Search

The article "The rise of non-typhoidal Salmonella: an emerging global public health concern" published in Frontiers in Microbiology discusses the increasing threat of non-typhoidal Salmonella infections, primarily transmitted through contaminated food. The paper highlights the rising incidence rates of NTS infections globally, focusing on regions like Sub-Saharan Africa, Asia, the United States, and Europe. It also addresses the challenges posed by antibiotic resistance in NTS strains and the economic burden associated with healthcare expenditures and productivity losses. The article concludes with recommendations for enhancing global efforts to monitor and control NTS outbreaks, emphasizing the importance of improving food safety standards, managing antibiotic resistance, and promoting public health interventions like clean water and sanitation. [Extracted from the article]

Gold nanoparticles (AuNPs) exhibit great promise in cancer therapy and drug delivery due to their unique physicochemical properties. The utilization of plant extracts and phytochemicals for the synthesis of AuNPs offers a simple, rapid, eco-friendly, and cost-effective alternative. This review provides an in-depth analysis of the role of plant-mediated AuNPs in cancer treatment, focusing on their core mechanisms, drug delivery applications, and future potential. It emphasizes the advantages of green synthesis methods for cancer therapy, detailing the processes involved and highlighting various plants used for nanoparticle biosynthesis. The review also explores the anti-cancer effects of plant-mediated AuNPs, such as their ability to selectively target cancer cells and induce apoptosis, supported by both in vitro and in vivo studies. Additionally, the application of these nanoparticles in targeted drug delivery for cancer therapy is examined. The review addresses biocompatibility and toxicity concerns, providing insights into the safety of these nanoparticles. Future research directions and challenges are discussed to overcome current limitations and maximize their clinical applicability. In summary, plant-mediated AuNPs offer a sustainable and effective approach for cancer therapy and drug delivery, with their green synthesis and diverse anti-cancer properties highlighting their potential. Further research is essential to fully realize their clinical benefits. [ABSTRACT FROM AUTHOR]

Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB. [ABSTRACT FROM AUTHOR]