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2. Correction to: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B (Nature Immunology, (2022), 23, 9, (1379-1392), 10.1038/s41590-022-01290-3)

Author

Musella M., Musella, M, Guarracino, A, Manduca, N, Galassi, C, Ruggiero, E, Potenza, A, Maccafeo, E, Manic, G, Mattiello, L, Soliman Abdel Rehim, S, Signore, M, Pietrosanto, M, Helmer-Citterich, M, Pallocca, M, Fanciulli, M, Bruno, T, De Nicola, F, Corleone, G, Di Benedetto, A, Ercolani, C, Pescarmona, E, Pizzuti, L, Guidi, F, Sperati, F, Vitale, S, Macchia, D, Spada, M, Schiavoni, G, Mattei, F, De Ninno, A, Businaro, L, Lucarini, V, Bracci, L, Arico, E, Ziccheddu, G, Facchiano, F, Rossi, S, Sanchez, M, Boe, A, Biffoni, M, De Maria, R, Vitale, I, Sistigu, A, Musella M., Guarracino A., Manduca N., Galassi C., Ruggiero E., Potenza A., Maccafeo E., Manic G., Mattiello L., Soliman Abdel Rehim S., Signore M., Pietrosanto M., Helmer-Citterich M., Pallocca M., Fanciulli M., Bruno T., De Nicola F., Corleone G., Di Benedetto A., Ercolani C., Pescarmona E., Pizzuti L., Guidi F., Sperati F., Vitale S., Macchia D., Spada M., Schiavoni G., Mattei F., De Ninno A., Businaro L., Lucarini V., Bracci L., Arico E., Ziccheddu G., Facchiano F., Rossi S., Sanchez M., Boe A., Biffoni M., De Maria R., Vitale I., Sistigu A., Musella M., Musella, M, Guarracino, A, Manduca, N, Galassi, C, Ruggiero, E, Potenza, A, Maccafeo, E, Manic, G, Mattiello, L, Soliman Abdel Rehim, S, Signore, M, Pietrosanto, M, Helmer-Citterich, M, Pallocca, M, Fanciulli, M, Bruno, T, De Nicola, F, Corleone, G, Di Benedetto, A, Ercolani, C, Pescarmona, E, Pizzuti, L, Guidi, F, Sperati, F, Vitale, S, Macchia, D, Spada, M, Schiavoni, G, Mattei, F, De Ninno, A, Businaro, L, Lucarini, V, Bracci, L, Arico, E, Ziccheddu, G, Facchiano, F, Rossi, S, Sanchez, M, Boe, A, Biffoni, M, De Maria, R, Vitale, I, Sistigu, A, Musella M., Guarracino A., Manduca N., Galassi C., Ruggiero E., Potenza A., Maccafeo E., Manic G., Mattiello L., Soliman Abdel Rehim S., Signore M., Pietrosanto M., Helmer-Citterich M., Pallocca M., Fanciulli M., Bruno T., De Nicola F., Corleone G., Di Benedetto A., Ercolani C., Pescarmona E., Pizzuti L., Guidi F., Sperati F., Vitale S., Macchia D., Spada M., Schiavoni G., Mattei F., De Ninno A., Businaro L., Lucarini V., Bracci L., Arico E., Ziccheddu G., Facchiano F., Rossi S., Sanchez M., Boe A., Biffoni M., De Maria R., Vitale I., and Sistigu A.

Abstract

Correction to: Nature Immunologyhttps://doi.org/10.1038/s41590-022-01290-3, published online 24 August 2022. In the version of this article initially published, due to an error during figure assembly, the image shown in the top-right WT mice, PAR cells, panel of Fig. 4d was a duplicate of the lower-left image in the CD4–/–CD8–/– mice, CD44L cells, panel. The figure has been updated in the HTML and PDF versions of the article.

Published
2024

3. Fat-to-blood recirculation of partially dysfunctional PD-1+CD4 Tconv cells is associated with dysglycemia in human obesity

Author

Giovenzana, A, Bezzecchi, E, Bichisecchi, A, Cardellini, S, Ragogna, F, Pedica, F, Invernizzi, F, Di Filippo, L, Tomajer, V, Aleotti, F, Scotti, G, Socci, C, Cesana, G, Olmi, S, Morelli, M, Falconi, M, Giustina, A, Bonini, C, Piemonti, L, Ruggiero, E, Petrelli, A, Giovenzana A., Bezzecchi E., Bichisecchi A., Cardellini S., Ragogna F., Pedica F., Invernizzi F., Di Filippo L., Tomajer V., Aleotti F., Scotti G. M., Socci C., Cesana G., Olmi S., Morelli M. J., Falconi M., Giustina A., Bonini C., Piemonti L., Ruggiero E., Petrelli A., Giovenzana, A, Bezzecchi, E, Bichisecchi, A, Cardellini, S, Ragogna, F, Pedica, F, Invernizzi, F, Di Filippo, L, Tomajer, V, Aleotti, F, Scotti, G, Socci, C, Cesana, G, Olmi, S, Morelli, M, Falconi, M, Giustina, A, Bonini, C, Piemonti, L, Ruggiero, E, Petrelli, A, Giovenzana A., Bezzecchi E., Bichisecchi A., Cardellini S., Ragogna F., Pedica F., Invernizzi F., Di Filippo L., Tomajer V., Aleotti F., Scotti G. M., Socci C., Cesana G., Olmi S., Morelli M. J., Falconi M., Giustina A., Bonini C., Piemonti L., Ruggiero E., and Petrelli A.

Published
2024

7. Rationale and design of the CV-PREVITAL study: an Italian multiple cohort randomised controlled trial investigating innovative digital strategies in primary cardiovascular prevention

Author

Baldassarre, D, Iacoviello, L, Baetta, R, Roncaglioni, M, Condorelli, G, Remuzzi, G, Gensini, G, Frati, L, Ricciardi, W, Conaldi, P, Uccelli, A, Blandini, F, Bosari, S, Scambia, G, Fini, M, Di Malta, A, Amato, M, Veglia, F, Bonomi, A, Klersy, C, Colazzo, F, Pengo, M, Gorini, F, Auteri, L, Ferrante, G, Baviera, M, Ambrosio, G, Catapano, A, Gialluisi, A, Malavazos, A, Castelvecchio, S, Corsi-Romanelli, M, Cardani, R, La Rovere, M, Agnese, V, Pane, B, Prati, D, Spinardi, L, Liuzzo, G, Arbustini, E, Volterrani, M, Visconti, M, Werba, J, Genovese, S, Bilo, G, Invitti, C, Di Blasio, A, Lombardi, C, Faini, A, Rosa, D, Ojeda-Fernandez, L, Foresta, A, De Curtis, A, Di Castelnuovo, A, Scalvini, S, Pierobon, A, Gorini, A, Valenti, L, Luzi, L, Racca, A, Bandi, M, Tremoli, E, Menicanti, L, Parati, G, Pompilio, G, Colombo, G, Vavassori, C, Biondi, M, Frigerio, B, Ravani, A, Sansaro, D, Coggi, D, Romandini, A, Giroli, M, Giuliani, M, Bonmi, A, Rondinelli, M, Trudu, C, Cinieri, C, Monturano, M, Colazo, F, Inviti, C, Di Blasi, A, Torlasco, C, Gilardini, L, Soranna, D, Zambon, A, Perger, E, Zanotti, L, Badano, L, Cova, L, Gentilini, D, Grappiolo, L, Condoreli, G, Ferante, G, Papa, L, Savevski, V, Ieva, F, Romano, I, Remzzi, G, Ojeda, L, Clerici, F, Palumbo, A, Genini, G, Catpano, A, Mattioli, R, Longhi, E, Mantovani, L, Madotto, F, Bonaccio, M, Gianfagna, F, Ghulam, A, Magnacca, S, Noro, F, Costanzo, S, Esposito, S, Orlandi, S, Persichillo, M, Bracone, F, Panzera, T, Ruggiero, E, Parisi, R, Franciosa, S, Morelli, M, De Rita, F, Cerletti, C, de Gaetano, G, Donati, M, Mencanti, L, Romanelli, M, Cerri, A, Dubini, C, Trevisan, M, Renna, L, Milani, V, Boveri, S, Giubbilini, P, Ramputi, L, Baroni, I, De Angeli, G, Riciardi, W, Olmetti, F, Bussotti, M, Gaetano, C, Baiardi, P, Bachetti, T, Balbi, M, Comini, L, Lorenzoni, M, Olivares, A, Traversi, E, Garre, C, Sideri, R, Clemenza, F, Gentile, G, Caruana, G, Cuscino, N, Di Gesaro, G, Greco, A, Loddo, I, Tuzzolino, F, Ucelli, A, Palombo, D, Spinella, G, Mozzetta, G, Ameri, P, Zoppoli, G, Finotello, A, Porto, I, Pratesi, G, Bladini, F, Spnardi, L, Clerici, M, Pelusi, S, Bianco, C, Carpani, R, Periti, G, Margarita, S, Lanza, G, Severino, A, Pedicino, D, D'Amario, D, D'Aiello, A, Vinci, R, Bonanni, A, Brecciaroli, M, Filomia, S, Pastorino, R, Boccia, S, Urbani, A, Sanguinetti, M, Santoliquido, A, Proto, L, Tarquini, D, Grimaldi, M, Leonardi, S, Elia, A, Currao, A, Urtis, M, Di Toro, A, Giuliani, L, Caminiti, G, Marcolongo, F, Sposato, B, Guadagni, F, Morsella, V, Marziale, A, Protti, G, Baldassarre D., Iacoviello L., Baetta R., Roncaglioni M. C., Condorelli G., Remuzzi G., Gensini G., Frati L., Ricciardi W., Conaldi P. G., Uccelli A., Blandini F., Bosari S., Scambia G., Fini M., Di Malta A., Amato M., Veglia F., Bonomi A., Klersy C., Colazzo F., Pengo M., Gorini F., Auteri L., Ferrante G., Baviera M., Ambrosio G., Catapano A., Gialluisi A., Malavazos A. E., Castelvecchio S., Corsi-Romanelli M. M., Cardani R., La Rovere M. T., Agnese V., Pane B., Prati D., Spinardi L., Liuzzo G., Arbustini E., Volterrani M., Visconti M., Werba J. P., Genovese S., Bilo G., Invitti C., Di Blasio A., Lombardi C., Faini A., Rosa D., Ojeda-Fernandez L., Foresta A., De Curtis A., Di Castelnuovo A., Scalvini S., Pierobon A., Gorini A., Valenti L., Luzi L., Racca A., Bandi M., Tremoli E., Menicanti L., Parati G., Pompilio G., Colombo G., Vavassori C., Biondi M. L., Frigerio B., Ravani A., Sansaro D., Coggi D., Romandini A., Giroli M., Giuliani M., Bonmi A., Rondinelli M., Trudu C., Cinieri C., Monturano M., Colazo F., Inviti C., Di Blasi A., Torlasco C., Gilardini L., Soranna D., Zambon A., Perger E., Zanotti L., Badano L., Cova L., Gentilini D., Grappiolo L., Condoreli G., Ferante G., Papa L., Savevski V., Ieva F., Romano I., Remzzi G., Ojeda L., Clerici F., Palumbo A., Genini G. F., Catpano A., Mattioli R., Longhi E., Mantovani L. G., Madotto F., Bonaccio M., Gianfagna F., Ghulam A., Magnacca S., Noro F., Costanzo S., Esposito S., Orlandi S., Persichillo M., Bracone F., Panzera T., Ruggiero E., Parisi R., Franciosa S., Morelli M., De Rita F., Cerletti C., de Gaetano G., Donati M. B., Mencanti L., Romanelli M. M. C., Cerri A., Dubini C., Trevisan M. B., Renna L. V., Milani V., Boveri S., Giubbilini P., Ramputi L., Baroni I., De Angeli G., Riciardi W., Olmetti F., Bussotti M., Gaetano C., Baiardi P., Bachetti T., Balbi M., Comini L., Lorenzoni M., Olivares A., Traversi E., Garre C., Sideri R., Clemenza F., Gentile G., Caruana G., Cuscino N., Di Gesaro G., Greco A., Loddo I., Tuzzolino F., Ucelli A., Palombo D., Spinella G., Mozzetta G., Ameri P., Zoppoli G., Finotello A., Porto I., Pratesi G., Bladini F., Spnardi L., Clerici M., Pelusi S., Bianco C., Carpani R., Periti G., Margarita S., Lanza G. A., Severino A., Pedicino D., D'Amario D., D'Aiello A., Vinci R., Bonanni A., Brecciaroli M., Filomia S., Pastorino R., Boccia S., Urbani A., Sanguinetti M., Santoliquido A., Proto L., Tarquini D., Grimaldi M. C., Leonardi S., Elia A., Currao A., Urtis M., Di Toro A., Giuliani L., Caminiti G., Marcolongo F., Sposato B., Guadagni F., Morsella V., Marziale A., Protti G., Baldassarre, D, Iacoviello, L, Baetta, R, Roncaglioni, M, Condorelli, G, Remuzzi, G, Gensini, G, Frati, L, Ricciardi, W, Conaldi, P, Uccelli, A, Blandini, F, Bosari, S, Scambia, G, Fini, M, Di Malta, A, Amato, M, Veglia, F, Bonomi, A, Klersy, C, Colazzo, F, Pengo, M, Gorini, F, Auteri, L, Ferrante, G, Baviera, M, Ambrosio, G, Catapano, A, Gialluisi, A, Malavazos, A, Castelvecchio, S, Corsi-Romanelli, M, Cardani, R, La Rovere, M, Agnese, V, Pane, B, Prati, D, Spinardi, L, Liuzzo, G, Arbustini, E, Volterrani, M, Visconti, M, Werba, J, Genovese, S, Bilo, G, Invitti, C, Di Blasio, A, Lombardi, C, Faini, A, Rosa, D, Ojeda-Fernandez, L, Foresta, A, De Curtis, A, Di Castelnuovo, A, Scalvini, S, Pierobon, A, Gorini, A, Valenti, L, Luzi, L, Racca, A, Bandi, M, Tremoli, E, Menicanti, L, Parati, G, Pompilio, G, Colombo, G, Vavassori, C, Biondi, M, Frigerio, B, Ravani, A, Sansaro, D, Coggi, D, Romandini, A, Giroli, M, Giuliani, M, Bonmi, A, Rondinelli, M, Trudu, C, Cinieri, C, Monturano, M, Colazo, F, Inviti, C, Di Blasi, A, Torlasco, C, Gilardini, L, Soranna, D, Zambon, A, Perger, E, Zanotti, L, Badano, L, Cova, L, Gentilini, D, Grappiolo, L, Condoreli, G, Ferante, G, Papa, L, Savevski, V, Ieva, F, Romano, I, Remzzi, G, Ojeda, L, Clerici, F, Palumbo, A, Genini, G, Catpano, A, Mattioli, R, Longhi, E, Mantovani, L, Madotto, F, Bonaccio, M, Gianfagna, F, Ghulam, A, Magnacca, S, Noro, F, Costanzo, S, Esposito, S, Orlandi, S, Persichillo, M, Bracone, F, Panzera, T, Ruggiero, E, Parisi, R, Franciosa, S, Morelli, M, De Rita, F, Cerletti, C, de Gaetano, G, Donati, M, Mencanti, L, Romanelli, M, Cerri, A, Dubini, C, Trevisan, M, Renna, L, Milani, V, Boveri, S, Giubbilini, P, Ramputi, L, Baroni, I, De Angeli, G, Riciardi, W, Olmetti, F, Bussotti, M, Gaetano, C, Baiardi, P, Bachetti, T, Balbi, M, Comini, L, Lorenzoni, M, Olivares, A, Traversi, E, Garre, C, Sideri, R, Clemenza, F, Gentile, G, Caruana, G, Cuscino, N, Di Gesaro, G, Greco, A, Loddo, I, Tuzzolino, F, Ucelli, A, Palombo, D, Spinella, G, Mozzetta, G, Ameri, P, Zoppoli, G, Finotello, A, Porto, I, Pratesi, G, Bladini, F, Spnardi, L, Clerici, M, Pelusi, S, Bianco, C, Carpani, R, Periti, G, Margarita, S, Lanza, G, Severino, A, Pedicino, D, D'Amario, D, D'Aiello, A, Vinci, R, Bonanni, A, Brecciaroli, M, Filomia, S, Pastorino, R, Boccia, S, Urbani, A, Sanguinetti, M, Santoliquido, A, Proto, L, Tarquini, D, Grimaldi, M, Leonardi, S, Elia, A, Currao, A, Urtis, M, Di Toro, A, Giuliani, L, Caminiti, G, Marcolongo, F, Sposato, B, Guadagni, F, Morsella, V, Marziale, A, Protti, G, Baldassarre D., Iacoviello L., Baetta R., Roncaglioni M. C., Condorelli G., Remuzzi G., Gensini G., Frati L., Ricciardi W., Conaldi P. G., Uccelli A., Blandini F., Bosari S., Scambia G., Fini M., Di Malta A., Amato M., Veglia F., Bonomi A., Klersy C., Colazzo F., Pengo M., Gorini F., Auteri L., Ferrante G., Baviera M., Ambrosio G., Catapano A., Gialluisi A., Malavazos A. E., Castelvecchio S., Corsi-Romanelli M. M., Cardani R., La Rovere M. T., Agnese V., Pane B., Prati D., Spinardi L., Liuzzo G., Arbustini E., Volterrani M., Visconti M., Werba J. P., Genovese S., Bilo G., Invitti C., Di Blasio A., Lombardi C., Faini A., Rosa D., Ojeda-Fernandez L., Foresta A., De Curtis A., Di Castelnuovo A., Scalvini S., Pierobon A., Gorini A., Valenti L., Luzi L., Racca A., Bandi M., Tremoli E., Menicanti L., Parati G., Pompilio G., Colombo G., Vavassori C., Biondi M. L., Frigerio B., Ravani A., Sansaro D., Coggi D., Romandini A., Giroli M., Giuliani M., Bonmi A., Rondinelli M., Trudu C., Cinieri C., Monturano M., Colazo F., Inviti C., Di Blasi A., Torlasco C., Gilardini L., Soranna D., Zambon A., Perger E., Zanotti L., Badano L., Cova L., Gentilini D., Grappiolo L., Condoreli G., Ferante G., Papa L., Savevski V., Ieva F., Romano I., Remzzi G., Ojeda L., Clerici F., Palumbo A., Genini G. F., Catpano A., Mattioli R., Longhi E., Mantovani L. G., Madotto F., Bonaccio M., Gianfagna F., Ghulam A., Magnacca S., Noro F., Costanzo S., Esposito S., Orlandi S., Persichillo M., Bracone F., Panzera T., Ruggiero E., Parisi R., Franciosa S., Morelli M., De Rita F., Cerletti C., de Gaetano G., Donati M. B., Mencanti L., Romanelli M. M. C., Cerri A., Dubini C., Trevisan M. B., Renna L. V., Milani V., Boveri S., Giubbilini P., Ramputi L., Baroni I., De Angeli G., Riciardi W., Olmetti F., Bussotti M., Gaetano C., Baiardi P., Bachetti T., Balbi M., Comini L., Lorenzoni M., Olivares A., Traversi E., Garre C., Sideri R., Clemenza F., Gentile G., Caruana G., Cuscino N., Di Gesaro G., Greco A., Loddo I., Tuzzolino F., Ucelli A., Palombo D., Spinella G., Mozzetta G., Ameri P., Zoppoli G., Finotello A., Porto I., Pratesi G., Bladini F., Spnardi L., Clerici M., Pelusi S., Bianco C., Carpani R., Periti G., Margarita S., Lanza G. A., Severino A., Pedicino D., D'Amario D., D'Aiello A., Vinci R., Bonanni A., Brecciaroli M., Filomia S., Pastorino R., Boccia S., Urbani A., Sanguinetti M., Santoliquido A., Proto L., Tarquini D., Grimaldi M. C., Leonardi S., Elia A., Currao A., Urtis M., Di Toro A., Giuliani L., Caminiti G., Marcolongo F., Sposato B., Guadagni F., Morsella V., Marziale A., and Protti G.

Abstract

Introduction Prevention of cardiovascular disease (CVD) is of key importance in reducing morbidity, disability and mortality worldwide. Observational studies suggest that digital health interventions can be an effective strategy to reduce cardiovascular (CV) risk. However, evidence from large randomised clinical trials is lacking. Methods and analysis The CV-PREVITAL study is a multicentre, prospective, randomised, controlled, open-label interventional trial designed to compare the effectiveness of an educational and motivational mobile health (mHealth) intervention versus usual care in reducing CV risk. The intervention aims at improving diet, physical activity, sleep quality, psycho-behavioural aspects, as well as promoting smoking cessation and adherence to pharmacological treatment for CV risk factors. The trial aims to enrol approximately 80 000 subjects without overt CVDs referring to general practitioners' offices, community pharmacies or clinics of Scientific Institute for Research, Hospitalization and Health Care (Italian acronym IRCCS) affiliated with the Italian Cardiology Network. All participants are evaluated at baseline and after 12 months to assess the effectiveness of the intervention on short-term endpoints, namely improvement in CV risk score and reduction of major CV risk factors. Beyond the funded life of the study, a long-term (7 years) follow-up is also planned to assess the effectiveness of the intervention on the incidence of major adverse CV events. A series of ancillary studies designed to evaluate the effect of the mHealth intervention on additional risk biomarkers are also performed. Ethics and dissemination This study received ethics approval from the ethics committee of the coordinating centre (Monzino Cardiology Center; R1256/20-CCM 1319) and from all other relevant IRBs and ethics committees. Findings are disseminated through scientific meetings and peer-reviewed journals and via social media. Partners are informed about the study's

Published
2023

9. Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study

Author

Iacoviello, L., Donati, M.B., de Gaetano, G., Vermylen, J., De Paula Carrasco, I., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., Spagnuolo, P., Staniscia, D., Zito, F., Bonanni, A., Cerletti, C., De Curtis, A., Di Castelnuovo, A., Lorenzet, R., Mascioli, A., Olivieri, M., Rotilio, D., Bonaccio, M., Costanzo, S., Gianfagna, F., Giacci, M., Padulo, A., Petraroia, D., Magnacca, S., Marracino, F., Spinelli, M., Silvestri, C., dell’Elba, G., Grippi, C., De Lucia, F., Vohnout, B., Persichillo, M., Verna, A., Di Lillo, M., Di Stefano, I., Pampuch, A., Pannichella, A., Vizzarri, A.R., Arcari, A., Barbato, D., Bracone, F., Di Giorgio, C., Panebianco, S., Chiovitti, A., Caccamo, S., Caruso, V., Rago, L., Cugino, D., Ferri, A., Castaldi, C., Mignogna, M., Guszcz, T., di Giuseppe, R., Barisciano, P., Buonaccorsi, L., Centritto, F., Cutrone, A., Fanelli, F., Santimone, I., Sciarretta, A., Sorella, I., Plescia, E., Molinaro, A., Cavone, C., Galuppo, G., D'Angelo, D., Ramacciato, R., and Ruggiero, E.

Published
2017
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11. Respective Effects of Helmet Pressure Support, Continuous Positive Airway Pressure, and Nasal High-Flow in Hypoxemic Respiratory Failure: A Randomized Crossover Clinical Trial

Author

Menga, Luca Salvatore, Delle Cese, Luca, Rosa, T., Cesarano, M., Scarascia, R., Michi, T., Biasucci, Daniele Guerino, Ruggiero, E., Dell'Anna, Antonio Maria, Cutuli, Salvatore Lucio, Tanzarella, E. S., Pintaudi, G., De Pascale, Gennaro, Sandroni, Claudio, Maggiore, S. M., Grieco, Domenico Luca, Antonelli, Massimo, Menga L. S., Delle Cese L., Biasucci D. G., Dell'Anna A. M., Cutuli S. L., De Pascale G. (ORCID:0000-0002-8255-0676), Sandroni C. (ORCID:0000-0002-8878-2611), Grieco D. L. (ORCID:0000-0002-4557-6308), Antonelli M. (ORCID:0000-0003-3007-1670), Menga, Luca Salvatore, Delle Cese, Luca, Rosa, T., Cesarano, M., Scarascia, R., Michi, T., Biasucci, Daniele Guerino, Ruggiero, E., Dell'Anna, Antonio Maria, Cutuli, Salvatore Lucio, Tanzarella, E. S., Pintaudi, G., De Pascale, Gennaro, Sandroni, Claudio, Maggiore, S. M., Grieco, Domenico Luca, Antonelli, Massimo, Menga L. S., Delle Cese L., Biasucci D. G., Dell'Anna A. M., Cutuli S. L., De Pascale G. (ORCID:0000-0002-8255-0676), Sandroni C. (ORCID:0000-0002-8878-2611), Grieco D. L. (ORCID:0000-0002-4557-6308), and Antonelli M. (ORCID:0000-0003-3007-1670)

Published
2023

12. Salt content of prepacked cereal-based products and their potential contribution to salt intake of the Italian adult population: Results from a simulation study

Author

Vici, G., Rosi, A., Angelino, D., Polzonetti, V., Scazzina, F., Pellegrini, N., Martini, D., Dall'Asta, Margherita, Moccia, S., Veneto, D. N., Paolella, G., Pignone, V., Ruggiero, E., Spagnuolo, C., Dall'Asta M. (ORCID:0000-0002-0558-0337), Vici, G., Rosi, A., Angelino, D., Polzonetti, V., Scazzina, F., Pellegrini, N., Martini, D., Dall'Asta, Margherita, Moccia, S., Veneto, D. N., Paolella, G., Pignone, V., Ruggiero, E., Spagnuolo, C., and Dall'Asta M. (ORCID:0000-0002-0558-0337)

Abstract

Background and aims: High sodium intake is one of the main risk factors for noncommunicable diseases, and its consumption should be reduced. This study aimed to simulate changes in the daily salt intake of the Italian adult population based on consumption scenarios of prepacked cereal-based foods sold in Italy. Methods and results: Information on food packages was retrieved from 2893 cereal-based products. Potential changes in salt intake were simulated based on food consumption scenarios that consider the daily consumption of cereal-based products suggested in the Italian Dietary Guidelines and their current daily consumption by Italian adults. The highest salt content was retrieved in bread (median, 25th-75th percentile: 1.3, 1.1-1.4 g/100 g) and bread substitutes (1.8, 1.0-2.2 g/100 g). If the suggested daily amounts were consumed, bread would contribute to 44% of the 5 g salt/day target, whereas bread substitutes, breakfast cereals, biscuits and sweet snacks would marginally contribute (1-2%). Compared to bread with median salt content, a -44% and +10% salt intake would be observed if products within the first and the last quartile of salt content were chosen, respectively. However, considering the actual intake of Italian consumers, bread would cover 25% and bread substitutes 7% of the daily salt target. Conclusion: Food labels have a pivotal role and efforts are required to encourage consumers to use them to make healthy choices. Moreover, these results may contribute to setting sodium benchmarks in cereal-based products and encourage the food industry to reduce the salt content in the products.

Published
2023

15. Piloting an evidence-based intervention for HIV prevention among street youth in Eldoret, Kenya

Author

Embleton, L., Di Ruggiero, E., Logie, C. H., Ayuku, D., and Braitstein, P.

Abstract

Objectives: This study presents findings from piloting an adapted evidence-based intervention, Stepping Stones and Creating Futures, to change street-connected young people’s HIV knowledge, condom-use self-efficacy, and sexual practices. Methods: Eighty street-connected young people participated in a pre- and post-test mixed methods design in Eldoret, Kenya. The primary outcome of interest was HIV knowledge. Secondary outcomes included condom-use self-efficacy and sexual practices. Multiple linear regression models for change scores with adjustment for socio-demographic variables were fitted. Qualitative and quantitative findings are presented together, where integration confirms, expands on, or uncovers discordant findings. Results: Participants had a significant increase in HIV knowledge from pre- to post-intervention. The median HIV knowledge score pre-intervention was 11 (IQR 8–13) and post-intervention 14 (IQR 12–16). Attendance was significantly associated with HIV knowledge change scores. Qualitatively participants reported increased HIV and condom-use knowledge and improved condom-use self-efficacy and health-seeking practices. Conclusions: Our findings support the potential for further testing with a rigorous study design to investigate how best to tailor the intervention, particularly by gender, and increase the overall effectiveness of the program.

Published
2024
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18. Egg consumption and risk of all-cause and cause-specific mortality in an Italian adult population

Author

Ruggiero, E, Di Castelnuovo, A, Costanzo, S, Persichillo, M, De Curtis, A, Cerletti, C, Donati, Mb, de Gaetano, G, Iacoviello, L, Bonaccio, M, Moli-sani Study Investigators: Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Marialaura, Bonaccio, Americo, Bonanni, Chiara, Cerletti, Simona, Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Francesco, Gianfagna, Mariarosaria, Persichillo, Teresa Di Prospero, Jos, Vermylen, Ignacio De Paula Carrasco, Antonio, Spagnuolo, Deodato, Assanelli, Vincenzo, Centritto, Marco, Olivieri, Teresa, Panzera, Marialaura Bonaccio Simona Costanzo Simona Esposito, Gialluisi, A, Emilia, Ruggiero, Sara, Magnacca, Benedetta, Izzi, Annalisa, Marotta, Fabrizia, Noro, Roberta, Parisi, Alfonsina, Tirozzi, Francesca, Bracone, Francesca De Lucia, Cristiana, Mignogna, and Livia, Rago

Subjects
Adult, Male, Mediterranean diet, Eggs, Medicine (miscellaneous), Physiology, Blood lipids, Disease, 030204 cardiovascular system & hematology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Cause of Death, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Mortality risk, Cause of death, Nutrition and Dietetics, business.industry, Hazard ratio, Original Contribution, Dietary cholesterol, Diet, Italy, Cardiovascular Diseases, Cohort, Female, business, Cohort study
Abstract

Purpose Dietary guidelines recommend to limit egg consumption to 4 servings per week but the relation between egg intake and health outcomes is still controversial. To evaluate the association of egg consumption and mortality risk in Italian adults and to investigate nutritional factors and serum lipids as potentially explaining such associations. Methods Longitudinal analysis on 20,562 men and women aged ≥ 35y, free from cardiovascular disease (CVD) and cancer belonging to the Moli-sani Study cohort (enrolled 2005–2010) followed up for a median of 8.2 years. Results In multivariable-adjusted analysis as compared to low intake (> 0 ≤ 1 egg/week), eating > 4 eggs/week led to an increased risk of all-cause (Hazard ratio [HR] = 1.50; 95%CI 1.13–1.99), CVD (HR = 1.75; 1.07–2.87) and cancer mortality (HR = 1.52; 0.99–2.33). Similarly, an intake of 2–4 eggs/week was associated with higher all-cause (HR = 1.22; 1.01–1.46) and CVD mortality risk (HR = 1.43; 1.03–1.97). An increase of 1 egg per week was associated with higher mortality risk among high-risk individuals, such as those with hypertension and hyperlipidaemia. Dietary cholesterol explained about 43.0% and 39.3% (p values e.g., total cholesterol) accounted for a small proportion of egg-mortality relation. Conclusions Among Italian adults, high egg consumption leads to an increased risk of all-cause and CVD mortality, with the risk being evident even at the recommended intake of 2–4 eggs per week. A substantial part of this association was likely due to the egg contribution to dietary cholesterol. Our findings suggest limiting the consumption of eggs in the diet and these results should be considered in the development of dietary guidelines and updates.

Published
2021
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19. Evaluation of nutritional quality of biscuits and sweet snacks sold on the Italian market: the Food Labelling of Italian Products (FLIP) study

Author

Dall'Asta, Margherita, Rosi, A., Angelino, D., Pellegrini, N., Martini, D., Nucci, D., Paolella, G., Ruggiero, E., Pignone, V., Moccia, S., Spagnuolo, C., and Dello Russo, M.

Subjects
Nutrition declaration, Salt content, media_common.quotation_subject, Medicine (miscellaneous), Nutritional quality, Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE, Toxicology, Diet, Gluten-Free, Health claims on food labels, Food Labeling, Food labelling, Gluten-free, Health claims, Nutrition claims, Quality (business), Product (category theory), media_common, Nutrition and Dietetics, Public Health, Environmental and Occupational Health, Product type, Italy, Gluten free, Business, Snacks, Nutritive Value, Research Paper
Abstract

Objective:The present study aimed at surveying the nutritional quality of prepacked biscuits and sweet snacks sold on the Italian market, and at identifying whether the product type and other information reported on the pack could discriminate the overall quality of products analysed.Design:Data on energy, nutrient and salt content of the products from two different categories of prepacked sweet cereal products (i.e. biscuits and sweet snacks) were collected from thirteen retailers present on the Italian market. Based on the product type, nutrition and health claim (NHC) and gluten-free (GF) declaration, a comparison of nutrient profile within each category was performed.Setting:This work is part of the Food Labelling of Italian Products (FLIP) study that aims at systematically investigating the overall quality of the prepacked foods sold on the Italian market.Results:A total of 1290 products were analysed (63 % biscuits and 37 % sweet snacks). After comparing different product types within each category, a high intra-type product variability was evidenced, which was more pronounced for biscuits. Overall, NHC-carrying products seemed to have a better nutrition profile than those without claims, except for salt content. Conversely, a comparison between GF and gluten-containing products did not show consistent results within the two categories analysed.Conclusions:Due to the high intra-type variability within each category, the different characteristics and regulated information reported on the pack do not seem to be a clear marker of the overall nutritional quality of biscuits and snacks.

Published
2020
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20. Evaluating research co-production: protocol for the Research Quality Plus for Co-Production (RQ+ 4 Co-Pro) framework

Author

McLean, RKD, Carden, F, Graham, ID, Aiken, AB, Armstrong, R, Bray, J, Cassidy, CE, Daub, O, Di Ruggiero, E, Fierro, LA, Gagnon, M, Hutchinson, Alison, Kislov, R, Kothari, A, Kreindler, S, McCutcheon, C, Reszel, J, Scarrow, G, McLean, RKD, Carden, F, Graham, ID, Aiken, AB, Armstrong, R, Bray, J, Cassidy, CE, Daub, O, Di Ruggiero, E, Fierro, LA, Gagnon, M, Hutchinson, Alison, Kislov, R, Kothari, A, Kreindler, S, McCutcheon, C, Reszel, J, and Scarrow, G

Abstract

Abstract Background Research co-production is an umbrella term used to describe research users and researchers working together to generate knowledge. Research co-production is used to create knowledge that is relevant to current challenges and to increase uptake of that knowledge into practice, programs, products, and/or policy. Yet, rigorous theories and methods to assess the quality of co-production are limited. Here we describe a framework for assessing the quality of research co-production—Research Quality Plus for Co-Production (RQ+ 4 Co-Pro)—and outline our field test of this approach. Methods Using a co-production approach, we aim to field test the relevance and utility of the RQ+ 4 Co-Pro framework. To do so, we will recruit participants who have led research co-production projects from the international Integrated Knowledge Translation Research Network. We aim to sample 16 to 20 co-production project leads, assign these participants to dyadic groups (8 to 10 dyads), train each participant in the RQ+ 4 Co-Pro framework using deliberative workshops and oversee a simulation assessment exercise using RQ+ 4 Co-Pro within dyadic groups. To study this experience, we use a qualitative design to collect participant demographic information and project demographic information and will use in-depth semi-structured interviews to collect data related to the experience each participant has using the RQ+ 4 Co-Pro framework. Discussion This study will yield knowledge about a new way to assess research co-production. Specifically, it will address the relevance and utility of using RQ+ 4 Co-Pro, a framework that includes context as an inseparable component of research, identifies dimensions of quality matched to the aims of co-production, and applies a systematic and tra

Published
2022

21. Time to evolve: predicting engineered T cell-associated toxicity with next-generation models

Author

Donnadieu, E., Luu, M., Alb, M., Anliker, B., Arcangeli, S., Bonini, C., De Angelis, B., Choudhary, R., Espie, D., Galy, A., Holland, C., Ivics, Z., Kantari-Mimoun, C., Kersten, M. J., Kohl, U., Kuhn, C., Laugel, B., Locatelli, Franco, Marchiq, I., Markman, J., Moresco, M. A., Morris, E., Negre, H., Quintarelli, C., Rade, M., Reiche, K., Renner, M., Ruggiero, E., Sanges, C., Stauss, H., Themeli, M., Van den Brulle, J., Hudecek, M., Casucci, M., Locatelli F. (ORCID:0000-0002-7976-3654), Donnadieu, E., Luu, M., Alb, M., Anliker, B., Arcangeli, S., Bonini, C., De Angelis, B., Choudhary, R., Espie, D., Galy, A., Holland, C., Ivics, Z., Kantari-Mimoun, C., Kersten, M. J., Kohl, U., Kuhn, C., Laugel, B., Locatelli, Franco, Marchiq, I., Markman, J., Moresco, M. A., Morris, E., Negre, H., Quintarelli, C., Rade, M., Reiche, K., Renner, M., Ruggiero, E., Sanges, C., Stauss, H., Themeli, M., Van den Brulle, J., Hudecek, M., Casucci, M., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are associated with serious adverse events, including cytokine release syndrome and neurotoxicity. These toxicities are sometimes so severe that they significantly hinder the implementation of this therapeutic strategy. For a long time, existing preclinical models failed to predict severe toxicities seen in human clinical trials after engineered T-cell infusion. However, in recent years, there has been a concerted effort to develop models, including humanized mouse models, which can better recapitulate toxicities observed in patients. The Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy (T2EVOLVE) consortium is a public-private partnership directed at accelerating the preclinical development and increasing access to engineered T-cell therapy for patients with cancer. A key ambition in T2EVOLVE is to design new models and tools with higher predictive value for clinical safety and efficacy, in order to improve and accelerate the selection of lead T-cell products for clinical translation. Herein, we review existing preclinical models that are used to test the safety of engineered T cells. We will also highlight limitations of these models and propose potential measures to improve them.

Published
2022

22. BIODIVERSITY ASSOCIATED WITH THE CORALLIGENOUS: THE CASE OF A COLUMNAR BUILD-UP AT 36m DEPTH OFF MARZAMEMI (SE SICILY, IONIAN SEA) Gemma Donato, Rosso A., Sanfilippo R., Sciuto F., D’Alpa F., Taddei Ruggiero E., Bracchi V.A., Bazzicalupo P., Serio D., Leonardi R., Viola A., Guido A., Negri M.P., Bertolino M., Costa G., Basso D

Author

Donato, GEMMA MARIA ELISA, Rosso, A., Sanfilippo, R., Sciuto, F., D'Alpa, Francesco, Taddei Ruggiero, E., Bracchi, V. A., Bazzicalupo, P., Serio, D., Leonardi, R., Viola, A., Guido, A., Negri, M. P., Bertolino, M., Costa, G., and Basso, D.

Published
2022

23. TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

Author

Manfredi, F, Cianciotti, B, Potenza, A, Tassi, E, Noviello, M, Biondi, A, Ciceri, F, Bonini, C, Ruggiero, E, Manfredi F., Cianciotti B. C., Potenza A., Tassi E., Noviello M., Biondi A., Ciceri F., Bonini C., Ruggiero E., Manfredi, F, Cianciotti, B, Potenza, A, Tassi, E, Noviello, M, Biondi, A, Ciceri, F, Bonini, C, Ruggiero, E, Manfredi F., Cianciotti B. C., Potenza A., Tassi E., Noviello M., Biondi A., Ciceri F., Bonini C., and Ruggiero E.

Abstract

Adoptive T cell therapy (ACT) is a rapidly evolving therapeutic approach designed to harness T cell specificity and function to fight diseases. Based on the evidence that T lymphocytes can mediate a potent anti-tumor response, initially ACT solely relied on the isolation, in vitro expansion, and infusion of tumor-infiltrating or circulating tumor-specific T cells. Although effective in a subset of cases, in the first ACT clinical trials several patients experienced disease progression, in some cases after temporary disease control. This evidence prompted researchers to improve ACT products by taking advantage of the continuously evolving gene engineering field and by improving manufacturing protocols, to enable the generation of effective and long-term persisting tumor-specific T cell products. Despite recent advances, several challenges, including prioritization of antigen targets, identification, and optimization of tumor-specific T cell receptors, in the development of tools enabling T cells to counteract the immunosuppressive tumor microenvironment, still need to be faced. This review aims at summarizing the major achievements, hurdles and possible solutions designed to improve the ACT efficacy and safety profile in the context of liquid and solid tumors.

Published
2020

24. Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Author

Romagnoni, A., Jegou, S., Van Steen, K., Wainrib, G., Hugot, J. -P., Peyrin-Biroulet, L., Chamaillard, M., Colombel, J. -F., Cottone, M., D'Amato, M., D'Inca, R., Halfvarson, J., Henderson, P., Karban, A., Kennedy, N. A., Khan, M. A., Lemann, M., Levine, A., Massey, D., Milla, M., S. M. E., Ng, Oikonomou, I., Peeters, H., Proctor, D. D., Rahier, J. -F., Rutgeerts, P., Seibold, F., Stronati, L., Taylor, K. M., Torkvist, L., Ublick, K., Van Limbergen, J., Van Gossum, A., Vatn, M. H., Zhang, H., Zhang, W., Andrews, J. M., Bampton, P. A., Barclay, M., Florin, T. H., Gearry, R., Krishnaprasad, K., Lawrance, I. C., Mahy, G., Montgomery, G. W., Radford-Smith, G., Roberts, R. L., Simms, L. A., Hanigan, K., Croft, A., Amininijad, L., Cleynen, I., Dewit, O., Franchimont, D., Georges, M., Laukens, D., Theatre, E., Vermeire, S., Aumais, G., Baidoo, L., Barrie, A. M., Beck, K., Bernard, E. -J., Binion, D. G., Bitton, A., Brant, S. R., Cho, J. H., Cohen, A., Croitoru, K., Daly, M. J., Datta, L. W., Deslandres, C., Duerr, R. H., Dutridge, D., Ferguson, J., Fultz, J., Goyette, P., Greenberg, G. R., Haritunians, T., Jobin, G., Katz, S., Lahaie, R. G., Mcgovern, D. P., Nelson, L., S. M., Ng, Ning, K., Pare, P., Regueiro, M. D., Rioux, J. D., Ruggiero, E., Schumm, L. P., Schwartz, M., Scott, R., Sharma, Y., Silverberg, M. S., Spears, D., Steinhart, A. H., Stempak, J. M., Swoger, J. M., Tsagarelis, C., Zhang, C., Zhao, H., Aerts, J., Ahmad, T., Arbury, H., Attwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barnes, C., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Byrnes, J., Caesar, S., Cardin, N., Clee, C. M., Coffey, A. J., MC Connell, J., Conrad, D. F., Cooper, J. D., Dominiczak, A. F., Downes, K., Drummond, H. E., Dudakia, D., Dunham, A., Ebbs, B., Eccles, D., Edkins, S., Edwards, C., Elliot, A., Emery, P., Evans, D. M., Evans, G., Eyre, S., Farmer, A., Ferrier, I. N., Flynn, E., Forbes, A., Forty, L., Franklyn, J. A., Frayling, T. M., Freathy, R. M., Giannoulatou, E., Gibbs, P., Gilbert, P., Gordon-Smith, K., Gray, E., Green, E., Groves, C. J., Grozeva, D., Gwilliam, R., Hall, A., Hammond, N., Hardy, M., Harrison, P., Hassanali, N., Hebaishi, H., Hines, S., Hinks, A., Hitman, G. A., Hocking, L., Holmes, C., Howard, E., Howard, P., Howson, J. M. M., Hughes, D., Hunt, S., Isaacs, J. D., Jain, M., Jewell, D. P., Johnson, T., Jolley, J. D., Jones, I. R., Jones, L. A., Kirov, G., Langford, C. F., Lango-Allen, H., Lathrop, G. M., Lee, J., Lee, K. L., Lees, C., Lewis, K., Lindgren, C. M., Maisuria-Armer, M., Maller, J., Mansfield, J., Marchini, J. L., Martin, P., Massey, D. C., Mcardle, W. L., Mcguffin, P., Mclay, K. E., Mcvean, G., Mentzer, A., Mimmack, M. L., Morgan, A. E., Morris, A. P., Mowat, C., Munroe, P. B., Myers, S., Newman, W., Nimmo, E. R., O'Donovan, M. C., Onipinla, A., Ovington, N. R., Owen, M. J., Palin, K., Palotie, A., Parnell, K., Pearson, R., Pernet, D., Perry, J. R., Phillips, A., Plagnol, V., Prescott, N. J., Prokopenko, I., Quail, M. A., Rafelt, S., Rayner, N. W., Reid, D. M., Renwick, A., Ring, S. M., Robertson, N., Robson, S., Russell, E., Clair, D. S., Sambrook, J. G., Sanderson, J. D., Sawcer, S. J., Schuilenburg, H., Scott, C. E., Seal, S., Shaw-Hawkins, S., Shields, B. M., Simmonds, M. J., Smyth, D. J., Somaskantharajah, E., Spanova, K., Steer, S., Stephens, J., Stevens, H. E., Stirrups, K., Stone, M. A., Strachan, D. P., Su, Z., Symmons, D. P. M., Thompson, J. R., Thomson, W., Tobin, M. D., Travers, M. E., Turnbull, C., Vukcevic, D., Wain, L. V., Walker, M., Walker, N. M., Wallace, C., Warren-Perry, M., Watkins, N. A., Webster, J., Weedon, M. N., Wilson, A. G., Woodburn, M., Wordsworth, B. P., Yau, C., Young, A. H., Zeggini, E., Brown, M. A., Burton, P. R., Caulfield, M. J., Compston, A., Farrall, M., Gough, S. C. L., Hall, A. S., Hattersley, A. T., Hill, A. V. S., Mathew, C. G., Pembrey, M., Satsangi, J., Stratton, M. R., Worthington, J., Hurles, M. E., Duncanson, A., Ouwehand, W. H., Parkes, M., Rahman, N., Todd, J. A., Samani, N. J., Kwiatkowski, D. P., Mccarthy, M. I., Craddock, N., Deloukas, P., Donnelly, P., Blackwell, J. M., Bramon, E., Casas, J. P., Corvin, A., Jankowski, J., Markus, H. S., Palmer, C. N., Plomin, R., Rautanen, A., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Pirinen, M., Strange, A., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Jayakumar, A., Mccann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Romagnoni, A., Jegou, S., Van Steen, K., Wainrib, G., Hugot, J. -P., Peyrin-Biroulet, L., Chamaillard, M., Colombel, J. -F., Cottone, M., D'Amato, M., D'Inca, R., Halfvarson, J., Henderson, P., Karban, A., Kennedy, N. A., Khan, M. A., Lemann, M., Levine, A., Massey, D., Milla, M., Ng, S. M. E., Oikonomou, I., Peeters, H., Proctor, D. D., Rahier, J. -F., Rutgeerts, P., Seibold, F., Stronati, L., Taylor, K. M., Torkvist, L., Ublick, K., Van Limbergen, J., Van Gossum, A., Vatn, M. H., Zhang, H., Zhang, W., Andrews, J. M., Bampton, P. A., Barclay, M., Florin, T. H., Gearry, R., Krishnaprasad, K., Lawrance, I. C., Mahy, G., Montgomery, G. W., Radford-Smith, G., Roberts, R. L., Simms, L. A., Hanigan, K., Croft, A., Amininijad, L., Cleynen, I., Dewit, O., Franchimont, D., Georges, M., Laukens, D., Theatre, E., Vermeire, S., Aumais, G., Baidoo, L., Barrie, A. M., Beck, K., Bernard, E. -J., Binion, D. G., Bitton, A., Brant, S. R., Cho, J. H., Cohen, A., Croitoru, K., Daly, M. J., Datta, L. W., Deslandres, C., Duerr, R. H., Dutridge, D., Ferguson, J., Fultz, J., Goyette, P., Greenberg, G. R., Haritunians, T., Jobin, G., Katz, S., Lahaie, R. G., Mcgovern, D. P., Nelson, L., Ng, S. M., Ning, K., Pare, P., Regueiro, M. D., Rioux, J. D., Ruggiero, E., Schumm, L. P., Schwartz, M., Scott, R., Sharma, Y., Silverberg, M. S., Spears, D., Steinhart, A. H., Stempak, J. M., Swoger, J. M., Tsagarelis, C., Zhang, C., Zhao, H., Aerts, J., Ahmad, T., Arbury, H., Attwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barnes, C., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Byrnes, J., Caesar, S., Cardin, N., Clee, C. M., Coffey, A. J., MC Connell, J., Conrad, D. F., Cooper, J. D., Dominiczak, A. F., Downes, K., Drummond, H. E., Dudakia, D., Dunham, A., Ebbs, B., Eccles, D., Edkins, S., Edwards, C., Elliot, A., Emery, P., Evans, D. M., Evans, G., Eyre, S., Farmer, A., Ferrier, I. N., Flynn, E., Forbes, A., Forty, L., Franklyn, J. A., Frayling, T. M., Freathy, R. M., Giannoulatou, E., Gibbs, P., Gilbert, P., Gordon-Smith, K., Gray, E., Green, E., Groves, C. J., Grozeva, D., Gwilliam, R., Hall, A., Hammond, N., Hardy, M., Harrison, P., Hassanali, N., Hebaishi, H., Hines, S., Hinks, A., Hitman, G. A., Hocking, L., Holmes, C., Howard, E., Howard, P., Howson, J. M. M., Hughes, D., Hunt, S., Isaacs, J. D., Jain, M., Jewell, D. P., Johnson, T., Jolley, J. D., Jones, I. R., Jones, L. A., Kirov, G., Langford, C. F., Lango-Allen, H., Lathrop, G. M., Lee, J., Lee, K. L., Lees, C., Lewis, K., Lindgren, C. M., Maisuria-Armer, M., Maller, J., Mansfield, J., Marchini, J. L., Martin, P., Massey, D. C., Mcardle, W. L., Mcguffin, P., Mclay, K. E., Mcvean, G., Mentzer, A., Mimmack, M. L., Morgan, A. E., Morris, A. P., Mowat, C., Munroe, P. B., Myers, S., Newman, W., Nimmo, E. R., O'Donovan, M. C., Onipinla, A., Ovington, N. R., Owen, M. J., Palin, K., Palotie, A., Parnell, K., Pearson, R., Pernet, D., Perry, J. R., Phillips, A., Plagnol, V., Prescott, N. J., Prokopenko, I., Quail, M. A., Rafelt, S., Rayner, N. W., Reid, D. M., Renwick, A., Ring, S. M., Robertson, N., Robson, S., Russell, E., Clair, D. S., Sambrook, J. G., Sanderson, J. D., Sawcer, S. J., Schuilenburg, H., Scott, C. E., Seal, S., Shaw-Hawkins, S., Shields, B. M., Simmonds, M. J., Smyth, D. J., Somaskantharajah, E., Spanova, K., Steer, S., Stephens, J., Stevens, H. E., Stirrups, K., Stone, M. A., Strachan, D. P., Su, Z., Symmons, D. P. M., Thompson, J. R., Thomson, W., Tobin, M. D., Travers, M. E., Turnbull, C., Vukcevic, D., Wain, L. V., Walker, M., Walker, N. M., Wallace, C., Warren-Perry, M., Watkins, N. A., Webster, J., Weedon, M. N., Wilson, A. G., Woodburn, M., Wordsworth, B. P., Yau, C., Young, A. H., Zeggini, E., Brown, M. A., Burton, P. R., Caulfield, M. J., Compston, A., Farrall, M., Gough, S. C. L., Hall, A. S., Hattersley, A. T., Hill, A. V. S., Mathew, C. G., Pembrey, M., Satsangi, J., Stratton, M. R., Worthington, J., Hurles, M. E., Duncanson, A., Ouwehand, W. H., Parkes, M., Rahman, N., Todd, J. A., Samani, N. J., Kwiatkowski, D. P., Mccarthy, M. I., Craddock, N., Deloukas, P., Donnelly, P., Blackwell, J. M., Bramon, E., Casas, J. P., Corvin, A., Jankowski, J., Markus, H. S., Palmer, C. N., Plomin, R., Rautanen, A., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Pirinen, M., Strange, A., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Jayakumar, A., Mccann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Daly, Mark J. [0000-0002-0949-8752], Apollo - University of Cambridge Repository, Hugot, Jean-Pierre [0000-0002-8446-6056], UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Romagnoni, A, Jegou, S, VAN STEEN, Kristel, Wainrib, G, Hugot, JP, Peyrin-Biroulet, L, Chamaillard, M, Colombel, JF, Cottone, M, D'Amato, M, D'Inca, R, Halfvarson, J, Henderson, P, Karban, A, Kennedy, NA, Khan, MA, Lemann, M, Levine, A, Massey, D, Milla, M, Ng, SME, Oikonomou, I, Peeters, H, Proctor, DD, Rahier, JF, Rutgeerts, P, Seibold, F, Stronati, L, Taylor, KM, Torkvist, L, Ublick, K, Van Limbergen, J, Van Gossum, A, Vatn, MH, Zhang, H, Zhang, W, Andrews, JM, Bampton, PA, Barclay, M, Florin, TH, Gearry, R, Krishnaprasad, K, Lawrance, IC, Mahy, G, Montgomery, GW, Radford-Smith, G, Roberts, RL, Simms, LA, Hanigan, K, Croft, A, Amininijad, L, Cleynen, I, Dewit, O, Franchimont, D, Georges, M, Laukens, D, Theatre, E, Vermeire, S, Aumais, G, Baidoo, L, Barrie, AM, Beck, K, Bernard, EJ, Binion, DG, Bitton, A, Brant, SR, Cho, JH, Cohen, A, Croitoru, K, Daly, MJ, Datta, LW, Deslandres, C, Duerr, RH, Dutridge, D, Ferguson, J, Fultz, J, Goyette, P, Greenberg, GR, Haritunians, T, Jobin, G, Katz, S, Lahaie, RG, McGovern, DP, Nelson, L, Ng, SM, Ning, K, Pare, P, Regueiro, MD, Rioux, JD, Ruggiero, E, Schumm, LP, Schwartz, M, Scott, R, Sharma, Y, Silverberg, MS, Spears, D, Steinhart, AH, Stempak, JM, Swoger, JM, Tsagarelis, C, Zhang, C, Zhao, HY, AERTS, Jan, Ahmad, T, Arbury, H, Attwood, A, Auton, A, Ball, SG, Balmforth, AJ, Barnes, C, Barrett, JC, Barroso, I, Barton, A, Bennett, AJ, Bhaskar, S, Blaszczyk, K, Bowes, J, Brand, OJ, Braund, PS, Bredin, F, Breen, G, Brown, MJ, Bruce, IN, Bull, J, Burren, OS, Burton, J, Byrnes, J, Caesar, S, Cardin, N, Clee, CM, Coffey, AJ, Mc Connell, J, Conrad, DF, Cooper, JD, Dominiczak, AF, Downes, K, Drummond, HE, Dudakia, D, Dunham, A, Ebbs, B, Eccles, D, Edkins, S, Edwards, C, Elliot, A, Emery, P, Evans, DM, Evans, G, Eyre, S, Farmer, A, Ferrier, IN, Flynn, E, Forbes, A, Forty, L, Franklyn, JA, Frayling, TM, Freathy, RM, Giannoulatou, E, Gibbs, P, Gilbert, P, Gordon-Smith, K, Gray, E, Green, E, Groves, CJ, Grozeva, D, Gwilliam, R, Hall, A, Hammond, N, Hardy, M, Harrison, P, Hassanali, N, Hebaishi, H, Hines, S, Hinks, A, Hitman, GA, Hocking, L, Holmes, C, Howard, E, Howard, P, Howson, JMM, Hughes, D, Hunt, S, Isaacs, JD, Jain, M, Jewell, DP, Johnson, T, Jolley, JD, Jones, IR, Jones, LA, Kirov, G, Langford, CF, Lango-Allen, H, Lathrop, GM, Lee, J, Lee, KL, Lees, C, Lewis, K, Lindgren, CM, Maisuria-Armer, M, Maller, J, Mansfield, J, Marchini, JL, Martin, P, Massey, DCO, McArdle, WL, McGuffin, P, McLay, KE, McVean, G, Mentzer, A, Mimmack, ML, Morgan, AE, Morris, AP, Mowat, C, Munroe, PB, Myers, S, Newman, W, Nimmo, ER, O'Donovan, MC, Onipinla, A, Ovington, NR, Owen, MJ, Palin, K, Palotie, A, Parnell, K, Pearson, R, Pernet, D, Perry, JRB, Phillips, A, Plagnol, V, Prescott, NJ, Prokopenko, I, Quail, MA, Rafelt, S, Rayner, NW, Reid, DM, Renwick, A, Ring, SM, Robertson, N, Robson, S, Russell, E, St Clair, D, Sambrook, JG, Sanderson, JD, Sawcer, SJ, Schuilenburg, H, Scott, CE, Seal, S, Shaw-Hawkins, S, Shields, BM, Simmonds, MJ, Smyth, DJ, Somaskantharajah, E, Spanova, K, Steer, S, Stephens, J, Stevens, HE, Stirrups, K, Stone, MA, Strachan, DP, Su, Z, Symmons, DPM, Thompson, JR, Thomson, W, Tobin, MD, Travers, ME, Turnbull, C, Vukcevic, D, Wain, LV, Walker, M, Walker, NM, Wallace, C, Warren-Perry, M, Watkins, NA, Webster, J, Weedon, MN, Wilson, AG, Woodburn, M, Wordsworth, BP, Yau, C, Young, AH, Zeggini, E, Brown, MA, Burton, PR, Caulfield, MJ, Compston, A, Farrall, M, Gough, SCL, Hall, AS, Hattersley, AT, Hill, AVS, Mathew, CG, Pembrey, M, Satsangi, J, Stratton, MR, Worthington, J, Hurles, ME, Duncanson, A, Ouwehand, WH, Parkes, M, Rahman, N, Todd, JA, Samani, NJ, Kwiatkowski, DP, McCarthy, MI, Craddock, N, Deloukas, P, Donnelly, P, Blackwell, JM, Bramon, E, Casas, JP, Corvin, A, Jankowski, J, Markus, HS, Palmer, CNA, Plomin, R, Rautanen, A, Trembath, RC, Viswanathan, AC, Wood, NW, Spencer, CCA, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Pirinen, M, Strange, A, Blackburn, H, Bumpstead, SJ, Dronov, S, Gillman, M, Jayakumar, A, McCann, OT, Liddle, J, Potter, SC, Ravindrarajah, R, Ricketts, M, Waller, M, Weston, P, Widaa, S, Whittaker, P, and Kwiatkowski, D

Subjects
Male, 692/4020/1503/257/1402, Genotype, Genotyping Techniques, LOCI, 45/43, lcsh:Medicine, Polymorphism, Single Nucleotide, Crohn's disease, genetics, genome wide association, Article, Deep Learning, Crohn Disease, INDEL Mutation, Genetics research, Humans, genetics, Genetic Predisposition to Disease, 129, lcsh:Science, Alleles, Science & Technology, genome wide association, RISK PREDICTION, 45, Models, Genetic, lcsh:R, Decision Trees, 692/308/2056, ASSOCIATION, Multidisciplinary Sciences, Crohn's disease, Logistic Models, Nonlinear Dynamics, ROC Curve, Area Under Curve, Science & Technology - Other Topics, lcsh:Q, Female, Neural Networks, Computer, INFLAMMATORY-BOWEL-DISEASE, Genome-Wide Association Study
Abstract

Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural networks (NN). The main score used to compare the methods was the Area Under the ROC Curve (AUC) statistics. The impact of quality control (QC), imputing and coding methods on LR results showed that QC methods and imputation of missing genotypes may artificially increase the scores. At the opposite, neither the patient/control ratio nor marker preselection or coding strategies significantly affected the results. LR methods, including Lasso, Ridge and ElasticNet provided similar results with a maximum AUC of 0.80. GBT methods like XGBoost, LightGBM and CatBoost, together with dense NN with one or more hidden layers, provided similar AUC values, suggesting limited epistatic effects in the genetic architecture of the trait. ML methods detected near all the genetic variants previously identified by GWAS among the best predictors plus additional predictors with lower effects. The robustness and complementarity of the different methods are also studied. Compared to LR, non-linear models such as GBT or NN may provide robust complementary approaches to identify and classify genetic markers. Tis work was supported by Fondation pour la Recherche Médical (ref DEI20151234405) and Investissements d’Avenir programme ANR-11-IDEX-0005-02, Sorbonne Paris Cite, Laboratoire d’excellence INFLAMEX. Te authors thank the students that participated to the wisdom of the crowd exercise.

Published
2019

28. An upward trajectory in adherence to Mediterranean diet is associated with favourable changes in inflammation biomarkers

Author

Bonaccio, M., primary, Costanzo, S., additional, Di Castelnuovo, A., additional, Gialluisi, A., additional, De Curtis, A., additional, Persichillo, M., additional, Ruggiero, E., additional, Tabolacci, C., additional, Facchiano, F., additional, Cerletti, C., additional, Donati, M.B., additional, De Gaetano, G., additional, and Iacoviello, L., additional

Published
2021
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29. Association of a traditional Mediterranean diet and non-Mediterranean dietary patterns with biological age: cross-sectional findings from the Moli-sani Study cohort

Author

Esposito, S., primary, Gialluisi, A., additional, Costanzo, S., additional, Di Castelnuovo, A., additional, Ruggiero, E., additional, De Curtis, A., additional, Persichillo, M., additional, Cerletti, C., additional, Donati, M.B., additional, De Gaetano, G., additional, Iacoviello, L., additional, and Bonaccio, M., additional

Published
2021
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31. Highly processed foods intake is positively associated with pro-inflammatory potential of diet: cross-sectional analysis from the Moli-sani Study

Author

Mignogna, C., primary, Costanzo, S., additional, Ruggiero, E., additional, Shivappa, N., additional, Hebert, J.R., additional, Esposito, S., additional, Di Castelnuovo, A., additional, Persichillo, M., additional, Cerletti, C., additional, Donati, M.B., additional, De Gaetano, G., additional, Iacoviello, L., additional, and Bonaccio, M., additional

Published
2021
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32. Changes in ultra-processed food consumption during the first Italian lockdown following the COVID-19 pandemic and major correlates: results from two population-based cohorts

Author

Esposito, S., primary, Costanzo, S., additional, Ruggiero, E., additional, Persichillo, M., additional, Olivieri, M., additional, Di Castelnuovo, A., additional, Cerletti, C., additional, Donati, M.B., additional, De Gaetano, G., additional, Iacoviello, L., additional, and Bonaccio, M., additional

Published
2021
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33. Comparison of the Nutritional Quality of Branded and Private-Label Food Products Sold in Italy: Focus on the Cereal-Based Products Collected From the Food Labeling of Italian Products Study

Author

Angelino, D., Del Bo', C., Pellegrini, N., Martini, D., Dall'Asta, Margherita, Dello Russo, M., Nucci, D., Moccia, S., Paolella, G., Pignone, V., Rosi, A., Ruggiero, E., Spagnuolo, C., and Vici, G.

Subjects
0301 basic medicine, cereal, brand, food labeling, nutrition and health claims, nutrition declaration, private label, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, 030209 endocrinology & metabolism, Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE, Nutritional quality, 03 medical and health sciences, Agricultural science, 0302 clinical medicine, Food choice, Independent samples, TX341-641, Quality (business), Nutrition, Original Research, media_common, 030109 nutrition & dietetics, Nutrition and Dietetics, Nutrition. Foods and food supply, Food labeling, Nutrient content, Private label, Food products, Business, Food Science
Abstract

The packaged foods sold in food stores may be “private-label” products (PL), when branded by the supermarket, and “branded” products (BR). PL products are generally cheaper than the BR counterparts, and this can be perceived as a sign of general low quality by consumers, when items are compared with their branded counterparts. Thus, the aim of the present study was to compare the nutrient content of BR and PL cereal-based foods, by evaluating the nutritional declaration reported on the food pack of products on the home-shopping website of major retailers present on the Italian market. A total of 3,775 items (~58% BR and ~42% PL), collected in the period from July 2018 to March 2019 and updated in March 2020, were included in the final analysis. Data were analyzed by means of the Mann–Whitney nonparametric test for two independent samples for differences between BR and PL categories and types. Overall, BR products showed higher contents of total and saturates than PL items. When products were grouped for categories and types, items only differed for the content of total fats, saturates, total carbohydrates, proteins, and salt. No differences were instead found for energy and sugar contents among any of the categories. However, we did not find any consistency in the direction of results. These results could be useful for future education activities aimed to help consumers in making informed food choices.

Published
2021
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34. Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Author

Noviello, M, Manfredi, F, Ruggiero, E, Perini, T, Oliveira, G, Cortesi, F, De Simone, P, Toffalori, C, Gambacorta, V, Greco, R, Peccatori, J, Casucci, M, Casorati, G, Dellabona, P, Onozawa, M, Teshima, T, Griffioen, M, Halkes, C, Falkenburg, J, Stolzel, F, Altmann, H, Bornhauser, M, Waterhouse, M, Zeiser, R, Finke, J, Cieri, N, Bondanza, A, Vago, L, Ciceri, F, Bonini, C, Noviello M., Manfredi F., Ruggiero E., Perini T., Oliveira G., Cortesi F., De Simone P., Toffalori C., Gambacorta V., Greco R., Peccatori J., Casucci M., Casorati G., Dellabona P., Onozawa M., Teshima T., Griffioen M., Halkes C. J. M., Falkenburg J. H. F., Stolzel F., Altmann H., Bornhauser M., Waterhouse M., Zeiser R., Finke J., Cieri N., Bondanza A., Vago L., Ciceri F., Bonini C., Noviello, M, Manfredi, F, Ruggiero, E, Perini, T, Oliveira, G, Cortesi, F, De Simone, P, Toffalori, C, Gambacorta, V, Greco, R, Peccatori, J, Casucci, M, Casorati, G, Dellabona, P, Onozawa, M, Teshima, T, Griffioen, M, Halkes, C, Falkenburg, J, Stolzel, F, Altmann, H, Bornhauser, M, Waterhouse, M, Zeiser, R, Finke, J, Cieri, N, Bondanza, A, Vago, L, Ciceri, F, Bonini, C, Noviello M., Manfredi F., Ruggiero E., Perini T., Oliveira G., Cortesi F., De Simone P., Toffalori C., Gambacorta V., Greco R., Peccatori J., Casucci M., Casorati G., Dellabona P., Onozawa M., Teshima T., Griffioen M., Halkes C. J. M., Falkenburg J. H. F., Stolzel F., Altmann H., Bornhauser M., Waterhouse M., Zeiser R., Finke J., Cieri N., Bondanza A., Vago L., Ciceri F., and Bonini C.

Abstract

The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of Inhibitory Receptors (IR; PD-1/CTLA-4/TIM-3/LAG-3/2B4/KLRG1/GITR) on T cells infiltrating the bone marrow (BM) of 32 AML patients relapsing (median 251 days) or maintaining complete remission (CR; median 1 year) after HSCT. A higher proportion of early-differentiated Memory Stem (T SCM ) and Central Memory BM-T cells express multiple IR in relapsing patients than in CR patients. Exhausted BM-T cells at relapse display a restricted TCR repertoire, impaired effector functions and leukemia-reactive specificities. In 57 patients, early detection of severely exhausted (PD-1 + Eomes + T-bet − ) BM-T SCM predicts relapse. Accordingly, leukemia-specific T cells in patients prone to relapse display exhaustion markers, absent in patients maintaining long-term CR. These results highlight a wide, though reversible, immunological dysfunction in the BM of AML patients relapsing after HSCT and suggest new therapeutic opportunities for the disease.

Published
2019

35. Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Author

Xydia, M, Rahbari, R, Ruggiero, E, Macaulay, I, Tarabichi, M, Lohmayer, R, Wilkening, S, Michels, T, Brown, D, Vanuytven, S, Mastitskaya, S, Laidlaw, S, Grabe, N, Pritsch, M, Fronza, R, Hexel, K, Schmitt, S, Mueller-Steinhardt, M, Halama, N, Domschke, C, Schmidt, M, von Kalle, C, Schuetz, F, Voet, T, Beckhove, P, Xydia, M, Rahbari, R, Ruggiero, E, Macaulay, I, Tarabichi, M, Lohmayer, R, Wilkening, S, Michels, T, Brown, D, Vanuytven, S, Mastitskaya, S, Laidlaw, S, Grabe, N, Pritsch, M, Fronza, R, Hexel, K, Schmitt, S, Mueller-Steinhardt, M, Halama, N, Domschke, C, Schmidt, M, von Kalle, C, Schuetz, F, Voet, T, and Beckhove, P

Abstract

Regulatory CD4+ T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we analyze Treg clonal origin in breast cancer patients using T-Cell Receptor and single-cell transcriptome sequencing. While Treg in peripheral blood and breast tumors are clonally distinct, Tconv clones, including tumor-antigen reactive effectors (Teff), are detected in both compartments. Tumor-infiltrating CD4+ cells accumulate into distinct transcriptome clusters, including early activated Tconv, uncommitted Teff, Th1 Teff, suppressive Treg and pro-tumorigenic Treg. Trajectory analysis suggests early activated Tconv differentiation either into Th1 Teff or into suppressive and pro-tumorigenic Treg. Importantly, Tconv, activated Tconv and Treg share highly-expanded clones contributing up to 65% of intratumoral Treg. Here we show that Treg in human breast cancer may considerably stem from antigen-experienced Tconv converting into secondary induced Treg through intratumoral activation.

Published
2021

37. Association of a traditional Mediterranean diet and non-Mediterranean dietary scores with all-cause and cause-specific mortality: prospective findings from the Moli-sani Study

Author

Bonaccio, M., Di Castelnuovo, A., Costanzo, S., De Curtis, A., Persichillo, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., Bonanni, A., Decurtis, A., Dicastelnuovo, A., Diprospero, T., Vermylen, J., DePaula Carrasco, I., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., Olivieri, M., Gialluisi, A., Gianfagna, F., Ruggiero, E., Magnacca, S., Izzi, B., Marotta, A., Noro, F., Delucia, F., Bracone, F., Dudiez, S., Rago, L., and Panzera, T.

Subjects
0301 basic medicine, Adult, Male, Mediterranean diet, DASH diet, Population, Medicine (miscellaneous), 030209 endocrinology & metabolism, Lower risk, Diet, Mediterranean, 03 medical and health sciences, 0302 clinical medicine, Palaeolithic diet, Risk Factors, Cause of Death, CVD risk factors, Inflammation, Mortality, Nordic diet, Dash, Risk of mortality, Medicine, Humans, Prospective Studies, education, education.field_of_study, 030109 nutrition & dietetics, Nutrition and Dietetics, Proportional hazards model, business.industry, Hazard ratio, Italy, Cardiovascular Diseases, Female, business, Demography
Abstract

To evaluate in an Italian general population, the association with mortality of a traditional Mediterranean diet (MD) and non-Mediterranean dietary (non-MD) patterns, and their combined effect, and to test some biomarkers of cardiovascular (CVD) risk as potential mediators of such associations. Longitudinal analysis on 22,849 men and women aged ≥ 35 years, recruited in the Moli-sani Study (2005–2010), followed up for 8.2 years (median). The MD was assessed by the Mediterranean diet score (MDS). The Dietary Approaches to Stop Hypertension (DASH), the Palaeolithic diet, and the Nordic diet were chosen as reportedly healthy non-MD patterns. Hazard ratios (HR) with 95% confidence intervals (95% CI) were calculated by multivariable Cox regression. Participants reaching higher MDS or DASH diet score experienced lower risk of both all-cause (HR 0.77; 95% CI 0.66–0.90 and 0.81; 0.69–0.96, respectively, highest vs lowest quartile) and CVD (0.77; 0.59–1.00 and 0.81; 0.69–0.96, respectively) death risk; risk reduction associated with the Palaeolithic diet was limited to total and other cause death, whereas the Nordic diet did not alter risk of mortality. Increasing adherence to MD was associated with higher survival in each stratum of non-MD diets. Biomarkers of glucose metabolism accounted for 7% and 21.6% of the association between either MDS or DASH diet, respectively, with total mortality risk. Both the traditional MD and DASH diet may reduce risk of all-cause mortality among Italians, as well as risk of dying from cardiovascular causes. The Palaeolithic diet did not appear to reduce cardiovascular risk, while the Nordic eating pattern was unlikely to be associated with any substantial health advantage.

Published
2020

38. Bridging the academic and practice/policy gap in public health:Perspectives from Scotland and Canada

Author

McAteer, John, Di Ruggiero, E., Fraser, A, and Frank, John

Subjects
organizations, Canada, models, research, Scotland, public health, organizational, public health medicine
Abstract

This article presents a critical commentary of specific organizational models and practices for bridging ‘the gap’ between public health research and policy and practice. The authors draw on personal experiences of such models in addition to the wider knowledge translation and exchange literature to reflect on their strengths and weaknesses as implemented in Scotland and Canada since the early 1990s.

Published
2019
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39. Evaluation of nutritional quality of biscuits and sweet snacks sold on the Italian market: The Food Labelling of Italian Products (FLIP) study

Author

Dall'Asta, M., Rosi, A., Angelino, D., Pellegrini, N., Martini, D., Nucci, D., Paolella, G., Ruggiero, E., Pignone, V., Moccia, S., Spagnuolo, C., Dello Russo, M., Dall'Asta M. (ORCID:0000-0002-0558-0337), Dall'Asta, M., Rosi, A., Angelino, D., Pellegrini, N., Martini, D., Nucci, D., Paolella, G., Ruggiero, E., Pignone, V., Moccia, S., Spagnuolo, C., Dello Russo, M., and Dall'Asta M. (ORCID:0000-0002-0558-0337)

Abstract

Objective:The present study aimed at surveying the nutritional quality of prepacked biscuits and sweet snacks sold on the Italian market, and at identifying whether the product type and other information reported on the pack could discriminate the overall quality of products analysed.Design:Data on energy, nutrient and salt content of the products from two different categories of prepacked sweet cereal products (i.e. biscuits and sweet snacks) were collected from thirteen retailers present on the Italian market. Based on the product type, nutrition and health claim (NHC) and gluten-free (GF) declaration, a comparison of nutrient profile within each category was performed.Setting:This work is part of the Food Labelling of Italian Products (FLIP) study that aims at systematically investigating the overall quality of the prepacked foods sold on the Italian market.Results:A total of 1290 products were analysed (63 % biscuits and 37 % sweet snacks). After comparing different product types within each category, a high intra-type product variability was evidenced, which was more pronounced for biscuits. Overall, NHC-carrying products seemed to have a better nutrition profile than those without claims, except for salt content. Conversely, a comparison between GF and gluten-containing products did not show consistent results within the two categories analysed.Conclusions:Due to the high intra-type variability within each category, the different characteristics and regulated information reported on the pack do not seem to be a clear marker of the overall nutritional quality of biscuits and snacks.

Published
2020

40. Evaluation of the nutritional quality of breakfast cereals sold on the italian market: The food labelling of italian products (flip) study

Author

Angelino, D., Rosi, A., Dall'Asta, M., Pellegrini, N., Martini, D, Dello Russo, M, Moccia, S, Nucci, D, Paolella, G, Pignone, V, Ruggiero, E, and Spagnuolo, C

Subjects
0301 basic medicine, Dietary Sugars, Declaration, Distribution (economics), Breakfast cereals, Food labelling, Gluten free, Nutrition and health claims, Nutrition declaration, Nutritional quality, Diet, Gluten-Free, Dietary Fats, Edible Grain, Humans, Italy, Recommended Dietary Allowances, Sodium Chloride, Dietary, Breakfast, Commerce, Diet, Healthy, Food Labeling, Nutritive Value, Sodium Chloride, Agricultural science, 0302 clinical medicine, Nutrition and Dietetics, Food label, lcsh:Nutrition. Foods and food supply, Dietary, 030209 endocrinology & metabolism, lcsh:TX341-641, Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE, Article, 03 medical and health sciences, food, Sugar, Healthy, 030109 nutrition & dietetics, business.industry, Breakfast cereal, food.food, Diet, Gluten-Free, Business, Food Science
Abstract

Breakfast cereals are present on the market as different types and, in general, are one of the food categories in which voluntary information, such as nutrition or health claims (NHC) or gluten free (GF) declarations, have the largest distribution. The aims of the present study were to compare (i) the nutritional declaration among different types of breakfast cereals, as well as among products with and without NHC or GF declarations, and (ii) the salt and sugar contents with the &ldquo, Italian shared objectives for the improvement of the nutritional characteristics of food&rdquo, To this aim, the nutrition declarations of 371 different breakfast cereal items, available in 13 retailers present on the Italian market, were analysed. Data showed an elevated inter-product variability, with cereal bars and muesli having the highest energy, total fat, and saturate contents per 100 g. Limited differences were found comparing products with and without NHC, as well as those with GF declaration. Most of the breakfast cereals were compliant to the shared objectives, although some items with NHC or GF declaration still have sugar or salt contents higher than these objectives. In conclusion, these data suggest that the different characteristics and the regulated information reported on the food label should not be considered as a marker of the overall nutritional quality. Thus, this study supports the importance of reading and understanding the information made on food label.

Published
2019
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44. P169 Activated effector T cells co-expressing multiple inhibitory receptors are enriched in the tumor immune microenvironment of HGSOC expressing high and uniform WT-1 antigen

Author

Bergamini, A, primary, Tassi, E, additional, Wignall, J, additional, Ruggiero, E, additional, Bocciolone, L, additional, Candiani, M, additional, Potenza, A, additional, Manfredi, F, additional, Taccagni, G, additional, Scalisi, F, additional, Doglioni, C, additional, Schultes, B, additional, McKee, M, additional, Mangili, G, additional, and Bonini, C, additional

Published
2019
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45. Structural and dielectric properties of hot-pressed PVDF-based composites

Author

Ruggiero, E., Reboredo, Maria Marta, and Castro, Miriam Susana

Subjects
Recubrimientos y Películas, BaTiO3, Dielectric properties, Ingeniería de los Materiales, Físico-Química, Ciencia de los Polímeros, Electroquímica, PVDF, ZnO, Ciencias Químicas, INGENIERÍAS Y TECNOLOGÍAS, Poly(vinylidene fluoride), Polymer composite, CIENCIAS NATURALES Y EXACTAS
Abstract

The characterization of ceramic/polymer composites was performed on zinc oxide/ poly(vinylidene fluoride) - ZnO/PVDF and barium titanate/poly(vinylidene fluoride) - BT/PVDF composites with varying filler concentration in order to evaluate the main interactions responsible for the composite dielectric behavior. The materials, PVDF and its composites, were melt-blended using a two-roller mixer and then hot-pressed. The permittivity of composites was enhanced compared with that of the pure PVDF with the addition of 20 w/w% of ZnO particles. However, samples with 40 or 60 w/w% of ZnO registered a diminution in the real permittivity values which was connected to particle-matrix adhesion problems. On the other hand, BT composites presented a more homogeneous morphology with less presence of voids and a better adhesion between the filler and the polymer, where real permittivity increased with the addition of BT particles. Fil: Ruggiero, E.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina Fil: Reboredo, Maria Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina Fil: Castro, Miriam Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina

Published
2017
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46. Riboflavin as a bioorthogonal photocatalyst for the activation of a PtIV prodrug

Author

Alonso-de Castro, S., Ruggiero, E., Ruiz-de-Angulo, A., Rezabal, E., Mareque-Rivas, J.C, Lopez, X, López-Gallego, F, and Salass, L

Abstract

Encouraging developments demonstrate that few transition metal and organometallic catalysts can operate in a bioorthogonal fashion and promote non-natural chemistry in living systems by minimizing undesired side reactions with cellular components. These catalytic processes have potential for applications in medicinal chemistry and chemical biology. However, the stringent conditions of the cell environment severely limit the number of accessible metal catalysts and exogenous reactions. Herein, we report an unorthodox approach and a new type of bioorthogonal catalytic reaction, in which a metal complex is an unconventional substrate and an exogenous biological molecule acts as a catalyst. In this reaction, riboflavin photocatalytically converts a PtIV prodrug into cisplatin within the biological environment. Due to the catalytic activity of riboflavin, cisplatin-like apoptosis is induced in cancer cells under extremely low doses of light, potentially preventing systemic off-target reactions. Photocatalytic and bioorthogonal turnover of PtIV into PtII species is an attractive strategy to amplify the antineoplastic action of metal-based chemotherapeutics with spatio-temporal control.

Published
2017

50. Searches for lepton number violation and resonances in K± → πμμ decays

Author

Batley, Kalmus, J. R., G, Lazzeroni, G., Munday, C., Slater, D. J., Wotton, M. W., Arcidiacono, S. A., Bocquet, R., Cabibbo, G., Ceccucci, N., Cundy, A., Falaleev, D., Fidecaro, V., Gatignon, M., Gonidec, L., Kubischta, A., Maier, W., Massri, A., Norton, K., Patel, A., Peters, M., Balev, A., Frabetti, S., Gersabeck, P. L., Goudzovski, E., Hristov, E., Kekelidze, P., Kozhuharov, V., Litov, V., Madigozhin, L., Molokanova, D., Polenkevich, N., Potrebenikov, I., Stoynev, Y., Zinchenko, S., Monnier, A., Swallow, E., Winston, E., Rubin, R., Walker, P., Baldini, A., Cotta Ramusino, W., Dalpiaz, A., Damiani, P., Fiorini, C., Gianoli, M., Martini, A., Petrucci, M., Savrié, F., Scarpa, M., Wahl, M., Bizzeti, H., Lenti, A., Veltri, M., Calvetti, M., Celeghini, M., Iacopini, E., Ruggiero, E., Behler, G., Eppard, M., Kleinknecht, K., Marouelli, K., Masetti, P., Moosbrugger, L., Morales Morales, U., Renk, C., Wache, B., Wanke, M., Winhart, R., Coward, A., Dabrowski, D., Fonseca Martin, A., Shieh, T., Szleper, M., Velasco, M., Wood, M., Cenci, M. D., Pepe, P., Anzivino, M. C., Imbergamo, G., Nappi, E., Piccini, A., Raggi, M., Valdata Nappi, M., Cerri, M., Fantechi, C., Collazuol, Gianmaria, Dilella, G., Lamanna, L., Mannelli, G., Michetti, I., Costantini, A., Doble, F., Fiorini, N., Giudici, L., Pierazzini, S., Sozzi, G., Venditti, M., Bloch Devaux, S., Cheshkov, B., Chèze, C., De Beer, J. B., Derré, M., Marel, J., Mazzucato, G., Peyaud, E., Vallage, B., Holder, B., Ziolkowski, M., Biino, M., Cartiglia, C., Marchetto, N., Bifani, F., Clemencic, S., Goy Lopez, M., Dibon, S., Jeitler, H., Markytan, M., Mikulec, M., Neuhofer, I., and Widhalm, G.

Subjects
lepton, BEAM, 01 natural sciences, 7. Clean energy, Physics, Particles & Fields, High Energy Physics - Experiment, LIMITS, kaon physics, CERN, Intermediate state, lepton number violation, neutrinos, dark matter, kaon physics, Physics, VMSM, Large Hadron Collider, Charge Kaons, neutrinos, Nuclear and High Energy Physics, leptons, Lepton number violation, Nuclear & Particles Physics, Charged particle, lcsh:QC1-999, NEUTRAL HEAVY-LEPTONS, Physics, Nuclear, lepton number violation, Physical Sciences, Particle physics, kaon decays, lepton number violation, Nuclear and High Energy Physics, lepton, kaon meson, lepton number violation, NA48, Socio-culturale, Astronomy & Astrophysics, UPPER-BOUNDS, dark matter, Nuclear physics, 0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics, 0103 physical sciences, DARK-MATTER, PARTICLES, 010306 general physics, Science & Technology, kaon decays, 010308 nuclear & particles physics, Branching fraction, Resonance, Inflaton, Lepton number, kaon meson, NA48, High Energy Physics::Experiment, lcsh:Physics, Lepton
Abstract

The NA48/2 experiment at CERN collected a large sample of charged kaon decays to final states with multiple charged particles in 2003–2004. A new upper limit on the rate of the lepton number violating decay K±→π∓μ±μ± is reported: B(K±→π∓μ±μ±)

Published
2017

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