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20 results on '"Shahnaij, Mohammad"'

5. Shigella infections in household contacts of pediatric shigellosis patients in rural Bangladesh

Author

George, Christine Marie, Ahmed, Shahnawaz, Talukder, Kaisar A., Azmi, Ishrat J., Perin, Jamie, Sack, R. Bradley, Sack, David A., Stine, O. Colin, Oldja, Lauren, Shahnaij, Mohammad, Chakraborty, Subhra, Parvin, Tahmina, Bhuyian, Sazzadul Islam, Bouwer, Edward, Zhang, Xiaotong, Hasan, Trisheeta N., Luna, Sharmin J., Akter, Fatema, and Faruque, Abu S.G.

Subjects
Health aspects, Bacillary dysentery -- Health aspects, Pediatrics -- Health aspects, Infection -- Health aspects, Households -- Health aspects
Abstract

In South Asia and Africa, an estimated 88.5 million diarrhea episodes are attributed to Shigella infections annually (1). Shigellosis occurs most often in children < 5 years of age (2,3). [...]

Published
2015
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6. Liver-Directed AAV8 Booster Vaccine Expressing Plasmodium falciparum Antigen Following Adenovirus Vaccine Priming Elicits Sterile Protection in a Murine Model

Author

Shahnaij, Mohammad, primary, Iyori, Mitsuhiro, additional, Mizukami, Hiroaki, additional, Kajino, Mayu, additional, Yamagoshi, Iroha, additional, Syafira, Intan, additional, Yusuf, Yenni, additional, Fujiwara, Ken, additional, Yamamoto, Daisuke S., additional, Kato, Hirotomo, additional, Ohno, Nobuhiko, additional, and Yoshida, Shigeto, additional

Published
2021
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7. 669 GASTROINTESTINAL DISEASE-RELATED SINGLE-NUCLEOTIDE VARIANTS (SNVS) COLOCALIZE WITH CIS-REGULATORY ELEMENTS (CRES) OF THE ELECTRICAL SLOW WAVE (SW)-ASSOCIATED GENE SLC4A4 IN A HUMAN MODEL OF PACEMAKER INTERSTITIAL CELLS OF CAJAL (ICC)

Author

Shahnaij, Mohammad, Bhagwate, Aditya V., Bonfiglio, Ferdinando, LEE, JEONG-HEON, Hayashi, Yujiro, Wertish, Natalie R., Strege, Peter R., Linden, David R., Cipriani, Gianluca, Hsi, Linda C., Romero, Michael F., D'Amato, Mauro, Farrugia, Gianrico, and Ordog, Tamas

Published
2023
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8. PCR-Based Method for Shigella flexneri Serotyping: International Multicenter Validation

Author

Brengi, Silvina P., primary, Sun, Qiangzheng, additional, Bolaños, Hilda, additional, Duarte, Francisco, additional, Jenkins, Claire, additional, Pichel, Mariana, additional, Shahnaij, Mohammad, additional, Sowers, Evangeline G., additional, Strockbine, Nancy, additional, Talukder, Kaisar A., additional, Derado, Gordana, additional, Viñas, María Rosa, additional, Kam, Kai Man, additional, and Xu, Jianguo, additional

Published
2019
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12. Enteric Infections in Young Children are Associated with Environmental Enteropathy and Impaired Growth

Author

George, Christine Marie, primary, Burrowes, Vanessa, additional, Perin, Jamie, additional, Oldja, Lauren, additional, Biswas, Shwapon, additional, Sack, David, additional, Ahmed, Shahnawaz, additional, Haque, Rashidul, additional, Bhuiyan, Nurul Amin, additional, Parvin, Tahmina, additional, Bhuyian, Sazzadul Islam, additional, Akter, Mahmuda, additional, Li, Shan, additional, Natarajan, Gayathri, additional, Shahnaij, Mohammad, additional, Faruque, Abu G., additional, and Stine, O. Colin, additional

Published
2017
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13. Mouthing of Soil Contaminated Objects is Associated with Environmental Enteropathy in Young Children

Author

Morita, Tomohiko, primary, Perin, Jamie, additional, Oldja, Lauren, additional, Biswas, Shwapon, additional, Sack, R. Bradley, additional, Ahmed, Shahnawaz, additional, Haque, Rashidul, additional, Bhuiyan, Nurul Amin, additional, Parvin, Tahmina, additional, Bhuyian, Sazzadul Islam, additional, Akter, Mahmuda, additional, Talukder, Kaisar A., additional, Shahnaij, Mohammad, additional, Faruque, Abu G., additional, and George, Christine Marie, additional

Published
2017
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14. Geophagy Is Associated with Environmental Enteropathy and Stunting in Children in Rural Bangladesh

Author

Shahnawaz Ahmed, Kaisar A. Talukder, Shwapon Biswas, Margaret Kosek, Gwenyth O. Lee, R. Bradley Sack, Lauren Oldja, Shahnaij Mohammad, Abu Syeed Golam Faruque, Tahmina Parvin, Sazzadul Islam Bhuyian, Christine Marie George, Rashidul Haque, Jamie Perin, and Ishrat J. Azmi

Subjects
Male, Rural Population, Pediatrics, medicine.medical_specialty, chemistry.chemical_compound, Feces, Soil, Virology, Environmental health, Escherichia coli, Medicine, Humans, Prospective Studies, Risk factor, Prospective cohort study, Growth Disorders, Soil Microbiology, Bangladesh, Environmental enteropathy, business.industry, Neopterin, Infant, Odds ratio, Articles, medicine.disease, Confidence interval, Intestinal Diseases, Infectious Diseases, chemistry, Child, Preschool, Pica, Parasitology, Female, Calprotectin, business
Abstract

There is a growing body of literature indicating an association between stunting and environmental enteropathy (EE), a disorder thought to be caused by repeated exposures to enteric pathogens. To investigate the relationship between exposure to enteric pathogens through geophagy, consumption of soil, EE, and stunting, we conducted a prospective cohort study of 216 children under 5 years of age in rural Bangladesh. Geophagy was assessed at baseline using 5 hour structured observation and caregiver reports. Stool was analyzed for fecal markers of intestinal inflammation: alpha-1-antitrypsin, myeloperoxidase, neopterin (all three combined to form an EE disease activity score), and calprotectin. Eighteen percent of children had observed geophagy events by structured observation and 28% had caregiver reported events in the past week. Nearly all households had Escherichia coli (97%) in soil, and 14% had diarrheagenic E. coli. Children with caregiver-reported geophagy had significantly higher EE scores (0.72 point difference, 95% confidence interval [CI]: 0.01, 1.42) and calprotectin concentrations (237.38 μg/g, 95% CI: 12.77, 462.00). Furthermore, at the 9-month follow-up the odds of being stunted (height-for-age z-score < -2) was double for children with caregiver-reported geophagy (odds ratio [OR]: 2.27, 95% CI: 1.14, 4.51). These findings suggest that geophagy in young children may be an important unrecognized risk factor for EE and stunting.

Published
2015

17. ShigellaInfections in Household Contacts of Pediatric Shigellosis Patients in Rural Bangladesh

Author

George, Christine Marie, primary, Ahmed, Shahnawaz, additional, Talukder, Kaisar A., additional, Azmi, Ishrat J., additional, Perin, Jamie, additional, Sack, R. Bradley, additional, Sack, David A, additional, Stine, O. Colin, additional, Oldja, Lauren, additional, Shahnaij, Mohammad, additional, Chakraborty, Subhra, additional, Parvin, Tahmina, additional, Bhuyian, Sazzadul Islam, additional, Bouwer, Edward, additional, Zhang, Xiaotong, additional, Hasan, Trisheeta N., additional, Luna, Sharmin J., additional, Akter, Fatema, additional, and Faruque, Abu S.G., additional

Published
2015
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18. Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting spp. Serine Protease Autotransporter Subfamily Protein SigA.

Author

Oany, Arafat Rahman, Pervin, Tahmina, Mia, Mamun, Hossain, Motaher, Shahnaij, Mohammad, Mahmud, Shahin, and Kibria, K. M. Kaderi

Subjects
SHIGELLOSIS, DYSENTERY, DIARRHEA, SERINE proteinases, ENTEROBACTERIACEAE, HLA histocompatibility antigens
Abstract

Shigellosis, a bacillary dysentery, is closely associated with diarrhoea in human and causes infection of 165 million people worldwide per year. Casein-degrading serine protease autotransporter of enterobacteriaceae (SPATE) subfamily protein SigA, an outer membrane protein, exerts both cytopathic and enterotoxic effects especially cytopathic to human epithelial cell type-2 (HEp-2) and is shown to be highly immunogenic. In the present study, we have tried to impose the vaccinomics approach for designing a common peptide vaccine candidate against the immunogenic SigA of Shigella spp. At first, 44 SigA proteins from different variants of S. flexneri, S. dysenteriae, S. boydii, and S. sonnei were assessed to find the most antigenic protein. We retrieved 12 peptides based on the highest score for human leukocyte antigen (HLA) supertypes analysed by NetCTL. Initially, these peptides were assessed for the affinity with MHC class I and class II alleles, and four potential core epitopes VTARAGLGY, FHTVTVNTL, HTTWTLTGY, and IELAGTLTL were selected. From these, FHTVTVNTL and IELAGTLTL peptides were shown to have 100% conservancy. Finally, IELAGTLTL was shown to have the highest population coverage (83.86%) among the whole world population. In vivo study of the proposed epitope might contribute to the development of functional and unique widespread vaccine, which might be an operative alleyway to thwart dysentery from the world. [ABSTRACT FROM AUTHOR]

Published
2017
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19. Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA.

Author

Oany, Arafat Rahman, Pervin, Tahmina, Mia, Mamun, Hossain, Motaher, Shahnaij, Mohammad, Mahmud, Shahin, and Kaderi Kibria, K. M.

Subjects
PEPTIDES, SHIGELLA sonnei, SERINE proteinases, IMMUNOGENETICS, ENTEROBACTERIACEAE, THERAPEUTICS
Abstract

Shigellosis, a bacillary dysentery, is closely associated with diarrhoea in human and causes infection of 165 million people worldwide per year. Casein-degrading serine protease autotransporter of enterobacteriaceae (SPATE) subfamily protein SigA, an outer membrane protein, exerts both cytopathic and enterotoxic effects especially cytopathic to human epithelial cell type-2 (HEp-2) and is shown to be highly immunogenic. In the present study, we have tried to impose the vaccinomics approach for designing a common peptide vaccine candidate against the immunogenic SigA of Shigella spp. At first, 44 SigA proteins from different variants of S. flexneri, S. dysenteriae, S. boydii, and S. sonnei were assessed to find the most antigenic protein. We retrieved 12 peptides based on the highest score for human leukocyte antigen (HLA) supertypes analysed by NetCTL. Initially, these peptides were assessed for the affinity with MHC class I and class II alleles, and four potential core epitopes VTARAGLGY, FHTVTVNTL, HTTWTLTGY, and IELAGTLTL were selected. From these, FHTVTVNTL and IELAGTLTL peptides were shown to have 100% conservancy. Finally, IELAGTLTL was shown to have the highest population coverage (83.86%) among the whole world population. In vivo study of the proposed epitope might contribute to the development of functional and unique widespread vaccine, which might be an operative alleyway to thwart dysentery from the world. [ABSTRACT FROM AUTHOR]

Published
2017
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20. PCR-Based Method for Shigella flexneriSerotyping: International Multicenter Validation

Author

Brengi, Silvina P., Sun, Qiangzheng, Bolaños, Hilda, Duarte, Francisco, Jenkins, Claire, Pichel, Mariana, Shahnaij, Mohammad, Sowers, Evangeline G., Strockbine, Nancy, Talukder, Kaisar A., Derado, Gordana, Viñas, María Rosa, Kam, Kai Man, and Xu, Jianguo

Abstract

Shigellaspp. are a leading cause of human diarrheal disease worldwide, with Shigella flexneribeing the most frequently isolated species in developing countries.

Published
2019
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