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In this article, Fishbone-based advanced computational thinking (FACT) pedagogy is proposed by fusing fishbone pedagogy and computational thinking pedagogy for enhancing teaching-learning process while teaching engineering and science courses, for engineering and science students respectively. The proposed FACT pedagogy has been implemented using the concept of X-ray machine in biomedical instrumentation course and biomolecules, in biochemistry course. Using fishbone approach, various components of X-ray machine in biomedical course and the components of biomolecules in biochemistry course are visually explained as ribs and riblets of a fishbone diagram, without coining the keywords X-ray and biomolecules in an engineering institution and science institution respectively. Finally, the targeted concept is arrived and explained. Similarly, the same concepts of X-ray and biomolecules are coined among students and they are asked to divide or decompose the concepts into sub-concepts separately. To implement and evaluate the proposed pedagogy, an engineering institution and a science institution have been selected and evaluation results have been published in this article. In this pedagogical approach, the same complex concept is taught as a backward thinking by the teacher using fishbone pedagogy and forward thinking by the students using computational thinking pedagogy. This combined approach helps students to understand any complex concept in science courses. Also, it helps the teachers to easily convey and embed the same among the student community while teaching science courses.

Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases. This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes. Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes.

Conventional Maximum Power Point Tracking (MPPT) controllers in photovoltaic (PV) systems are seen to achieve tracking speeds in range of milliseconds. Power-electronic circuits in these systems many-a-time demand faster control actions in microseconds, as they operate at high frequencies, and also, a delay in control action would lead to a corresponding power-loss. Hence, an MPPT controller delivering such fast tracking speeds would improve overall system performance. In this work, an Field Programmable Gate Array (FPGA) based Statechart Controller is developed to perform MPPT control of the PV system. The developed Statechart Controller is tested using software-in-the-loop simulation(SILS) and results are presented. With inputs from a programmable logic controller emulating PV characteristic curves, the Statechart Controller is then deployed in a target FPGA. A comparison between performance with conventional MPPT controller and Statechart Controller is presented and results indicate that the latter is more effective in terms of tracking speeds, determinism, and modularity. [ABSTRACT FROM AUTHOR]

Background: Considering the high cost of fertilizers and adverse effect of its overuse on environment and soil health, proper organic manure-fertilizer recommendations on the basis of soil test values, residual effect and yield targets of chilli becomes vital. Methods: Field experiment was carried out on Periyanaickenpalayam soil series of Inceptisol soil order at farmers holding, Dindigul, Tamil Nadu during 2021-2022 after establishment of marked fertility gradient with respect to soil available N, P and K by gradient experiment with fodder sorghum. The test crop experiment with chilli was laid out in a fractional factorial design comprising of 24 treatments with 4 levels of N (0, 50, 100 and 150 kg ha-1), 4 levels for both phosphorus pentoxide (P2O5) and potassium dioxide (K2O). Farmyard manure (FYM) levels were 0, 6.25 and 12.5 kg ha-1. From the field experiment data, the fundamental parametersnutrient requirement (NR) and nutrients contributions from soil (Cs), fertiliser (Cf) and farmyard manure (Co)-were determined. Result: The percentage of nutrients estimated from fertiliser (%Cf) that contributed towards the total amount of nutrients taken up by dry chilli was calculated to be 44.09, 39.29 and 76.91 per cent of N, P2O5 and K2O, respectively. K2O>N>P2O5 was seen as the order of the fertiliser nutrient per cent contributions to total nutrient uptake. Incase of nutrient contribution form soil (% Cs) the order is P2O5>N>K2O. FYM contributed (% Co) 29.42, 14.40 and 38.73 per cent of N, P2O5 and K2O. One quintal of dry chilli production was estimated to require (NR) 4.24 kg of nitrogen, 1.91 kg of phosphorus pentoxide (P2O5) and 4.80 kg of potassium oxide (K2O) as nutrients. Fertiliser prescription equations (FPEs) for dry chilli and ready reckoners for the operating range of soil test values for the intended yield target experiment under NPK alone and IPNS were built using basic data. [ABSTRACT FROM AUTHOR]

In the advent of precision agriculture, applying fertilizer based on soil testing is a crucial tool to prescribe nutrient levels for crops, to increase nutrient use efficiency and production. A field experiment was conducted in a farmer's field in the Dindigul district, Southern agro-climatic zone of Tamil Nadu to ascertain the effect of artificial soil fertility gradient method on soil fertility, green fodder production of sorghum (Sorghum bicolor (L.) Moench) (var. CO 30) and nutrient absorption. A fertility gradient technique has been investigated to produce fertilizer recommendations for location-specific in red soils (Alfisols, Typic Rhodustalf). The experimental field was separated into three equal strips: strip I, II, and III, which received applications of the three graded levels of ertilizer N0P0K0, N1P1K1, and N2P2K2, respectively. Urea, single super phosphate, and muriate of potash fertilizers, respectively, were used to apply NPK. As a gradient crop, S. bicolor was raised. The N1 level was set based on the general fertilizer recommendation of feed sorghum, while the P1 and K1 values were set based on the soil’s ability to fix 100 kg ha-1 of phosphorus and 100 kg ha-1 of potassium, respectively. Plant samples were taken at harvest time, and their NPK content and nutrient uptake were determined. With addition of graded doses of nitrogen, phosphorus and potassium fertilizer in Strip I, II & III increased the soil's available N, P & K status substantially in the order of Strip I

Neutrosophic set and Neutrosophic Topological spaces has been introduced by Salama. Neutrosophic Closed set and Neutrosophic Continuous Functions were introduced by Salama et. al.. In this paper, we introduce the concept of Nω- closed sets and their properties in Neutrosophic topological spaces.