional, Pennestrì, Francesco, additional, Pradhan, Roma, additional, Prichard, Ruth, additional, Raffaelli, Marco, additional, Randolph, Gregory W., additional, Rastatter, Jeff, additional, Reid, Lisa M., additional, Richer, Sara L., additional, Richmon, Jeremy D., additional, Ringel, Matthew D., additional, Roman, Benjamin R., additional, Romanchishen, Anatoly F., additional, Ross, Douglas S., additional, Russell, Jonathon O., additional, Russell, Marika D., additional, Ryder, Mabel, additional, Sabra, Mona M., additional, Sachdeva, Uma M., additional, Sadow, Peter M., additional, Scharpf, Joseph, additional, Schlumberger, Martin, additional, Schneider, Rick, additional, Scott-Coombes, David, additional, Sewell, Andrew B., additional, Shah, Jatin, additional, Shah, Manisha H., additional, Shindo, Maisie, additional, Shonka, David, additional, Silverberg, Shonni Joy, additional, Sims, John Randall, additional, Sinclair, Catherine F., additional, Singer, Michael C., additional, Siperstein, Allan E., additional, Sipos, Jennifer A., additional, Slough, Cristian Martin, additional, Sosa, Julie A., additional, Soylu, Selen, additional, Stack, Brendan C., additional, Stathatos, Nikolaos, additional, Stechman, Michael James, additional, Stephen, Antonia E., additional, Steward, David L., additional, Suh, Hyun, additional, Sywak, Mark, additional, Tang, Alice, additional, Terris, David J., additional, Thompson, Geoffrey Bruce, additional, Tolley, Neil, additional, Tominaga, Yoshihiro, additional, Triponez, Frédéric, additional, Tsang, Richard W., additional, Tuttle, R. Michael, additional, Urken, Mark L., additional, Vabalayte, Kristina V., additional, Vahabzadeh-Hagh, Andrew M., additional, Volpi, Erivelto Martinho, additional, Wang, Tracy S., additional, Wu, Che-Wei, additional, Wirth, Lori J., additional, Witterick, Ian, additional, Wong, Richard J., additional, Woodson, Gayle E., additional, Wright, Cameron D., additional, Zafereo, Mark E., additional, and Zubiaur, Fermin M., additional

Published
2021
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7. Radioactive Iodine: A Living History.

Author

Daniels, Gilbert H. and Ross, Douglas S.

Subjects
*IODINE isotopes, *THYROID cancer, *HISTORICAL reenactments, *THYROID eye disease, *RADIOISOTOPES, *RECEPTOR antibodies
Abstract

Background: Before the development of antithyroid drugs in the 1940s, treatment of Graves' hyperthyroidism was primarily surgical. Surgical mortality was quite variable, but a significant minority of patients died during or after surgery. Summary: In 1936, Karl Compton, President of the Massachusetts Institute of Technology, in a lecture attended by Massachusetts General Hospital physicians, suggested that artificially radioactive isotopes might be useful for studying metabolism. By 1942, Hertz and Roberts reported on the successful use of radioactive iodine (RAI) to treat Graves' hyperthyroidism. RAI uptake was subsequently demonstrated in well-differentiated thyroid cancer metastases. In 1948, Seidlin demonstrated stimulation of uptake in thyroid cancer metastases by thyrotropin (TSH). By 1990, 69% of endocrinologists in North America recommended RAI for Graves' hyperthyroidism. Currently RAI is less frequently used for Graves' hyperthyroidism, related to concerns about exacerbation of thyroid eye disease, about radiation exposure, and about potential adverse consequences of permanent hypothyroidism. Similarly, RAI was administered to the majority of patients with thyroid cancer for decades, but its use is now more selective. Conclusions: RAI is a remarkable example of interinstitutional cooperation between physicians and scientists to transition from bench to bedside in only three years. It is the model for a theranostic approach to disease (the simultaneous use of a radioactive drug for diagnosis and therapy). The future of RAI is less certain; inhibition of TSH receptor stimulating antibodies in Graves' disease and more precise targeting of genes that drive thyroid oncogenesis may diminish the use of RAI. Alternatively, redifferentiation techniques may improve the efficacy of RAI in RAI-refractory thyroid cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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8. What's in a Name? A Cost-Effectiveness Analysis of the Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features' Nomenclature Revision

Author

Mehta, Vikas, primary, Naraparaju, Ankita, additional, Liao, David, additional, Davies, Louise, additional, Haugen, Bryan R., additional, Kopp, Peter A., additional, Mandel, Susan J., additional, Nikiforov, Yuri E., additional, Ross, Douglas S., additional, Shin, Jennifer J., additional, Tuttle, R. Michael, additional, and Randolph, Gregory W., additional

Published
2022
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14. A Survey of American Thyroid Association Members Regarding the 2015 Adult Thyroid Nodule and Differentiated Thyroid Cancer Clinical Practice Guidelines

Author

Sawka, Anna M., primary, Gagliardi, Anna R., additional, Haymart, Megan R., additional, Sturgeon, Cord, additional, Bernet, Victor, additional, Hoff, Kelly, additional, Angelos, Peter, additional, Brito, Juan P., additional, Haugen, Bryan R., additional, Kim, Brian, additional, Kopp, Peter A., additional, Mandel, Susan J., additional, Ross, Douglas S., additional, Samuels, Mary, additional, Sarne, David, additional, Sinclair, Catherine, additional, and Jonklaas, Jacqueline, additional

Published
2020
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16. Comparison of long‐term antithyroid drugs versus radioactive iodine or surgery for Graves' disease: A review of the literature.

Author

El Kawkgi, Omar M., Ross, Douglas S., and Stan, Marius N.

Subjects
*IODINE isotopes, *THYROID antagonists, *LITERATURE reviews, *MEDICAL personnel, *PATIENT decision making
Abstract

Background: The management of Graves' disease (GD) in the US is shifting towards increased use of anti‐thyroid drugs (ATD). If patients fail to achieve remission after a standard course of therapy of 12–18 months, long‐term treatment with ATD (≥24 months) may be chosen over definitive therapy with radioiodine (RAI) or surgery. Clinicians will need to contrast this strategy to ablative therapies as they help patients in decision making. Summary: Review of the literature illustrates that long‐term ATD delivers euthyroidism with minimal complications, low financial cost and with an advantageous profile regarding quality of life (QoL) and other biological outcomes. Conclusions: Long‐term ATD is a viable alternative to ablative therapies in the management of GD offering advantages across multiple patient centred outcomes. Decision making must factor differences in this approach compared to ablative therapies and ultimately be tailored to individualized patient situations. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Is the Risk of Thyroid Storm Higher When Patient-Related Factors Delay Treatment of Hyperthyroidism, Or Is It Higher When Patients Undergo Thyroidectomy While Still Thyrotoxic?

Author

Ross, Douglas S.

Subjects
*THYROID crisis, *THYROIDECTOMY, *TREATMENT delay (Medicine), *HYPERTHYROIDISM, *PATIENT compliance, *MEDICALLY underserved persons
Abstract

The ATA guidelines, which recommends that patients be rendered euthyroid before surgery whenever possible, are still valid.[3] While the risk of an adverse outcome from operating on a thyrotoxic patient may be quite low, the risk should not be considered negligible. They compared 134 euthyroid patients who had a thyroidectomy after attaining a euthyroid state with medical treatment with 141 patients who were hyperthyroid at the time of surgery. [Extracted from the article]

Published
2023
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18. An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction

Author

Peterson, Sarah J., primary, Cappola, Anne R., additional, Castro, M. Regina, additional, Dayan, Colin M., additional, Farwell, Alan P., additional, Hennessey, James V., additional, Kopp, Peter A., additional, Ross, Douglas S., additional, Samuels, Mary H., additional, Sawka, Anna M., additional, Taylor, Peter N., additional, Jonklaas, Jacqueline, additional, and Bianco, Antonio C., additional

Published
2018
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19. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis

Author

Ross, Douglas S., primary, Burch, Henry B., additional, Cooper, David S., additional, Greenlee, M. Carol, additional, Laurberg, Peter, additional, Maia, Ana Luiza, additional, Rivkees, Scott A., additional, Samuels, Mary, additional, Sosa, Julie Ann, additional, Stan, Marius N., additional, and Walter, Martin A., additional

Published
2016
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20. ROS1 Rearrangement in Thyroid Cancer

Author

Ritterhouse, Lauren L., primary, Wirth, Lori J., additional, Randolph, Gregory W., additional, Sadow, Peter M., additional, Ross, Douglas S., additional, Liddy, Whitney, additional, and Lennerz, Jochen K., additional

Published
2016
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21. Active Surveillance for Papillary Thyroid Microcarcinoma: New Challenges and Opportunities for The Health Care System

Author

Haser, Grace C., primary, Tuttle, R. Michael, additional, Su, Henry K., additional, Alon, Eran E., additional, Bergman, Donald, additional, Bernet, Victor, additional, Brett, Elise, additional, Cobin, Rhoda, additional, Dewey, Eliza H., additional, Doherty, Gerard, additional, Dos Reis, Laura L., additional, Harris, Jeffrey, additional, Klopper, Joshua, additional, Lee, Stephanie L., additional, Levine, Robert A., additional, Lepore, Stephen J., additional, Likhterov, Ilya, additional, Lupo, Mark A., additional, Machac, Josef, additional, Mechanick, Jeffrey I., additional, Mehra, Saral, additional, Milas, Mira, additional, Orloff, Lisa A., additional, Randolph, Gregory, additional, Revenson, Tracey A., additional, Roberts, Katherine J., additional, Ross, Douglas S., additional, Rowe, Meghan E., additional, Smallridge, Robert C., additional, Terris, David, additional, Tufano, Ralph P., additional, and Urken, Mark L., additional

Published
2016
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22. Improving the adoption of thyroid cancer clinical practice guidelines

Author

Likhterov, Ilya, primary, Tuttle, R. Michael, additional, Haser, Grace C., additional, Su, Henry K., additional, Bergman, Donald, additional, Alon, Eran E., additional, Bernet, Victor, additional, Brett, Elise, additional, Cobin, Rhoda, additional, Dewey, Eliza H., additional, Doherty, Gerard, additional, Dos Reis, Laura L., additional, Klopper, Joshua, additional, Lee, Stephanie L., additional, Lupo, Mark A., additional, Machac, Josef, additional, Mechanick, Jeffrey I., additional, Milas, Mira, additional, Orloff, Lisa, additional, Randolph, Gregory, additional, Ross, Douglas S., additional, Rowe, Meghan E., additional, Smallridge, Robert, additional, Terris, David, additional, Tufano, Ralph P., additional, and Urken, Mark L., additional

Published
2016
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23. Reassessing the NTCTCS Staging Systems for Differentiated Thyroid Cancer, Including Age at Diagnosis

Author

McLeod, Donald S.A., primary, Jonklaas, Jacqueline, additional, Brierley, James D., additional, Ain, Kenneth B., additional, Cooper, David S., additional, Fein, Henry G., additional, Haugen, Bryan R., additional, Ladenson, Paul W., additional, Magner, James, additional, Ross, Douglas S., additional, Skarulis, Monica C., additional, Steward, David L., additional, Xing, Mingzhao, additional, Litofsky, Danielle R., additional, Maxon, Harry R., additional, and Sherman, Steven I., additional

Published
2015
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24. Database and Registry Research in Thyroid Cancer: Striving for a New and Improved National Thyroid Cancer Database

Author

Mehra, Saral, primary, Tuttle, R. Michael, additional, Milas, Mira, additional, Orloff, Lisa, additional, Bergman, Donald, additional, Bernet, Victor, additional, Brett, Elise, additional, Cobin, Rhoda, additional, Doherty, Gerard, additional, Judson, Benjamin L., additional, Klopper, Joshua, additional, Lee, Stephanie, additional, Lupo, Mark, additional, Machac, Josef, additional, Mechanick, Jeffrey I., additional, Randolph, Gregory, additional, Ross, Douglas S., additional, Smallridge, Robert, additional, Terris, David, additional, Tufano, Ralph, additional, Alon, Eran, additional, Clain, Jason, additional, DosReis, Laura, additional, Scherl, Sophie, additional, and Urken, Mark L., additional

Published
2015
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25. What Is the Gold Standard for Comprehensive Interinstitutional Communication of Perioperative Information for Thyroid Cancer Patients? A Comparison of Existing Electronic Health Records with the Current American Thyroid Association Recommendations

Author

Dos Reis, Laura L., primary, Tuttle, R. Michael, additional, Alon, Eran, additional, Bergman, Donald A., additional, Bernet, Victor, additional, Brett, Elise M., additional, Cobin, Rhoda, additional, Doherty, Gerard, additional, Harris, Jeffrey R., additional, Klopper, Joshua, additional, Lee, Stephanie L., additional, Lupo, Mark, additional, Milas, Mira, additional, Machac, Josef, additional, Mechanick, Jeffrey I., additional, Orloff, Lisa, additional, Randolph, Gregory, additional, Ross, Douglas S., additional, Smallridge, Robert C., additional, Terris, David James, additional, Tufano, Ralph P., additional, Mehra, Saral, additional, Scherl, Sophie, additional, Clain, Jason B., additional, and Urken, Mark L., additional

Published
2014
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26. Treating hypothyroidism is not always easy: When to treat subclinical hypothyroidism, TSH goals in the elderly, and alternatives to levothyroxine monotherapy.

Author

Ross DS

Subjects
Aged, Aged, 80 and over, Humans, Thyroid Hormones therapeutic use, Thyrotropin blood, Hypothyroidism drug therapy, Thyroxine therapeutic use
Abstract

The majority of patients with hypothyroidism feel better when levothyroxine treatment restores thyroid-stimulating hormone (TSH) concentrations to normal. Increasingly, a significant minority of patients remain symptomatic and are dissatisfied with their treatment. Overzealous treatment of symptomatic patients with subclinical hypothyroidism may contribute to dissatisfaction among hypothyroidism patients, as potential hypothyroid symptoms in patients with minimal hypothyroidism rarely respond to treatment. Thyroid hormone prescriptions have increased by 30% in the United States in the last decade. The diagnosis of subclinical hypothyroidism should be confirmed by repeat thyroid function tests ideally obtained at least 2 months later, as 62% of elevated TSH levels may revert to normal spontaneously. Generally, treatment is not necessary unless the TSH exceeds 7.0-10 mIU/L. In double-blinded randomized controlled trials, treatment does not improve symptoms or cognitive function if the TSH is less than 10 mIU/L. While cardiovascular events may be reduced in patients under age 65 with subclinical hypothyroidism who are treated with levothyroxine, treatment may be harmful in elderly patients with subclinical hypothyroidism. TSH goals are age dependent, with a 97.5 percentile (upper limit of normal) of 3.6 mIU/L for patients under age 40, and 7.5 mIU/L for patients over age 80. In some hypothyroid patients who are dissatisfied with treatment, especially those with a polymorphism in type 2 deiodinase, combined treatment with levothyroxine and liothyronine may be preferred., (© 2021 The Association for the Publication of the Journal of Internal Medicine.)

Published
2022
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