1. Epidemiology and outcome of Clostridium difficile infections in patients hospitalized in Internal Medicine: findings from the nationwide FADOI-PRACTICE study
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Giorgio Cioni, Pierluigi Viale, Stefania Frasson, Francesco Cipollini, Francesco Menichetti, Nicola Petrosillo, Sergio Brunati, Patrizia Spigaglia, Chiara Vismara, Alessandra Bielli, Fabrizio Barbanti, Giancarlo Landini, Grazia Panigada, Gualberto Gussoni, Erminio Bonizzoni, Giovanni Pietro Gesu, and for the Research Department of FADOI
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Clostridium difficile ,Internal Medicine ,Incidence ,Predictors ,Outcome ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Clostridium difficile (CD) is a leading cause of diarrhoea among hospitalized patients. The objective of this study was to evaluate the rate, the optimal diagnostic work-up, and outcome of CD infections (CDI) in Internal Medicine (IM) wards in Italy. Methods PRACTICE is an observational prospective study, involving 40 IM Units and evaluating all consecutive patients hospitalized during a 4-month period. CDI were defined in case of diarrhoea when both enzyme immunoassay for GDH, and test for A/B toxin were positive. Patients with CDI were followed-up for recurrences for 4 weeks after the end of therapy. Results Among the 10,780 patients observed, 103 (0.96 %) showed CDI, at admission or during hospitalization. A positive history for CD, antibiotics in the previous 4 weeks, recent hospitalization, female gender and age were significantly associated with CDI (multivariable analysis). In-hospital mortality was 16.5 % in CD group vs 6.7 % in No-CD group (p
- Published
- 2016
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