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Your search keyword '"S., Satya Lakshmi"' showing total 5 results
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5 results on '"S., Satya Lakshmi"'

2. ROSUVASTATIN CALCIUM NANOSPONGES IN THE FORMULATION OF EXTENDED RELEASE TABLETS.

Author

S., Satya Lakshmi, P., Jyothsna, Y., Srinivasa Rao, and P., Naga Mallikarjun

Subjects
*ROSUVASTATIN, *ETHYLCELLULOSE, *POLYVINYL alcohol, *CYCLODEXTRINS
Abstract

Cyclodextrin has been recognized as a linker molecule that can link with the various drug substances to produce a nano-porous structure called nanosponges (NS) and increase the dissolution rate of poorly soluble drug substances. This work aimed to load rosuvastatin calcium (RSC) with solubility enhancer's ß-cyclodextrin (ß-CD) or polyvinyl alcohol (PVA). ß-CD based RSC-NS were fabricated by the emulsion solvent diffusion technique; with solubilizer dichloromethane and different ratios of ethyl cellulose as a co-polymer. Characterization of the prepared nanosponges was done by various testing procedures that confirm its nanosize and particle size and drug release. RSC loading in NS was assessed by DSC, FTIR and SEM. Among all the formulations F5 has 78.23 % entrapment efficiency. 2-3 folds of increased solubility were obtained with RSC-NS. F1-F6 formulations released 76.35 % - 98.69 % of the drug at the end of 30 min. In the preparation of extended-release tablets, NS prepared from F5 formulation was used and the best tablet formulation was selected based on various evaluation tests. All the formulations except S3, S8 followed first-order release kinetics. S1 & S2 drug release mechanism is Higuchi while other formulations are Korsemeyer-Peppas, so the release mechanism for most of the formulations is erosion than diffusion. [ABSTRACT FROM AUTHOR]

Published
2021
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3. Statistical optimization of amylase production and its purification from a palm wine isolate Bacillus sp., Q-164

Author

C.H. Mahesh, K. Aishwarya, K. Gayatri, P. Manisha, and S. Satya Lakshmi

Subjects
0106 biological sciences, Wine, biology, Chemistry, food and beverages, Bacillus, Bioengineering, Environmental pollution, biology.organism_classification, 01 natural sciences, Applied Microbiology and Biotechnology, Hydrolysis, 010608 biotechnology, biology.protein, Fermentation, Amylase, Food science, Response surface methodology, Agronomy and Crop Science, Bacteria, 010606 plant biology & botany, Food Science, Biotechnology
Abstract

Adaptation of eco-friendly fermentation methods not only reduce environmental pollution and also reduce the cost of large scale production of enzymes. In the present study, the most significant amylase producing strain was isolated from palm wine and identified as Bacillus sp., Q-164 by the molecular 16SrRNA sequence technique. The bacterium exhibited maximum enzyme production in 3 days of the time interval, at neutral pH with 1% of lotus and pineapple stem residues. Enzyme yield further improved to 126.17 ± 0.2 U/mL and 113.4 ± 0.26 U/mL by acid hydrolyzed lotus and pineapple stems respectively. Three factors were selected to optimize amylase production statistically by Response Surface Methodology (RSM). The most significant factors that promote maximum enzyme production were ATLS, temperature, and peptone concentration (P

Published
2020
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4. Formulation and evaluation of rosuvastatin-calcium drug transdermal patch

Author

Y. Srinivasa Rao, P.N. Mallikarjun, D. Asha, S. Satya Lakshmi, and P. V. Kamala Kumari

Subjects
Drug, Chromatography, Transdermal patch, Chemistry, media_common.quotation_subject, nutritional and metabolic diseases, medicine.disease_cause, Bioavailability, Solvent, First pass effect, Rosuvastatin Calcium, medicine, Pharmacology (medical), Solubility, Irritation, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), media_common
Abstract

Rosuvastatin calcium is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Like remaining statins Rosuvastatin-calcium is also a poorly soluble drug and not exceeding 20% of bioavailability due to first pass metabolism. To overcome these drawbacks the present study aimed to formulate transdermal patch of Rosuvastatin calcium. Totally seven patches were developed by incorporating HPMC and PVP using solvent casting method. The formulations were evaluated for hardness, compatibility studies, solubility, weight variation, thickness, physical appearance, tensile strength, % drug content, % moisture content, % moisture uptake and in vitro drug release. The evaluated parameters were within the limit only. FTIR spectroscopy revealed that the drug, polymers and other excipients were compatible with each other. When compared to other formulations T1 formulation exhibited better in vitro drug release profile across the cellulose membrane. The skin irritation studies using rabbits revealed no signs of irritation or oedema, which confirms that the drug loaded and plain patches were compatible with skin. The trandermal patch loaded with Rosuvastatin-calcium used conveniently as an antilipemic agent.

Published
2020
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